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The map label for this gene is atoC [H]

Identifier: 119775434

GI number: 119775434

Start: 2764199

End: 2765539

Strand: Reverse

Name: atoC [H]

Synonym: Sama_2299

Alternate gene names: 119775434

Gene position: 2765539-2764199 (Counterclockwise)

Preceding gene: 119775435

Following gene: 119775433

Centisome position: 64.22

GC content: 56.82

Gene sequence:

>1341_bases
ATGCCTGAAGGCAGACTGCTACTTGTCGAGGACGATGCGTCTCTGCGTGAGGCGCTGCTCGACACCCTGATGCTGGCGCA
GTTTGACTGTGTGGCGCTTCCCAGCGCTGAAGAAGCCATTCTTGCGTTGAAAGAATCACGTTTTGACATGGTCATCAGCG
ATGTGCAAATGGAAGGCATCGGCGGCATGGGGCTTTTGGCCTATTTGCGGCAGTATCATCCCAAGGTCCCGTTATTGCTG
ATGACGGCCTTCGCCACCATAGACAGTGCCGTGAGTGCCATCAAACTTGGTGCGGTGGATTATCTTGCCAAGCCGTTTTC
ACCCGAAGTACTGCTTAACCAGGTCAGTCGCTACATGCCCGCGCAAGCCGATACGGGCGCACCCGTGGTGGCCGATGAGC
GCAGTCAGGCGCTGCTTGCCCTTGCCGGACGGGTAGCCAAATCCGAGGCGTCTGTGATGATCCTCGGGCCTTCTGGTTCG
GGTAAGGAAGTGCTGGCCCGCTATATCCATAAGCAAAGTTTGCGCTCAGATGGCCCCTTCGTGGCCATCAACTGCGCTGC
CATTCCGGAAAATATGCTCGAAGCCACACTGTTCGGCTATGAAAAGGGCGCCTTCACCGGTGCCTATCAGGCCTGCCCCG
GAAAATTCGAGCAGGCTCAGGGAGGCACCCTGCTGCTGGATGAAATCTCCGAAATGGATCTGGGATTACAGGCCAAGTTG
TTGCGGGTATTGCAGGAGCGGGAAGTTGAGCGTCTCGGTGGCCGTAAAACTATTAAGCTGGATGTGCGTGTGCTTGCCAC
CTCCAACCGTGAGCTCAAGGCTATGGCGGAGCGGGGGGATTTCCGTGAAGATCTTTATTACCGTATCAACGTATTCCCAC
TGACCTGGCCGGCTCTGAACCAGCGTCCGAAAGACATTTTGCCACTTGCGCGGCATTTGCTGGCACGCCATGCAGAGCGT
CTGGGCACAGAAGTACCCGAATTTGACGAAGCGGCCTGTCGCAGATTACTGGCACATCGCTGGCCGGGGAATGTCAGAGA
ACTCGATAATGTGGTGCAGCGGGCGTTGATCCTGTCCGCCGGCGTTAAGATAGGCGTGCAGGACATCATTATCGACGCCA
TGGACGTTACTCAAATCACTCAGGAAGAGACAGCCGTCAAGGCCGAGCCCGAAGGATTGGGAGATGAGCTCAAGGCCCAG
GAGCATGTGATAATCCTTGAGACCCTGAGCCAGTGCCGCGGCAGTCGCAAACTGGTGGCTGAGCGTCTGGGGATCAGTGC
CAGGACCCTGAGGTACAAGATGGCCCGTATGCGGGAAATGGGTATTCAGCTACCTGCCTGA

Upstream 100 bases:

>100_bases
CATGGTGGTGAGCTCAAAATGCAATGTGCTGCCAACCGTGGCTGTAGTGTCATGCTTAAATTCCCCGTGATTTCAGAAGA
TTCAGTAAAGGAGGTTAGCC

Downstream 100 bases:

>100_bases
TATTTGGGCAAGAACATCACAAAAAGCAGGCTTAGCCTGCTTTTTTAGTTTATTGGCAAGGCTTTTGCAGTACCCCAATA
TCAGCGATTTATCCCGTCAA

Product: response regulator receiver protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MPEGRLLLVEDDASLREALLDTLMLAQFDCVALPSAEEAILALKESRFDMVISDVQMEGIGGMGLLAYLRQYHPKVPLLL
MTAFATIDSAVSAIKLGAVDYLAKPFSPEVLLNQVSRYMPAQADTGAPVVADERSQALLALAGRVAKSEASVMILGPSGS
GKEVLARYIHKQSLRSDGPFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRELKAMAERGDFREDLYYRINVFPLTWPALNQRPKDILPLARHLLARHAER
LGTEVPEFDEAACRRLLAHRWPGNVRELDNVVQRALILSAGVKIGVQDIIIDAMDVTQITQEETAVKAEPEGLGDELKAQ
EHVIILETLSQCRGSRKLVAERLGISARTLRYKMARMREMGIQLPA

Sequences:

>Translated_446_residues
MPEGRLLLVEDDASLREALLDTLMLAQFDCVALPSAEEAILALKESRFDMVISDVQMEGIGGMGLLAYLRQYHPKVPLLL
MTAFATIDSAVSAIKLGAVDYLAKPFSPEVLLNQVSRYMPAQADTGAPVVADERSQALLALAGRVAKSEASVMILGPSGS
GKEVLARYIHKQSLRSDGPFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRELKAMAERGDFREDLYYRINVFPLTWPALNQRPKDILPLARHLLARHAER
LGTEVPEFDEAACRRLLAHRWPGNVRELDNVVQRALILSAGVKIGVQDIIIDAMDVTQITQEETAVKAEPEGLGDELKAQ
EHVIILETLSQCRGSRKLVAERLGISARTLRYKMARMREMGIQLPA
>Mature_445_residues
PEGRLLLVEDDASLREALLDTLMLAQFDCVALPSAEEAILALKESRFDMVISDVQMEGIGGMGLLAYLRQYHPKVPLLLM
TAFATIDSAVSAIKLGAVDYLAKPFSPEVLLNQVSRYMPAQADTGAPVVADERSQALLALAGRVAKSEASVMILGPSGSG
KEVLARYIHKQSLRSDGPFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKLL
RVLQEREVERLGGRKTIKLDVRVLATSNRELKAMAERGDFREDLYYRINVFPLTWPALNQRPKDILPLARHLLARHAERL
GTEVPEFDEAACRRLLAHRWPGNVRELDNVVQRALILSAGVKIGVQDIIIDAMDVTQITQEETAVKAEPEGLGDELKAQE
HVIILETLSQCRGSRKLVAERLGISARTLRYKMARMREMGIQLPA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=463, Percent_Identity=40.3887688984881, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=38.4787472035794, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1790299, Length=479, Percent_Identity=35.9081419624217, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=39.1982182628062, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082117, Length=341, Percent_Identity=41.9354838709677, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1789087, Length=314, Percent_Identity=42.6751592356688, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1789233, Length=306, Percent_Identity=41.8300653594771, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI87082152, Length=273, Percent_Identity=42.4908424908425, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI87081872, Length=301, Percent_Identity=37.2093023255814, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1787583, Length=301, Percent_Identity=37.2093023255814, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786524, Length=228, Percent_Identity=46.0526315789474, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789828, Length=292, Percent_Identity=34.5890410958904, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081858, Length=243, Percent_Identity=31.6872427983539, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49111; Mature: 48980

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGRLLLVEDDASLREALLDTLMLAQFDCVALPSAEEAILALKESRFDMVISDVQMEGI
CCCCCEEEEECCHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
GGMGLLAYLRQYHPKVPLLLMTAFATIDSAVSAIKLGAVDYLAKPFSPEVLLNQVSRYMP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
AQADTGAPVVADERSQALLALAGRVAKSEASVMILGPSGSGKEVLARYIHKQSLRSDGPF
CCCCCCCCEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEHHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRELKAMAERGDFREDLYYRINVFPLTWPALN
HHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHCCCCCCCEEEEEEEEEEECHHCC
QRPKDILPLARHLLARHAERLGTEVPEFDEAACRRLLAHRWPGNVRELDNVVQRALILSA
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GVKIGVQDIIIDAMDVTQITQEETAVKAEPEGLGDELKAQEHVIILETLSQCRGSRKLVA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEHHHHHHHHCCCHHHHH
ERLGISARTLRYKMARMREMGIQLPA
HHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PEGRLLLVEDDASLREALLDTLMLAQFDCVALPSAEEAILALKESRFDMVISDVQMEGI
CCCCEEEEECCHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
GGMGLLAYLRQYHPKVPLLLMTAFATIDSAVSAIKLGAVDYLAKPFSPEVLLNQVSRYMP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
AQADTGAPVVADERSQALLALAGRVAKSEASVMILGPSGSGKEVLARYIHKQSLRSDGPF
CCCCCCCCEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEHHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRELKAMAERGDFREDLYYRINVFPLTWPALN
HHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHCCCCCCCEEEEEEEEEEECHHCC
QRPKDILPLARHLLARHAERLGTEVPEFDEAACRRLLAHRWPGNVRELDNVVQRALILSA
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GVKIGVQDIIIDAMDVTQITQEETAVKAEPEGLGDELKAQEHVIILETLSQCRGSRKLVA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEHHHHHHHHCCCHHHHH
ERLGISARTLRYKMARMREMGIQLPA
HHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]