Click here to switch to the map view.

The map label for this gene is echA8 [H]

Identifier: 119867571

GI number: 119867571

Start: 1634660

End: 1635517

Strand: Direct

Name: echA8 [H]

Synonym: Mkms_1523

Alternate gene names: 119867571

Gene position: 1634660-1635517 (Clockwise)

Preceding gene: 119867570

Following gene: 119867572

Centisome position: 28.49

GC content: 69.11

Gene sequence:

>858_bases
ATGAGCGCTCAGCAGCCGGCCCAGCCGACGTACGAAGAAGTCGACTATCGCTTCGACGACGGTGTCGCGATCATCGCGCT
CAACGCCCCGCAACGCCGAAATGCGTTGCGTAACCAGATGTTGCGCGACCTGTGGGAGGCGCTCGACACCGCCGACCGGG
ATCCGCACGTGCGTGCCGTCGTGCTCACCGGTGCCGGAAAGCATTTCTGTGTCGGGGCGGAGCTCACCGGGCCGGACACG
CTGATCGAAGCCCTCGAAGAGGATCGGGCGGGGCACACCCCGACCGGGTACCGCGAGCCGGGCGGCCGAGTCAGTGAGCG
GCTCTTCGACATGCGCACCCCCGTCGTCGCGGCTGTCAACGGAGACGCCGTCGGCGGCGGGGCCTCCATCATGGCGGCCA
CCGACGTCCGGATCTCCGGTGAGGCATCGCGTTTCGGGTTCGTGTTCACCCGACGCGGGGTTGTTCCGGAGAGCGCGTCG
TCCTGGTTCCTGCCGCGGCTGGTGGGACTGACCAGAGCTACCGACTGGGTGCTCAGCGGCCGCGTGTTCGATGCCGCGGA
GGCCTACGACGCCGGTCTGCTCACGAAAGTCGTCGCACCGGATGCCGTACTCGACGAGGCCCTGGCGTACGCACGGGTGT
TCGTCACCGAGACCTCACCGACGTCAGTGGCGTTGGCGCGCCGGCTGCTCGGCCGCAGCTGGGGCCACCCGACCCCGAGG
TCGGCAGCCGAGGACGAATCCAGGGTGTACGCCGGTCGGCTCCGGTCGGCCGACGTCCACGAAGGCGTGATGTCGTTCCT
GGAGCGGCGGCCTGCGGTGTTCCCGCCGCTGGACGACCACCCAGCCGATCACTTCTGA

Upstream 100 bases:

>100_bases
CGTCGAGGAGGCCGCGGGCGCCGTGTACCTGCTGTGCGCCCCGGAGTCCAGCTACATCACCGCGCAGACGCTGGTGTGCA
GCGGCGGGGCCTGAGAGCCC

Downstream 100 bases:

>100_bases
CCCCAACACATCCCGGAGGATCACGTGGACACGTCAGCCCCCTTCACCGCATGCCAGTACGGACCGGACGCCGAATTCAC
CCATGAGTTCGCCGGAATCG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSAQQPAQPTYEEVDYRFDDGVAIIALNAPQRRNALRNQMLRDLWEALDTADRDPHVRAVVLTGAGKHFCVGAELTGPDT
LIEALEEDRAGHTPTGYREPGGRVSERLFDMRTPVVAAVNGDAVGGGASIMAATDVRISGEASRFGFVFTRRGVVPESAS
SWFLPRLVGLTRATDWVLSGRVFDAAEAYDAGLLTKVVAPDAVLDEALAYARVFVTETSPTSVALARRLLGRSWGHPTPR
SAAEDESRVYAGRLRSADVHEGVMSFLERRPAVFPPLDDHPADHF

Sequences:

>Translated_285_residues
MSAQQPAQPTYEEVDYRFDDGVAIIALNAPQRRNALRNQMLRDLWEALDTADRDPHVRAVVLTGAGKHFCVGAELTGPDT
LIEALEEDRAGHTPTGYREPGGRVSERLFDMRTPVVAAVNGDAVGGGASIMAATDVRISGEASRFGFVFTRRGVVPESAS
SWFLPRLVGLTRATDWVLSGRVFDAAEAYDAGLLTKVVAPDAVLDEALAYARVFVTETSPTSVALARRLLGRSWGHPTPR
SAAEDESRVYAGRLRSADVHEGVMSFLERRPAVFPPLDDHPADHF
>Mature_284_residues
SAQQPAQPTYEEVDYRFDDGVAIIALNAPQRRNALRNQMLRDLWEALDTADRDPHVRAVVLTGAGKHFCVGAELTGPDTL
IEALEEDRAGHTPTGYREPGGRVSERLFDMRTPVVAAVNGDAVGGGASIMAATDVRISGEASRFGFVFTRRGVVPESASS
WFLPRLVGLTRATDWVLSGRVFDAAEAYDAGLLTKVVAPDAVLDEALAYARVFVTETSPTSVALARRLLGRSWGHPTPRS
AAEDESRVYAGRLRSADVHEGVMSFLERRPAVFPPLDDHPADHF

