Click here to switch to the map view.

The map label for this gene is echA12 [H]

Identifier: 119867850

GI number: 119867850

Start: 1922543

End: 1923325

Strand: Reverse

Name: echA12 [H]

Synonym: Mkms_1811

Alternate gene names: 119867850

Gene position: 1923325-1922543 (Counterclockwise)

Preceding gene: 119867851

Following gene: 119867849

Centisome position: 33.52

GC content: 67.82

Gene sequence:

>783_bases
ATGACCTTCGAGACGATCACGCTCGACGTCGACGCCGCGGTCCACGTCGCGACCATCACGCTCAACCGCCCCGAGCGGCT
CAACGCGTTCAACCGCACCATGTGTGCGGAGATGGCCGAGGCGTGGCGCGTCGTCAAGGCCGACGACACGGTGCACGCGG
TGGTGTTGCGCGCCGCTGGAGATCGGGCGTTCAGCGCCGGGCTGGACGTCAAATCGACCTACGGTCAACCAGACAACGTA
TGGAATCACGAGGATCCCGGCGAGCTGTTGAGCCCCAAGTGGCAGAAGATGTGGAAACCGGTGGTGTGTGCGGTGCAGGG
CATGTGCACCGCAGGCGCGTTCTACTTCCTCAACGAGGCCGACGTGGTGATCTGCTCGGAGGAGGCGACGTTCTTCGACT
CCCACGTCAGCGCCGGGCTGGTGTGCGCACTGGAACCGATCGGCCTGATGCGCAGGGTCGGTCTGGGTGACACCCTGCGC
ATCGCGCTGATGGGCAACGACGAACGGGTCGGCGCCGAGACCGCGCTGCGCATCGGACTGGTCACCGAAGTCGTTGCCCG
CGAACGGCTCTGGGAACGCGCCCACGAGATCGCCGCGACCATCGCCGCCAAACCGCCGTCGGCCACGCAGGGCACCGTGA
AGGCCATCTGGGAGTCGCTGGACCGGCCGTACCGGGCGGCCATGGAGCAGGGGTTGATCTACACCCGGTTGGGCAATCCC
ATCGGCCAGGCCGAGCTCGCCGCGCATCCGCCTGCGGCCCGCCCGGACCCGAGGGTGCGGTGA

Upstream 100 bases:

>100_bases
TGCTCGGTGAGGCGTTCCGTGAGCGGAACCTGCACACCGAGGACTCCCTGGAGGGGCCGAAGGCGTTCGTCGAGAAGCGC
ACCCCGGACTGGAAGTGCCG

Downstream 100 bases:

>100_bases
TGGCCCCCCACCGCCTGAGCCGGCGCATCGCCCACGTCCTGGATCTGTGTCCCGAGGGCAACGCCGTGGAATACGACGGG
CAGTGGGTGACGTGGGCGCA

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTFETITLDVDAAVHVATITLNRPERLNAFNRTMCAEMAEAWRVVKADDTVHAVVLRAAGDRAFSAGLDVKSTYGQPDNV
WNHEDPGELLSPKWQKMWKPVVCAVQGMCTAGAFYFLNEADVVICSEEATFFDSHVSAGLVCALEPIGLMRRVGLGDTLR
IALMGNDERVGAETALRIGLVTEVVARERLWERAHEIAATIAAKPPSATQGTVKAIWESLDRPYRAAMEQGLIYTRLGNP
IGQAELAAHPPAARPDPRVR

Sequences:

>Translated_260_residues
MTFETITLDVDAAVHVATITLNRPERLNAFNRTMCAEMAEAWRVVKADDTVHAVVLRAAGDRAFSAGLDVKSTYGQPDNV
WNHEDPGELLSPKWQKMWKPVVCAVQGMCTAGAFYFLNEADVVICSEEATFFDSHVSAGLVCALEPIGLMRRVGLGDTLR
IALMGNDERVGAETALRIGLVTEVVARERLWERAHEIAATIAAKPPSATQGTVKAIWESLDRPYRAAMEQGLIYTRLGNP
IGQAELAAHPPAARPDPRVR
>Mature_259_residues
TFETITLDVDAAVHVATITLNRPERLNAFNRTMCAEMAEAWRVVKADDTVHAVVLRAAGDRAFSAGLDVKSTYGQPDNVW
NHEDPGELLSPKWQKMWKPVVCAVQGMCTAGAFYFLNEADVVICSEEATFFDSHVSAGLVCALEPIGLMRRVGLGDTLRI
ALMGNDERVGAETALRIGLVTEVVARERLWERAHEIAATIAAKPPSATQGTVKAIWESLDRPYRAAMEQGLIYTRLGNPI
GQAELAAHPPAARPDPRVR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=237, Percent_Identity=29.1139240506329, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI194097323, Length=225, Percent_Identity=28, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1787660, Length=196, Percent_Identity=35.7142857142857, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI221142681, Length=230, Percent_Identity=29.1304347826087, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082183, Length=194, Percent_Identity=26.8041237113402, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787659, Length=217, Percent_Identity=26.2672811059908, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=233, Percent_Identity=31.3304721030043, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=226, Percent_Identity=27.8761061946903, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=218, Percent_Identity=26.605504587156, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=218, Percent_Identity=26.605504587156, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129971, Length=225, Percent_Identity=27.1111111111111, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24653477, Length=225, Percent_Identity=27.1111111111111, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24650670, Length=220, Percent_Identity=27.7272727272727, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357171, Length=233, Percent_Identity=25.3218884120172, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28420; Mature: 28289

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFETITLDVDAAVHVATITLNRPERLNAFNRTMCAEMAEAWRVVKADDTVHAVVLRAAG
CCEEEEEEEECCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCC
DRAFSAGLDVKSTYGQPDNVWNHEDPGELLSPKWQKMWKPVVCAVQGMCTAGAFYFLNEA
CCHHHCCCCCHHCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCEEEEECCC
DVVICSEEATFFDSHVSAGLVCALEPIGLMRRVGLGDTLRIALMGNDERVGAETALRIGL
CEEEECCCCHHHHHHHCCCEEEEECHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHH
VTEVVARERLWERAHEIAATIAAKPPSATQGTVKAIWESLDRPYRAAMEQGLIYTRLGNP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCEEEEECCCC
IGQAELAAHPPAARPDPRVR
CCCCHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TFETITLDVDAAVHVATITLNRPERLNAFNRTMCAEMAEAWRVVKADDTVHAVVLRAAG
CEEEEEEEECCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCC
DRAFSAGLDVKSTYGQPDNVWNHEDPGELLSPKWQKMWKPVVCAVQGMCTAGAFYFLNEA
CCHHHCCCCCHHCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCEEEEECCC
DVVICSEEATFFDSHVSAGLVCALEPIGLMRRVGLGDTLRIALMGNDERVGAETALRIGL
CEEEECCCCHHHHHHHCCCEEEEECHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHH
VTEVVARERLWERAHEIAATIAAKPPSATQGTVKAIWESLDRPYRAAMEQGLIYTRLGNP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCEEEEECCCC
IGQAELAAHPPAARPDPRVR
CCCCHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]