BacMap

Definition	Mycobacterium sp. KMS chromosome, complete genome.
Accession	NC_008705
Length	5,737,227

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The map label for this gene is fabG [C]

Identifier: 119867612

GI number: 119867612

Start: 1681170

End: 1681940

Strand: Reverse

Name: fabG [C]

Synonym: Mkms_1565

Alternate gene names: 119867612

Gene position: 1681940-1681170 (Counterclockwise)

Preceding gene: 119867613

Following gene: 119867611

Centisome position: 29.32

GC content: 69.26

Gene sequence:

>771_bases
GTGAGCGAGAAGTCGTATGCCGTCATCGTCGGCGGGGCGTCGGGTATCGGCGCCACCATCGTCCGCGCCATGGCCGATCG
CGGCTACGCGGTGGTCGTCGCCGATCGCAACATCGACGCGGCGAACGCGCTGGTCGAACAACTCGGTGCGGGTGGACATA
CCGCCGCCGAGGTCGACGTCGTCGACGAAGCAGGCGTGGCAACGCTTTTCGAGTCGGTGGCCGCACTGCCCGGGAGATTC
GAGGTCGCGGTCAACTGCGCGGGCATCACCGCGCTCGGCCTGGTCACGGATCTGCCCGTCAACAAGTTCCGCCGCGTCGT
CGACGTGTGCCTGGCCGGCGCGTTCCTCGTCATCCAGCATGCCGGCAGGCACCTCGCCGACGGCGGCACGATCATCTCGC
TGAGCTCACTCAACGCCCGGCAGCCCGCGGTCGGCATGAGCGCCTACAGTTCCGCCAAGGCCGGGCTGTCGATGCTGACC
CAGGTGGCCGCACTGGAACTCGCCCCGCGGCTCCGAGTCAACGCGGTGGCGCCCGGGCTGGTGCGAACCCCGTTGACCTC
CGGAGCGTTGGGCGTGCCCGGCGTGGAGGACGAGTACGTCGAGAACATCCCACTGGGCCGGCCCGGTACGCCGGAGGAGA
TCGCGGATGCGGTGATGTACCTGGCCACCGCCGAGTGGATCACCGGCGAAGTGCTCGACCTCAACGGCGGCGCGCATCTG
ATGCGCTACCCGAACGTGCACGCCCACTTCGAACAGGCCCGCACCCGGTGA

Upstream 100 bases:

>100_bases
TAATTAACAATCGCGGCCTGACCGCCGGAACCGGGACGCCTGCGCGTCGAGCCCGGGGCACCGCACGCCGCGCACCATCA
AACAGTCAGAGGGAGTCACG

Downstream 100 bases:

>100_bases
CGCGAAGCGGGCACGCCAGCGTGTCCTCGATGAAACTCGCGACGGGTGCCGAGAAGTCGTCGGGGCGGCCCAGGCGCGTC
AGGAAGATGTGACGCCTCCG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSEKSYAVIVGGASGIGATIVRAMADRGYAVVVADRNIDAANALVEQLGAGGHTAAEVDVVDEAGVATLFESVAALPGRF
EVAVNCAGITALGLVTDLPVNKFRRVVDVCLAGAFLVIQHAGRHLADGGTIISLSSLNARQPAVGMSAYSSAKAGLSMLT
QVAALELAPRLRVNAVAPGLVRTPLTSGALGVPGVEDEYVENIPLGRPGTPEEIADAVMYLATAEWITGEVLDLNGGAHL
MRYPNVHAHFEQARTR

Sequences:

>Translated_256_residues
MSEKSYAVIVGGASGIGATIVRAMADRGYAVVVADRNIDAANALVEQLGAGGHTAAEVDVVDEAGVATLFESVAALPGRF
EVAVNCAGITALGLVTDLPVNKFRRVVDVCLAGAFLVIQHAGRHLADGGTIISLSSLNARQPAVGMSAYSSAKAGLSMLT
QVAALELAPRLRVNAVAPGLVRTPLTSGALGVPGVEDEYVENIPLGRPGTPEEIADAVMYLATAEWITGEVLDLNGGAHL
MRYPNVHAHFEQARTR
>Mature_255_residues
SEKSYAVIVGGASGIGATIVRAMADRGYAVVVADRNIDAANALVEQLGAGGHTAAEVDVVDEAGVATLFESVAALPGRFE
VAVNCAGITALGLVTDLPVNKFRRVVDVCLAGAFLVIQHAGRHLADGGTIISLSSLNARQPAVGMSAYSSAKAGLSMLTQ
VAALELAPRLRVNAVAPGLVRTPLTSGALGVPGVEDEYVENIPLGRPGTPEEIADAVMYLATAEWITGEVLDLNGGAHLM
RYPNVHAHFEQARTR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=236, Percent_Identity=35.5932203389831, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=35.1778656126482, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI4758504, Length=247, Percent_Identity=34.0080971659919, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI32483357, Length=241, Percent_Identity=30.2904564315353, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=32.5301204819277, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI83715985, Length=246, Percent_Identity=32.520325203252, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI4503301, Length=228, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7705925, Length=236, Percent_Identity=30.5084745762712, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5031737, Length=236, Percent_Identity=29.2372881355932, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=30.7359307359307, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31542939, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=31.9838056680162, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787905, Length=239, Percent_Identity=31.7991631799163, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=31.5573770491803, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=31.4516129032258, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789057, Length=251, Percent_Identity=29.4820717131474, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790717, Length=242, Percent_Identity=27.6859504132231, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1786812, Length=196, Percent_Identity=31.6326530612245, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082100, Length=248, Percent_Identity=30.6451612903226, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789378, Length=243, Percent_Identity=28.8065843621399, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367365, Length=235, Percent_Identity=30.2127659574468, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082160, Length=248, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=37.037037037037, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25147288, Length=241, Percent_Identity=36.9294605809129, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=29.8039215686275, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=28.6852589641434, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=29.368029739777, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17563726, Length=255, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=29.5019157088123, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=29.9595141700405, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=29.0196078431373, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=31.3725490196078, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=26.6932270916335, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=28.5171102661597, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=28.5171102661597, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=30.8550185873606, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561272, Length=239, Percent_Identity=27.6150627615063, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=30.9701492537313, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=273, Percent_Identity=27.8388278388278, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=243, Percent_Identity=28.3950617283951, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=28.2945736434109, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=26.9961977186312, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=25.9398496240602, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=262, Percent_Identity=27.4809160305344, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=26.1029411764706, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=28.1368821292776, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=27.6752767527675, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=244, Percent_Identity=30.7377049180328, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639444, Length=242, Percent_Identity=35.9504132231405, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=34.765625, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=34.5238095238095, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=32.8125, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21355319, Length=240, Percent_Identity=30.8333333333333, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24643142, Length=233, Percent_Identity=30.0429184549356, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24644339, Length=245, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737361, Length=260, Percent_Identity=29.6153846153846, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24644337, Length=176, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI116007236, Length=238, Percent_Identity=24.7899159663866, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26434; Mature: 26302

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKSYAVIVGGASGIGATIVRAMADRGYAVVVADRNIDAANALVEQLGAGGHTAAEVDV
CCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEE
VDEAGVATLFESVAALPGRFEVAVNCAGITALGLVTDLPVNKFRRVVDVCLAGAFLVIQH
CCCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AGRHLADGGTIISLSSLNARQPAVGMSAYSSAKAGLSMLTQVAALELAPRLRVNAVAPGL
CCCEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCH
VRTPLTSGALGVPGVEDEYVENIPLGRPGTPEEIADAVMYLATAEWITGEVLDLNGGAHL
HHCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCEEE
MRYPNVHAHFEQARTR
EECCCHHHHHHHHCCC
>Mature Secondary Structure 
SEKSYAVIVGGASGIGATIVRAMADRGYAVVVADRNIDAANALVEQLGAGGHTAAEVDV
CCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEE
VDEAGVATLFESVAALPGRFEVAVNCAGITALGLVTDLPVNKFRRVVDVCLAGAFLVIQH
CCCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AGRHLADGGTIISLSSLNARQPAVGMSAYSSAKAGLSMLTQVAALELAPRLRVNAVAPGL
CCCEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCH
VRTPLTSGALGVPGVEDEYVENIPLGRPGTPEEIADAVMYLATAEWITGEVLDLNGGAHL
HHCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCEEE
MRYPNVHAHFEQARTR
EECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]