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=256, Percent_Identity=29.296875, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI45643119, Length=260, Percent_Identity=25.7692307692308, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI260275230, Length=260, Percent_Identity=25.7692307692308, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI260274832, Length=260, Percent_Identity=25.7692307692308, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI221136756, Length=261, Percent_Identity=27.2030651340996, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI221136753, Length=261, Percent_Identity=27.2030651340996, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI221307494, Length=261, Percent_Identity=27.2030651340996, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI68989263, Length=196, Percent_Identity=32.1428571428571, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4502327, Length=264, Percent_Identity=26.5151515151515, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4757968, Length=263, Percent_Identity=25.0950570342205, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI49355787, Length=263, Percent_Identity=25.0950570342205, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI70995211, Length=221, Percent_Identity=26.6968325791855, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4757966, Length=200, Percent_Identity=26.5, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI51538581, Length=200, Percent_Identity=26.5, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI25453481, Length=262, Percent_Identity=24.4274809160305, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI51538573, Length=262, Percent_Identity=24.4274809160305, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI37594469, Length=200, Percent_Identity=28.5, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI37594471, Length=200, Percent_Identity=28.5, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI116235487, Length=275, Percent_Identity=24.3636363636364, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI20127408, Length=194, Percent_Identity=25.7731958762887, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31542718, Length=263, Percent_Identity=25.8555133079848, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI213417737, Length=259, Percent_Identity=26.2548262548263, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI157694516, Length=259, Percent_Identity=26.2548262548263, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=31.3253012048193, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=31.0861423220974, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI221142681, Length=255, Percent_Identity=27.843137254902, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788597, Length=282, Percent_Identity=25.886524822695, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1790281, Length=195, Percent_Identity=29.2307692307692, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082183, Length=274, Percent_Identity=24.4525547445255, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788682, Length=238, Percent_Identity=22.2689075630252, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=271, Percent_Identity=29.1512915129151, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=252, Percent_Identity=29.3650793650794, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25145438, Length=253, Percent_Identity=29.2490118577075, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=276, Percent_Identity=25.3623188405797, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=213, Percent_Identity=30.5164319248826, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17560910, Length=220, Percent_Identity=29.0909090909091, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17540306, Length=285, Percent_Identity=28.0701754385965, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=262, Percent_Identity=26.7175572519084, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17536985, Length=262, Percent_Identity=22.1374045801527, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25141363, Length=218, Percent_Identity=25.2293577981651, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129971, Length=255, Percent_Identity=30.9803921568627, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653477, Length=255, Percent_Identity=30.9803921568627, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653139, Length=262, Percent_Identity=27.8625954198473, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357171, Length=248, Percent_Identity=26.2096774193548, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920382, Length=218, Percent_Identity=28.8990825688073, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24654903, Length=263, Percent_Identity=22.0532319391635, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24650670, Length=193, Percent_Identity=27.979274611399, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 30968; Mature: 30837

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQQPAQPTYEEVDYRFDDGVAIIALNAPQRRNALRNQMLRDLWEALDTADRDPHVRAV
CCCCCCCCCCHHHCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VLTGAGKHFCVGAELTGPDTLIEALEEDRAGHTPTGYREPGGRVSERLFDMRTPVVAAVN
EEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEC
GDAVGGGASIMAATDVRISGEASRFGFVFTRRGVVPESASSWFLPRLVGLTRATDWVLSG
CCCCCCCCEEEEEECEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RVFDAAEAYDAGLLTKVVAPDAVLDEALAYARVFVTETSPTSVALARRLLGRSWGHPTPR
CEECHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCC
SAAEDESRVYAGRLRSADVHEGVMSFLERRPAVFPPLDDHPADHF
CCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAQQPAQPTYEEVDYRFDDGVAIIALNAPQRRNALRNQMLRDLWEALDTADRDPHVRAV
CCCCCCCCCHHHCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VLTGAGKHFCVGAELTGPDTLIEALEEDRAGHTPTGYREPGGRVSERLFDMRTPVVAAVN
EEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEC
GDAVGGGASIMAATDVRISGEASRFGFVFTRRGVVPESASSWFLPRLVGLTRATDWVLSG
CCCCCCCCEEEEEECEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RVFDAAEAYDAGLLTKVVAPDAVLDEALAYARVFVTETSPTSVALARRLLGRSWGHPTPR
CEECHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCC
SAAEDESRVYAGRLRSADVHEGVMSFLERRPAVFPPLDDHPADHF
CCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]