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The map label for this gene is 119866787

Identifier: 119866787

GI number: 119866787

Start: 778116

End: 779000

Strand: Direct

Name: 119866787

Synonym: Mkms_0733

Alternate gene names: NA

Gene position: 778116-779000 (Clockwise)

Preceding gene: 119866785

Following gene: 119866790

Centisome position: 13.56

GC content: 70.4

Gene sequence:

>885_bases
ATGTCTTCGTCTGTCACCACCCACGGCATCGTTGTCGGTGTCGACGGGTCCGCCGCCGGCAAGGTCGCGGCGGATTGGGC
GGCACGCGACGCCGCCCGGCGCGGGGTGCCGCTCACGCTCGTCCACGTCATCGCGCCGAAGGACCTGCAGATGTGGATCG
AGGTCCCGGCCCCGCAGGAGTATCTGCGCTGGCAGTCCGAACGCAGTGAGCGTGTCATGGCGGAGGCGACGGCGATCGCC
GAACGGGCCGCCGAGAACCGGCAGCTCACGGTGGTGCGGCAGGTCGTCCCCGGCGAGGCGAAGGCGACGTTGATCGACAT
GTCCAAGGACGCCGACATGGTCGTCGTCGGCAGCCGCGGCCTCGGCGCCTGGGGCAGGCGGCTGCTCGGCTCGGTGAGCA
CCGCCGTCGTGCACCACGCCCAGTGTCCGGTCGCGGTGATCCACGACGAAGACCCGCTGATGGACCACCCCGACCAGGCT
CCCGTCGTGGTCGGGGTCGACGGCTCCAAGGCCGCCGAACAGGCGATCGCGATCGCGTTCGAAGAGGCATCCCTGCGCGG
CGTCGACCTGGTCGCCGTCCACGCCTGGAACGACGTCGACTACGAATTCCCCGACATCAAGTGGGTGGACTACACGGCCC
GTGGCGAGCGCATCGTCGCCGAATGCCTGGCCGGCTACTGCGAGACCTACCCCGACGTGACGGTGCGCAAGGTGCTGGTG
CGCGACCGCCCGGCCCACCAGTTGCTGCAGCAGTCCGAGGCGGCGCAACTGCTCGTCGTGGGCAGCCACGGCCGCGGCGG
GTTCCCTGGCATGCTGCTCGGCTCGGTCAGCTCCGAGGTGGTGCAGTCCGCGCGAATGCCGGTGATCGTGGCCCGCAGCA
ACTGA

Upstream 100 bases:

>100_bases
ACCACGCGGCGCAACACCTCGCCCGCGAACGCACACGGGTTGAGGACTTTGGTGCGGCTGTCACCGTAGTGTTCGTAGGG
AAGCCCACTGAAGGAGCGCC

Downstream 100 bases:

>100_bases
TCACCGATTCCGAATACTTGCAGCGATGCCGTGGACCAGCAGCACCACGGTATCCGCACCGGCCCGTCGGTCGACCGAGA
TCTGTTGGTACTCGGGAGAA

Product: UspA domain-containing protein

Products: NA

Alternate protein names: USP Rv2623 [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSSSVTTHGIVVGVDGSAAGKVAADWAARDAARRGVPLTLVHVIAPKDLQMWIEVPAPQEYLRWQSERSERVMAEATAIA
ERAAENRQLTVVRQVVPGEAKATLIDMSKDADMVVVGSRGLGAWGRRLLGSVSTAVVHHAQCPVAVIHDEDPLMDHPDQA
PVVVGVDGSKAAEQAIAIAFEEASLRGVDLVAVHAWNDVDYEFPDIKWVDYTARGERIVAECLAGYCETYPDVTVRKVLV
RDRPAHQLLQQSEAAQLLVVGSHGRGGFPGMLLGSVSSEVVQSARMPVIVARSN

Sequences:

>Translated_294_residues
MSSSVTTHGIVVGVDGSAAGKVAADWAARDAARRGVPLTLVHVIAPKDLQMWIEVPAPQEYLRWQSERSERVMAEATAIA
ERAAENRQLTVVRQVVPGEAKATLIDMSKDADMVVVGSRGLGAWGRRLLGSVSTAVVHHAQCPVAVIHDEDPLMDHPDQA
PVVVGVDGSKAAEQAIAIAFEEASLRGVDLVAVHAWNDVDYEFPDIKWVDYTARGERIVAECLAGYCETYPDVTVRKVLV
RDRPAHQLLQQSEAAQLLVVGSHGRGGFPGMLLGSVSSEVVQSARMPVIVARSN
>Mature_293_residues
SSSVTTHGIVVGVDGSAAGKVAADWAARDAARRGVPLTLVHVIAPKDLQMWIEVPAPQEYLRWQSERSERVMAEATAIAE
RAAENRQLTVVRQVVPGEAKATLIDMSKDADMVVVGSRGLGAWGRRLLGSVSTAVVHHAQCPVAVIHDEDPLMDHPDQAP
VVVGVDGSKAAEQAIAIAFEEASLRGVDLVAVHAWNDVDYEFPDIKWVDYTARGERIVAECLAGYCETYPDVTVRKVLVR
DRPAHQLLQQSEAAQLLVVGSHGRGGFPGMLLGSVSSEVVQSARMPVIVARSN

Specific function: May play a role in the establisment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not sho

COG id: COG0589

COG function: function code T; Universal stress protein UspA and related nucleotide-binding proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the universal stress protein A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014729
- InterPro:   IPR006015
- InterPro:   IPR006016 [H]

Pfam domain/function: PF00582 Usp [H]

EC number: NA

Molecular weight: Translated: 31576; Mature: 31445

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSVTTHGIVVGVDGSAAGKVAADWAARDAARRGVPLTLVHVIAPKDLQMWIEVPAPQE
CCCCEEECEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCHH
YLRWQSERSERVMAEATAIAERAAENRQLTVVRQVVPGEAKATLIDMSKDADMVVVGSRG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCCCCEEEECCCC
LGAWGRRLLGSVSTAVVHHAQCPVAVIHDEDPLMDHPDQAPVVVGVDGSKAAEQAIAIAF
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHEEEEEE
EEASLRGVDLVAVHAWNDVDYEFPDIKWVDYTARGERIVAECLAGYCETYPDVTVRKVLV
ECCCCCCEEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHH
RDRPAHQLLQQSEAAQLLVVGSHGRGGFPGMLLGSVSSEVVQSARMPVIVARSN
CCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure 
SSSVTTHGIVVGVDGSAAGKVAADWAARDAARRGVPLTLVHVIAPKDLQMWIEVPAPQE
CCCEEECEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCHH
YLRWQSERSERVMAEATAIAERAAENRQLTVVRQVVPGEAKATLIDMSKDADMVVVGSRG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCCCCEEEECCCC
LGAWGRRLLGSVSTAVVHHAQCPVAVIHDEDPLMDHPDQAPVVVGVDGSKAAEQAIAIAF
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHEEEEEE
EEASLRGVDLVAVHAWNDVDYEFPDIKWVDYTARGERIVAECLAGYCETYPDVTVRKVLV
ECCCCCCEEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHH
RDRPAHQLLQQSEAAQLLVVGSHGRGGFPGMLLGSVSSEVVQSARMPVIVARSN
CCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]