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The map label for this gene is hmrR [H]

Identifier: 119866964

GI number: 119866964

Start: 995910

End: 996287

Strand: Reverse

Name: hmrR [H]

Synonym: Mkms_0912

Alternate gene names: 119866964

Gene position: 996287-995910 (Counterclockwise)

Preceding gene: 119866965

Following gene: 119866963

Centisome position: 17.37

GC content: 71.16

Gene sequence:

>378_bases
GTGTCCGAGCGCCTGCAGATCGGTGAGGTCGCCGCCCGCACCGAGCTGTCGATCAAGACCATCCGCCACTACGACGACGT
CGGCCTGGTCACCCCGTCGGCGCGTTCGGCGGGCGGGTTCCGCCTCTACACCGACGACGACGTCGAACGGCTGCTCACCA
TCCGGCGGATGAAACCGCTGGGCTTCACGCTCGAGGAGATGCGGGACCTGTTGACCGCCCTCGACACCCTCGCCGGTCCG
GCCGCCGACGCGCAGCGGGCACAGGCGACCGCCTACCTCGCCGAGTGCCACACCCGCGCGCAGCAGGCGTGTGCCGACCT
CGCGCGCCAGCTCGCCTACGCCCACGAGCTCACCGAGCGACTCGCCCGTTACTGCTGA

Upstream 100 bases:

>100_bases
GTACGCGGCCAAAGGCAAGACGGCCACGATCGTCGGCCTCGACGACACCAGCGCCGAACGCCACCGGCGCCTCACAGGCC
GGCTCGCGGGTTCGCACTAG

Downstream 100 bases:

>100_bases
CCATCGCAGACCCCGCACCGTAGGGTGGCCCTGTGGTGGCCCAGCTCAGTCGTCGTCGGACCATGCGCGCCGACCCGCAG
CAGGTGTGGGAGGTGCTCGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MSERLQIGEVAARTELSIKTIRHYDDVGLVTPSARSAGGFRLYTDDDVERLLTIRRMKPLGFTLEEMRDLLTALDTLAGP
AADAQRAQATAYLAECHTRAQQACADLARQLAYAHELTERLARYC

Sequences:

>Translated_125_residues
MSERLQIGEVAARTELSIKTIRHYDDVGLVTPSARSAGGFRLYTDDDVERLLTIRRMKPLGFTLEEMRDLLTALDTLAGP
AADAQRAQATAYLAECHTRAQQACADLARQLAYAHELTERLARYC
>Mature_124_residues
SERLQIGEVAARTELSIKTIRHYDDVGLVTPSARSAGGFRLYTDDDVERLLTIRRMKPLGFTLEEMRDLLTALDTLAGPA
ADAQRAQATAYLAECHTRAQQACADLARQLAYAHELTERLARYC

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=66, Percent_Identity=45.4545454545455, Blast_Score=66, Evalue=6e-13,
Organism=Escherichia coli, GI1786695, Length=82, Percent_Identity=37.8048780487805, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 13941; Mature: 13810

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERLQIGEVAARTELSIKTIRHYDDVGLVTPSARSAGGFRLYTDDDVERLLTIRRMKPL
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCC
GFTLEEMRDLLTALDTLAGPAADAQRAQATAYLAECHTRAQQACADLARQLAYAHELTER
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LARYC
HHHCC
>Mature Secondary Structure 
SERLQIGEVAARTELSIKTIRHYDDVGLVTPSARSAGGFRLYTDDDVERLLTIRRMKPL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCC
GFTLEEMRDLLTALDTLAGPAADAQRAQATAYLAECHTRAQQACADLARQLAYAHELTER
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LARYC
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]