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The map label for this gene is alsR [H]

Identifier: 119867434

GI number: 119867434

Start: 1485451

End: 1486362

Strand: Reverse

Name: alsR [H]

Synonym: Mkms_1384

Alternate gene names: 119867434

Gene position: 1486362-1485451 (Counterclockwise)

Preceding gene: 119867438

Following gene: 119867433

Centisome position: 25.91

GC content: 72.26

Gene sequence:

>912_bases
ATGGAACTGCGGCACCTCCGCTACTTCCGGGCGGTCGCCGAGGAGTTGCACTTCGGCCGCGCGGCCGAGCGACTGCACAT
CGCGCAGCCCCCGCTGTCCCAGCAGATCCGAGCCCTCGAGCGGGAGCTCGGCGTCTCCCTCTTGACGCGCTCCACCCGCA
AGGTCGAGCTGACGCCTGCCGGCGCGGCCTACCTCGACCGGGCGGTGGCGATCCTCGACGCGGTCGACGACGCCACCGAG
TTGGCGCAACGGGTCGCCGGCGGCTCGGCGGGCCGGCTGGTGATCGGCTGCGTCGGATCGGCCACCTACTCGCTGCTGCC
CGCGCTGGTACGCGCGCTGCGCGAGGCGCTGCCCGGCGTGGACGTCAACGTGCGCGGGGAGATGCTGGCACCGGCCCAGA
TCACCGCGCTGGTGTCCGGGGAGATCGACCTGGCGCTGCTGCGTCCGCCGGTGCAGCATCCGGCGGTGCAGGTGGAAACG
ATCCGCCGCGACCGGTTGCTGGTGGCGCTTCCGGACGGCCATCGGCTGGCCGCCTCTACCGGGGTGAGCATCGCCGAGCT
GCGCGGTGAGGAGTTCATCGTGCACGCCGGACACGGGCACTCCGTGATGAACAGCGTGGTGACCGCACTGTGCGCCGAGG
CGGGTTTCGTACCCCTGGTGCGTCACGAGGTCGAGGAGACCTCGACGCTGGTCACGCTCGTCGCAGCCGGGCTGGGCGTG
GCGGTGGTGCCCGAACCCACCGCCGCGCTGGGGGTGACCGGTGTCCGCTACCGGCCGTTGGCCGGCGACCGGCCCGTCAC
CGTCGATCTGCTGGCCGCACACGCCGTGCGGGCCCATTCGCCGCTGGTCGAACGTGTTCTGGAGGTCTTGCGTGGAGTCG
CCCGAACCCAGCAGCGGCCCGACATAGGCTGA

Upstream 100 bases:

>100_bases
GCGTGTGCACATCTACCGAAGCCATGCCTGCAACTGTAGTGACGTGCTCTTATATTGAGAAATACGTGTTTACGAGTGAT
TAATACAAGGGGAGTATGAG

Downstream 100 bases:

>100_bases
GACCATGGCCGACAAACCCCTGAGCGGGAAAACCATGTTCATCTCCGGCGCGAGCCGCGGTATCGGCTTGGCCATCGCCA
AGCGCGTCGCCGCCGACGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MELRHLRYFRAVAEELHFGRAAERLHIAQPPLSQQIRALERELGVSLLTRSTRKVELTPAGAAYLDRAVAILDAVDDATE
LAQRVAGGSAGRLVIGCVGSATYSLLPALVRALREALPGVDVNVRGEMLAPAQITALVSGEIDLALLRPPVQHPAVQVET
IRRDRLLVALPDGHRLAASTGVSIAELRGEEFIVHAGHGHSVMNSVVTALCAEAGFVPLVRHEVEETSTLVTLVAAGLGV
AVVPEPTAALGVTGVRYRPLAGDRPVTVDLLAAHAVRAHSPLVERVLEVLRGVARTQQRPDIG

Sequences:

