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The map label for this gene is mpg1 [H]

Identifier: 119867388

GI number: 119867388

Start: 1432750

End: 1433829

Strand: Direct

Name: mpg1 [H]

Synonym: Mkms_1338

Alternate gene names: 119867388

Gene position: 1432750-1433829 (Clockwise)

Preceding gene: 119867387

Following gene: 119867392

Centisome position: 24.97

GC content: 70.19

Gene sequence:

>1080_bases
ATGGTGAATCCGGCTGAGGTCGACGCCGTCGTACTCGTGGGCGGGCAGGGCACCCGTCTGCGTCCCCTGACGCTGTCGGC
GCCCAAACCGATGCTGCCGACGGCCGGGTTGGCGTTCCTGACCCACCTGCTGTCGCGCATCGCCGCGGCGGGTATCGAGC
ACGTCATACTCGGGACGTCCTACAAGGCGGAGGTCTTCGAGGCCGAGTTCGGTGACGGCTCGAAGCTCGGCCTGCAGATC
GAGTACGTCTACGAATCCGAGCCGATGGGCACCGGCGGTGCGATCGCCAACGTCGCCGAGAAGTTGCGCCACGACACCGC
GATGGTGTTCAACGGCGATGTGCTGTCGGGCTGTGACCTGCGCGCGCTGCTGGACAGCCACGTGAGCAAGGACGCCGACG
TCACCCTGCACCTGGTGCGGGTGGGCGACCCCCGGGCCTTCGGTTGCGTGCCGACCGACGCCGACGGTGTGGTCACCGCG
TTCCTGGAGAAGACGCAGGATCCGCCGACGGACCAGATCAACGCCGGCTGCTATGTGTTCAAGCGTTCCGTCATCGACCG
CATTCCGCGCGACCGCGCCGTCTCGGTCGAACGGGAGGTGTTCCCCGGTCTGCTGTCGGACGGCCTGCGTGTCTGCGGGT
ACGTCGACGCGACGTACTGGCGGGACATGGGCACCCCCGAGGACTTCGTGCGCGGTTCGGCCGACCTGGTTCGCGGGATC
GCACCGTCGCCGGCGTTGGAGGGACACCGCGGCGAAAACCTCGTCCACGACGGTGCGGCCGTCGGACCCGGCGCGCTGCT
GATCGGCGGCACCGTGGTGGGTCGGGGCGCCGAGGTGGGTGCGGGCGCGCGGCTCGACGGCGCGGTGATCTTCGACGGTG
TGCGCGTCGGCGCCGGCGCGGTGATCGAGCGGTCCATCATCGGGTTCGGCGCGCGGATCGGTCCGCGGGCCCTGATCCGC
GACGCGGTCATCGGCGACGGCGCCGACATCGGCGCGCGCTGTGAGTTGTTGCGTGGGGCGCGGGTGTGGCCGGGAGTGAA
GATCCCCGACGGCGGCATCCGCTACTCGACCGACGTCTGA

Upstream 100 bases:

>100_bases
TGCGGGGAGCGATGAAGGGCGCGCTGGCCGTGCGAGCAGGTCTGGTGGTGCGCAAAGCGCGGCGCAGTCAGGGCGAAATC
AGGCCAAAGGGGGGTAGGTA

Downstream 100 bases:

>100_bases
CCGCGGCGTCGCGCCTCGGCGGCCAGCTGCGCCAACCCGAAGTCCGTGTCCGGGGGCAGCGCGTCGAGCGGCCACCACCG
CAGATCCAGCGACTCGTCCG

Product: nucleotidyl transferase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MVNPAEVDAVVLVGGQGTRLRPLTLSAPKPMLPTAGLAFLTHLLSRIAAAGIEHVILGTSYKAEVFEAEFGDGSKLGLQI
EYVYESEPMGTGGAIANVAEKLRHDTAMVFNGDVLSGCDLRALLDSHVSKDADVTLHLVRVGDPRAFGCVPTDADGVVTA
FLEKTQDPPTDQINAGCYVFKRSVIDRIPRDRAVSVEREVFPGLLSDGLRVCGYVDATYWRDMGTPEDFVRGSADLVRGI
APSPALEGHRGENLVHDGAAVGPGALLIGGTVVGRGAEVGAGARLDGAVIFDGVRVGAGAVIERSIIGFGARIGPRALIR
DAVIGDGADIGARCELLRGARVWPGVKIPDGGIRYSTDV

Sequences:

>Translated_359_residues
MVNPAEVDAVVLVGGQGTRLRPLTLSAPKPMLPTAGLAFLTHLLSRIAAAGIEHVILGTSYKAEVFEAEFGDGSKLGLQI
EYVYESEPMGTGGAIANVAEKLRHDTAMVFNGDVLSGCDLRALLDSHVSKDADVTLHLVRVGDPRAFGCVPTDADGVVTA
FLEKTQDPPTDQINAGCYVFKRSVIDRIPRDRAVSVEREVFPGLLSDGLRVCGYVDATYWRDMGTPEDFVRGSADLVRGI
APSPALEGHRGENLVHDGAAVGPGALLIGGTVVGRGAEVGAGARLDGAVIFDGVRVGAGAVIERSIIGFGARIGPRALIR
DAVIGDGADIGARCELLRGARVWPGVKIPDGGIRYSTDV
>Mature_359_residues
MVNPAEVDAVVLVGGQGTRLRPLTLSAPKPMLPTAGLAFLTHLLSRIAAAGIEHVILGTSYKAEVFEAEFGDGSKLGLQI
EYVYESEPMGTGGAIANVAEKLRHDTAMVFNGDVLSGCDLRALLDSHVSKDADVTLHLVRVGDPRAFGCVPTDADGVVTA
FLEKTQDPPTDQINAGCYVFKRSVIDRIPRDRAVSVEREVFPGLLSDGLRVCGYVDATYWRDMGTPEDFVRGSADLVRGI
APSPALEGHRGENLVHDGAAVGPGALLIGGTVVGRGAEVGAGARLDGAVIFDGVRVGAGAVIERSIIGFGARIGPRALIR
DAVIGDGADIGARCELLRGARVWPGVKIPDGGIRYSTDV

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=353, Percent_Identity=32.0113314447592, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI11761619, Length=346, Percent_Identity=32.0809248554913, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI31881779, Length=347, Percent_Identity=25.3602305475504, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI45447090, Length=347, Percent_Identity=25.3602305475504, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1788351, Length=237, Percent_Identity=27.8481012658228, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790224, Length=183, Percent_Identity=26.2295081967213, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789837, Length=395, Percent_Identity=23.2911392405063, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=370, Percent_Identity=31.3513513513514, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17509979, Length=330, Percent_Identity=26.6666666666667, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17509981, Length=321, Percent_Identity=24.6105919003115, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=333, Percent_Identity=27.6276276276276, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21355443, Length=346, Percent_Identity=32.6589595375723, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24644084, Length=346, Percent_Identity=32.6589595375723, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24653912, Length=371, Percent_Identity=23.989218328841, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 37569; Mature: 37569

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNPAEVDAVVLVGGQGTRLRPLTLSAPKPMLPTAGLAFLTHLLSRIAAAGIEHVILGTS
CCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCC
YKAEVFEAEFGDGSKLGLQIEYVYESEPMGTGGAIANVAEKLRHDTAMVFNGDVLSGCDL
CCCEEEEEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCHH
RALLDSHVSKDADVTLHLVRVGDPRAFGCVPTDADGVVTAFLEKTQDPPTDQINAGCYVF
HHHHHHHCCCCCCEEEEEEEECCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHH
KRSVIDRIPRDRAVSVEREVFPGLLSDGLRVCGYVDATYWRDMGTPEDFVRGSADLVRGI
HHHHHHHCCCCCCEEHHHHHHHHHHHCCHHHHEEECHHHHHCCCCHHHHHCCCHHHHHCC
APSPALEGHRGENLVHDGAAVGPGALLIGGTVVGRGAEVGAGARLDGAVIFDGVRVGAGA
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCCEEEECCEEECCCH
VIERSIIGFGARIGPRALIRDAVIGDGADIGARCELLRGARVWPGVKIPDGGIRYSTDV
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCC
>Mature Secondary Structure
MVNPAEVDAVVLVGGQGTRLRPLTLSAPKPMLPTAGLAFLTHLLSRIAAAGIEHVILGTS
CCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCC
YKAEVFEAEFGDGSKLGLQIEYVYESEPMGTGGAIANVAEKLRHDTAMVFNGDVLSGCDL
CCCEEEEEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCHH
RALLDSHVSKDADVTLHLVRVGDPRAFGCVPTDADGVVTAFLEKTQDPPTDQINAGCYVF
HHHHHHHCCCCCCEEEEEEEECCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHH
KRSVIDRIPRDRAVSVEREVFPGLLSDGLRVCGYVDATYWRDMGTPEDFVRGSADLVRGI
HHHHHHHCCCCCCEEHHHHHHHHHHHCCHHHHEEECHHHHHCCCCHHHHHCCCHHHHHCC
APSPALEGHRGENLVHDGAAVGPGALLIGGTVVGRGAEVGAGARLDGAVIFDGVRVGAGA
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCCEEEECCEEECCCH
VIERSIIGFGARIGPRALIRDAVIGDGADIGARCELLRGARVWPGVKIPDGGIRYSTDV
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]