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The map label for this gene is yngG [H]

Identifier: 119867657

GI number: 119867657

Start: 1727692

End: 1728597

Strand: Reverse

Name: yngG [H]

Synonym: Mkms_1612

Alternate gene names: 119867657

Gene position: 1728597-1727692 (Counterclockwise)

Preceding gene: 119867658

Following gene: 119867656

Centisome position: 30.13

GC content: 71.41

Gene sequence:

>906_bases
GTGAGCGACTTGCCCGCCAAGGTCGACATCCGTGAGGTCTCGCTGCGCGACGGCCTGCAGATCGAACAGCCGATTCCCCT
GTCGGCCAAGCTCGAACTGCTCGAAGCGGTGGTGGCCACCGGTGTGCGTGAGGTCGAGGCCACCGCCTTCGTCTCACCGT
CGAAGGTGCCCGCACTCGCCGACGCGGCCGAACTCGCCGCCGAACTCGGCCGATTCGACCAGGTCGAGTTCTCGGCGCTG
GTGGCCAGCCCGAACGGGGCCAAGCGGGCGATCGCGGCGGGGCTGCGCTCGATCGAATACGTGGTGTCGGCCGCCGACTC
GCACAGCCGCGCCAACGTCGGGCGGTCCAGCATGGAGTCGGTCGCGGCCATCCCCGACATCGTCGCGATCGCCCACGACA
GCAGCGCCACCGTCGAGGTGATCATCGCGACCGCGTGGGACTGTCCGTTCGACGGCCCGACGCCACCGCAGCGTGTGCTT
GAGATCGTCGACGCTGCAGTGGAATTCGGTGTCGACCGGTTGGCGATCGCCGACACCATCGGCACCGCCACCCCCCGCCG
GGTCAGCGACCTCGTCGCGCAGGTGCGTCCCCGCATCGGCGACCTGCCGCTGGGCGCCCATTTCCACAACACCCGCGGTG
CGGGGCTGGCCAGCGCGTACGCCGCGGTCCAGGCCGGGATCACCCGGCTCGACGCCTCGGTCGGCGGGCTGGGCGGCTGC
CCCTTCGCACCGGGTGCGAGCGGCAACATCGCCACCGAGGACTTGGTCTACCTGTTGCGCGACAGCGGGATCGACTGCGA
CGTCGACCTGCAGGGGGCCATCGCCGCCGCCGAGGTCGCCCGCACGGTCGTCGGCCACGACCTGCCCAGTGCGCTGCTGC
GCGCCGGGGACCGGATCATCGGCTGA

Upstream 100 bases:

>100_bases
CCGGGCCGGCGCATCCGGGCCAGCACAACATCGAGGTGTACACCGGGCTTCTCGGCAAGACCGCCGAAGAAGTCGCGCAA
CTGCAGGCCGAGGGGGTGCT

Downstream 100 bases:

>100_bases
GCGCGGGTATGGCCCCGGAGTCGTCCACGCTGAGCAGCAAGGGTCGCCAGACCCGCCTCGCCATCGAGCAGGCGGCCCGA
AAGCTCTTCGCCGAGCGCGG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSDLPAKVDIREVSLRDGLQIEQPIPLSAKLELLEAVVATGVREVEATAFVSPSKVPALADAAELAAELGRFDQVEFSAL
VASPNGAKRAIAAGLRSIEYVVSAADSHSRANVGRSSMESVAAIPDIVAIAHDSSATVEVIIATAWDCPFDGPTPPQRVL
EIVDAAVEFGVDRLAIADTIGTATPRRVSDLVAQVRPRIGDLPLGAHFHNTRGAGLASAYAAVQAGITRLDASVGGLGGC
PFAPGASGNIATEDLVYLLRDSGIDCDVDLQGAIAAAEVARTVVGHDLPSALLRAGDRIIG

Sequences:

>Translated_301_residues
MSDLPAKVDIREVSLRDGLQIEQPIPLSAKLELLEAVVATGVREVEATAFVSPSKVPALADAAELAAELGRFDQVEFSAL
VASPNGAKRAIAAGLRSIEYVVSAADSHSRANVGRSSMESVAAIPDIVAIAHDSSATVEVIIATAWDCPFDGPTPPQRVL
EIVDAAVEFGVDRLAIADTIGTATPRRVSDLVAQVRPRIGDLPLGAHFHNTRGAGLASAYAAVQAGITRLDASVGGLGGC
PFAPGASGNIATEDLVYLLRDSGIDCDVDLQGAIAAAEVARTVVGHDLPSALLRAGDRIIG
>Mature_300_residues
SDLPAKVDIREVSLRDGLQIEQPIPLSAKLELLEAVVATGVREVEATAFVSPSKVPALADAAELAAELGRFDQVEFSALV
ASPNGAKRAIAAGLRSIEYVVSAADSHSRANVGRSSMESVAAIPDIVAIAHDSSATVEVIIATAWDCPFDGPTPPQRVLE
IVDAAVEFGVDRLAIADTIGTATPRRVSDLVAQVRPRIGDLPLGAHFHNTRGAGLASAYAAVQAGITRLDASVGGLGGCP
FAPGASGNIATEDLVYLLRDSGIDCDVDLQGAIAAAEVARTVVGHDLPSALLRAGDRIIG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=279, Percent_Identity=34.7670250896057, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI109150422, Length=296, Percent_Identity=34.4594594594595, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI109150427, Length=296, Percent_Identity=34.4594594594595, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI260654708, Length=127, Percent_Identity=40.1574803149606, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17510563, Length=281, Percent_Identity=34.8754448398576, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6320019, Length=230, Percent_Identity=24.7826086956522, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320071, Length=230, Percent_Identity=24.3478260869565, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24582381, Length=293, Percent_Identity=35.1535836177474, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 30978; Mature: 30847

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLPAKVDIREVSLRDGLQIEQPIPLSAKLELLEAVVATGVREVEATAFVSPSKVPALA
CCCCCCCCCCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHEECCCCCCHHH
DAAELAAELGRFDQVEFSALVASPNGAKRAIAAGLRSIEYVVSAADSHSRANVGRSSMES
HHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHH
VAAIPDIVAIAHDSSATVEVIIATAWDCPFDGPTPPQRVLEIVDAAVEFGVDRLAIADTI
HHHCCHHEEEECCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
GTATPRRVSDLVAQVRPRIGDLPLGAHFHNTRGAGLASAYAAVQAGITRLDASVGGLGGC
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PFAPGASGNIATEDLVYLLRDSGIDCDVDLQGAIAAAEVARTVVGHDLPSALLRAGDRII
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCC
G
C
>Mature Secondary Structure 
SDLPAKVDIREVSLRDGLQIEQPIPLSAKLELLEAVVATGVREVEATAFVSPSKVPALA
CCCCCCCCCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHEECCCCCCHHH
DAAELAAELGRFDQVEFSALVASPNGAKRAIAAGLRSIEYVVSAADSHSRANVGRSSMES
HHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHH
VAAIPDIVAIAHDSSATVEVIIATAWDCPFDGPTPPQRVLEIVDAAVEFGVDRLAIADTI
HHHCCHHEEEECCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
GTATPRRVSDLVAQVRPRIGDLPLGAHFHNTRGAGLASAYAAVQAGITRLDASVGGLGGC
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PFAPGASGNIATEDLVYLLRDSGIDCDVDLQGAIAAAEVARTVVGHDLPSALLRAGDRII
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]