>Translated_303_residues
MELRHLRYFRAVAEELHFGRAAERLHIAQPPLSQQIRALERELGVSLLTRSTRKVELTPAGAAYLDRAVAILDAVDDATE
LAQRVAGGSAGRLVIGCVGSATYSLLPALVRALREALPGVDVNVRGEMLAPAQITALVSGEIDLALLRPPVQHPAVQVET
IRRDRLLVALPDGHRLAASTGVSIAELRGEEFIVHAGHGHSVMNSVVTALCAEAGFVPLVRHEVEETSTLVTLVAAGLGV
AVVPEPTAALGVTGVRYRPLAGDRPVTVDLLAAHAVRAHSPLVERVLEVLRGVARTQQRPDIG
>Mature_303_residues
MELRHLRYFRAVAEELHFGRAAERLHIAQPPLSQQIRALERELGVSLLTRSTRKVELTPAGAAYLDRAVAILDAVDDATE
LAQRVAGGSAGRLVIGCVGSATYSLLPALVRALREALPGVDVNVRGEMLAPAQITALVSGEIDLALLRPPVQHPAVQVET
IRRDRLLVALPDGHRLAASTGVSIAELRGEEFIVHAGHGHSVMNSVVTALCAEAGFVPLVRHEVEETSTLVTLVAAGLGV
AVVPEPTAALGVTGVRYRPLAGDRPVTVDLLAAHAVRAHSPLVERVLEVLRGVARTQQRPDIG

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=282, Percent_Identity=38.6524822695035, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI2367136, Length=294, Percent_Identity=34.0136054421769, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1788887, Length=272, Percent_Identity=36.0294117647059, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790399, Length=271, Percent_Identity=32.4723247232472, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=26.6393442622951, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI157672245, Length=231, Percent_Identity=29.4372294372294, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787806, Length=253, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787530, Length=285, Percent_Identity=28.7719298245614, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790208, Length=298, Percent_Identity=29.5302013422819, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=29.8804780876494, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87081904, Length=148, Percent_Identity=32.4324324324324, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788748, Length=296, Percent_Identity=25, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787601, Length=248, Percent_Identity=26.6129032258064, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789639, Length=248, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789173, Length=166, Percent_Identity=31.9277108433735, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790262, Length=244, Percent_Identity=26.2295081967213, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693193, Length=120, Percent_Identity=37.5, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787589, Length=123, Percent_Identity=35.7723577235772, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1786401, Length=142, Percent_Identity=30.9859154929577, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32205; Mature: 32205

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFRAVAEELHFGRAAERLHIAQPPLSQQIRALERELGVSLLTRSTRKVELTPA
CCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GAAYLDRAVAILDAVDDATELAQRVAGGSAGRLVIGCVGSATYSLLPALVRALREALPGV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCC
DVNVRGEMLAPAQITALVSGEIDLALLRPPVQHPAVQVETIRRDRLLVALPDGHRLAAST
CEECCCCEECCHHEEEEECCCEEEEEECCCCCCCCHHHEEECCCEEEEECCCCCEEHHHC
GVSIAELRGEEFIVHAGHGHSVMNSVVTALCAEAGFVPLVRHEVEETSTLVTLVAAGLGV
CCHHEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCE
AVVPEPTAALGVTGVRYRPLAGDRPVTVDLLAAHAVRAHSPLVERVLEVLRGVARTQQRP
EECCCCCHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
DIG
CCC
>Mature Secondary Structure
MELRHLRYFRAVAEELHFGRAAERLHIAQPPLSQQIRALERELGVSLLTRSTRKVELTPA
CCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GAAYLDRAVAILDAVDDATELAQRVAGGSAGRLVIGCVGSATYSLLPALVRALREALPGV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCC
DVNVRGEMLAPAQITALVSGEIDLALLRPPVQHPAVQVETIRRDRLLVALPDGHRLAAST
CEECCCCEECCHHEEEEECCCEEEEEECCCCCCCCHHHEEECCCEEEEECCCCCEEHHHC
GVSIAELRGEEFIVHAGHGHSVMNSVVTALCAEAGFVPLVRHEVEETSTLVTLVAAGLGV
CCHHEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCE
AVVPEPTAALGVTGVRYRPLAGDRPVTVDLLAAHAVRAHSPLVERVLEVLRGVARTQQRP
EECCCCCHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
DIG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]