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The map label for this gene is betA [C]

Identifier: 119867074

GI number: 119867074

Start: 1115365

End: 1116795

Strand: Direct

Name: betA [C]

Synonym: Mkms_1022

Alternate gene names: 119867074

Gene position: 1115365-1116795 (Clockwise)

Preceding gene: 119867073

Following gene: 119867077

Centisome position: 19.44

GC content: 71.77

Gene sequence:

>1431_bases
GTGCACAGCGACGTTCTGATCGTCGGCGCCGGAAGCGCCGGATCCGTTTTGGCCGAACGACTTTCCGCCGACCCGCGGTG
CCGCGTCACCGTGGTGGAGGCGGGCCCGGCGCCGTCCGATCCGCGGGTGGCCCAACAGATCAGCGACGGGCTGCGGCTGC
CGATCGGCAGCGCCAGCTCGGTGGTCCGGCACTACCTGACCACGCTCACCGACGCACCGCCGCGGCGCGCGCAGATCACG
CGCGGCGCCGTCGTCGGCGGATCCGGGGCGGTCAACGGCGGATACTTCTGCCGCGGGCTGCCCGCCGATTTCGACGGATG
GCGGGTTCCCGGCTGGACGTGGCGCGACGTGCTGCCGCACTTCCGGGCGATCGAGACCGACCTCGACTTCACCGGGCCAC
TGCACGGGGACAGCGGGCCGATCACGGTCAGCCGGGTGCGTGACTTCGACGGATGTACGGCGTCTTTCGTCGAGGCCGCC
CGGCGTGCCGGTTTCCGGTGGGTCGAGGATCTGAGCGGGCTCGACGCGGACGTGCCCGTCGACGGCGTGGGTGCGGTGCC
GTTGAACGTCGACAGTGGAACCCGCCTCGGACCGGGCGGGGCGTTCCTGCAACCGGCGCTCGAACGGGACAACCTCGACC
TGCTGCCCGACACGCGGGTCACGCGGGTCCAGATCGACCGGGGACGCGCCGTGGCGGTCGAGTGCGCAGGCCCCACCGGT
CGGCAGACCCTCACCGCGGACCGGATCGTGCTGTGCGCGGGCGCGATCGCCACCGCGCAGCTGCTGATGATCTCAGGCGT
GGGCCCGGCAGAGGCATTGCGGGCGTTGGGCATTCGGGTGTGGTCCGATGTGCCCGTCGGCGCCTCGACGTCCGACCACC
CCGAATGGGTGATCCCGGTGAGGTGGACGCCGACCCACGACCTGCCGCCACTGGAGGCGGTCCTCACCACCGACTCCGGT
ATCGAGATCCGGCCGTACACATCGGGTTTCGCGGCCATGGTGCACGGGCCGGGGGACGACCCCGCCGACCATCCGCACAT
CGGCGTCGCGTTGATGCGGCCGCGGTCCAGGGGCAGGCTCACTCTCGCCTCGGCGGATCCGCTGGTCCCCCCGCTGATCG
AACACCGCTACGACAGTGAACCCGATGACGTGGCCGACCTGGCCGCGGGCGCGCAGATCGCCCACGAGATCATCAGCGGC
ACAGTGCCTTCCGGTGAGGCGTCCTGGTCGACGTCCCAGCATCTGGCCGGAACCGCGCCCATGGGCGACGAGGACGATCC
GCGTGCGGTGCTCGACCCTCGGTGCCGGGTGCGCGGCGTCGACGCGTTGTGGGTGGTCGACGGTTCGGTCATGCCCGCCC
TCACCAGCCGGGGCCCACATGCGACGATCACGATGATCGGGCACCGGGCCGCGGAGTTCATCGCGGGCTGA

Upstream 100 bases:

>100_bases
TCGCCTACGGGCTCGGCCTGTGGACCGGGGTGGTGCGCGAACGGCACCTCGGGGCGCTCAAACCCCAGATCCGGACGTAA
GACGGCCCTTGACCGAGGCT

Downstream 100 bases:

>100_bases
GCGGGGTCAACGCCTCGGCCAGGCGGGTGGCGGCCGCGACGCCGTCGATGACCGGGACACCCAGACGCTGCGAGAGCGGC
TCGGCGAAGCGGGCCATCGC

Product: glucose-methanol-choline oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MHSDVLIVGAGSAGSVLAERLSADPRCRVTVVEAGPAPSDPRVAQQISDGLRLPIGSASSVVRHYLTTLTDAPPRRAQIT
RGAVVGGSGAVNGGYFCRGLPADFDGWRVPGWTWRDVLPHFRAIETDLDFTGPLHGDSGPITVSRVRDFDGCTASFVEAA
RRAGFRWVEDLSGLDADVPVDGVGAVPLNVDSGTRLGPGGAFLQPALERDNLDLLPDTRVTRVQIDRGRAVAVECAGPTG
RQTLTADRIVLCAGAIATAQLLMISGVGPAEALRALGIRVWSDVPVGASTSDHPEWVIPVRWTPTHDLPPLEAVLTTDSG
IEIRPYTSGFAAMVHGPGDDPADHPHIGVALMRPRSRGRLTLASADPLVPPLIEHRYDSEPDDVADLAAGAQIAHEIISG
TVPSGEASWSTSQHLAGTAPMGDEDDPRAVLDPRCRVRGVDALWVVDGSVMPALTSRGPHATITMIGHRAAEFIAG

Sequences:

>Translated_476_residues
MHSDVLIVGAGSAGSVLAERLSADPRCRVTVVEAGPAPSDPRVAQQISDGLRLPIGSASSVVRHYLTTLTDAPPRRAQIT
RGAVVGGSGAVNGGYFCRGLPADFDGWRVPGWTWRDVLPHFRAIETDLDFTGPLHGDSGPITVSRVRDFDGCTASFVEAA
RRAGFRWVEDLSGLDADVPVDGVGAVPLNVDSGTRLGPGGAFLQPALERDNLDLLPDTRVTRVQIDRGRAVAVECAGPTG
RQTLTADRIVLCAGAIATAQLLMISGVGPAEALRALGIRVWSDVPVGASTSDHPEWVIPVRWTPTHDLPPLEAVLTTDSG
IEIRPYTSGFAAMVHGPGDDPADHPHIGVALMRPRSRGRLTLASADPLVPPLIEHRYDSEPDDVADLAAGAQIAHEIISG
TVPSGEASWSTSQHLAGTAPMGDEDDPRAVLDPRCRVRGVDALWVVDGSVMPALTSRGPHATITMIGHRAAEFIAG
>Mature_476_residues
MHSDVLIVGAGSAGSVLAERLSADPRCRVTVVEAGPAPSDPRVAQQISDGLRLPIGSASSVVRHYLTTLTDAPPRRAQIT
RGAVVGGSGAVNGGYFCRGLPADFDGWRVPGWTWRDVLPHFRAIETDLDFTGPLHGDSGPITVSRVRDFDGCTASFVEAA
RRAGFRWVEDLSGLDADVPVDGVGAVPLNVDSGTRLGPGGAFLQPALERDNLDLLPDTRVTRVQIDRGRAVAVECAGPTG
RQTLTADRIVLCAGAIATAQLLMISGVGPAEALRALGIRVWSDVPVGASTSDHPEWVIPVRWTPTHDLPPLEAVLTTDSG
IEIRPYTSGFAAMVHGPGDDPADHPHIGVALMRPRSRGRLTLASADPLVPPLIEHRYDSEPDDVADLAAGAQIAHEIISG
TVPSGEASWSTSQHLAGTAPMGDEDDPRAVLDPRCRVRGVDALWVVDGSVMPALTSRGPHATITMIGHRAAEFIAG

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=538, Percent_Identity=30.6691449814126, Blast_Score=189, Evalue=4e-48,
Organism=Escherichia coli, GI1786503, Length=545, Percent_Identity=29.3577981651376, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17532301, Length=550, Percent_Identity=27.0909090909091, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24642042, Length=562, Percent_Identity=29.7153024911032, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17137792, Length=549, Percent_Identity=28.4153005464481, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24642048, Length=564, Percent_Identity=29.7872340425532, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24642035, Length=568, Percent_Identity=26.9366197183099, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI45551458, Length=569, Percent_Identity=26.8892794376098, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI45549471, Length=567, Percent_Identity=26.984126984127, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24642059, Length=564, Percent_Identity=27.4822695035461, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24642039, Length=309, Percent_Identity=33.0097087378641, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18859995, Length=304, Percent_Identity=34.5394736842105, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI18859993, Length=575, Percent_Identity=24.3478260869565, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24642037, Length=304, Percent_Identity=34.5394736842105, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24650267, Length=309, Percent_Identity=32.6860841423948, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24642051, Length=305, Percent_Identity=33.4426229508197, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24642055, Length=307, Percent_Identity=32.2475570032573, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24645930, Length=234, Percent_Identity=27.3504273504274, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 50059; Mature: 50059

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSDVLIVGAGSAGSVLAERLSADPRCRVTVVEAGPAPSDPRVAQQISDGLRLPIGSASS
CCCCEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHH
VVRHYLTTLTDAPPRRAQITRGAVVGGSGAVNGGYFCRGLPADFDGWRVPGWTWRDVLPH
HHHHHHHHHCCCCCCHHEEECCEEECCCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHHH
FRAIETDLDFTGPLHGDSGPITVSRVRDFDGCTASFVEAARRAGFRWVEDLSGLDADVPV
HHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCC
DGVGAVPLNVDSGTRLGPGGAFLQPALERDNLDLLPDTRVTRVQIDRGRAVAVECAGPTG
CCCCEEEEECCCCCEECCCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCC
RQTLTADRIVLCAGAIATAQLLMISGVGPAEALRALGIRVWSDVPVGASTSDHPEWVIPV
CCEECCCCEEEEHHHHHHHEEHEEECCCHHHHHHHHCEEEECCCCCCCCCCCCCCEEEEE
RWTPTHDLPPLEAVLTTDSGIEIRPYTSGFAAMVHGPGDDPADHPHIGVALMRPRSRGRL
EECCCCCCCCCEEEEECCCCCEEEECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCE
TLASADPLVPPLIEHRYDSEPDDVADLAAGAQIAHEIISGTVPSGEASWSTSQHLAGTAP
EEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
MGDEDDPRAVLDPRCRVRGVDALWVVDGSVMPALTSRGPHATITMIGHRAAEFIAG
CCCCCCCCCCCCCCCEEECCCEEEEECCCCHHHHHCCCCCEEEEEECHHHHHHHCC
>Mature Secondary Structure
MHSDVLIVGAGSAGSVLAERLSADPRCRVTVVEAGPAPSDPRVAQQISDGLRLPIGSASS
CCCCEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHH
VVRHYLTTLTDAPPRRAQITRGAVVGGSGAVNGGYFCRGLPADFDGWRVPGWTWRDVLPH
HHHHHHHHHCCCCCCHHEEECCEEECCCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHHH
FRAIETDLDFTGPLHGDSGPITVSRVRDFDGCTASFVEAARRAGFRWVEDLSGLDADVPV
HHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCC
DGVGAVPLNVDSGTRLGPGGAFLQPALERDNLDLLPDTRVTRVQIDRGRAVAVECAGPTG
CCCCEEEEECCCCCEECCCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCC
RQTLTADRIVLCAGAIATAQLLMISGVGPAEALRALGIRVWSDVPVGASTSDHPEWVIPV
CCEECCCCEEEEHHHHHHHEEHEEECCCHHHHHHHHCEEEECCCCCCCCCCCCCCEEEEE
RWTPTHDLPPLEAVLTTDSGIEIRPYTSGFAAMVHGPGDDPADHPHIGVALMRPRSRGRL
EECCCCCCCCCEEEEECCCCCEEEECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCE
TLASADPLVPPLIEHRYDSEPDDVADLAAGAQIAHEIISGTVPSGEASWSTSQHLAGTAP
EEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
MGDEDDPRAVLDPRCRVRGVDALWVVDGSVMPALTSRGPHATITMIGHRAAEFIAG
CCCCCCCCCCCCCCCEEECCCEEEEECCCCHHHHHCCCCCEEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7836301 [H]