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The map label for this gene is (rmlA1 [H]

Identifier: 119775375

GI number: 119775375

Start: 2703745

End: 2704662

Strand: Reverse

Name: (rmlA1 [H]

Synonym: Sama_2240

Alternate gene names: 119775375

Gene position: 2704662-2703745 (Counterclockwise)

Preceding gene: 119775376

Following gene: 119775374

Centisome position: 62.81

GC content: 51.96

Gene sequence:

>918_bases
ATGTCACTTAACATTCAGCATTCAGCATTTAACACTCAAAAGACCAAAGGCATTATCCTGGCGGGCGGTACCGGTAGCAG
GCTTTATCCTATTACCCGCGGCGTATCCAAGCAGTTGTTGCCCGTGTACGACAAACCCATGGTGTACTATCCACTGTCGG
TGCTTATGCTTGCCGGCATTCGCGACATCCTGCTGATATCCACGGCAAGTGACCTTGCAGGTTTCCAATCTTTGCTCGGT
GATGGCAGTGGCCTTGGCATTCGCATCAGTTATGCAGTTCAATCCAAACCCGAAGGGATAGCCCAGGCGTTTTTAATCGG
TGAAGACTTTATCGGTAATGACAAGGTTGCCCTCATCCTGGGTGACAATATTTTCTACGGCCAAAGCTTTTCCCGGCAGC
TGCAGCAGGCCGCGGATTGCTCCCTTGGCGCTACGGTTTTTGCCTACCATGTCACGAACCCCGAGCGATTTGGCGTGGTG
GAGTTTGATAACACAGGCCGTGCTGTCAGCATTGAAGAAAAGCCTCGCGAGCCCAAGTCCCATTACGCTGTCACCGGCTT
GTATTTTTACGATAACCAGGTCATTGAGTTTGCAAAAAGCCTTAGGCCCTCGGCACGCGGAGAGCTTGAAATTACCGACA
TCAATAATGCCTATCTCGCAGCCAACCAGTTGCAGGTCAGTGTGCTTGGTCGCGGCTTTGCCTGGTTGGACACGGGGACC
CACGATGCTCTAATGGAAGCCGGGCATTTTGTGCAAACCATAGAGAAGCGTCAGGGGCTGAAAATTGCCTGCTTGGAGGA
AATTGCATACCGCAACGGTTGGATATCGACAGAGACCTTGTTGCAGCACGCAAAGGCGCTTAGTCAGAGTGGGTATGGGG
ATTATTTACGGCAGCTGGTCTGGGACGCTTCGCTTTAG

Upstream 100 bases:

>100_bases
GATTCCCATGTTCTGTCGCTGTTGGAACAAAGTGAAGAGCTAATCAAGCTCATTGTTGCTATCGTAAAATCTGCTCAGCA
GAATCAAACTAAGTAAAGTC

Downstream 100 bases:

>100_bases
GGCGGAGGCGAAGCCAGCTTCTAGAAAGCCACTTTGTGGCGACAGAAGGGCCTTCGGCCTACAGAACGCTGCTTCGCAGC
TACAGAGCGCCCGAGTAGCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSLNIQHSAFNTQKTKGIILAGGTGSRLYPITRGVSKQLLPVYDKPMVYYPLSVLMLAGIRDILLISTASDLAGFQSLLG
DGSGLGIRISYAVQSKPEGIAQAFLIGEDFIGNDKVALILGDNIFYGQSFSRQLQQAADCSLGATVFAYHVTNPERFGVV
EFDNTGRAVSIEEKPREPKSHYAVTGLYFYDNQVIEFAKSLRPSARGELEITDINNAYLAANQLQVSVLGRGFAWLDTGT
HDALMEAGHFVQTIEKRQGLKIACLEEIAYRNGWISTETLLQHAKALSQSGYGDYLRQLVWDASL

Sequences:

>Translated_305_residues
MSLNIQHSAFNTQKTKGIILAGGTGSRLYPITRGVSKQLLPVYDKPMVYYPLSVLMLAGIRDILLISTASDLAGFQSLLG
DGSGLGIRISYAVQSKPEGIAQAFLIGEDFIGNDKVALILGDNIFYGQSFSRQLQQAADCSLGATVFAYHVTNPERFGVV
EFDNTGRAVSIEEKPREPKSHYAVTGLYFYDNQVIEFAKSLRPSARGELEITDINNAYLAANQLQVSVLGRGFAWLDTGT
HDALMEAGHFVQTIEKRQGLKIACLEEIAYRNGWISTETLLQHAKALSQSGYGDYLRQLVWDASL
>Mature_304_residues
SLNIQHSAFNTQKTKGIILAGGTGSRLYPITRGVSKQLLPVYDKPMVYYPLSVLMLAGIRDILLISTASDLAGFQSLLGD
GSGLGIRISYAVQSKPEGIAQAFLIGEDFIGNDKVALILGDNIFYGQSFSRQLQQAADCSLGATVFAYHVTNPERFGVVE
FDNTGRAVSIEEKPREPKSHYAVTGLYFYDNQVIEFAKSLRPSARGELEITDINNAYLAANQLQVSVLGRGFAWLDTGTH
DALMEAGHFVQTIEKRQGLKIACLEEIAYRNGWISTETLLQHAKALSQSGYGDYLRQLVWDASL

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=251, Percent_Identity=24.7011952191235, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI11761619, Length=251, Percent_Identity=24.7011952191235, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=65.2631578947368, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=62.6297577854671, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1787488, Length=242, Percent_Identity=24.3801652892562, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=191, Percent_Identity=23.5602094240838, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=26.8774703557312, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=22.6190476190476, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=22.6190476190476, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33451; Mature: 33320

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNIQHSAFNTQKTKGIILAGGTGSRLYPITRGVSKQLLPVYDKPMVYYPLSVLMLAGI
CCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHCH
RDILLISTASDLAGFQSLLGDGSGLGIRISYAVQSKPEGIAQAFLIGEDFIGNDKVALIL
HHEEEEECHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHEEEECCCCCCCCEEEEEE
GDNIFYGQSFSRQLQQAADCSLGATVFAYHVTNPERFGVVEFDNTGRAVSIEEKPREPKS
CCCEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEECCCCCCCCC
HYAVTGLYFYDNQVIEFAKSLRPSARGELEITDINNAYLAANQLQVSVLGRGFAWLDTGT
CEEEEEEEEECCHHHHHHHHCCCCCCCCEEEEECCCEEEEECEEEEEEECCCEEEEECCC
HDALMEAGHFVQTIEKRQGLKIACLEEIAYRNGWISTETLLQHAKALSQSGYGDYLRQLV
HHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
WDASL
HCCCC
>Mature Secondary Structure 
SLNIQHSAFNTQKTKGIILAGGTGSRLYPITRGVSKQLLPVYDKPMVYYPLSVLMLAGI
CCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHCH
RDILLISTASDLAGFQSLLGDGSGLGIRISYAVQSKPEGIAQAFLIGEDFIGNDKVALIL
HHEEEEECHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHEEEECCCCCCCCEEEEEE
GDNIFYGQSFSRQLQQAADCSLGATVFAYHVTNPERFGVVEFDNTGRAVSIEEKPREPKS
CCCEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEECCCCCCCCC
HYAVTGLYFYDNQVIEFAKSLRPSARGELEITDINNAYLAANQLQVSVLGRGFAWLDTGT
CEEEEEEEEECCHHHHHHHHCCCCCCCCEEEEECCCEEEEECEEEEEEECCCEEEEECCC
HDALMEAGHFVQTIEKRQGLKIACLEEIAYRNGWISTETLLQHAKALSQSGYGDYLRQLV
HHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
WDASL
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]