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The map label for this gene is cynR [H]

Identifier: 119775350

GI number: 119775350

Start: 2677804

End: 2678685

Strand: Direct

Name: cynR [H]

Synonym: Sama_2215

Alternate gene names: 119775350

Gene position: 2677804-2678685 (Clockwise)

Preceding gene: 119775348

Following gene: 119775358

Centisome position: 62.19

GC content: 54.2

Gene sequence:

>882_bases
ATGGATATTAAGCAGCTCAACCACCTCATCGCAATATGCGAAACTGGCAGCTTTACCCGTGCAGCAAAGCGACTGTCACT
TGCCCAGCCAGCCCTGAGCCAGAGCATCAAAAAACTCGAGCAGGAGCTGGGCGTCACCCTCATTGGCCGCAGCCAGGGCA
TGAATGACAAGGGCATCAAGCTCACCGCCGAGGGCCAGGTACTGCTGGAACATGCCAGACGCATAGTGAACCAACTCGGT
CAGGCCAAGGCACAGATTCAGGCCATGGCCGACCTGCGTCAGGGTGAAGTCAGGGTGGCGGTTCCCGGCATGTTGGGCTC
CTTTTATCTGCCGTCACGGTTGATGGCCTTTCGTCACCGGTACGGTGGCCTCAAACTGAGTCTGTTTGAGGGTGGCACCC
GGGATGCGCTGCGGATGCTGGAGCAGGAAGAGGTGGATATTGCCATCATCACGGCCAAAGATCTGACCCCGGCGCTGAAC
TCTTGCCTGCTGCTGACCGAAGAAATGGTCGTGGCCATGGGCCATGAACACCCGCTTTGCGATAAAACCAGCGTCACCCT
GGAAGAGTTTTTCGACCATGAGTTGGTCATATTCAAACCCGGTTACTTTCATCGGGAATGGCTGCTCTCCCAGGCAAGGG
AGCTTGGGATATCCCCCACTATCGCCTTTGAAACCAACCTGATTAATCTTATCAAACAGGTGGTTTCTCAGGGCTTTGCC
ATTACCAGTGTGCTGGACATGGTGATATCTGCCAAAGATGAGATAGAGAAACGGCCTTTTAACCCGAGGGTATTTCTGGA
CCTGCATATCGCCTGGAAAAAGAAACGTCCACTGGGTCAGGCCGACAAAGCCTTTGTCGAGTTTTTGCTGGCCAACAAAT
AA

Upstream 100 bases:

>100_bases
CTGATTGCTTCAGGGTAGCGGCGCGGCTAACATTAACATAATAGATATTTCATCTATTATTTATTGATATTTTTTATATT
TAGCTAAGTAGCGGTAACGG

Downstream 100 bases:

>100_bases
AAAAGCCCGGCGCTGCCGGGCTTTTTTTTAACAGCAATCACTTACATTGGCTGCTGTTTCAGTACCGCTCTATCCAGTTT
CACACGTTCAACTTGTGAGT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MDIKQLNHLIAICETGSFTRAAKRLSLAQPALSQSIKKLEQELGVTLIGRSQGMNDKGIKLTAEGQVLLEHARRIVNQLG
QAKAQIQAMADLRQGEVRVAVPGMLGSFYLPSRLMAFRHRYGGLKLSLFEGGTRDALRMLEQEEVDIAIITAKDLTPALN
SCLLLTEEMVVAMGHEHPLCDKTSVTLEEFFDHELVIFKPGYFHREWLLSQARELGISPTIAFETNLINLIKQVVSQGFA
ITSVLDMVISAKDEIEKRPFNPRVFLDLHIAWKKKRPLGQADKAFVEFLLANK

Sequences:

>Translated_293_residues
MDIKQLNHLIAICETGSFTRAAKRLSLAQPALSQSIKKLEQELGVTLIGRSQGMNDKGIKLTAEGQVLLEHARRIVNQLG
QAKAQIQAMADLRQGEVRVAVPGMLGSFYLPSRLMAFRHRYGGLKLSLFEGGTRDALRMLEQEEVDIAIITAKDLTPALN
SCLLLTEEMVVAMGHEHPLCDKTSVTLEEFFDHELVIFKPGYFHREWLLSQARELGISPTIAFETNLINLIKQVVSQGFA
ITSVLDMVISAKDEIEKRPFNPRVFLDLHIAWKKKRPLGQADKAFVEFLLANK
>Mature_293_residues
MDIKQLNHLIAICETGSFTRAAKRLSLAQPALSQSIKKLEQELGVTLIGRSQGMNDKGIKLTAEGQVLLEHARRIVNQLG
QAKAQIQAMADLRQGEVRVAVPGMLGSFYLPSRLMAFRHRYGGLKLSLFEGGTRDALRMLEQEEVDIAIITAKDLTPALN
SCLLLTEEMVVAMGHEHPLCDKTSVTLEEFFDHELVIFKPGYFHREWLLSQARELGISPTIAFETNLINLIKQVVSQGFA
ITSVLDMVISAKDEIEKRPFNPRVFLDLHIAWKKKRPLGQADKAFVEFLLANK

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=251, Percent_Identity=31.8725099601594, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI2367136, Length=303, Percent_Identity=28.7128712871287, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787879, Length=245, Percent_Identity=27.3469387755102, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790399, Length=242, Percent_Identity=24.7933884297521, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693105, Length=195, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1787530, Length=255, Percent_Identity=23.5294117647059, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790262, Length=253, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=24.6666666666667, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788297, Length=179, Percent_Identity=29.0502793296089, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788481, Length=301, Percent_Identity=24.9169435215947, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=206, Percent_Identity=28.1553398058252, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786401, Length=148, Percent_Identity=32.4324324324324, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789506, Length=298, Percent_Identity=23.489932885906, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788296, Length=226, Percent_Identity=23.8938053097345, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787601, Length=151, Percent_Identity=27.1523178807947, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32802; Mature: 32802

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKQLNHLIAICETGSFTRAAKRLSLAQPALSQSIKKLEQELGVTLIGRSQGMNDKGIK
CCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEE
LTAEGQVLLEHARRIVNQLGQAKAQIQAMADLRQGEVRVAVPGMLGSFYLPSRLMAFRHR
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
YGGLKLSLFEGGTRDALRMLEQEEVDIAIITAKDLTPALNSCLLLTEEMVVAMGHEHPLC
HCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
DKTSVTLEEFFDHELVIFKPGYFHREWLLSQARELGISPTIAFETNLINLIKQVVSQGFA
CCCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCH
ITSVLDMVISAKDEIEKRPFNPRVFLDLHIAWKKKRPLGQADKAFVEFLLANK
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDIKQLNHLIAICETGSFTRAAKRLSLAQPALSQSIKKLEQELGVTLIGRSQGMNDKGIK
CCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEE
LTAEGQVLLEHARRIVNQLGQAKAQIQAMADLRQGEVRVAVPGMLGSFYLPSRLMAFRHR
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
YGGLKLSLFEGGTRDALRMLEQEEVDIAIITAKDLTPALNSCLLLTEEMVVAMGHEHPLC
HCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
DKTSVTLEEFFDHELVIFKPGYFHREWLLSQARELGISPTIAFETNLINLIKQVVSQGFA
CCCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCH
ITSVLDMVISAKDEIEKRPFNPRVFLDLHIAWKKKRPLGQADKAFVEFLLANK
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]