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The map label for this gene is pyrC

Identifier: 119776002

GI number: 119776002

Start: 3407998

End: 3409026

Strand: Direct

Name: pyrC

Synonym: Sama_2870

Alternate gene names: 119776002

Gene position: 3407998-3409026 (Clockwise)

Preceding gene: 119775999

Following gene: 119776004

Centisome position: 79.14

GC content: 58.11

Gene sequence:

>1029_bases
ATGACTCATTTGACCCTCACCCGTCCCGATGACTGGCATATCCACCTGCGCGACGGCGACTCCCTTGCCGACACTGTGCG
CGACGCCGGTCGTTACATGGGCCGTGCCATAGTAATGCCCAATCTGGTGCCGCCGGTGACCACTACAGAAGCCGCGATTG
CCTACTACGAGCGCATCAAGGCCCACAGCAGCACTGCCTTCGAGCCCTTAATGGTGCTGTATCTCACCGACAAGACCAGC
CCGGATGAAATCCGCGCCGCCAAGGCCTCCGGCAAGGTGGTTGCCGCCAAGCTTTATCCTGCCGGTGCCACCACCAACTC
TGATTCGGGCGTGACCGACGTCAACAACATCTATGGCGTGCTCAAGGCCATGGAAGAAGAAGGTTTACTGCTGCTGGTAC
ACGGTGAGGTCACTGATTCTGCTATCGATATTTTCGACAGGGAGCGCATCTTTATCGAAAACATCCTCTCCAAAGTGGTC
GCCGACTTTCCCGGCCTCAAGATAGTGCTCGAGCACATCACTACCAAGGATGCGGTGGATTTCGTGATGTCTGCCGGTGA
CAATGTCGCCGCCACCATCACAGCCCATCACCTGCTGTATAACCGCAACCATATGCTGGCCGGCGGTATTCGCCCGCACT
TCTACTGCCTGCCCATCCTTAAGCGCAATACCCACCAGCAGGCGCTGTTGGCAGCGGCCACCAGCGGCAGCAAGAAGTTT
TTCCTTGGCACCGACTCGGCTCCCCACGCCAAAGACAAAAAAGAAGCCGCCTGTGGCTGCGCCGGTTCTTACACAGCCCA
CGCGGCACTGGAACTGTACGCTGAAGCCTTTGAGGCGGAAGGTGCCCTGGACAAGCTGGAAGCCTTTGCCAGCTTTAATG
GCCCGGACTTCTACGGCCTGCCCCGCAATGCCGATACCGTTGCTCTGGTGAAAAGTCCCTGGCAGGTGCCCGAGTCTTAT
CCCCTGGGCAGCACCACTGTGGTGCCTATCCGTGCAGGTGAAATCATTGGCTGGAAAGTCGAAGACTGA

Upstream 100 bases:

>100_bases
AGATTGATGCCATTGAGGCAGGGATAATTCCCTTCCCGCCTTGCCCTTTGAGACCGCGATACTTAAAATCTGCCCACCCT
CACAGCAGAAGAACACCCTA

Downstream 100 bases:

>100_bases
GCCCATGGCCGCCTGAGCAGAAAAAAGCCGCGATAACGCGGCTTTTTTAATACCTGATGTTTTGATTTCTGATTAGCAAG
CGGATGTCAGCAAGCTCTTA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTHLTLTRPDDWHIHLRDGDSLADTVRDAGRYMGRAIVMPNLVPPVTTTEAAIAYYERIKAHSSTAFEPLMVLYLTDKTS
PDEIRAAKASGKVVAAKLYPAGATTNSDSGVTDVNNIYGVLKAMEEEGLLLLVHGEVTDSAIDIFDRERIFIENILSKVV
ADFPGLKIVLEHITTKDAVDFVMSAGDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAATSGSKKF
FLGTDSAPHAKDKKEAACGCAGSYTAHAALELYAEAFEAEGALDKLEAFASFNGPDFYGLPRNADTVALVKSPWQVPESY
PLGSTTVVPIRAGEIIGWKVED

Sequences:

>Translated_342_residues
MTHLTLTRPDDWHIHLRDGDSLADTVRDAGRYMGRAIVMPNLVPPVTTTEAAIAYYERIKAHSSTAFEPLMVLYLTDKTS
PDEIRAAKASGKVVAAKLYPAGATTNSDSGVTDVNNIYGVLKAMEEEGLLLLVHGEVTDSAIDIFDRERIFIENILSKVV
ADFPGLKIVLEHITTKDAVDFVMSAGDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAATSGSKKF
FLGTDSAPHAKDKKEAACGCAGSYTAHAALELYAEAFEAEGALDKLEAFASFNGPDFYGLPRNADTVALVKSPWQVPESY
PLGSTTVVPIRAGEIIGWKVED
>Mature_341_residues
THLTLTRPDDWHIHLRDGDSLADTVRDAGRYMGRAIVMPNLVPPVTTTEAAIAYYERIKAHSSTAFEPLMVLYLTDKTSP
DEIRAAKASGKVVAAKLYPAGATTNSDSGVTDVNNIYGVLKAMEEEGLLLLVHGEVTDSAIDIFDRERIFIENILSKVVA
DFPGLKIVLEHITTKDAVDFVMSAGDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAATSGSKKFF
LGTDSAPHAKDKKEAACGCAGSYTAHAALELYAEAFEAEGALDKLEAFASFNGPDFYGLPRNADTVALVKSPWQVPESYP
LGSTTVVPIRAGEIIGWKVED

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=341, Percent_Identity=54.8387096774194, Blast_Score=377, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=36.2359550561798, Blast_Score=187, Evalue=3e-48,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_SHEAM (A1S9L6)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928742.1
- ProteinModelPortal:   A1S9L6
- SMR:   A1S9L6
- STRING:   A1S9L6
- GeneID:   4605117
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2870
- NMPDR:   fig|326297.7.peg.2689
- eggNOG:   COG0418
- HOGENOM:   HBG628648
- OMA:   KESACGC
- PhylomeDB:   A1S9L6
- ProtClustDB:   PRK05451
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 37081; Mature: 36950

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLTLTRPDDWHIHLRDGDSLADTVRDAGRYMGRAIVMPNLVPPVTTTEAAIAYYERIK
CCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHHHH
AHSSTAFEPLMVLYLTDKTSPDEIRAAKASGKVVAAKLYPAGATTNSDSGVTDVNNIYGV
HCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHH
LKAMEEEGLLLLVHGEVTDSAIDIFDRERIFIENILSKVVADFPGLKIVLEHITTKDAVD
HHHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHH
FVMSAGDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAATSGSKKF
HHHHCCCCEEEEEEEEEHEECCCCEEECCCCCCEEEEEHHHCCCHHHHHEEEECCCCCEE
FLGTDSAPHAKDKKEAACGCAGSYTAHAALELYAEAFEAEGALDKLEAFASFNGPDFYGL
EEECCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
PRNADTVALVKSPWQVPESYPLGSTTVVPIRAGEIIGWKVED
CCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCEEEEEECC
>Mature Secondary Structure 
THLTLTRPDDWHIHLRDGDSLADTVRDAGRYMGRAIVMPNLVPPVTTTEAAIAYYERIK
CEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHHHH
AHSSTAFEPLMVLYLTDKTSPDEIRAAKASGKVVAAKLYPAGATTNSDSGVTDVNNIYGV
HCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHH
LKAMEEEGLLLLVHGEVTDSAIDIFDRERIFIENILSKVVADFPGLKIVLEHITTKDAVD
HHHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHH
FVMSAGDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAATSGSKKF
HHHHCCCCEEEEEEEEEHEECCCCEEECCCCCCEEEEEHHHCCCHHHHHEEEECCCCCEE
FLGTDSAPHAKDKKEAACGCAGSYTAHAALELYAEAFEAEGALDKLEAFASFNGPDFYGL
EEECCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
PRNADTVALVKSPWQVPESYPLGSTTVVPIRAGEIIGWKVED
CCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA