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The map label for this gene is mltA [H]

Identifier: 119776124

GI number: 119776124

Start: 3565041

End: 3566153

Strand: Reverse

Name: mltA [H]

Synonym: Sama_2992

Alternate gene names: 119776124

Gene position: 3566153-3565041 (Counterclockwise)

Preceding gene: 119776126

Following gene: 119776119

Centisome position: 82.82

GC content: 58.31

Gene sequence:

>1113_bases
GTGAAATCAGCCCCGTTTAAATCTCTGAGTTGTGTCGTGTTGGCTGCCGTTATCAGTGCCTGTGCAAGTCAGCCAGACAG
GGAGCTTGGCAAGCGTTATCTGGATGGTGAACTCCAGCAGCCGCTCAATTGGGTTGCAGCGGTGCAATCCGATGCCAATC
GCAACTACACCCGCTTTGCCGACCAAAGCAGTTTGGTGCTTGAGCGTTCACCGCGTCTGGCCTCCCGTTACGCGCCCCTC
TACCGGCAGCTGTCTCAGTGGCTTGAGAGTGGTGGCGATCCGCTTTCACTGGGGAATTTTGGGATTGAAGCGGCCCAGTT
TGGTGGCGCCGATCGCCAGGGGCATGTGCTCTTTACCGGCTACTTTTCTCCAGTGCTGGAGGTGCGCCATAGCCCCGACA
GCCGCTTTCAATACCCGCTTTATGGTGTGCCCGACTGTGTGAAACACAACTCGCCATGCCCAAGCCGCGAGGCCATTTTA
CAGGGAGCACTGTCGGGGCAGGGGTTGGAGCTGGCCTACAGCGACAGCCTTATCGACAGTTTTCTGATGGAAGTGCAGGG
CTCAGGCTTTGTCCATTATGGAGATAACGACGAGCTGCAATACCTGGGCTATGGCGGTAAAAATGGCCATGCGTACCGGA
GCATAGGTAAAGTTTTGATTGAACAGGGTGAAGTGGCAAAAGAGCAAATGTCGCTGCGGGCCATTAAAGCCTGGGCCGAC
AGCCATTCTGAAGACGAAGTGAAGCAACTGCTCGCCCACAATGCATCCTTTGTGTTTTTCCAGGCACGGCCCAACCATGA
TGTCTTGGGCAGTGCAGGTATTCCCTTGTTACCCATGGCGGCCGTGGCGGCCGATAAACAGCTGCTGCCCATGGGCACGC
CGCTGCTGGCCGAGGTGCCTTTGCTCGATGACGTAGGCAACTGGACCGGCAGGCATGAACTCCGGTTGCTGATTGCGCTG
GATACCGGGGGCGCTGTGGATGGCGGCCACCTGGACCTTTACCACGGCATGGGGCCCGAGGCCGGAATGGCAGCAGGGCA
CTACAAACACTTTGGCCGTGTATGGCGGCTGGGACTGGGCGCAGGCTCCAGTGTCACCCCGGGGACGCCCTGA

Upstream 100 bases:

>100_bases
GAATCAGTCAAGCCGAAACTGGCTCTCCATGATGAATGGCTTTGCCTTTGTCCGGGATTTTTGGCATGGTGCCGCAATAT
TTACCGGTTTGGAGCCAAAG

Downstream 100 bases:

>100_bases
CCTCATCAGCCAGCGACATACAGGTAAGCCTGTGACAGGCACCTGCCGCTAAGTTTGTTGGGGTGTTTTTAAAAACAGCA
CCAGCATAAGCACCATCGCC

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKSAPFKSLSCVVLAAVISACASQPDRELGKRYLDGELQQPLNWVAAVQSDANRNYTRFADQSSLVLERSPRLASRYAPL
YRQLSQWLESGGDPLSLGNFGIEAAQFGGADRQGHVLFTGYFSPVLEVRHSPDSRFQYPLYGVPDCVKHNSPCPSREAIL
QGALSGQGLELAYSDSLIDSFLMEVQGSGFVHYGDNDELQYLGYGGKNGHAYRSIGKVLIEQGEVAKEQMSLRAIKAWAD
SHSEDEVKQLLAHNASFVFFQARPNHDVLGSAGIPLLPMAAVAADKQLLPMGTPLLAEVPLLDDVGNWTGRHELRLLIAL
DTGGAVDGGHLDLYHGMGPEAGMAAGHYKHFGRVWRLGLGAGSSVTPGTP

Sequences:

>Translated_370_residues
MKSAPFKSLSCVVLAAVISACASQPDRELGKRYLDGELQQPLNWVAAVQSDANRNYTRFADQSSLVLERSPRLASRYAPL
YRQLSQWLESGGDPLSLGNFGIEAAQFGGADRQGHVLFTGYFSPVLEVRHSPDSRFQYPLYGVPDCVKHNSPCPSREAIL
QGALSGQGLELAYSDSLIDSFLMEVQGSGFVHYGDNDELQYLGYGGKNGHAYRSIGKVLIEQGEVAKEQMSLRAIKAWAD
SHSEDEVKQLLAHNASFVFFQARPNHDVLGSAGIPLLPMAAVAADKQLLPMGTPLLAEVPLLDDVGNWTGRHELRLLIAL
DTGGAVDGGHLDLYHGMGPEAGMAAGHYKHFGRVWRLGLGAGSSVTPGTP
>Mature_370_residues
MKSAPFKSLSCVVLAAVISACASQPDRELGKRYLDGELQQPLNWVAAVQSDANRNYTRFADQSSLVLERSPRLASRYAPL
YRQLSQWLESGGDPLSLGNFGIEAAQFGGADRQGHVLFTGYFSPVLEVRHSPDSRFQYPLYGVPDCVKHNSPCPSREAIL
QGALSGQGLELAYSDSLIDSFLMEVQGSGFVHYGDNDELQYLGYGGKNGHAYRSIGKVLIEQGEVAKEQMSLRAIKAWAD
SHSEDEVKQLLAHNASFVFFQARPNHDVLGSAGIPLLPMAAVAADKQLLPMGTPLLAEVPLLDDVGNWTGRHELRLLIAL
DTGGAVDGGHLDLYHGMGPEAGMAAGHYKHFGRVWRLGLGAGSSVTPGTP

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=364, Percent_Identity=46.978021978022, Blast_Score=336, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 39974; Mature: 39974

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAPFKSLSCVVLAAVISACASQPDRELGKRYLDGELQQPLNWVAAVQSDANRNYTRFA
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHC
DQSSLVLERSPRLASRYAPLYRQLSQWLESGGDPLSLGNFGIEAAQFGGADRQGHVLFTG
CCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCCCCCCCCEEEEE
YFSPVLEVRHSPDSRFQYPLYGVPDCVKHNSPCPSREAILQGALSGQGLELAYSDSLIDS
CHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHH
FLMEVQGSGFVHYGDNDELQYLGYGGKNGHAYRSIGKVLIEQGEVAKEQMSLRAIKAWAD
HHHHHCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
SHSEDEVKQLLAHNASFVFFQARPNHDVLGSAGIPLLPMAAVAADKQLLPMGTPLLAEVP
CCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHCCCC
LLDDVGNWTGRHELRLLIALDTGGAVDGGHLDLYHGMGPEAGMAAGHYKHFGRVWRLGLG
CHHCCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHEECC
AGSSVTPGTP
CCCCCCCCCC
>Mature Secondary Structure
MKSAPFKSLSCVVLAAVISACASQPDRELGKRYLDGELQQPLNWVAAVQSDANRNYTRFA
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHC
DQSSLVLERSPRLASRYAPLYRQLSQWLESGGDPLSLGNFGIEAAQFGGADRQGHVLFTG
CCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCCCCCCCCEEEEE
YFSPVLEVRHSPDSRFQYPLYGVPDCVKHNSPCPSREAILQGALSGQGLELAYSDSLIDS
CHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHH
FLMEVQGSGFVHYGDNDELQYLGYGGKNGHAYRSIGKVLIEQGEVAKEQMSLRAIKAWAD
HHHHHCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
SHSEDEVKQLLAHNASFVFFQARPNHDVLGSAGIPLLPMAAVAADKQLLPMGTPLLAEVP
CCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHCCCC
LLDDVGNWTGRHELRLLIALDTGGAVDGGHLDLYHGMGPEAGMAAGHYKHFGRVWRLGLG
CHHCCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHEECC
AGSSVTPGTP
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]