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The map label for this gene is rnd [H]

Identifier: 119775068

GI number: 119775068

Start: 2359614

End: 2360729

Strand: Reverse

Name: rnd [H]

Synonym: Sama_1933

Alternate gene names: 119775068

Gene position: 2360729-2359614 (Counterclockwise)

Preceding gene: 119775069

Following gene: 119775064

Centisome position: 54.82

GC content: 52.6

Gene sequence:

>1116_bases
TTGCTGGAGTTTCACTACGTAAAGGACGATGAAGCGCTGACCGCTTTGGTCGACCAATACAGCCAAAGCCGATTATTGGT
ATTGGACACCGAGTTTGTGCGTACCCGTACCTATTACGCCAAGTTGGGTCTAATTCAGGTATACGATGGCAATACTCTGG
CCCTGATAGACCCGCTCGATATTCAGGATTTATCTGGCTTTTGGGCGCTGCTTACCAACCCGAATATCCTTAAGTTGGTT
CATTCCTGCTCTGAAGATCTGGAAGTCTTTGCCCGTTATGGCAAGGTTCAGCCCACCCCCCTGTTTGATTCGCAGATTGC
GGCCGCGCTCAGTGGGATGGGCCATGGACTTGGCTATGCCAAACTGGTCGAAGAATGTTTGGGGCAGACCCTGGACAAGG
GAGAATCCCGTACAGACTGGATAAAGCGCCCTCTGACCGATGCCCAGCTGCAGTACGCCGCCAATGATGTGTTCTATCTG
TACCAGCTTTATCCTCAGCTTGAACAAAAGCTTAAAACGCTGGGCCGCTTCGATTGGGTACTGGAGGAAGGCGCCCGCCT
GACAGAAGGGCGTTTGCAGCGCCCTGAGGCTGCAACGGCATATCTTAAGGTGAAGAACGCATTTCAGCTGACCCCGAAGC
AATTGGCCTACCTGAAAGTGCTGGCAGCCTGGCGGTTGGAGCGCGCACTTGACCGGGACCTTGCGCTTGGCTTTGTGATT
AAAGACCACGCCCTGATTGCCCTTGCGAAAAAGCCGCCTCGCTCCATCAGTGATTTATTGAAAATCAACGATCTCTCTGA
GCATGAGAAACGCATTCACGGCAAGGACATCCTGAAAGTGTTGCAAAAGGCCGATGTGGAGAATCCACCGGCCGCCATTG
ATGTGATTGCACTCAAGCCCGCTTATAAGCAGGCGTTTAAAAACATCAAGGCCGCGCTCACCGAGATTTGTGAGCGTGAA
GGGTTACCGAGCGAGCTTTTCTGCTCAAAACGTCATATCCACGAATATCTCGAGTATCGCTGGCAAGGTGATGCAGAGGA
TACGCCGCTGTTGCTGCAGGGATGGCGCGGGAAACTCGCAACTGACGTACTGCAAGCTTTGGTACTGGAACCCTAA

Upstream 100 bases:

>100_bases
CGCCGAGAGCTTAGAAACGAGGAGCTTAACAAGGCGTGATAGAAAAACCGGCGTAAAGCCGGTTTTTTATTGCCATGAGC
CAAGATAAGGGGAGAGGGGT

Downstream 100 bases:

>100_bases
CCTCGGTGATAGATATGCTGCAATGCTTAAGCCGCGATGATTAAGCTGCTTCACGTCATAGCAATCAGTTGGGATATCAG
AAAAACACAGTAAAAAAGCC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MLEFHYVKDDEALTALVDQYSQSRLLVLDTEFVRTRTYYAKLGLIQVYDGNTLALIDPLDIQDLSGFWALLTNPNILKLV
HSCSEDLEVFARYGKVQPTPLFDSQIAAALSGMGHGLGYAKLVEECLGQTLDKGESRTDWIKRPLTDAQLQYAANDVFYL
YQLYPQLEQKLKTLGRFDWVLEEGARLTEGRLQRPEAATAYLKVKNAFQLTPKQLAYLKVLAAWRLERALDRDLALGFVI
KDHALIALAKKPPRSISDLLKINDLSEHEKRIHGKDILKVLQKADVENPPAAIDVIALKPAYKQAFKNIKAALTEICERE
GLPSELFCSKRHIHEYLEYRWQGDAEDTPLLLQGWRGKLATDVLQALVLEP

Sequences:

>Translated_371_residues
MLEFHYVKDDEALTALVDQYSQSRLLVLDTEFVRTRTYYAKLGLIQVYDGNTLALIDPLDIQDLSGFWALLTNPNILKLV
HSCSEDLEVFARYGKVQPTPLFDSQIAAALSGMGHGLGYAKLVEECLGQTLDKGESRTDWIKRPLTDAQLQYAANDVFYL
YQLYPQLEQKLKTLGRFDWVLEEGARLTEGRLQRPEAATAYLKVKNAFQLTPKQLAYLKVLAAWRLERALDRDLALGFVI
KDHALIALAKKPPRSISDLLKINDLSEHEKRIHGKDILKVLQKADVENPPAAIDVIALKPAYKQAFKNIKAALTEICERE
GLPSELFCSKRHIHEYLEYRWQGDAEDTPLLLQGWRGKLATDVLQALVLEP
>Mature_371_residues
MLEFHYVKDDEALTALVDQYSQSRLLVLDTEFVRTRTYYAKLGLIQVYDGNTLALIDPLDIQDLSGFWALLTNPNILKLV
HSCSEDLEVFARYGKVQPTPLFDSQIAAALSGMGHGLGYAKLVEECLGQTLDKGESRTDWIKRPLTDAQLQYAANDVFYL
YQLYPQLEQKLKTLGRFDWVLEEGARLTEGRLQRPEAATAYLKVKNAFQLTPKQLAYLKVLAAWRLERALDRDLALGFVI
KDHALIALAKKPPRSISDLLKINDLSEHEKRIHGKDILKVLQKADVENPPAAIDVIALKPAYKQAFKNIKAALTEICERE
GLPSELFCSKRHIHEYLEYRWQGDAEDTPLLLQGWRGKLATDVLQALVLEP

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=260, Percent_Identity=23.8461538461538, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI50301240, Length=260, Percent_Identity=23.8461538461538, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788105, Length=374, Percent_Identity=41.4438502673797, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17531757, Length=281, Percent_Identity=29.5373665480427, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324574, Length=281, Percent_Identity=24.1992882562278, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161078302, Length=273, Percent_Identity=26.007326007326, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42090; Mature: 42090

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFHYVKDDEALTALVDQYSQSRLLVLDTEFVRTRTYYAKLGLIQVYDGNTLALIDPLD
CCEEEEECCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCEEEEECCCEEEEECCCC
IQDLSGFWALLTNPNILKLVHSCSEDLEVFARYGKVQPTPLFDSQIAAALSGMGHGLGYA
CHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHH
KLVEECLGQTLDKGESRTDWIKRPLTDAQLQYAANDVFYLYQLYPQLEQKLKTLGRFDWV
HHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEEGARLTEGRLQRPEAATAYLKVKNAFQLTPKQLAYLKVLAAWRLERALDRDLALGFVI
HHCCCCCCCCCCCCCCHHHHHHEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
KDHALIALAKKPPRSISDLLKINDLSEHEKRIHGKDILKVLQKADVENPPAAIDVIALKP
ECCEEEEEECCCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEECH
AYKQAFKNIKAALTEICEREGLPSELFCSKRHIHEYLEYRWQGDAEDTPLLLQGWRGKLA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHH
TDVLQALVLEP
HHHHHHHHCCC
>Mature Secondary Structure
MLEFHYVKDDEALTALVDQYSQSRLLVLDTEFVRTRTYYAKLGLIQVYDGNTLALIDPLD
CCEEEEECCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCEEEEECCCEEEEECCCC
IQDLSGFWALLTNPNILKLVHSCSEDLEVFARYGKVQPTPLFDSQIAAALSGMGHGLGYA
CHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHH
KLVEECLGQTLDKGESRTDWIKRPLTDAQLQYAANDVFYLYQLYPQLEQKLKTLGRFDWV
HHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEEGARLTEGRLQRPEAATAYLKVKNAFQLTPKQLAYLKVLAAWRLERALDRDLALGFVI
HHCCCCCCCCCCCCCCHHHHHHEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
KDHALIALAKKPPRSISDLLKINDLSEHEKRIHGKDILKVLQKADVENPPAAIDVIALKP
ECCEEEEEECCCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEECH
AYKQAFKNIKAALTEICEREGLPSELFCSKRHIHEYLEYRWQGDAEDTPLLLQGWRGKLA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHH
TDVLQALVLEP
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]