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The map label for this gene is desA3 [H]

Identifier: 119867326

GI number: 119867326

Start: 1365782

End: 1366891

Strand: Direct

Name: desA3 [H]

Synonym: Mkms_1276

Alternate gene names: 119867326

Gene position: 1365782-1366891 (Clockwise)

Preceding gene: 119867325

Following gene: 119867333

Centisome position: 23.81

GC content: 64.5

Gene sequence:

>1110_bases
ATGACTTCCACCATCACCCCCGCACCCCCGCAACGGGGCGTCGAGAAGACCGTCGCCGGCCAGCCCGTGCGCCTGTCCGC
CGAACAGGTCGAGGAATTCGGCCGTGAACTCGACGCGCTGCGCGAACAGGTGGTCGCCGACCTCGGCGAACGCGACACCA
CCTACATCCGCAAGGTCATCAAGGCCCAGCGAACACTCGAAATCGGCGGCCGCGCCATGCTCTTCGGCGGCATCTTCCCA
CCGTTCTGGCTCGCCGGCACGGCGATGCTGGGCCTGTCGAAGATCATCGACAACATGGAGATCGGCCACAACGTCATGCA
CGGCCAGTACGACTGGACCGGCGACCCGGCGTTGTCCAGCAAGAAGTTCGAATGGGACAACGCCTGCCCGGGCGACCAGT
GGCGGCATTCGCACAACTACATGCACCACACCTACACCAACATCGTCGGCATGGACCGCGACATCGGCTACGGCATCCTG
CGGATGAGCGAGAACCAGCGGTGGCAGCCGTACTTCCTGGGCAACCCGGTTTACGCGTTCCTGCTGATGGTGCTGTTCCA
GTACGGCGTCGCACTGCACGAACTGGAGACCGAGCGCATCCGGGCCGGTGAGATCAGCATCGCCGACAAACGCGAGATCC
TGCAGGGTATCTGGCGTAAGACAAAGCGGCAGACGCTCAAGGACTACGTCGCCTTCCCGCTGCTGGCCGGACCGTTCGCG
CCGTGGGTGTTCACCGGTAACCTGACCGCGAACCTGATGCGCAACGTGTGGTCGTACATGATCATCTTCTGCGGTCATTT
CCCCGAAGACGTGCAGGAGTTCTCGATCGAGGAGACCAAGGCCGAATCACGCGGCCAGTGGTACTTCCGCCAAGTGCTCG
GATCGGCGAACCTGACCGGGGGCAAGCTCTTTCACCTGCTGAGCGGGAACCTGTCGTTCCAGATCGAGCACCACCTGTTC
CCCGACATCCCGGCCCACCGCCACGCCGAACTCGCACCCGCGGTGCGTGACATCTGCCGCCGCTACGGGTTGCCGTACAA
CTCCGGGCCGCTGCCGCGCCAGTTCGCCAGCGTGGTGCGCAAGATCGTGCGGCTGGCGCTGCCGGGCTGA

Upstream 100 bases:

>100_bases
TCACCGGCGCGGTGTCGGGGGTCGACGAGGAGGACGTGCAGATCTGCGTGTCCGCACCCGTCGGCGACGTCGAGATCGCG
CTCTAGGAAAGGAATCAGCC

Downstream 100 bases:

>100_bases
CCGATCGCGTTCGCGCCGAGACTACGGTTGTTGCGCACAATTCCCCGAAATCCGTCAACAACCGTAGTATCGGCGTCTCG
CGGTCGGAGTCACCAGCCCC

Product: fatty acid desaturase

Products: NA

Alternate protein names: Delta(9)-desaturase; Stearoyl-CoA desaturase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTSTITPAPPQRGVEKTVAGQPVRLSAEQVEEFGRELDALREQVVADLGERDTTYIRKVIKAQRTLEIGGRAMLFGGIFP
PFWLAGTAMLGLSKIIDNMEIGHNVMHGQYDWTGDPALSSKKFEWDNACPGDQWRHSHNYMHHTYTNIVGMDRDIGYGIL
RMSENQRWQPYFLGNPVYAFLLMVLFQYGVALHELETERIRAGEISIADKREILQGIWRKTKRQTLKDYVAFPLLAGPFA
PWVFTGNLTANLMRNVWSYMIIFCGHFPEDVQEFSIEETKAESRGQWYFRQVLGSANLTGGKLFHLLSGNLSFQIEHHLF
PDIPAHRHAELAPAVRDICRRYGLPYNSGPLPRQFASVVRKIVRLALPG

Sequences:

>Translated_369_residues
MTSTITPAPPQRGVEKTVAGQPVRLSAEQVEEFGRELDALREQVVADLGERDTTYIRKVIKAQRTLEIGGRAMLFGGIFP
PFWLAGTAMLGLSKIIDNMEIGHNVMHGQYDWTGDPALSSKKFEWDNACPGDQWRHSHNYMHHTYTNIVGMDRDIGYGIL
RMSENQRWQPYFLGNPVYAFLLMVLFQYGVALHELETERIRAGEISIADKREILQGIWRKTKRQTLKDYVAFPLLAGPFA
PWVFTGNLTANLMRNVWSYMIIFCGHFPEDVQEFSIEETKAESRGQWYFRQVLGSANLTGGKLFHLLSGNLSFQIEHHLF
PDIPAHRHAELAPAVRDICRRYGLPYNSGPLPRQFASVVRKIVRLALPG
>Mature_368_residues
TSTITPAPPQRGVEKTVAGQPVRLSAEQVEEFGRELDALREQVVADLGERDTTYIRKVIKAQRTLEIGGRAMLFGGIFPP
FWLAGTAMLGLSKIIDNMEIGHNVMHGQYDWTGDPALSSKKFEWDNACPGDQWRHSHNYMHHTYTNIVGMDRDIGYGILR
MSENQRWQPYFLGNPVYAFLLMVLFQYGVALHELETERIRAGEISIADKREILQGIWRKTKRQTLKDYVAFPLLAGPFAP
WVFTGNLTANLMRNVWSYMIIFCGHFPEDVQEFSIEETKAESRGQWYFRQVLGSANLTGGKLFHLLSGNLSFQIEHHLFP
DIPAHRHAELAPAVRDICRRYGLPYNSGPLPRQFASVVRKIVRLALPG

Specific function: Desaturates stearoyl-CoA to form oleoyl-CoA [H]

COG id: COG3239

COG function: function code I; Fatty acid desaturase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Probable). Note=Has been shown to be membrane-associated but no reliable trans-membrane regions are predicted by bioinformatics tools [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fatty acid desaturase family [H]

Homologues:

Organism=Homo sapiens, GI4758334, Length=256, Percent_Identity=23.4375, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI13375616, Length=138, Percent_Identity=28.2608695652174, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI214831730, Length=76, Percent_Identity=36.8421052631579, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005804 [H]

Pfam domain/function: PF00487 FA_desaturase [H]

EC number: NA

Molecular weight: Translated: 42031; Mature: 41900

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTITPAPPQRGVEKTVAGQPVRLSAEQVEEFGRELDALREQVVADLGERDTTYIRKVI
CCCCCCCCCCCCCCHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAQRTLEIGGRAMLFGGIFPPFWLAGTAMLGLSKIIDNMEIGHNVMHGQYDWTGDPALSS
HHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCC
KKFEWDNACPGDQWRHSHNYMHHTYTNIVGMDRDIGYGILRMSENQRWQPYFLGNPVYAF
CCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEECCCHHHHH
LLMVLFQYGVALHELETERIRAGEISIADKREILQGIWRKTKRQTLKDYVAFPLLAGPFA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PWVFTGNLTANLMRNVWSYMIIFCGHFPEDVQEFSIEETKAESRGQWYFRQVLGSANLTG
CEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
GKLFHLLSGNLSFQIEHHLFPDIPAHRHAELAPAVRDICRRYGLPYNSGPLPRQFASVVR
HHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
KIVRLALPG
HHHHHHCCC
>Mature Secondary Structure 
TSTITPAPPQRGVEKTVAGQPVRLSAEQVEEFGRELDALREQVVADLGERDTTYIRKVI
CCCCCCCCCCCCCHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAQRTLEIGGRAMLFGGIFPPFWLAGTAMLGLSKIIDNMEIGHNVMHGQYDWTGDPALSS
HHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCC
KKFEWDNACPGDQWRHSHNYMHHTYTNIVGMDRDIGYGILRMSENQRWQPYFLGNPVYAF
CCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEECCCHHHHH
LLMVLFQYGVALHELETERIRAGEISIADKREILQGIWRKTKRQTLKDYVAFPLLAGPFA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PWVFTGNLTANLMRNVWSYMIIFCGHFPEDVQEFSIEETKAESRGQWYFRQVLGSANLTG
CEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
GKLFHLLSGNLSFQIEHHLFPDIPAHRHAELAPAVRDICRRYGLPYNSGPLPRQFASVVR
HHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
KIVRLALPG
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]