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The map label for this gene is cyoE

Identifier: 119776623

GI number: 119776623

Start: 4122255

End: 4123154

Strand: Direct

Name: cyoE

Synonym: Sama_3491

Alternate gene names: 119776623

Gene position: 4122255-4123154 (Clockwise)

Preceding gene: 119776622

Following gene: 119776624

Centisome position: 95.73

GC content: 55.78

Gene sequence:

>900_bases
ATGGCCAAATCTCTCTCCATTACCCCTGTGTCAGGCCTGTCCCGTTTACCATGGCGCGCCTATTTGGAAATGACCAAACC
CAAGGTGGTTACCTTGATGCTGCTGACAGTGCTTGTGGGCATGTGCCTGGCATTGCCGGGGGCCGTACCACTGCAGCCAT
TGATTGCCGGCATGCTGGGGATCGCCATGATGGCGGGCGCCGCAGCCGCGATGAACCATCTCATTGACCGTCGTATCGAT
GGTCTGATGGCACGCACCTATAATCGTCCGCTCCCCAAGGGCAAGGTGCCCGTCAGCCATGCCGCTACCTTTGCCGCCCT
GCTGGCACTGCTTGGTTTTGCCTGCCTCTACTGGTTGGTTAATCCACTCACTGCCTGGCTGACACTGGCGAGCCTGCTTG
GCTATGCTGTGGTCTACACCGCTTACCTCAAGCGTGCGACACCACAAAACATTGTGATTGGCGGACTCGCCGGCGCCATG
CCCCCCTTACTGGGCTGGACAGCGGTGACCAATGATTTCCACGGCCATGGGTTGCTGCTGGTGATTATTATCTTCGCCTG
GACCCCACCCCACTTTTGGGCGCTGGCGATACATCGTAAAGCGGACTACGCCAAAGTCGACATTCCCATGCTGCCCGTCA
CCCACGGCGTGGCATTTACCAAGACCTGTATCTTTCTTTACACTATCTTGCTTGCATTGGCCTGCCTGCTACCCGTATTG
GTTGGCATGAGTGGGGCCTTGTATTTGCTGGGTTCAACCTTGCTGAGTATCGGCTTTATCTACAAGGCATGGCAGCTTAA
GTATCATGAGACCCCAGGCATGGCGATGGACGTGTTCCGCTTTTCTATCTATCACCTGATGCTGCTGTTTATCCTGCTGC
TGGTTGACCACTACATATAG

Upstream 100 bases:

>100_bases
CCATTGCCGTTGCCCACAATCTGGGGGCCGCATTTTTGCTGGTCACACTGGTCTTTATTAATTACGCACTGTGGCGTAAA
GCCTGAAAAAAGGAGTTGTT

Downstream 100 bases:

>100_bases
GGGCAAGCATGAAAAAATCCTGGATGATGGCCGTCTTCTTCCTGGTGGGGATGGGCGGTCTGACACTGCTGATAAACTCG
GGCGACACCAGTGATAGCCA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MAKSLSITPVSGLSRLPWRAYLEMTKPKVVTLMLLTVLVGMCLALPGAVPLQPLIAGMLGIAMMAGAAAAMNHLIDRRID
GLMARTYNRPLPKGKVPVSHAATFAALLALLGFACLYWLVNPLTAWLTLASLLGYAVVYTAYLKRATPQNIVIGGLAGAM
PPLLGWTAVTNDFHGHGLLLVIIIFAWTPPHFWALAIHRKADYAKVDIPMLPVTHGVAFTKTCIFLYTILLALACLLPVL
VGMSGALYLLGSTLLSIGFIYKAWQLKYHETPGMAMDVFRFSIYHLMLLFILLLVDHYI

Sequences:

>Translated_299_residues
MAKSLSITPVSGLSRLPWRAYLEMTKPKVVTLMLLTVLVGMCLALPGAVPLQPLIAGMLGIAMMAGAAAAMNHLIDRRID
GLMARTYNRPLPKGKVPVSHAATFAALLALLGFACLYWLVNPLTAWLTLASLLGYAVVYTAYLKRATPQNIVIGGLAGAM
PPLLGWTAVTNDFHGHGLLLVIIIFAWTPPHFWALAIHRKADYAKVDIPMLPVTHGVAFTKTCIFLYTILLALACLLPVL
VGMSGALYLLGSTLLSIGFIYKAWQLKYHETPGMAMDVFRFSIYHLMLLFILLLVDHYI
>Mature_298_residues
AKSLSITPVSGLSRLPWRAYLEMTKPKVVTLMLLTVLVGMCLALPGAVPLQPLIAGMLGIAMMAGAAAAMNHLIDRRIDG
LMARTYNRPLPKGKVPVSHAATFAALLALLGFACLYWLVNPLTAWLTLASLLGYAVVYTAYLKRATPQNIVIGGLAGAMP
PLLGWTAVTNDFHGHGLLLVIIIFAWTPPHFWALAIHRKADYAKVDIPMLPVTHGVAFTKTCIFLYTILLALACLLPVLV
GMSGALYLLGSTLLSIGFIYKAWQLKYHETPGMAMDVFRFSIYHLMLLFILLLVDHYI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=193, Percent_Identity=35.2331606217617, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786631, Length=280, Percent_Identity=34.6428571428571, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71998235, Length=252, Percent_Identity=29.7619047619048, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325085, Length=266, Percent_Identity=28.1954887218045, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19921064, Length=277, Percent_Identity=31.0469314079422, Blast_Score=131, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE_SHEAM (A1SBD7)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929363.1
- STRING:   A1SBD7
- GeneID:   4605738
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3491
- NMPDR:   fig|326297.7.peg.3289
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   A1SBD7
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32626; Mature: 32495

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x169bade0)-; HASH(0x17280cf4)-; HASH(0x162dbd90)-; HASH(0x16f01c14)-; HASH(0x15dc873c)-; HASH(0x17303588)-; HASH(0x16a54844)-; HASH(0x17303678)-; HASH(0x1730edc8)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSLSITPVSGLSRLPWRAYLEMTKPKVVTLMLLTVLVGMCLALPGAVPLQPLIAGMLG
CCCCCCCCCCCCCHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IAMMAGAAAAMNHLIDRRIDGLMARTYNRPLPKGKVPVSHAATFAALLALLGFACLYWLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NPLTAWLTLASLLGYAVVYTAYLKRATPQNIVIGGLAGAMPPLLGWTAVTNDFHGHGLLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCHHHH
VIIIFAWTPPHFWALAIHRKADYAKVDIPMLPVTHGVAFTKTCIFLYTILLALACLLPVL
HHHHHHCCCCHHHHHHEECCCCCCEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VGMSGALYLLGSTLLSIGFIYKAWQLKYHETPGMAMDVFRFSIYHLMLLFILLLVDHYI
HCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
AKSLSITPVSGLSRLPWRAYLEMTKPKVVTLMLLTVLVGMCLALPGAVPLQPLIAGMLG
CCCCCCCCCCCCHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IAMMAGAAAAMNHLIDRRIDGLMARTYNRPLPKGKVPVSHAATFAALLALLGFACLYWLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NPLTAWLTLASLLGYAVVYTAYLKRATPQNIVIGGLAGAMPPLLGWTAVTNDFHGHGLLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCHHHH
VIIIFAWTPPHFWALAIHRKADYAKVDIPMLPVTHGVAFTKTCIFLYTILLALACLLPVL
HHHHHHCCCCHHHHHHEECCCCCCEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VGMSGALYLLGSTLLSIGFIYKAWQLKYHETPGMAMDVFRFSIYHLMLLFILLLVDHYI
HCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA