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The map label for this gene is pepA [H]

Identifier: 119775650

GI number: 119775650

Start: 3025211

End: 3026806

Strand: Reverse

Name: pepA [H]

Synonym: Sama_2518

Alternate gene names: 119775650

Gene position: 3026806-3025211 (Counterclockwise)

Preceding gene: 119775652

Following gene: 119775649

Centisome position: 70.29

GC content: 56.39

Gene sequence:

>1596_bases
ATGATGTTGATTGCAGGAATAATCAGCCGAGCCTTGCAATACACAATCAAAACAATAGGACGGGTCATGTTTCAGGCACA
ATTTGTTGTTGAACAGGATGAAAATGGCATCTTCGCCGGTGAGGGCTTTGATGCCCTGTTGGTGCTGAGCCCCTCATTGG
ATGCAGTTTCCCTCGATGAAGTACGTCTGCTGGCAGGCCACGCCGCCAGTATCGACAAGCGGGTGGGAAAGACCACTACC
TTACTGCTGGCACCGGGCCTCGCCGGCGGCCGCTTGATATACGCCCCCATCGGTAGCAGCTATGGCGATTATGACGATGT
GCGCTCTGTCACCCAGGCCGCTCGAAGCGCCATTGCCATGGCAAGAGACGCAGGAGCCACCCGGCCACTGCTGGCGGTGT
TTGGCCGTGACGATAAGGTTGAAGCTATACTCGCCGCCGCCCTTGGCTGTGGGCAGGAATTATGGATCAGCCTTGAAGCC
CGCGAGCAGGGCGCTGCCCCTTGCAGTATCGAAACCATTGGCCTTTACGGTGCCGATGAATCCCTCGCCACACTGGCAAG
CGCCCTTGAAACCGGCCGCAATCTTGCCCGTGACCTGTGTGGCACTGAGCCTGAGCGTATGTCGGCCCCCGCATTTGCCG
ATTATTGTGTTAAAGCCTTTGCTGGCACCGATATTCACACCCGGGTGATTGAAGGTCGTGACGAACTGGAGCGCGATTAT
CCGCTTTTGAGCGCCGTGGGCCGCGCTTCTTTTGCGGTTGCGCGTCATCAGCCCAGAGTCGTGAAACTGGAATACGTGGG
CGAGGGCGAGATTGAGCGCACATTCCTGTTTGCCGGTAAAGGCGTGGTGTACGACACCGGTGGCGCCGATTTGAAAATTG
GCGGCGCCATGGCAGGCATGAGCCGTGATAAAGGTGGCGCCGCTGCGGTAGCTGGCCTGATGAAAACGCTGTCGCTGCTG
AAACCCAAAGGTATTCGCGTAATTGCTGAGCTGGGACTGGTGCGTAACAGCATCGGCTCAGAGGCGTTTGTCACCGATGA
AATCATCCCAAGCCATGCCGGTGTGCGGGTGAGGATTGGCAACACAGATGCAGAAGGTCGCTTGGTACTGGCCGACTTGT
TGAGCCATTTACGCCAAAAGGCGGTTGCAGCTGTGAATCCTGAGCTTTTTTCGGTAGCGACCCTGACCGGCCATGTGGTT
CGTGCCTACGGTGGCTATCCTGCTGCAGTAGCCAATTCGGTGGCACATCAGCGCGGTGTTGCTGCTCTGATAGCTTCGCT
GGGGGACAGTGTTGGCGAGCCATTTGAGGTGTCAAGACTGCGCCGGGAGGATTTCGACAAGATCAAAGACGTATCAGGCG
CGTCGGATATTCTGTCATCCAACAATGCGCCTTCGTCTGTCACGGCCCGTGGCCATCAATATCCGGCTGCGTTTCTTATC
CGTGCATCAGGGCTTGAAGCACATGGTATTGGCAGCAGTACACCACTGCCCTACGTGCATCTGGACATCGCCGGCAGTGC
CACAGAAGGGGACCCTTTGTATGGTAAACCAACAGCCTCACCTCTGGCAGTAATGTGTCATTACATTACAAAATAA

Upstream 100 bases:

>100_bases
TTGCGCCGAGTTTACCACAGTGTGCGTCCCGGGTGGATGGGCAAACATCCCTGTTGTGGAAGCCAAAGTTTCCAGCGAAA
GGCCTTGCCACGGGTGGCAA

Downstream 100 bases:

>100_bases
TTACAAGATTTATAACTTGTTGAAAAAGAGCGGAATCATTTTTTGGTTCCGCTCTTTTATTAGATGCCAATCACAAATAA
CCCCAGTTTCAATGTGTAAT

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MMLIAGIISRALQYTIKTIGRVMFQAQFVVEQDENGIFAGEGFDALLVLSPSLDAVSLDEVRLLAGHAASIDKRVGKTTT
LLLAPGLAGGRLIYAPIGSSYGDYDDVRSVTQAARSAIAMARDAGATRPLLAVFGRDDKVEAILAAALGCGQELWISLEA
REQGAAPCSIETIGLYGADESLATLASALETGRNLARDLCGTEPERMSAPAFADYCVKAFAGTDIHTRVIEGRDELERDY
PLLSAVGRASFAVARHQPRVVKLEYVGEGEIERTFLFAGKGVVYDTGGADLKIGGAMAGMSRDKGGAAAVAGLMKTLSLL
KPKGIRVIAELGLVRNSIGSEAFVTDEIIPSHAGVRVRIGNTDAEGRLVLADLLSHLRQKAVAAVNPELFSVATLTGHVV
RAYGGYPAAVANSVAHQRGVAALIASLGDSVGEPFEVSRLRREDFDKIKDVSGASDILSSNNAPSSVTARGHQYPAAFLI
RASGLEAHGIGSSTPLPYVHLDIAGSATEGDPLYGKPTASPLAVMCHYITK

Sequences:

>Translated_531_residues
MMLIAGIISRALQYTIKTIGRVMFQAQFVVEQDENGIFAGEGFDALLVLSPSLDAVSLDEVRLLAGHAASIDKRVGKTTT
LLLAPGLAGGRLIYAPIGSSYGDYDDVRSVTQAARSAIAMARDAGATRPLLAVFGRDDKVEAILAAALGCGQELWISLEA
REQGAAPCSIETIGLYGADESLATLASALETGRNLARDLCGTEPERMSAPAFADYCVKAFAGTDIHTRVIEGRDELERDY
PLLSAVGRASFAVARHQPRVVKLEYVGEGEIERTFLFAGKGVVYDTGGADLKIGGAMAGMSRDKGGAAAVAGLMKTLSLL
KPKGIRVIAELGLVRNSIGSEAFVTDEIIPSHAGVRVRIGNTDAEGRLVLADLLSHLRQKAVAAVNPELFSVATLTGHVV
RAYGGYPAAVANSVAHQRGVAALIASLGDSVGEPFEVSRLRREDFDKIKDVSGASDILSSNNAPSSVTARGHQYPAAFLI
RASGLEAHGIGSSTPLPYVHLDIAGSATEGDPLYGKPTASPLAVMCHYITK
>Mature_531_residues
MMLIAGIISRALQYTIKTIGRVMFQAQFVVEQDENGIFAGEGFDALLVLSPSLDAVSLDEVRLLAGHAASIDKRVGKTTT
LLLAPGLAGGRLIYAPIGSSYGDYDDVRSVTQAARSAIAMARDAGATRPLLAVFGRDDKVEAILAAALGCGQELWISLEA
REQGAAPCSIETIGLYGADESLATLASALETGRNLARDLCGTEPERMSAPAFADYCVKAFAGTDIHTRVIEGRDELERDY
PLLSAVGRASFAVARHQPRVVKLEYVGEGEIERTFLFAGKGVVYDTGGADLKIGGAMAGMSRDKGGAAAVAGLMKTLSLL
KPKGIRVIAELGLVRNSIGSEAFVTDEIIPSHAGVRVRIGNTDAEGRLVLADLLSHLRQKAVAAVNPELFSVATLTGHVV
RAYGGYPAAVANSVAHQRGVAALIASLGDSVGEPFEVSRLRREDFDKIKDVSGASDILSSNNAPSSVTARGHQYPAAFLI
RASGLEAHGIGSSTPLPYVHLDIAGSATEGDPLYGKPTASPLAVMCHYITK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI47155554, Length=358, Percent_Identity=31.0055865921788, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI41393561, Length=370, Percent_Identity=26.7567567567568, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1790710, Length=347, Percent_Identity=28.8184438040346, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082123, Length=266, Percent_Identity=31.203007518797, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565172, Length=422, Percent_Identity=43.8388625592417, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17556903, Length=359, Percent_Identity=31.1977715877437, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24646701, Length=495, Percent_Identity=41.4141414141414, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24646703, Length=495, Percent_Identity=41.4141414141414, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI21358201, Length=495, Percent_Identity=41.4141414141414, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI221379063, Length=188, Percent_Identity=38.8297872340425, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221379062, Length=188, Percent_Identity=38.8297872340425, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357381, Length=188, Percent_Identity=38.8297872340425, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24661038, Length=236, Percent_Identity=30.0847457627119, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355725, Length=186, Percent_Identity=30.6451612903226, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 55699; Mature: 55699

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLIAGIISRALQYTIKTIGRVMFQAQFVVEQDENGIFAGEGFDALLVLSPSLDAVSLDE
CEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCCCEEEEECCCCCCCCHHH
VRLLAGHAASIDKRVGKTTTLLLAPGLAGGRLIYAPIGSSYGDYDDVRSVTQAARSAIAM
HHHHHCCHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
ARDAGATRPLLAVFGRDDKVEAILAAALGCGQELWISLEAREQGAAPCSIETIGLYGADE
HHCCCCCCCEEEEECCCCHHHHHHHHHHCCCHHHEEEEEEHHCCCCCCCEEEEEEECCCH
SLATLASALETGRNLARDLCGTEPERMSAPAFADYCVKAFAGTDIHTRVIEGRDELERDY
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHCCCCHHHHEECCHHHHHHCC
PLLSAVGRASFAVARHQPRVVKLEYVGEGEIERTFLFAGKGVVYDTGGADLKIGGAMAGM
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCEEEECCCCCEEECCHHCCC
SRDKGGAAAVAGLMKTLSLLKPKGIRVIAELGLVRNSIGSEAFVTDEIIPSHAGVRVRIG
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEC
NTDAEGRLVLADLLSHLRQKAVAAVNPELFSVATLTGHVVRAYGGYPAAVANSVAHQRGV
CCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AALIASLGDSVGEPFEVSRLRREDFDKIKDVSGASDILSSNNAPSSVTARGHQYPAAFLI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEECCCCCCCEEEEE
RASGLEAHGIGSSTPLPYVHLDIAGSATEGDPLYGKPTASPLAVMCHYITK
EECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MMLIAGIISRALQYTIKTIGRVMFQAQFVVEQDENGIFAGEGFDALLVLSPSLDAVSLDE
CEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCCCEEEEECCCCCCCCHHH
VRLLAGHAASIDKRVGKTTTLLLAPGLAGGRLIYAPIGSSYGDYDDVRSVTQAARSAIAM
HHHHHCCHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
ARDAGATRPLLAVFGRDDKVEAILAAALGCGQELWISLEAREQGAAPCSIETIGLYGADE
HHCCCCCCCEEEEECCCCHHHHHHHHHHCCCHHHEEEEEEHHCCCCCCCEEEEEEECCCH
SLATLASALETGRNLARDLCGTEPERMSAPAFADYCVKAFAGTDIHTRVIEGRDELERDY
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHCCCCHHHHEECCHHHHHHCC
PLLSAVGRASFAVARHQPRVVKLEYVGEGEIERTFLFAGKGVVYDTGGADLKIGGAMAGM
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCEEEECCCCCEEECCHHCCC
SRDKGGAAAVAGLMKTLSLLKPKGIRVIAELGLVRNSIGSEAFVTDEIIPSHAGVRVRIG
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEC
NTDAEGRLVLADLLSHLRQKAVAAVNPELFSVATLTGHVVRAYGGYPAAVANSVAHQRGV
CCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AALIASLGDSVGEPFEVSRLRREDFDKIKDVSGASDILSSNNAPSSVTARGHQYPAAFLI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEECCCCCCCEEEEE
RASGLEAHGIGSSTPLPYVHLDIAGSATEGDPLYGKPTASPLAVMCHYITK
EECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]