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The map label for this gene is yycF [H]

Identifier: 119855088

GI number: 119855088

Start: 212243

End: 212983

Strand: Reverse

Name: yycF [H]

Synonym: Mkms_5700

Alternate gene names: 119855088

Gene position: 212983-212243 (Counterclockwise)

Preceding gene: 119855092

Following gene: 119855087

Centisome position: 70.5

GC content: 65.32

Gene sequence:

>741_bases
ATGGACAAGCCTGCGGCCACCCCTTCTGCGGGTTATCGAGCGTTGGTGGTCGACGACGAGGTACCGCTGGCCGAAGTCGT
GGCGAGCTACCTCCGACGCGAGCAGTTTGACGTCAGCCTCGCCCACAGCGGAGCGGACGCCTTGGCGCAGGCCCGTGAGA
TCGACCCGGACGTGGTCATCTTGGACCTCGCGTTGCCGGGCATCGACGGCGTGGAGGTATGCCGCCAACTTCGCACGTTC
TCCGATGCCTACGTGGTGATGCTGACCGCACGCGATACCGAAATGGACACCATCGTGGGCCTGTCGGTCGGTGCCGACGA
CTATGTCACCAAACCTTTCAGTCCCCGCGAACTGGTCGCGCGGATCCGCGCCATGTTGCGCCGGCCTCGCACCGTCGCAA
CGCCGACCAGTGCTGCGACCGCGGCCGACGAACCCCCGCCGCGGGCCTTCGGGCCGTTGTCCATCGACGTTGCGGGCCGA
CAGGTATTCATCGACGACGAACCAGTTCTGCTCACCCGCACCGAGTTCGACATCTTGGCCGCGTTATCGTCGCGACCGGC
CGTGGTCTTCAGCCGCCGCCAACTCCTCGAGGCCGTCTGGGGAGACTCCTGGGGCGGAAACAAACATCTAGTCGACGTCC
ACATCGGACATCTGCGCCGCAAATTGTCGGATGACCCCGCCGGTCCCCGCTACGTGATCACCGTCCGCGGAGTCGGATAC
CGAATGGGAAGCGGCCAATGA

Upstream 100 bases:

>100_bases
CTCGTGCGGTCGAGTAGCGAATCGACGATGGTTTTATGAAGATTCGCTCAAGACCTGGGTCGCGGGTTCCTGAATCCCTT
CGGGGCGGCACGATGAGGAC

Downstream 100 bases:

>100_bases
GGACAGACACGAGCATTCAACCCAGGTCGCGGCGCAGTCCTGGAGTCGGGGCGCGACTCCTGCTGGCGCAAGCCTTGGTG
CTCCTCGCCGGCGGCGCAAC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MDKPAATPSAGYRALVVDDEVPLAEVVASYLRREQFDVSLAHSGADALAQAREIDPDVVILDLALPGIDGVEVCRQLRTF
SDAYVVMLTARDTEMDTIVGLSVGADDYVTKPFSPRELVARIRAMLRRPRTVATPTSAATAADEPPPRAFGPLSIDVAGR
QVFIDDEPVLLTRTEFDILAALSSRPAVVFSRRQLLEAVWGDSWGGNKHLVDVHIGHLRRKLSDDPAGPRYVITVRGVGY
RMGSGQ

Sequences:

>Translated_246_residues
MDKPAATPSAGYRALVVDDEVPLAEVVASYLRREQFDVSLAHSGADALAQAREIDPDVVILDLALPGIDGVEVCRQLRTF
SDAYVVMLTARDTEMDTIVGLSVGADDYVTKPFSPRELVARIRAMLRRPRTVATPTSAATAADEPPPRAFGPLSIDVAGR
QVFIDDEPVLLTRTEFDILAALSSRPAVVFSRRQLLEAVWGDSWGGNKHLVDVHIGHLRRKLSDDPAGPRYVITVRGVGY
RMGSGQ
>Mature_246_residues
MDKPAATPSAGYRALVVDDEVPLAEVVASYLRREQFDVSLAHSGADALAQAREIDPDVVILDLALPGIDGVEVCRQLRTF
SDAYVVMLTARDTEMDTIVGLSVGADDYVTKPFSPRELVARIRAMLRRPRTVATPTSAATAADEPPPRAFGPLSIDVAGR
QVFIDDEPVLLTRTEFDILAALSSRPAVVFSRRQLLEAVWGDSWGGNKHLVDVHIGHLRRKLSDDPAGPRYVITVRGVGY
RMGSGQ

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=42.2413793103448, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=40.6113537117904, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=40.7894736842105, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=40.3508771929825, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1786599, Length=236, Percent_Identity=41.1016949152542, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=33.6244541484716, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=34.9137931034483, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=33.7719298245614, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI145693140, Length=226, Percent_Identity=32.7433628318584, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=32.034632034632, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=33.0434782608696, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=33.0434782608696, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789402, Length=235, Percent_Identity=32.3404255319149, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790552, Length=186, Percent_Identity=34.9462365591398, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=34.2342342342342, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=129, Percent_Identity=31.0077519379845, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26732; Mature: 26732

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKPAATPSAGYRALVVDDEVPLAEVVASYLRREQFDVSLAHSGADALAQAREIDPDVVI
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCEEE
LDLALPGIDGVEVCRQLRTFSDAYVVMLTARDTEMDTIVGLSVGADDYVTKPFSPRELVA
EEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHH
RIRAMLRRPRTVATPTSAATAADEPPPRAFGPLSIDVAGRQVFIDDEPVLLTRTEFDILA
HHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCEEEEECCCEEEECCCCEEEEECCHHHHH
ALSSRPAVVFSRRQLLEAVWGDSWGGNKHLVDVHIGHLRRKLSDDPAGPRYVITVRGVGY
HHCCCCEEEHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHCCCCCCCEEEEEEEECEE
RMGSGQ
ECCCCC
>Mature Secondary Structure
MDKPAATPSAGYRALVVDDEVPLAEVVASYLRREQFDVSLAHSGADALAQAREIDPDVVI
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCEEE
LDLALPGIDGVEVCRQLRTFSDAYVVMLTARDTEMDTIVGLSVGADDYVTKPFSPRELVA
EEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHH
RIRAMLRRPRTVATPTSAATAADEPPPRAFGPLSIDVAGRQVFIDDEPVLLTRTEFDILA
HHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCEEEEECCCEEEECCCCEEEEECCHHHHH
ALSSRPAVVFSRRQLLEAVWGDSWGGNKHLVDVHIGHLRRKLSDDPAGPRYVITVRGVGY
HHCCCCEEEHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHCCCCCCCEEEEEEEECEE
RMGSGQ
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]