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The map label for this gene is ubiE

Identifier: 119776334

GI number: 119776334

Start: 3793193

End: 3793948

Strand: Direct

Name: ubiE

Synonym: Sama_3202

Alternate gene names: 119776334

Gene position: 3793193-3793948 (Clockwise)

Preceding gene: 119776333

Following gene: 119776335

Centisome position: 88.09

GC content: 55.56

Gene sequence:

>756_bases
ATGTCCGACGGCACATCAAATAGTACTCACTTTGGTTTCAAGACAGTCGAAGCCGATAAAAAGGCGGATCTGGTTGCCGG
TGTATTTCACTCGGTTGCAGCCAAGTACGACATCATGAACGACGTGATGTCTTTCGGGATCCATCGCCTGTGGAAGCGAT
TCACCATCGAGACCGCGGGCGCTCGCCCCGGCATGAAGGTACTGGATCTGGCCGGGGGTACTGGCGATCTGACCGCCAAG
TTTTCCCGTTTGGTAGGCGATCGCGGCGAAGTGGTTCTGGCCGACATCAACGACTCCATGCTGAAAGTGGGCCGCGCCAA
ACTCAGAGATCTGGGTGTGGTGGGTAACGTCAGCTATGTGCAAGCCAACGCCGAGGCGCTGCCGTTTCCAGACAATCATT
TCGACATCATCACCATCGCCTTTGGTCTGCGTAACGTGACTGACAAGGACGCGGCCCTGCGCTCCATGCAACGGGTGCTC
AAGCCCGGTGGCAAACTGCTGGTACTGGAATTTTCCAAGCCGCAGCACGAAGTGATGCGTAAACTGTACGACCTCTACAG
CTTCAAAATTCTGCCCAAAATGGGCGAGTTTATTGCCCAGGATGCCGGCAGCTATGAGTATCTGGCTGAATCCATCCGGA
TGCACCCGGATCAGGATACCCTCAAGGGCATGATGCAGGACGCTGGCCTGGAGCAGGTAGACTACATCAACATGACCGAC
GGCGTTGTTGCACTGCACCGGGGTTACAAGTTCTGA

Upstream 100 bases:

>100_bases
AGGCACTGGATCACAAAGCTGGTGGCTCAAGGATTCAGCTAACCTGCTGCTTTGGCGTACACTCGCGTTTAACAGTTTGG
GAAACAATAGGAAAGAGCAG

Downstream 100 bases:

>100_bases
TGTTAAAGCGGGAGCTGGCACTTATCCTTTGCGGCGCCGTGGAACTCGGCTTTGAAAAATTATTGGCGCAAACCGGTGTC
AGCCCCAGACAGTACGGCCT

Product: ubiquinone/menaquinone biosynthesis methlytransferase UbiE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSDGTSNSTHFGFKTVEADKKADLVAGVFHSVAAKYDIMNDVMSFGIHRLWKRFTIETAGARPGMKVLDLAGGTGDLTAK
FSRLVGDRGEVVLADINDSMLKVGRAKLRDLGVVGNVSYVQANAEALPFPDNHFDIITIAFGLRNVTDKDAALRSMQRVL
KPGGKLLVLEFSKPQHEVMRKLYDLYSFKILPKMGEFIAQDAGSYEYLAESIRMHPDQDTLKGMMQDAGLEQVDYINMTD
GVVALHRGYKF

Sequences:

>Translated_251_residues
MSDGTSNSTHFGFKTVEADKKADLVAGVFHSVAAKYDIMNDVMSFGIHRLWKRFTIETAGARPGMKVLDLAGGTGDLTAK
FSRLVGDRGEVVLADINDSMLKVGRAKLRDLGVVGNVSYVQANAEALPFPDNHFDIITIAFGLRNVTDKDAALRSMQRVL
KPGGKLLVLEFSKPQHEVMRKLYDLYSFKILPKMGEFIAQDAGSYEYLAESIRMHPDQDTLKGMMQDAGLEQVDYINMTD
GVVALHRGYKF
>Mature_250_residues
SDGTSNSTHFGFKTVEADKKADLVAGVFHSVAAKYDIMNDVMSFGIHRLWKRFTIETAGARPGMKVLDLAGGTGDLTAKF
SRLVGDRGEVVLADINDSMLKVGRAKLRDLGVVGNVSYVQANAEALPFPDNHFDIITIAFGLRNVTDKDAALRSMQRVLK
PGGKLLVLEFSKPQHEVMRKLYDLYSFKILPKMGEFIAQDAGSYEYLAESIRMHPDQDTLKGMMQDAGLEQVDYINMTDG
VVALHRGYKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=276, Percent_Identity=44.5652173913043, Blast_Score=240, Evalue=7e-64,
Organism=Escherichia coli, GI48994983, Length=251, Percent_Identity=75.2988047808765, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1786404, Length=88, Percent_Identity=39.7727272727273, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557039, Length=245, Percent_Identity=43.265306122449, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323526, Length=257, Percent_Identity=42.4124513618677, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24641702, Length=262, Percent_Identity=44.6564885496183, Blast_Score=241, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_SHEAM (A1SAJ8)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929074.1
- ProteinModelPortal:   A1SAJ8
- SMR:   A1SAJ8
- STRING:   A1SAJ8
- GeneID:   4605449
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3202
- NMPDR:   fig|326297.7.peg.3014
- eggNOG:   COG2226
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- PhylomeDB:   A1SAJ8
- ProtClustDB:   CLSK907539
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 27770; Mature: 27639

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDGTSNSTHFGFKTVEADKKADLVAGVFHSVAAKYDIMNDVMSFGIHRLWKRFTIETAG
CCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ARPGMKVLDLAGGTGDLTAKFSRLVGDRGEVVLADINDSMLKVGRAKLRDLGVVGNVSYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCEECCCCEE
QANAEALPFPDNHFDIITIAFGLRNVTDKDAALRSMQRVLKPGGKLLVLEFSKPQHEVMR
EECCCCCCCCCCCEEEEEEEEHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
KLYDLYSFKILPKMGEFIAQDAGSYEYLAESIRMHPDQDTLKGMMQDAGLEQVDYINMTD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCC
GVVALHRGYKF
CHHHHHCCCCC
>Mature Secondary Structure 
SDGTSNSTHFGFKTVEADKKADLVAGVFHSVAAKYDIMNDVMSFGIHRLWKRFTIETAG
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ARPGMKVLDLAGGTGDLTAKFSRLVGDRGEVVLADINDSMLKVGRAKLRDLGVVGNVSYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCEECCCCEE
QANAEALPFPDNHFDIITIAFGLRNVTDKDAALRSMQRVLKPGGKLLVLEFSKPQHEVMR
EECCCCCCCCCCCEEEEEEEEHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
KLYDLYSFKILPKMGEFIAQDAGSYEYLAESIRMHPDQDTLKGMMQDAGLEQVDYINMTD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCC
GVVALHRGYKF
CHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA