Click here to switch to the map view.

The map label for this gene is adhc1 [H]

Identifier: 119867921

GI number: 119867921

Start: 1995332

End: 1996384

Strand: Reverse

Name: adhc1 [H]

Synonym: Mkms_1883

Alternate gene names: 119867921

Gene position: 1996384-1995332 (Counterclockwise)

Preceding gene: 119867922

Following gene: 119867919

Centisome position: 34.8

GC content: 67.81

Gene sequence:

>1053_bases
ATGGGTATCACTGTTTCTGCTTATGCCGCCACGTCGGCGACCGCACCGTTGACCGAGACCACGATCACGCGCCGCGAGGT
CGGTCCGCACGACGTCGCCTTCGACATCCACTTCAGCGGCATCTGCCACTCCGACATCCACACCGTCAAGGGCGAGTGGG
GCCGCACGCAGTACCCGATCGTGCCGGGTCACGAGATCGCGGGCGTGGTGACCGAGGTCGGCGCCGAGGTGACGAAGTAC
AAGGTCGGCGACCGTGTCGGCGTGGGCTGTTTCGTGGACTCGTGCCGTGAGTGCGACAACTGCCGCGCCGGCATCGAGCA
GTACTGCACCGGCTCCGGCATGGTCGGCACCTACAACGCCGTCGGCCGCGACGGCGAGCGCACCCAGGGCGGGTACAGCG
GCGCGATCGTCGTCGACGAGAACTACGTGCTGCGCATCCCCGACGCGCTGCCCCTCGACGCCGCGGCACCGCTGCTGTGC
GCCGGCATCACCACCTACTCGCCACTGCGGCACTGGAACGCCGGGCCGGGCAGCCGCGTGGCGGTGATCGGGCTCGGCGG
ACTGGGCCACCTGGCCGTCAAGCTCGCCAAGGCGATGGGCGCGGAGGTCACCGTGCTCAGCCAGTCGCTGAAGAAGATGG
AGGACGGGCTGCGGCTCGGCGCCGACGCCTACTACGCCACCTCGGATCCGGACACCTTCGCCGAGCTGAAGGGCACCTTC
GACCTGATCCTCAATACCGTCTCGGCCAATATCGACCTCGCAGCGATCTTGAGCCTGCTGCGCGTCGACGGCACGGTGGT
CGAACTCGGCATGCCCGAGCACCCGATGTCGGTGCCGGCCGGTGCACTCATCGGCGGCCGCCGCAGCATCTCCGGCTCGC
TGATCGGTGGCATCGCCGAAACCCAGGAGATGCTGGACTTCTGCGCCGAACACGGGGTGCGTCCGGAGATCGAGATCATC
GAACCGACCTACATCAACGAGGCGTACGAGCGCGTGGTCGCCAGCGATGTGCGGTACCGATTCGTCATCGACACCGCGGC
ACTGCGCAACTGA

Upstream 100 bases:

>100_bases
ATCCCGGTCGGGGATCGATCGGTTCCCGCGACCCGTTGCCTTATGGGGGTGCCGCATCGTCGCGGCCCGAATTGCGAGAT
TTTCCTGACAAAGAGGACTG

Downstream 100 bases:

>100_bases
CCTACGACTGACCTAAGACGACAGCGGCCGGATTGCGGTTACCCCGCAATCCGGCCGCTGTCGTTTCGGCTCAGACGCCC
AGCGTGCGCTGGATGTCGCC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MGITVSAYAATSATAPLTETTITRREVGPHDVAFDIHFSGICHSDIHTVKGEWGRTQYPIVPGHEIAGVVTEVGAEVTKY
KVGDRVGVGCFVDSCRECDNCRAGIEQYCTGSGMVGTYNAVGRDGERTQGGYSGAIVVDENYVLRIPDALPLDAAAPLLC
AGITTYSPLRHWNAGPGSRVAVIGLGGLGHLAVKLAKAMGAEVTVLSQSLKKMEDGLRLGADAYYATSDPDTFAELKGTF
DLILNTVSANIDLAAILSLLRVDGTVVELGMPEHPMSVPAGALIGGRRSISGSLIGGIAETQEMLDFCAEHGVRPEIEII
EPTYINEAYERVVASDVRYRFVIDTAALRN

Sequences:

>Translated_350_residues
MGITVSAYAATSATAPLTETTITRREVGPHDVAFDIHFSGICHSDIHTVKGEWGRTQYPIVPGHEIAGVVTEVGAEVTKY
KVGDRVGVGCFVDSCRECDNCRAGIEQYCTGSGMVGTYNAVGRDGERTQGGYSGAIVVDENYVLRIPDALPLDAAAPLLC
AGITTYSPLRHWNAGPGSRVAVIGLGGLGHLAVKLAKAMGAEVTVLSQSLKKMEDGLRLGADAYYATSDPDTFAELKGTF
DLILNTVSANIDLAAILSLLRVDGTVVELGMPEHPMSVPAGALIGGRRSISGSLIGGIAETQEMLDFCAEHGVRPEIEII
EPTYINEAYERVVASDVRYRFVIDTAALRN
>Mature_349_residues
GITVSAYAATSATAPLTETTITRREVGPHDVAFDIHFSGICHSDIHTVKGEWGRTQYPIVPGHEIAGVVTEVGAEVTKYK
VGDRVGVGCFVDSCRECDNCRAGIEQYCTGSGMVGTYNAVGRDGERTQGGYSGAIVVDENYVLRIPDALPLDAAAPLLCA
GITTYSPLRHWNAGPGSRVAVIGLGGLGHLAVKLAKAMGAEVTVLSQSLKKMEDGLRLGADAYYATSDPDTFAELKGTFD
LILNTVSANIDLAAILSLLRVDGTVVELGMPEHPMSVPAGALIGGRRSISGSLIGGIAETQEMLDFCAEHGVRPEIEIIE
PTYINEAYERVVASDVRYRFVIDTAALRN

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=317, Percent_Identity=29.9684542586751, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI34577061, Length=317, Percent_Identity=29.3375394321767, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI262073058, Length=317, Percent_Identity=27.4447949526814, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=317, Percent_Identity=27.4447949526814, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501929, Length=308, Percent_Identity=28.2467532467532, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI71565154, Length=215, Percent_Identity=32.5581395348837, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI71565152, Length=222, Percent_Identity=28.3783783783784, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=351, Percent_Identity=53.2763532763533, Blast_Score=331, Evalue=4e-92,
Organism=Escherichia coli, GI87082401, Length=341, Percent_Identity=37.2434017595308, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI87081918, Length=329, Percent_Identity=30.0911854103343, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788075, Length=280, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082125, Length=260, Percent_Identity=29.6153846153846, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790045, Length=304, Percent_Identity=27.9605263157895, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787863, Length=307, Percent_Identity=25.7328990228013, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788073, Length=223, Percent_Identity=27.3542600896861, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI226510992, Length=265, Percent_Identity=27.1698113207547, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788407, Length=201, Percent_Identity=29.3532338308458, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790718, Length=302, Percent_Identity=26.8211920529801, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786825, Length=189, Percent_Identity=30.1587301587302, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=346, Percent_Identity=27.1676300578035, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562584, Length=350, Percent_Identity=28.5714285714286, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=322, Percent_Identity=28.2608695652174, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=204, Percent_Identity=31.8627450980392, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=200, Percent_Identity=31, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=216, Percent_Identity=31.4814814814815, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=218, Percent_Identity=31.651376146789, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=183, Percent_Identity=31.6939890710383, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=320, Percent_Identity=40, Blast_Score=208, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6319949, Length=327, Percent_Identity=36.697247706422, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=31.9018404907975, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324486, Length=332, Percent_Identity=33.433734939759, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319621, Length=338, Percent_Identity=30.1775147928994, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=29.483282674772, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319258, Length=297, Percent_Identity=27.9461279461279, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=237, Percent_Identity=31.6455696202532, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=283, Percent_Identity=27.208480565371, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=309, Percent_Identity=25.8899676375405, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=309, Percent_Identity=25.8899676375405, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737895, Length=370, Percent_Identity=27.5675675675676, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737897, Length=201, Percent_Identity=30.3482587064677, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17137530, Length=201, Percent_Identity=29.8507462686567, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37088; Mature: 36956

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGITVSAYAATSATAPLTETTITRREVGPHDVAFDIHFSGICHSDIHTVKGEWGRTQYPI
CCEEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEEECCEECCCHHHHCCCCCCCCCCC
VPGHEIAGVVTEVGAEVTKYKVGDRVGVGCFVDSCRECDNCRAGIEQYCTGSGMVGTYNA
CCCHHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHH
VGRDGERTQGGYSGAIVVDENYVLRIPDALPLDAAAPLLCAGITTYSPLRHWNAGPGSRV
CCCCCCCCCCCCCEEEEECCCEEEECCCCCCCCHHCHHHHHCCCCCCHHHCCCCCCCCEE
AVIGLGGLGHLAVKLAKAMGAEVTVLSQSLKKMEDGLRLGADAYYATSDPDTFAELKGTF
EEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCEEEECCCCHHHHHHHHHH
DLILNTVSANIDLAAILSLLRVDGTVVELGMPEHPMSVPAGALIGGRRSISGSLIGGIAE
HHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEECCCCCCCCHHHHHHHH
TQEMLDFCAEHGVRPEIEIIEPTYINEAYERVVASDVRYRFVIDTAALRN
HHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCEEEEEEEHHHHCC
>Mature Secondary Structure 
GITVSAYAATSATAPLTETTITRREVGPHDVAFDIHFSGICHSDIHTVKGEWGRTQYPI
CEEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEEECCEECCCHHHHCCCCCCCCCCC
VPGHEIAGVVTEVGAEVTKYKVGDRVGVGCFVDSCRECDNCRAGIEQYCTGSGMVGTYNA
CCCHHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHH
VGRDGERTQGGYSGAIVVDENYVLRIPDALPLDAAAPLLCAGITTYSPLRHWNAGPGSRV
CCCCCCCCCCCCCEEEEECCCEEEECCCCCCCCHHCHHHHHCCCCCCHHHCCCCCCCCEE
AVIGLGGLGHLAVKLAKAMGAEVTVLSQSLKKMEDGLRLGADAYYATSDPDTFAELKGTF
EEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCEEEECCCCHHHHHHHHHH
DLILNTVSANIDLAAILSLLRVDGTVVELGMPEHPMSVPAGALIGGRRSISGSLIGGIAE
HHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEECCCCCCCCHHHHHHHH
TQEMLDFCAEHGVRPEIEIIEPTYINEAYERVVASDVRYRFVIDTAALRN
HHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCEEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]