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The map label for this gene is tetR [H]

Identifier: 119867569

GI number: 119867569

Start: 1632978

End: 1633712

Strand: Direct

Name: tetR [H]

Synonym: Mkms_1521

Alternate gene names: 119867569

Gene position: 1632978-1633712 (Clockwise)

Preceding gene: 119867564

Following gene: 119867570

Centisome position: 28.46

GC content: 68.03

Gene sequence:

>735_bases
ATGGCCAAACGGGCGGCTCGAACCGCTGACGGACAGGGCGGCGCGGAAGCCGGCCCCGACCTCGGCGACGCTCCGATCAC
CCGCGCCCTGATCCTTCGGACCGCGTTGGCGATCTTGGACCGCGACGGCGAGAGCGGACTGTCGATGCGTCGCCTCAGCG
AGGCGCTGAAGCGGGACCCGACGGTGCTCTACCGGCATGTCCCCAACAAAGCCGCTGTGCTCGACGGTGTCGTCGAGGTC
GTTCTGAGCCAGCTCGTCGTGGACAGCGCCGATCCCGACTGGGCCGACCAGCTGCGTCTGGTCGCCCACGATTTCCGCAG
GCTCGCGCTGGCCCACCCGAACGTGGTCCCGCTGCTGGTGACCCGCCCGCTGGCGACGTCGCTGGGGCAGCGGCCCCCGG
GGACGCTGCGGCCCCTCGAAGCGGTCCTGACGCTGCTGACGTCAGCGGGATTCGCCGGTGTGGACGCCCTGCACATCTAC
CGCGTCCTCTTCGCATATCTGCACGGCCACATCCTCGATGAGCTGCAGGAGATCGTGGAACGCCCCGAGGAATCCGACCA
TGTACTGCGACTGGGCCTACACCGGTTACCGATCACCGAGTTTCCCCGATTGCGCGAGTTGGCACCCGTACTCGCGTCCT
ACGACGGCGCCGCCGAACTCGACCGCGGCCTGGACCTCATCCTCAGCGGCTTGATCGCCACCTTCGGACGCCAGAGCTCT
TCGATCAACTCATAG

Upstream 100 bases:

>100_bases
TCAGTAGACACCCCGCCAGACCGGGTGTCAACACTGTCGGACATCGGTGTTGGTCTATGGTGTTGTGAGACCACGACCGA
GCCGGAAGGTGTAGAAACTC

Downstream 100 bases:

>100_bases
TCACTATTTACGTTAGATCTAAAACGCCACGTCAATTGGTAGTTGACCCAGCGAAGCGCCGAAGTTAAGGTTCACAACAA
CACGTTGGAATGCACTTTGG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAKRAARTADGQGGAEAGPDLGDAPITRALILRTALAILDRDGESGLSMRRLSEALKRDPTVLYRHVPNKAAVLDGVVEV
VLSQLVVDSADPDWADQLRLVAHDFRRLALAHPNVVPLLVTRPLATSLGQRPPGTLRPLEAVLTLLTSAGFAGVDALHIY
RVLFAYLHGHILDELQEIVERPEESDHVLRLGLHRLPITEFPRLRELAPVLASYDGAAELDRGLDLILSGLIATFGRQSS
SINS

Sequences:

>Translated_244_residues
MAKRAARTADGQGGAEAGPDLGDAPITRALILRTALAILDRDGESGLSMRRLSEALKRDPTVLYRHVPNKAAVLDGVVEV
VLSQLVVDSADPDWADQLRLVAHDFRRLALAHPNVVPLLVTRPLATSLGQRPPGTLRPLEAVLTLLTSAGFAGVDALHIY
RVLFAYLHGHILDELQEIVERPEESDHVLRLGLHRLPITEFPRLRELAPVLASYDGAAELDRGLDLILSGLIATFGRQSS
SINS
>Mature_243_residues
AKRAARTADGQGGAEAGPDLGDAPITRALILRTALAILDRDGESGLSMRRLSEALKRDPTVLYRHVPNKAAVLDGVVEVV
LSQLVVDSADPDWADQLRLVAHDFRRLALAHPNVVPLLVTRPLATSLGQRPPGTLRPLEAVLTLLTSAGFAGVDALHIYR
VLFAYLHGHILDELQEIVERPEESDHVLRLGLHRLPITEFPRLRELAPVLASYDGAAELDRGLDLILSGLIATFGRQSSS
INS

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26435; Mature: 26304

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRAARTADGQGGAEAGPDLGDAPITRALILRTALAILDRDGESGLSMRRLSEALKRDP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
TVLYRHVPNKAAVLDGVVEVVLSQLVVDSADPDWADQLRLVAHDFRRLALAHPNVVPLLV
CEEHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
TRPLATSLGQRPPGTLRPLEAVLTLLTSAGFAGVDALHIYRVLFAYLHGHILDELQEIVE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPEESDHVLRLGLHRLPITEFPRLRELAPVLASYDGAAELDRGLDLILSGLIATFGRQSS
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SINS
CCCC
>Mature Secondary Structure 
AKRAARTADGQGGAEAGPDLGDAPITRALILRTALAILDRDGESGLSMRRLSEALKRDP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
TVLYRHVPNKAAVLDGVVEVVLSQLVVDSADPDWADQLRLVAHDFRRLALAHPNVVPLLV
CEEHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
TRPLATSLGQRPPGTLRPLEAVLTLLTSAGFAGVDALHIYRVLFAYLHGHILDELQEIVE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPEESDHVLRLGLHRLPITEFPRLRELAPVLASYDGAAELDRGLDLILSGLIATFGRQSS
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SINS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3916707 [H]