Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 119776736

GI number: 119776736

Start: 4240343

End: 4241677

Strand: Reverse

Name: hemN [H]

Synonym: Sama_3604

Alternate gene names: 119776736

Gene position: 4241677-4240343 (Counterclockwise)

Preceding gene: 119776737

Following gene: 119776733

Centisome position: 98.5

GC content: 55.51

Gene sequence:

>1335_bases
ATGACCAGCAGTTCAACCTTAGCCATTACCGCCGCCCATCAGGCGCAAGTCGATATTACTCTGCCGGCATGGCTGCTGGG
CACCGCCGAACGGGTGATGAACTTCTATGTTGATCGCAATCTGCGGCTCGATAACCTGTCTGTTGATACCATGCCCGCCC
CAGTGCCCGGTAAAAAGTACATGCTTTATGCACATGTGCCTTTCTGCCATACCCTCTGTTCTTACTGCACCTTCCACCGC
TTTACCTTCAAGGAAGACAAGGCTCGCGCTTATTTTATTTCCCTGCGTAAAGAGATGACCATGGCGAAGGAGCTCGGTTA
CGACTTCGAGTCCATGTATATCGGTGGCGGCACCACCACTGTGCTGGAAGACGAGCTGGCCCGCACCATTGAGCATGCCA
GACTGCTGTTCCCCTCCATTAAGGAAGTCTCCTGCGAGTCAGACCCGCGCCACCTGGCGAGCCCCGAGTTCCGTCAGCTC
AAGGGGCTGGTTGACCGCATGTCCATTGGGGTGCAGAGTTTCGATGACGGCATCCTCAAGATGACTGACCGTTTCGAAAA
GTTTGGCTCGGGGCTGCAAACCTTCGACCGTATTCAGGCGGCCAAGGAGCTGTTCCCCATCATCAACGTGGATCTGATTT
TCGGCTTCCGGGGCCAAACCGAAGAGGTGATCCAGCGGGATCTCGACATGGCCCGCCGCCTCGACCCAAGGCAGATCACC
ACCTACCCGCTGATGATCACCCATCAGACCCGTAAGAGTGTAAAGGGCAAGCTGGCGGCGCCCCAGGCGGATCTGGCTCG
TCAGTACAGCCAAATCCTCACCAGCCTGCGTGGCCAGTACAACCAGTTGTCGAGCTGGGCATTCGGCAAAGCCAACGATG
AGGGCTTTGATGAGTATGTAATTGATTATGATGAATATCTTGGTGTGGGTTCGGGTTCGTTCAGCTTCCTCGGCGACACC
CTGTATGTGAACACCTTCTCGCTGCGCAAATATCAGGAGCGCATTGAGGCGGGCAAGATGAGCGTCGAGCAGCAAAAACG
CTACGACACCAAGGCCATCATGCAGTACCGCTTCTTGCTGGGGCTCTTCTCGGGCAGGCTGTCGCGCCAGTATTTCCGCG
ACACCTTTGGCGTTAACCTTGATACCGCGCTGTTCAAGGAAATGGCCGCCATGAAGCTGATTGGCGCCCTGAAAAACGAC
CCAGCCAATCCAGAGGAACTCCTGGTTACCGACAACGGCAATCTGATGGGCCTGCTGATGATGAAGGAGTTTTACTCCGG
CATGGATAACGTACGGGCACAGCTGCGTCAACCGCTGAAGAATTGCGATATGTAA

Upstream 100 bases:

>100_bases
TTACCTATGTCTAAATGGGTAGGCTATGGATAGCAAACTCGAAATGTTTTCTTTTTATTTCAAAAAGATCCATTTCAGAT
AATCTTTGACAGGAAGCCCT

Downstream 100 bases:

>100_bases
GACGTGCTTGTACCTGGAGGCGGTTAGCGGCCTTCAATAATACAGCGTTTACTCTGCGCTAAGGGTTACGGGATGGCCTG
GTGCAACAAGGTCGCAATCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTSSSTLAITAAHQAQVDITLPAWLLGTAERVMNFYVDRNLRLDNLSVDTMPAPVPGKKYMLYAHVPFCHTLCSYCTFHR
FTFKEDKARAYFISLRKEMTMAKELGYDFESMYIGGGTTTVLEDELARTIEHARLLFPSIKEVSCESDPRHLASPEFRQL
KGLVDRMSIGVQSFDDGILKMTDRFEKFGSGLQTFDRIQAAKELFPIINVDLIFGFRGQTEEVIQRDLDMARRLDPRQIT
TYPLMITHQTRKSVKGKLAAPQADLARQYSQILTSLRGQYNQLSSWAFGKANDEGFDEYVIDYDEYLGVGSGSFSFLGDT
LYVNTFSLRKYQERIEAGKMSVEQQKRYDTKAIMQYRFLLGLFSGRLSRQYFRDTFGVNLDTALFKEMAAMKLIGALKND
PANPEELLVTDNGNLMGLLMMKEFYSGMDNVRAQLRQPLKNCDM

Sequences:

>Translated_444_residues
MTSSSTLAITAAHQAQVDITLPAWLLGTAERVMNFYVDRNLRLDNLSVDTMPAPVPGKKYMLYAHVPFCHTLCSYCTFHR
FTFKEDKARAYFISLRKEMTMAKELGYDFESMYIGGGTTTVLEDELARTIEHARLLFPSIKEVSCESDPRHLASPEFRQL
KGLVDRMSIGVQSFDDGILKMTDRFEKFGSGLQTFDRIQAAKELFPIINVDLIFGFRGQTEEVIQRDLDMARRLDPRQIT
TYPLMITHQTRKSVKGKLAAPQADLARQYSQILTSLRGQYNQLSSWAFGKANDEGFDEYVIDYDEYLGVGSGSFSFLGDT
LYVNTFSLRKYQERIEAGKMSVEQQKRYDTKAIMQYRFLLGLFSGRLSRQYFRDTFGVNLDTALFKEMAAMKLIGALKND
PANPEELLVTDNGNLMGLLMMKEFYSGMDNVRAQLRQPLKNCDM
>Mature_443_residues
TSSSTLAITAAHQAQVDITLPAWLLGTAERVMNFYVDRNLRLDNLSVDTMPAPVPGKKYMLYAHVPFCHTLCSYCTFHRF
TFKEDKARAYFISLRKEMTMAKELGYDFESMYIGGGTTTVLEDELARTIEHARLLFPSIKEVSCESDPRHLASPEFRQLK
GLVDRMSIGVQSFDDGILKMTDRFEKFGSGLQTFDRIQAAKELFPIINVDLIFGFRGQTEEVIQRDLDMARRLDPRQITT
YPLMITHQTRKSVKGKLAAPQADLARQYSQILTSLRGQYNQLSSWAFGKANDEGFDEYVIDYDEYLGVGSGSFSFLGDTL
YVNTFSLRKYQERIEAGKMSVEQQKRYDTKAIMQYRFLLGLFSGRLSRQYFRDTFGVNLDTALFKEMAAMKLIGALKNDP
ANPEELLVTDNGNLMGLLMMKEFYSGMDNVRAQLRQPLKNCDM

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=284, Percent_Identity=26.7605633802817, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI87082341, Length=312, Percent_Identity=27.2435897435897, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789325, Length=313, Percent_Identity=26.1980830670927, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 50711; Mature: 50580

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSSTLAITAAHQAQVDITLPAWLLGTAERVMNFYVDRNLRLDNLSVDTMPAPVPGKKY
CCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCEE
MLYAHVPFCHTLCSYCTFHRFTFKEDKARAYFISLRKEMTMAKELGYDFESMYIGGGTTT
EEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCHH
VLEDELARTIEHARLLFPSIKEVSCESDPRHLASPEFRQLKGLVDRMSIGVQSFDDGILK
HHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCCHHHH
MTDRFEKFGSGLQTFDRIQAAKELFPIINVDLIFGFRGQTEEVIQRDLDMARRLDPRQIT
HHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEE
TYPLMITHQTRKSVKGKLAAPQADLARQYSQILTSLRGQYNQLSSWAFGKANDEGFDEYV
EEEEEEEECHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHH
IDYDEYLGVGSGSFSFLGDTLYVNTFSLRKYQERIEAGKMSVEQQKRYDTKAIMQYRFLL
CCHHHHCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GLFSGRLSRQYFRDTFGVNLDTALFKEMAAMKLIGALKNDPANPEELLVTDNGNLMGLLM
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEHHHH
MKEFYSGMDNVRAQLRQPLKNCDM
HHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSSSTLAITAAHQAQVDITLPAWLLGTAERVMNFYVDRNLRLDNLSVDTMPAPVPGKKY
CCCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCEE
MLYAHVPFCHTLCSYCTFHRFTFKEDKARAYFISLRKEMTMAKELGYDFESMYIGGGTTT
EEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCHH
VLEDELARTIEHARLLFPSIKEVSCESDPRHLASPEFRQLKGLVDRMSIGVQSFDDGILK
HHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCCHHHH
MTDRFEKFGSGLQTFDRIQAAKELFPIINVDLIFGFRGQTEEVIQRDLDMARRLDPRQIT
HHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEE
TYPLMITHQTRKSVKGKLAAPQADLARQYSQILTSLRGQYNQLSSWAFGKANDEGFDEYV
EEEEEEEECHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHH
IDYDEYLGVGSGSFSFLGDTLYVNTFSLRKYQERIEAGKMSVEQQKRYDTKAIMQYRFLL
CCHHHHCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GLFSGRLSRQYFRDTFGVNLDTALFKEMAAMKLIGALKNDPANPEELLVTDNGNLMGLLM
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEHHHH
MKEFYSGMDNVRAQLRQPLKNCDM
HHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]