Click here to switch to the map view.

The map label for this gene is mbtN

Identifier: 119867808

GI number: 119867808

Start: 1878181

End: 1879350

Strand: Reverse

Name: mbtN

Synonym: Mkms_1769

Alternate gene names: 119867808

Gene position: 1879350-1878181 (Counterclockwise)

Preceding gene: 119867809

Following gene: 119867805

Centisome position: 32.76

GC content: 68.63

Gene sequence:

>1170_bases
GTGACACTCGCCGCCCACACCACCGAGGACTACGAAGAACTTCTCGGCCGGGTATTCGATGATCAGGTGAAGGCCTGGAC
GGCCGAAGCCGAAGCGTCCGAACGTTTCCCGCGACAGCTCATCGAACATCTCGGCCGAACCGGGGTGTTCACGCAGAAGT
GGGGCGACGGTCAGCAGCCCGATGTGGCGAAGTTGATCGCCCTGGCCCTCGAGTTGGGGAGGCTGGGCTCCGCGGGCATC
GGTGTGGGTGTCAGCCTGCACGATTCCGCGATCGCCCTGCTGCGCCGCTTCGCGAAGAACGACTACCTGCGGACCATCTG
CGAGCAGGCGATCCGCGGTGAAGCAGTGCTCTGCATCGGCGCCTCCGAGATATCCGGCGGCTCGGACCTGCAGATCGTCG
GGACCGAAGTGCGTTCCGTACGTGACGGTTACGAGGTGCGCGGCGTCAAGAAGTTCGTCTCGCTGTCGCCGATCGCCGAC
CACATCATGGTGGTGGCCCGCAACGTCGACCACGATCCGGGCAGCAGGCACGGCAACGTCGTCGTCATCGCCGTCCCGAC
CAGCCAGGTCGAGGCCCAGGCGCCGTACCGCAAGGTGGGCGCCGGGCCGTTGGACACCGCGGCGGTGCACATCGACACGT
GGGTACCCGGCGACGCGCTCATCGCCCGCCCCGGAACCGGCCTGGCGGCGATCTCGTGGGGCCTGGCACACGAACGGCTC
TCCATCGCCGGGCAGGTCGCCGGCGCCAGCCAGCGCGTCATCGGGATCACGTTGGCGCGCATGATGAAACGCCGCCAGTT
CGGCCACACCCTCTACGAGCACCAGGCCCTGCGCATGCGGATGGCCGATCTGCAGGCGCGGGTCGACATGCTGCGCTACG
CGCTGGCGGGTATCGCCGCCGGGGGCCGTCTCGACCTGCGCGCCGCGGCCGCCATCAAGGTCACCGCCGCGCGGCTGGGC
GAGGAGGTGCTGTCGGAATGCATGCACATCTTCGGCGGCTCCGGCTATCTGACCGACGAGACCCCGCTGGGCCGGTGGTG
GCGCGACATGAAGTTGGCCCGGGTGGGTGGCGGCACTGACGAAGTGTTGTGGGAACTGGTCGCCGCGGCGATGCGGCCGG
ACTACGACGGCTACGACGAGCTGATCGACTCCCCGACCGGCGACGACTGA

Upstream 100 bases:

>100_bases
CGTCGAACGTGGTGTTCCTCGAACCCGGCGCCCTCCCCCGCACGTCGTCGGGCAAGCTGCGCCGGCTGGAGGTCAAACGA
AGCATGGAGGACGTGAACCG

Downstream 100 bases:

>100_bases
AGGTCGCCGGTCGGCGGCGCGTCCGCCGGGGTGCGCGGCAGCGCGTAGAGGGCCATCCGGCGGTTGGCCATATCGTGCTC
GCCGAGGAACGTGCACCCGG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: Acyl-ACP dehydrogenase MbtN; Mycobactin synthase protein N

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTLAAHTTEDYEELLGRVFDDQVKAWTAEAEASERFPRQLIEHLGRTGVFTQKWGDGQQPDVAKLIALALELGRLGSAGI
GVGVSLHDSAIALLRRFAKNDYLRTICEQAIRGEAVLCIGASEISGGSDLQIVGTEVRSVRDGYEVRGVKKFVSLSPIAD
HIMVVARNVDHDPGSRHGNVVVIAVPTSQVEAQAPYRKVGAGPLDTAAVHIDTWVPGDALIARPGTGLAAISWGLAHERL
SIAGQVAGASQRVIGITLARMMKRRQFGHTLYEHQALRMRMADLQARVDMLRYALAGIAAGGRLDLRAAAAIKVTAARLG
EEVLSECMHIFGGSGYLTDETPLGRWWRDMKLARVGGGTDEVLWELVAAAMRPDYDGYDELIDSPTGDD

Sequences:

>Translated_389_residues
MTLAAHTTEDYEELLGRVFDDQVKAWTAEAEASERFPRQLIEHLGRTGVFTQKWGDGQQPDVAKLIALALELGRLGSAGI
GVGVSLHDSAIALLRRFAKNDYLRTICEQAIRGEAVLCIGASEISGGSDLQIVGTEVRSVRDGYEVRGVKKFVSLSPIAD
HIMVVARNVDHDPGSRHGNVVVIAVPTSQVEAQAPYRKVGAGPLDTAAVHIDTWVPGDALIARPGTGLAAISWGLAHERL
SIAGQVAGASQRVIGITLARMMKRRQFGHTLYEHQALRMRMADLQARVDMLRYALAGIAAGGRLDLRAAAAIKVTAARLG
EEVLSECMHIFGGSGYLTDETPLGRWWRDMKLARVGGGTDEVLWELVAAAMRPDYDGYDELIDSPTGDD
>Mature_388_residues
TLAAHTTEDYEELLGRVFDDQVKAWTAEAEASERFPRQLIEHLGRTGVFTQKWGDGQQPDVAKLIALALELGRLGSAGIG
VGVSLHDSAIALLRRFAKNDYLRTICEQAIRGEAVLCIGASEISGGSDLQIVGTEVRSVRDGYEVRGVKKFVSLSPIADH
IMVVARNVDHDPGSRHGNVVVIAVPTSQVEAQAPYRKVGAGPLDTAAVHIDTWVPGDALIARPGTGLAAISWGLAHERLS
IAGQVAGASQRVIGITLARMMKRRQFGHTLYEHQALRMRMADLQARVDMLRYALAGIAAGGRLDLRAAAAIKVTAARLGE
EVLSECMHIFGGSGYLTDETPLGRWWRDMKLARVGGGTDEVLWELVAAAMRPDYDGYDELIDSPTGDD

Specific function: Catalyzes the dehydrogenation at the alpha-beta position of ACP-bound acyl chains. This results in the introduction of a double bond in the lipidic chain, which is further transferred to the epsilon-amino group of lysine residue in the mycobactin core by

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=24.3967828418231, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=24.3386243386243, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226958414, Length=364, Percent_Identity=25, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4557233, Length=301, Percent_Identity=23.9202657807309, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4501859, Length=310, Percent_Identity=24.1935483870968, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=23.8726790450928, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4557235, Length=306, Percent_Identity=26.1437908496732, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI76496475, Length=306, Percent_Identity=26.1437908496732, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4557231, Length=281, Percent_Identity=24.1992882562278, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI187960098, Length=281, Percent_Identity=24.1992882562278, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI87081958, Length=354, Percent_Identity=25.1412429378531, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=26.158038147139, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=25.8760107816712, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17538396, Length=314, Percent_Identity=26.4331210191083, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=300, Percent_Identity=23.6666666666667, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=281, Percent_Identity=24.5551601423488, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17506239, Length=283, Percent_Identity=25.0883392226148, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=374, Percent_Identity=22.9946524064171, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=305, Percent_Identity=24.2622950819672, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=351, Percent_Identity=23.9316239316239, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355753, Length=285, Percent_Identity=27.719298245614, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=21.1640211640212, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=24.2587601078167, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24646207, Length=348, Percent_Identity=22.4137931034483, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281363737, Length=281, Percent_Identity=25.6227758007117, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24660351, Length=271, Percent_Identity=25.0922509225092, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MBTN_MYCSS (Q1BBA3)

Other databases:

- EMBL:   CP000384
- RefSeq:   YP_638887.1
- ProteinModelPortal:   Q1BBA3
- SMR:   Q1BBA3
- STRING:   Q1BBA3
- EnsemblBacteria:   EBMYCT00000063888
- GeneID:   4110556
- GenomeReviews:   CP000384_GR
- KEGG:   mmc:Mmcs_1722
- eggNOG:   COG1960
- GeneTree:   EBGT00050000015286
- HOGENOM:   HBG564726
- OMA:   ICERAIA
- ProtClustDB:   CLSK791110
- BioCyc:   MSP164756:MMCS_1722-MONOMER
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- Gene3D:   G3DSA:2.40.110.10
- Gene3D:   G3DSA:1.10.540.10
- Gene3D:   G3DSA:1.20.140.10

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; SSF56645 AcylCoA_dehyd_NM; SSF47203 AcylCoADH_C_like

EC number: NA

Molecular weight: Translated: 42009; Mature: 41878

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00072 ACYL_COA_DH_1; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAAHTTEDYEELLGRVFDDQVKAWTAEAEASERFPRQLIEHLGRTGVFTQKWGDGQQP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCC
DVAKLIALALELGRLGSAGIGVGVSLHDSAIALLRRFAKNDYLRTICEQAIRGEAVLCIG
HHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEE
ASEISGGSDLQIVGTEVRSVRDGYEVRGVKKFVSLSPIADHIMVVARNVDHDPGSRHGNV
CCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCE
VVIAVPTSQVEAQAPYRKVGAGPLDTAAVHIDTWVPGDALIARPGTGLAAISWGLAHERL
EEEEECCCHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHH
SIAGQVAGASQRVIGITLARMMKRRQFGHTLYEHQALRMRMADLQARVDMLRYALAGIAA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGRLDLRAAAAIKVTAARLGEEVLSECMHIFGGSGYLTDETPLGRWWRDMKLARVGGGTD
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
EVLWELVAAAMRPDYDGYDELIDSPTGDD
HHHHHHHHHHHCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
TLAAHTTEDYEELLGRVFDDQVKAWTAEAEASERFPRQLIEHLGRTGVFTQKWGDGQQP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCC
DVAKLIALALELGRLGSAGIGVGVSLHDSAIALLRRFAKNDYLRTICEQAIRGEAVLCIG
HHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEE
ASEISGGSDLQIVGTEVRSVRDGYEVRGVKKFVSLSPIADHIMVVARNVDHDPGSRHGNV
CCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCE
VVIAVPTSQVEAQAPYRKVGAGPLDTAAVHIDTWVPGDALIARPGTGLAAISWGLAHERL
EEEEECCCHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHH
SIAGQVAGASQRVIGITLARMMKRRQFGHTLYEHQALRMRMADLQARVDMLRYALAGIAA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGRLDLRAAAAIKVTAARLGEEVLSECMHIFGGSGYLTDETPLGRWWRDMKLARVGGGTD
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
EVLWELVAAAMRPDYDGYDELIDSPTGDD
HHHHHHHHHHHCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA