Click here to switch to the map view.

The map label for this gene is rmlD [H]

Identifier: 119867386

GI number: 119867386

Start: 1430949

End: 1431812

Strand: Direct

Name: rmlD [H]

Synonym: Mkms_1336

Alternate gene names: 119867386

Gene position: 1430949-1431812 (Clockwise)

Preceding gene: 119867382

Following gene: 119867387

Centisome position: 24.94

GC content: 74.42

Gene sequence:

>864_bases
ATGCCGCAACGTCTCGTGATCACCGGTGCCGGCGGCATGGTCGGGCGCATCCTGGCTGCTCAGGCACGCCGGCAGGGGCG
CGACGTGTCGGCGCTCACCTCGTCGGACTGCGATATCACCGACACCGCCGCCGTCGCGCGGGCGGTCGCTGCGGGTGACG
TGGTGGTCAACTGCGCGGCCTACACCGACGTCGACCGCGCGGAGTCCGAACCCGAGCGCGCGCATGCGGTCAACGCCGTC
GGTCCGGGCAACCTCGCGGCCGTCTGCGCGCGGGTCGGCGCCGGCCTGATCCACGTCTCGACCGACTACGTCTTCAGCGG
AGACTTCGGCGGGGCGTCGCCGCACCCCTATGAGATCGACGATGCGCCGGCGCCGCTGAGCGTCTACGGGCGCACCAAGC
TCGCCGGAGAGCGGGCGGTGCTCGACGCGCTGCCGCACGGGTACGTCGTGCGGACCGCCTGGGTCTACGAGGGCGCCGAC
GGCACCGACTTCGTCGCCGCGATGCGCCGCAAGGCACTCGGTGCGGACACCGTCGACGTGGTGGCCGACCAGATCGGCTC
ACCCACCAGCGCGCACGACCTGGTCGCGGCGCTACTCGAGATCGCCGACGGGGGAGTGCGCGGACCGCTGCTGCACGCCG
CCAACGACGGTCAGGCCAGCCGCTTCGACCAGGCCCGCGCGGTCTTCGAGACGGTGGGCGCCGACCCCGAGCGGGTGCGA
CCGGTCGGCAGTGACCGCGTCCCGCGGCCGGCACCCCGGCCCGCGTACTCGGCGCTGTCCGGCGCCGGCTCGGCGGCGTG
CGGCCTGACGGCGCTCCGGCCGTGGCGTGAGGCCCTGGTCTCGGCATTGCGCGAGAGCCGGTGA

Upstream 100 bases:

>100_bases
GCGAAGGACTCGAGCGGGCATCAGCCCAGGCTACTGGCGAGGGCAGCGCAGACGGGGTAGCGATCGTCGGCGCGCCAGGG
CGCGTGTCAAACTCACACGT

Downstream 100 bases:

>100_bases
CGTGCCGCTACCCTCTACGCCGTGTTGCGTGAACGGGCGGTCGCCGGATGAGTGACGAGTTGGTCGTCGTCACGGTGACG
TACTCGCCGGGCCCGCACCT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPQRLVITGAGGMVGRILAAQARRQGRDVSALTSSDCDITDTAAVARAVAAGDVVVNCAAYTDVDRAESEPERAHAVNAV
GPGNLAAVCARVGAGLIHVSTDYVFSGDFGGASPHPYEIDDAPAPLSVYGRTKLAGERAVLDALPHGYVVRTAWVYEGAD
GTDFVAAMRRKALGADTVDVVADQIGSPTSAHDLVAALLEIADGGVRGPLLHAANDGQASRFDQARAVFETVGADPERVR
PVGSDRVPRPAPRPAYSALSGAGSAACGLTALRPWREALVSALRESR

Sequences:

>Translated_287_residues
MPQRLVITGAGGMVGRILAAQARRQGRDVSALTSSDCDITDTAAVARAVAAGDVVVNCAAYTDVDRAESEPERAHAVNAV
GPGNLAAVCARVGAGLIHVSTDYVFSGDFGGASPHPYEIDDAPAPLSVYGRTKLAGERAVLDALPHGYVVRTAWVYEGAD
GTDFVAAMRRKALGADTVDVVADQIGSPTSAHDLVAALLEIADGGVRGPLLHAANDGQASRFDQARAVFETVGADPERVR
PVGSDRVPRPAPRPAYSALSGAGSAACGLTALRPWREALVSALRESR
>Mature_286_residues
PQRLVITGAGGMVGRILAAQARRQGRDVSALTSSDCDITDTAAVARAVAAGDVVVNCAAYTDVDRAESEPERAHAVNAVG
PGNLAAVCARVGAGLIHVSTDYVFSGDFGGASPHPYEIDDAPAPLSVYGRTKLAGERAVLDALPHGYVVRTAWVYEGADG
TDFVAAMRRKALGADTVDVVADQIGSPTSAHDLVAALLEIADGGVRGPLLHAANDGQASRFDQARAVFETVGADPERVRP
VGSDRVPRPAPRPAYSALSGAGSAACGLTALRPWREALVSALRESR

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=299, Percent_Identity=27.4247491638796, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI33519455, Length=299, Percent_Identity=27.4247491638796, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1788352, Length=298, Percent_Identity=33.5570469798658, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 29602; Mature: 29471

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQRLVITGAGGMVGRILAAQARRQGRDVSALTSSDCDITDTAAVARAVAAGDVVVNCAA
CCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCEEEEHH
YTDVDRAESEPERAHAVNAVGPGNLAAVCARVGAGLIHVSTDYVFSGDFGGASPHPYEID
HCCCHHHCCCCHHHHEECCCCCCHHHHHHHHHCCCEEEEEECEEEECCCCCCCCCCCCCC
DAPAPLSVYGRTKLAGERAVLDALPHGYVVRTAWVYEGADGTDFVAAMRRKALGADTVDV
CCCCCEEECCCCHHCCHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCHHHH
VADQIGSPTSAHDLVAALLEIADGGVRGPLLHAANDGQASRFDQARAVFETVGADPERVR
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHCC
PVGSDRVPRPAPRPAYSALSGAGSAACGLTALRPWREALVSALRESR
CCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PQRLVITGAGGMVGRILAAQARRQGRDVSALTSSDCDITDTAAVARAVAAGDVVVNCAA
CCEEEEECCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCEEEEHH
YTDVDRAESEPERAHAVNAVGPGNLAAVCARVGAGLIHVSTDYVFSGDFGGASPHPYEID
HCCCHHHCCCCHHHHEECCCCCCHHHHHHHHHCCCEEEEEECEEEECCCCCCCCCCCCCC
DAPAPLSVYGRTKLAGERAVLDALPHGYVVRTAWVYEGADGTDFVAAMRRKALGADTVDV
CCCCCEEECCCCHHCCHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCHHHH
VADQIGSPTSAHDLVAALLEIADGGVRGPLLHAANDGQASRFDQARAVFETVGADPERVR
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHCC
PVGSDRVPRPAPRPAYSALSGAGSAACGLTALRPWREALVSALRESR
CCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA