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The map label for this gene is eccD1 [H]

Identifier: 119866139

GI number: 119866139

Start: 92986

End: 94449

Strand: Direct

Name: eccD1 [H]

Synonym: Mkms_0082

Alternate gene names: 119866139

Gene position: 92986-94449 (Clockwise)

Preceding gene: 119866138

Following gene: 119866140

Centisome position: 1.62

GC content: 70.08

Gene sequence:

>1464_bases
GTGACGATCCTGACCGGCCGGCGTATGACGGATCTCGTACTGCCCGCGGCGGCCCCCGTCGAGACCTACATCGACGAGAC
CGTCGCGGTGCTCGCCGAGATCCTGGAGGACACCCCCAAGGATGTGCTGGCGGGCTTCGACTTCACCGCGCAGGGGGTGT
GGGCGTTCGCGCGTCCCGGGGCGCCGCCACTGAAGGCCGACGAGTCCCTCGACGACGCCGGGGTGGTCGACGGGTCGTTG
CTGACGCTGGTCTCGGTGAGCCGGACGGAACGCTACCGTCCGCTGGTCGAGGACGTGATCGACGCGATCGCGGTGCTCGA
CGAATCCCCGGAGTTCGACCGCGCCGCGCTCAACCGCTTCGTCGGTGTGTCGATACCCCTTGTCTCCGTTGCGATCACGC
TGATGTCCTTGGTCTCGTGGGACCGCACCGGGCAGAGCCTGTGGTGGGCGCTGGCGCTGGCCGTGCTCGGCCTCGGACTG
CTCGGCGGCAGCCTGCTGGCGCAGAACCGCTACGCCAACCTGAACATGGCCGAAAGCCTGCTGATCGCCTCGATTCCGGC
GCTCGCCGGAGGTGCGGCGCTGGCCGTGCCGCTGCCCAACGGCGTCGGATCGCTGGGTGCGCCGCAGCTGGCGGGCGCGG
GCGCCGTGGTGTTGCTGCTGACATTGGCGACCAGGGGCGGGCCCCGGAAGCGGGCCGAGGTCGCGGCCTTCCTGGCGATC
GCCACGGCGGCGCTGACGGCGGCCGCGGTGGGGTACGGATACGGGTGGCAGTACTGGGTGCCCGCGGGTGCGGTCGCATT
CGGCCTGATCGTGCTGACCAACGCGGCGAAGCTGACCGTGGCGGTCGCCCGCATCGCCCTGCCGCCGATCCCCGCACCCG
GTGAGACCGTCACCAACGACGAACTGCTCGATCCGGTCACTTCGCGCGAAGGCGTCGACGAGGAATCGCCGACATGGCAG
GCCATCATCGCCTCGGTGCCCGAATCGGCCGCCCGCCTGCAGGAACGCAGCGTGCTGGCCAAGAAGCTGCTGATCGGCTT
CCTCACGGCGGGCGCGCTCATCCTCGCGGTCGGGGCGGTCGCGGTGGTGGTGCAGGGTCACTTCTTCGTCCACAGCCTGA
TCGTGGCCGGACTGGTCGCCGCGATCTGCGGCTTCCGCTCCCGGTTGTACGCCGAGCGCTGGTGCGCGTGGGCGCTGCTT
GCGGTGACCGTGATCGTGCCGACGGGTGTGATGGTCAGGCTGTGCCAGTGGTATCCCGACGACGCGTGGTTGGTGCTGGC
GATCTACACCGCACTGGGCGCGGTGGCGTTGGTCGTCATCGGTGCCACCGACGGGGTGCGTCGCGTGTCGCCGGTGACCA
AACGGATCCTCGAACTGGTCGACGGCGCGGCGATCGCGGCGGTCATCCCGCTGCTGCTGTGGATCGCCAGCGTGTACGAC
GTGCTGCGCAACCTGCGTTTCTGA

Upstream 100 bases:

>100_bases
CCTTGTCTGACGATTTCGACAGGCTCGAACGGCGTTGACCACCACCGCCGCGGCATCCACCACCTCGAGCGTCACGCCCG
GGCGGCCGTCGACCACCCGG

Downstream 100 bases:

>100_bases
GGGGGACCGGTGAGTGGTGAAGTGCTGCAGGTGAATCCGCCCGCGCTGGCCGGCGCCGGGACGGCGTTCGGGCAGGCCGC
CTCGGGGGTCGCCGGCCTGC

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component D1; Type VII secretion system protein eccD1; T7SS protein eccD1 [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDTPKDVLAGFDFTAQGVWAFARPGAPPLKADESLDDAGVVDGSL
LTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRAALNRFVGVSIPLVSVAITLMSLVSWDRTGQSLWWALALAVLGLGL
LGGSLLAQNRYANLNMAESLLIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVLLLTLATRGGPRKRAEVAAFLAI
ATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKLTVAVARIALPPIPAPGETVTNDELLDPVTSREGVDEESPTWQ
AIIASVPESAARLQERSVLAKKLLIGFLTAGALILAVGAVAVVVQGHFFVHSLIVAGLVAAICGFRSRLYAERWCAWALL
AVTVIVPTGVMVRLCQWYPDDAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILELVDGAAIAAVIPLLLWIASVYD
VLRNLRF

Sequences:

>Translated_487_residues
MTILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDTPKDVLAGFDFTAQGVWAFARPGAPPLKADESLDDAGVVDGSL
LTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRAALNRFVGVSIPLVSVAITLMSLVSWDRTGQSLWWALALAVLGLGL
LGGSLLAQNRYANLNMAESLLIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVLLLTLATRGGPRKRAEVAAFLAI
ATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKLTVAVARIALPPIPAPGETVTNDELLDPVTSREGVDEESPTWQ
AIIASVPESAARLQERSVLAKKLLIGFLTAGALILAVGAVAVVVQGHFFVHSLIVAGLVAAICGFRSRLYAERWCAWALL
AVTVIVPTGVMVRLCQWYPDDAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILELVDGAAIAAVIPLLLWIASVYD
VLRNLRF
>Mature_486_residues
TILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDTPKDVLAGFDFTAQGVWAFARPGAPPLKADESLDDAGVVDGSLL
TLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRAALNRFVGVSIPLVSVAITLMSLVSWDRTGQSLWWALALAVLGLGLL
GGSLLAQNRYANLNMAESLLIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVLLLTLATRGGPRKRAEVAAFLAIA
TAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKLTVAVARIALPPIPAPGETVTNDELLDPVTSREGVDEESPTWQA
IIASVPESAARLQERSVLAKKLLIGFLTAGALILAVGAVAVVVQGHFFVHSLIVAGLVAAICGFRSRLYAERWCAWALLA
VTVIVPTGVMVRLCQWYPDDAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILELVDGAAIAAVIPLLLWIASVYDV
LRNLRF

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as esxA (ESAT-6) and esxB (CFP-10). Responsible for multiple suppressive effects on macrophages and required for bacterial replication after phagocytosis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eccD/snm4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006707 [H]

Pfam domain/function: PF04600 DUF571 [H]

EC number: NA

Molecular weight: Translated: 50981; Mature: 50850

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDTPKDVLAGFDFTAQGVWAFARPG
CCEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCCC
APPLKADESLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRAALNRF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGVSIPLVSVAITLMSLVSWDRTGQSLWWALALAVLGLGLLGGSLLAQNRYANLNMAESL
HCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVLLLTLATRGGPRKRAEVAAFLAI
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
ATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKLTVAVARIALPPIPAPGETVTND
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCH
ELLDPVTSREGVDEESPTWQAIIASVPESAARLQERSVLAKKLLIGFLTAGALILAVGAV
HHHCCHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVVQGHFFVHSLIVAGLVAAICGFRSRLYAERWCAWALLAVTVIVPTGVMVRLCQWYPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILELVDGAAIAAVIPLLLWIASVYD
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VLRNLRF
HHHHCCC
>Mature Secondary Structure 
TILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDTPKDVLAGFDFTAQGVWAFARPG
CEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCCC
APPLKADESLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRAALNRF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGVSIPLVSVAITLMSLVSWDRTGQSLWWALALAVLGLGLLGGSLLAQNRYANLNMAESL
HCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVLLLTLATRGGPRKRAEVAAFLAI
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
ATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKLTVAVARIALPPIPAPGETVTND
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCH
ELLDPVTSREGVDEESPTWQAIIASVPESAARLQERSVLAKKLLIGFLTAGALILAVGAV
HHHCCHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVVQGHFFVHSLIVAGLVAAICGFRSRLYAERWCAWALLAVTVIVPTGVMVRLCQWYPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILELVDGAAIAAVIPLLLWIASVYD
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VLRNLRF
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]