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The map label for this gene is moeZ [H]

Identifier: 119867467

GI number: 119867467

Start: 1516797

End: 1517999

Strand: Direct

Name: moeZ [H]

Synonym: Mkms_1417

Alternate gene names: 119867467

Gene position: 1516797-1517999 (Clockwise)

Preceding gene: 119867466

Following gene: 119867468

Centisome position: 26.44

GC content: 66.67

Gene sequence:

>1203_bases
GTGTCCGGGAATGTGGGAACGCTCCCTCAACAATCATTGCCTCCGCTGGTGGAGCCGGTCGGCGAACTGACCCGTGAAGA
GGTCGCCCGCTACAGCCGCCACCTGATCATCCCCGACCTCGGACTCGACGGTCAGAAGCGGCTCAAGAACGCCAAGGTGC
TCGTCATCGGCGCCGGCGGTCTGGGGTCGCCGACCCTGCTGTATCTCGCCGCGGCCGGAGTGGGCACCATCGGGATCGTC
GAGTTCGACGTCGTCGACGAGTCCAATCTGCAGCGCCAGGTCATCCACGGGCAGTCCGACATCGGCCGGCCCAAGGCGCA
GAGCGCACGCGACTCGATCCTCGAGATCAACCCGCTGGTGAACGTCCGTCTGCACGAGGAGCGCCTCGAGCCGGAGAACG
CCGTCGGACTGTTCGAGCAGTACGACCTGATCCTCGACGGCACCGACAACTTCGCCACCCGCTACCTGGTCAACGACGCC
GCGGTGCTCGCGCACAAGCCCTACGTGTGGGGTTCGATCTACCGCTTCGAAGGTCAGGTCTCGGTGTTCTGGGAGGACGC
CCCGAACGGCCTTGGCCTCAACTACCGCGATCTCTACCCCGAACCGCCGCCGCCGGGCATGGTCCCGTCCTGCGCCGAGG
GCGGGGTGCTGGGCATCCTGTGCGCGTCGATCGCGTCGGTGATGGGCACCGAGGCGATCAAGCTGATCACCGGTATCGGC
GAACCGCTGCTCGGCCGGCTGATGGTCTACGACGCACTCGACATGACCTACCGCACGATCAAGATCCGCAAGGATCCGGC
GACGCCGAAGATCACCGAGCTCATCGACTACGAGGCGTTCTGCGGTGTGGTCTCCGACGCGGCCGCCGCAGCCGCCGCAG
ACTCCACCGTCACGCCGCGGGAGCTGCGCGAGTTGATCGACGCGGGTAAGCCGGTGGCCCTCATCGACGTACGTGAACAG
GTCGAATGGGATATCAACCGCATCGAAGGCGCCGAGCTCATCCCGAAGTCGGCGATCGAGGCGGGCGACGGGCTGGCCAA
GCTGCCGCACGACCGGATCCCGGTGCTGTACTGCAAGACCGGCGTTCGCTCGGCGGAGGCGCTCGCGGCGGTCAAGAAGG
CCGGCTTCTCCGACGCGCTGCACCTGCAGGGCGGCATCGTGGCATGGGCGAAGCAACTCGAGCCCGACATGGTGATGTAC
TGA

Upstream 100 bases:

>100_bases
GGAAGCCTGCGGGGCTCTGCACTGTTGTGTCAGGTGCCTATTGTGAAGGTGACTCGACCGCCCACCGCGGTCGACGCACC
GCAGACTTGAGGAGATACCG

Downstream 100 bases:

>100_bases
CCGACCTTTGGTCTCAGCCCGGCAACGGCTCGGCGACACAGCAGGTCAGCGCGTCAATTGTCGGCACTGTCACCGGTAGC
CTGACCCTGTGAGCACCGAG

Product: molybdopterin biosynthesis-like protein MoeZ

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSGNVGTLPQQSLPPLVEPVGELTREEVARYSRHLIIPDLGLDGQKRLKNAKVLVIGAGGLGSPTLLYLAAAGVGTIGIV
EFDVVDESNLQRQVIHGQSDIGRPKAQSARDSILEINPLVNVRLHEERLEPENAVGLFEQYDLILDGTDNFATRYLVNDA
AVLAHKPYVWGSIYRFEGQVSVFWEDAPNGLGLNYRDLYPEPPPPGMVPSCAEGGVLGILCASIASVMGTEAIKLITGIG
EPLLGRLMVYDALDMTYRTIKIRKDPATPKITELIDYEAFCGVVSDAAAAAAADSTVTPRELRELIDAGKPVALIDVREQ
VEWDINRIEGAELIPKSAIEAGDGLAKLPHDRIPVLYCKTGVRSAEALAAVKKAGFSDALHLQGGIVAWAKQLEPDMVMY

Sequences:

>Translated_400_residues
MSGNVGTLPQQSLPPLVEPVGELTREEVARYSRHLIIPDLGLDGQKRLKNAKVLVIGAGGLGSPTLLYLAAAGVGTIGIV
EFDVVDESNLQRQVIHGQSDIGRPKAQSARDSILEINPLVNVRLHEERLEPENAVGLFEQYDLILDGTDNFATRYLVNDA
AVLAHKPYVWGSIYRFEGQVSVFWEDAPNGLGLNYRDLYPEPPPPGMVPSCAEGGVLGILCASIASVMGTEAIKLITGIG
EPLLGRLMVYDALDMTYRTIKIRKDPATPKITELIDYEAFCGVVSDAAAAAAADSTVTPRELRELIDAGKPVALIDVREQ
VEWDINRIEGAELIPKSAIEAGDGLAKLPHDRIPVLYCKTGVRSAEALAAVKKAGFSDALHLQGGIVAWAKQLEPDMVMY
>Mature_399_residues
SGNVGTLPQQSLPPLVEPVGELTREEVARYSRHLIIPDLGLDGQKRLKNAKVLVIGAGGLGSPTLLYLAAAGVGTIGIVE
FDVVDESNLQRQVIHGQSDIGRPKAQSARDSILEINPLVNVRLHEERLEPENAVGLFEQYDLILDGTDNFATRYLVNDAA
VLAHKPYVWGSIYRFEGQVSVFWEDAPNGLGLNYRDLYPEPPPPGMVPSCAEGGVLGILCASIASVMGTEAIKLITGIGE
PLLGRLMVYDALDMTYRTIKIRKDPATPKITELIDYEAFCGVVSDAAAAAAADSTVTPRELRELIDAGKPVALIDVREQV
EWDINRIEGAELIPKSAIEAGDGLAKLPHDRIPVLYCKTGVRSAEALAAVKKAGFSDALHLQGGIVAWAKQLEPDMVMY

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=416, Percent_Identity=39.1826923076923, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI4885649, Length=133, Percent_Identity=35.3383458646617, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI38045944, Length=114, Percent_Identity=38.5964912280702, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI38045942, Length=114, Percent_Identity=38.5964912280702, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787048, Length=248, Percent_Identity=37.5, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI87082356, Length=250, Percent_Identity=36, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17540406, Length=407, Percent_Identity=36.8550368550369, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI193203301, Length=141, Percent_Identity=30.4964539007092, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71984476, Length=118, Percent_Identity=34.7457627118644, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321903, Length=407, Percent_Identity=36.1179361179361, Blast_Score=212, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6320598, Length=140, Percent_Identity=32.1428571428571, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322639, Length=185, Percent_Identity=28.1081081081081, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325438, Length=126, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24582879, Length=397, Percent_Identity=38.7909319899244, Blast_Score=272, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24660640, Length=139, Percent_Identity=35.2517985611511, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573937, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129973, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 43150; Mature: 43019

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNVGTLPQQSLPPLVEPVGELTREEVARYSRHLIIPDLGLDGQKRLKNAKVLVIGAGG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHCCCEEEEEECCC
LGSPTLLYLAAAGVGTIGIVEFDVVDESNLQRQVIHGQSDIGRPKAQSARDSILEINPLV
CCCCHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHCCEEEECCEE
NVRLHEERLEPENAVGLFEQYDLILDGTDNFATRYLVNDAAVLAHKPYVWGSIYRFEGQV
EEEEEHHHCCCCHHHHHHHHCEEEEECCCCHHHHHEECCCHHEEECCCEEEEEEEECCEE
SVFWEDAPNGLGLNYRDLYPEPPPPGMVPSCAEGGVLGILCASIASVMGTEAIKLITGIG
EEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
EPLLGRLMVYDALDMTYRTIKIRKDPATPKITELIDYEAFCGVVSDAAAAAAADSTVTPR
HHHHHHHHHHHHHHCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ELRELIDAGKPVALIDVREQVEWDINRIEGAELIPKSAIEAGDGLAKLPHDRIPVLYCKT
HHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCHHCCHHHHHCCCCHHHCCCCCCCEEEECC
GVRSAEALAAVKKAGFSDALHLQGGIVAWAKQLEPDMVMY
CCCHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SGNVGTLPQQSLPPLVEPVGELTREEVARYSRHLIIPDLGLDGQKRLKNAKVLVIGAGG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHCCCEEEEEECCC
LGSPTLLYLAAAGVGTIGIVEFDVVDESNLQRQVIHGQSDIGRPKAQSARDSILEINPLV
CCCCHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHCCEEEECCEE
NVRLHEERLEPENAVGLFEQYDLILDGTDNFATRYLVNDAAVLAHKPYVWGSIYRFEGQV
EEEEEHHHCCCCHHHHHHHHCEEEEECCCCHHHHHEECCCHHEEECCCEEEEEEEECCEE
SVFWEDAPNGLGLNYRDLYPEPPPPGMVPSCAEGGVLGILCASIASVMGTEAIKLITGIG
EEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
EPLLGRLMVYDALDMTYRTIKIRKDPATPKITELIDYEAFCGVVSDAAAAAAADSTVTPR
HHHHHHHHHHHHHHCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ELRELIDAGKPVALIDVREQVEWDINRIEGAELIPKSAIEAGDGLAKLPHDRIPVLYCKT
HHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCHHCCHHHHHCCCCHHHCCCCCCCEEEECC
GVRSAEALAAVKKAGFSDALHLQGGIVAWAKQLEPDMVMY
CCCHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]