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The map label for this gene is atpA2 [H]

Identifier: 119776778

GI number: 119776778

Start: 4297038

End: 4298579

Strand: Reverse

Name: atpA2 [H]

Synonym: Sama_3646

Alternate gene names: 119776778

Gene position: 4298579-4297038 (Counterclockwise)

Preceding gene: 119776779

Following gene: 119776777

Centisome position: 99.82

GC content: 53.57

Gene sequence:

>1542_bases
ATGCAACTGAATTCCACTGAAATCAGCGATCTGATTAAGCAGCGGATCGAGCAGTTCGACGTAGTCAGCGAAGCCCGTAA
CGAAGGTACTATCGTTGCGGTAAGCGATGGCATCATCCGCGTACACGGCCTGGCCGATGTAATGCAGGGTGAGATGATCG
AACTGCCTGGCAACCGTTATGCAATCGCGTTGAACCTTGAGCGCGACTCTGTCGGTGCTGTAGTAATGGGTCCTTATGCC
GATCTGGCTGAGGGCGTAAAAGTGAAAACCACTGGCCGTATTCTGGAAGTTCCAGTTGGCCGCGGTCTGCTGGGCCGTGT
GGTAAACACGCTGGGTGAGCCAATCGACGGCAAGGGCCCCATCGACAACGATGGTTTTGCTCCTGTTGAAGTGATTGCTC
CAGGTGTAATTGACCGTAAGTCAGTTTCTCAGCCAGTTCAGACTGGTTACAAAGCCGTTGACTCCATGATCCCAATCGGT
CGTGGCCAGCGTGAGCTGATCATCGGTGACCGTCAGACTGGTAAAACTGCGATGGCTATCGACGCCATCATCAACCAGCG
CGATTCTGGCATCAAGTGTGTGTACGTGGCTGTAGGCCAGAAGGCTTCTACCATCGCCAACGTAGTACGCAAGCTGGAAG
AGCACGGTGCTCTGGCTAACACTGTTGTGGTTGTTGCTTCTGCTTCAGAAGCCGCTGCTCTGCAGTTCCTGGCGCCATAC
TCTGGTTGTACCATGGGTGAATACTTCCGTGACCGCGGTGAAGATGCCCTGATCGTATACGATGACCTGTCTAAGCAGGC
TGTTGCTTACCGTCAGATCTCCCTGCTGCTGCGTCGTCCTCCAGGACGTGAAGCTTACCCAGGTGACGTATTCTATTTGC
ACTCTCGTCTGCTGGAACGTGCTTCCCGCGTGAACGAAGAGTACGTTGAGAAGTTCACCAAGGGCGCCGTGACTGGCAAG
ACCGGTTCTTTGACCGCTCTGCCTATCATCGAAACCCAAGCCGGTGACGTATCTGCGTTCGTACCGACCAACGTAATTTC
GATTACCGACGGTCAGATCTTCCTGGAAACCAACCTGTTTAACTCTGGCCTGCGTCCAGCGGTTAACCCAGGTATTTCGG
TATCCCGTGTAGGTGGTGCCGCCCAGACCAAGATCATTAAGAAACTGTCCGGTGGTATCCGTACCGCGCTGGCACAGTAT
CGTGAGCTTGCTGCGTTCTCTCAGTTTGCATCTGATCTTGACGATGCAACTCGTGCCCAGTTGGAGCACGGTGAGCGTGT
TACCGAACTGATGAAGCAGAAGCAATATGCCCCAATGAGCGTAGCCGAACAGGCTGTGGTGATCTTCGCCGCAGAAAAAG
GCTTCCTGAAGGGTATTGCTCTGAAGAAAGTTGGTGATTTCGAAGCCGCTCTGCTCGCTTTCATGAACGCCGAGCATGCC
AACCTGATGAAGCTTATCAACGATACCGGCGACTATAACGCCGAAATCGAAGCTGAGCTGAAGGCTGGTCTCGACAAGTT
CGTGGCAACCCAAACCTGGTAA

Upstream 100 bases:

>100_bases
GTGTAATTATCAAGGCAGGGGACCTCGTTATCGATGGTTCTGTGAGCGGCAAACTGGCCCGCCTGTCTGATAAGCTGCAA
TCGTAATTGGGAGTTTGAGC

Downstream 100 bases:

>100_bases
AAATCGTCGAGGTGTCATAAGGCACCTCAGGTCCAGATTGGAGAGTAGAGATGGCCGGCGCAAAAGAGATTAAAACCAAG
ATCGCGAGTGTGAAGAACAC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha 2; F-ATPase subunit alpha 2 [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQLNSTEISDLIKQRIEQFDVVSEARNEGTIVAVSDGIIRVHGLADVMQGEMIELPGNRYAIALNLERDSVGAVVMGPYA
DLAEGVKVKTTGRILEVPVGRGLLGRVVNTLGEPIDGKGPIDNDGFAPVEVIAPGVIDRKSVSQPVQTGYKAVDSMIPIG
RGQRELIIGDRQTGKTAMAIDAIINQRDSGIKCVYVAVGQKASTIANVVRKLEEHGALANTVVVVASASEAAALQFLAPY
SGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVNEEYVEKFTKGAVTGK
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNSGLRPAVNPGISVSRVGGAAQTKIIKKLSGGIRTALAQY
RELAAFSQFASDLDDATRAQLEHGERVTELMKQKQYAPMSVAEQAVVIFAAEKGFLKGIALKKVGDFEAALLAFMNAEHA
NLMKLINDTGDYNAEIEAELKAGLDKFVATQTW

Sequences:

>Translated_513_residues
MQLNSTEISDLIKQRIEQFDVVSEARNEGTIVAVSDGIIRVHGLADVMQGEMIELPGNRYAIALNLERDSVGAVVMGPYA
DLAEGVKVKTTGRILEVPVGRGLLGRVVNTLGEPIDGKGPIDNDGFAPVEVIAPGVIDRKSVSQPVQTGYKAVDSMIPIG
RGQRELIIGDRQTGKTAMAIDAIINQRDSGIKCVYVAVGQKASTIANVVRKLEEHGALANTVVVVASASEAAALQFLAPY
SGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVNEEYVEKFTKGAVTGK
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNSGLRPAVNPGISVSRVGGAAQTKIIKKLSGGIRTALAQY
RELAAFSQFASDLDDATRAQLEHGERVTELMKQKQYAPMSVAEQAVVIFAAEKGFLKGIALKKVGDFEAALLAFMNAEHA
NLMKLINDTGDYNAEIEAELKAGLDKFVATQTW
>Mature_513_residues
MQLNSTEISDLIKQRIEQFDVVSEARNEGTIVAVSDGIIRVHGLADVMQGEMIELPGNRYAIALNLERDSVGAVVMGPYA
DLAEGVKVKTTGRILEVPVGRGLLGRVVNTLGEPIDGKGPIDNDGFAPVEVIAPGVIDRKSVSQPVQTGYKAVDSMIPIG
RGQRELIIGDRQTGKTAMAIDAIINQRDSGIKCVYVAVGQKASTIANVVRKLEEHGALANTVVVVASASEAAALQFLAPY
SGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVNEEYVEKFTKGAVTGK
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNSGLRPAVNPGISVSRVGGAAQTKIIKKLSGGIRTALAQY
RELAAFSQFASDLDDATRAQLEHGERVTELMKQKQYAPMSVAEQAVVIFAAEKGFLKGIALKKVGDFEAALLAFMNAEHA
NLMKLINDTGDYNAEIEAELKAGLDKFVATQTW

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=513, Percent_Identity=55.1656920077973, Blast_Score=557, Evalue=1e-158,
Organism=Homo sapiens, GI4757810, Length=513, Percent_Identity=55.1656920077973, Blast_Score=557, Evalue=1e-158,
Organism=Homo sapiens, GI32189394, Length=364, Percent_Identity=27.4725274725275, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI19913428, Length=323, Percent_Identity=27.2445820433437, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI19913426, Length=323, Percent_Identity=27.2445820433437, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI19913424, Length=267, Percent_Identity=27.3408239700375, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790172, Length=513, Percent_Identity=85.1851851851852, Blast_Score=912, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=340, Percent_Identity=27.0588235294118, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788251, Length=378, Percent_Identity=24.0740740740741, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=515, Percent_Identity=55.9223300970874, Blast_Score=559, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI71988080, Length=515, Percent_Identity=55.9223300970874, Blast_Score=558, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI71988074, Length=515, Percent_Identity=52.2330097087379, Blast_Score=513, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17510931, Length=368, Percent_Identity=25.8152173913043, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI25144756, Length=368, Percent_Identity=26.6304347826087, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17570191, Length=310, Percent_Identity=26.1290322580645, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17509265, Length=47, Percent_Identity=65.9574468085106, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=262, Percent_Identity=26.7175572519084, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=513, Percent_Identity=54.5808966861598, Blast_Score=567, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322581, Length=475, Percent_Identity=26.5263157894737, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319603, Length=376, Percent_Identity=27.3936170212766, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24658560, Length=514, Percent_Identity=54.6692607003891, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI281361666, Length=354, Percent_Identity=27.1186440677966, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646341, Length=354, Percent_Identity=27.1186440677966, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136796, Length=354, Percent_Identity=27.1186440677966, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24638766, Length=428, Percent_Identity=25.4672897196262, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574560, Length=321, Percent_Identity=25.8566978193146, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583992, Length=359, Percent_Identity=25.3481894150418, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583988, Length=267, Percent_Identity=27.7153558052434, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583986, Length=267, Percent_Identity=27.7153558052434, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583984, Length=267, Percent_Identity=27.7153558052434, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI20129479, Length=372, Percent_Identity=25.5376344086022, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55198; Mature: 55198

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNSTEISDLIKQRIEQFDVVSEARNEGTIVAVSDGIIRVHGLADVMQGEMIELPGNRY
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEECHHHHHCCCEEECCCCEE
AIALNLERDSVGAVVMGPYADLAEGVKVKTTGRILEVPVGRGLLGRVVNTLGEPIDGKGP
EEEEEECCCCCCEEEECCCHHHHCCCEEEECCCEEEECCCCCHHHHHHHHHCCCCCCCCC
IDNDGFAPVEVIAPGVIDRKSVSQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTAMAI
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DAIINQRDSGIKCVYVAVGQKASTIANVVRKLEEHGALANTVVVVASASEAAALQFLAPY
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHCCCC
SGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLER
CCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ASRVNEEYVEKFTKGAVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLF
HHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCC
NSGLRPAVNPGISVSRVGGAAQTKIIKKLSGGIRTALAQYRELAAFSQFASDLDDATRAQ
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEHGERVTELMKQKQYAPMSVAEQAVVIFAAEKGFLKGIALKKVGDFEAALLAFMNAEHA
HHCCHHHHHHHHHHCCCCHHHHCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCHH
NLMKLINDTGDYNAEIEAELKAGLDKFVATQTW
HHHHHHHCCCCCCCEEEHHHHHCHHHHHHCCCC
>Mature Secondary Structure
MQLNSTEISDLIKQRIEQFDVVSEARNEGTIVAVSDGIIRVHGLADVMQGEMIELPGNRY
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEECHHHHHCCCEEECCCCEE
AIALNLERDSVGAVVMGPYADLAEGVKVKTTGRILEVPVGRGLLGRVVNTLGEPIDGKGP
EEEEEECCCCCCEEEECCCHHHHCCCEEEECCCEEEECCCCCHHHHHHHHHCCCCCCCCC
IDNDGFAPVEVIAPGVIDRKSVSQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTAMAI
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DAIINQRDSGIKCVYVAVGQKASTIANVVRKLEEHGALANTVVVVASASEAAALQFLAPY
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHCCCC
SGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLER
CCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ASRVNEEYVEKFTKGAVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLF
HHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCC
NSGLRPAVNPGISVSRVGGAAQTKIIKKLSGGIRTALAQYRELAAFSQFASDLDDATRAQ
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEHGERVTELMKQKQYAPMSVAEQAVVIFAAEKGFLKGIALKKVGDFEAALLAFMNAEHA
HHCCHHHHHHHHHHCCCCHHHHCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCHH
NLMKLINDTGDYNAEIEAELKAGLDKFVATQTW
HHHHHHHCCCCCCCEEEHHHHHCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA