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The map label for this gene is camD [H]

Identifier: 119866373

GI number: 119866373

Start: 352532

End: 353638

Strand: Reverse

Name: camD [H]

Synonym: Mkms_0318

Alternate gene names: 119866373

Gene position: 353638-352532 (Counterclockwise)

Preceding gene: 119866374

Following gene: 119866372

Centisome position: 6.16

GC content: 68.02

Gene sequence:

>1107_bases
GTGTTCGAAGGACGGATCGCGCGTTTCGACGCACCCGGACAACCGTTCGTGATCGACACCGTCGACCTGGCCGACGTCGG
TCCGGGCGAGATCCTCGTCAAGGTCACGCGGACCAACATCTGCGGGTCGGATCTGCACGCCTGGCACGGCACCTTCGCCA
CCCGCGGACTCGGCGGGCAACTGCCCACCGTCCTCGGCCACGAGATGGTGGGTGCCGTCGCCGCACTGGGCGACGGCGTC
ACCGCGGATTCGAACGGCGTGCCGTTGGCCGAGGGCACCCGCGTGGTGTTCCCCTACTTCTACTCGTGCCACCGCTGCCG
CAACTGTCTGCTGGGGCGGCGGGGTGCCTGCCTGAACCTGAAGATGGCGATGCTCGGGCGTGCCGACGAACCGCCGTACT
TCGTCGGTGGGTACGGCGACTACTACCTGCTACCTGCGGGCGCAGTGGTCTACACCGTGCCCGACGTGGTGTCCGACGAG
GTCGCCTCGGGTGCGAATTGTGCACTCTCACAGGTCATGTACGGGCTCGAGCGGGTGGACCAGCAACTCGGTGAGGTGGT
GGTGGTGCAGGGCGCCGGGGCGCTCGGCCTGTACGCGGTCGCCGTGGCCAAGGCCCGCGGCGCCGCCAAGGTCATCGCGA
TCGACGGAGTCCCCGAGCGTCTGGAGTTGGCGACGGCGTTCGGCGCCGACGCGGTCGTCGACATCACCGAGGCGACCACG
GTCAAGGACCGCGCGAAGATCGTGCGCACGCTGACCGACGGCCACGGCGCCGACGTGGTCGTCGAGGTCGTCGGCCACCC
CGCGGCCATCGACGAGGGCCTCAAACTGCTCGGTCAGTTCGGCCGTTACGTCGAGATCGGCAACATCAACATCGGCAAGA
CCTTCGAGTTCGACCCGTCGCGTTTCGTATTCGGCAACAAGACGATGGTCGGTGTCTCGCTCTACGACCCAGCCGTGCTG
TCGCGGGCCCTGACGTTCCTCGAACAGCACCAGGACCACCTGCCGCTGGACCGTCTCGCCGCGGCGCACTACCCGCTCGA
CCACATCAACGAGGCATTCGCCGCCGCCGACGGCAAACGCGATGTCCGCGCGAGCATCATCCCCTGA

Upstream 100 bases:

>100_bases
CTTCGTCGACACACTGCCGAAGAACCCCAGCGGGAAGCTGCTCAAACGCGATCTGCGGCAACGGTTCAGCGCCGCCCACA
GCCACTGAGAGGGAACACCT

Downstream 100 bases:

>100_bases
TCGAGAAGGAATCCATGCACGACTACACCCGGAAGACCCTGTTCATCGACGGCCGCTGGGCGACCCCGGACGGCGGCGAC
GCGATCGAGGTCATCGACCC

Product: alcohol dehydrogenase

Products: L-sorbose; NADH; H+

Alternate protein names: FDEH [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQLPTVLGHEMVGAVAALGDGV
TADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNLKMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDE
VASGANCALSQVMYGLERVDQQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPSRFVFGNKTMVGVSLYDPAVL
SRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKRDVRASIIP

Sequences:

>Translated_368_residues
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQLPTVLGHEMVGAVAALGDGV
TADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNLKMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDE
VASGANCALSQVMYGLERVDQQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPSRFVFGNKTMVGVSLYDPAVL
SRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKRDVRASIIP
>Mature_368_residues
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQLPTVLGHEMVGAVAALGDGV
TADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNLKMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDE
VASGANCALSQVMYGLERVDQQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPSRFVFGNKTMVGVSLYDPAVL
SRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKRDVRASIIP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=374, Percent_Identity=26.4705882352941, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262073058, Length=374, Percent_Identity=26.4705882352941, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI156627571, Length=274, Percent_Identity=30.2919708029197, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=24.8677248677249, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71565154, Length=373, Percent_Identity=23.3243967828418, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082125, Length=291, Percent_Identity=30.5841924398625, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=27.0588235294118, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790718, Length=346, Percent_Identity=26.5895953757225, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786825, Length=276, Percent_Identity=30.4347826086957, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=316, Percent_Identity=28.1645569620253, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788073, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081918, Length=234, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI226510992, Length=336, Percent_Identity=25.297619047619, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=385, Percent_Identity=25.1948051948052, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788075, Length=316, Percent_Identity=24.3670886075949, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788407, Length=264, Percent_Identity=26.5151515151515, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=360, Percent_Identity=28.6111111111111, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=349, Percent_Identity=27.7936962750716, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=24.9329758713137, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=24.8, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=264, Percent_Identity=31.8181818181818, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=323, Percent_Identity=28.1733746130031, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=294, Percent_Identity=30.952380952381, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=24.5901639344262, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=285, Percent_Identity=30.8771929824561, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=272, Percent_Identity=30.1470588235294, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=321, Percent_Identity=28.3489096573209, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=270, Percent_Identity=28.5185185185185, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=299, Percent_Identity=25.0836120401338, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=26.5415549597855, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137530, Length=234, Percent_Identity=28.6324786324786, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737897, Length=227, Percent_Identity=29.5154185022026, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.14

Molecular weight: Translated: 38991; Mature: 38991

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQ
CCCCCEEEECCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHCCCHHHCCCCCC
LPTVLGHEMVGAVAALGDGVTADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEE
KMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDEVASGANCALSQVMYGLERVD
EHHHHCCCCCCCEEECCCCCEEEECCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHH
QQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
HHHCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCHH
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPS
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCC
RFVFGNKTMVGVSLYDPAVLSRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKR
EEEECCCEEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCC
DVRASIIP
CCEEECCC
>Mature Secondary Structure
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQ
CCCCCEEEECCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHCCCHHHCCCCCC
LPTVLGHEMVGAVAALGDGVTADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEE
KMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDEVASGANCALSQVMYGLERVD
EHHHHCCCCCCCEEECCCCCEEEECCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHH
QQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
HHHCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCHH
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPS
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCC
RFVFGNKTMVGVSLYDPAVLSRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKR
EEEECCCEEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCC
DVRASIIP
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-iditol; NAD+

Specific reaction: L-iditol + NAD+ = L-sorbose + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334169; 3011733 [H]