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The map label for this gene is nhaB

Identifier: 119775060

GI number: 119775060

Start: 2353434

End: 2355020

Strand: Direct

Name: nhaB

Synonym: Sama_1925

Alternate gene names: 119775060

Gene position: 2353434-2355020 (Clockwise)

Preceding gene: 119775058

Following gene: 119775061

Centisome position: 54.65

GC content: 50.85

Gene sequence:

>1587_bases
ATGCCATTGACTCTTGGGCAGTCACTGTTTGCCAACTTTCTGGGTAATTCGCCCAGATGGTATAAGTTCGCGATCCTGTC
GTTTCTGGCGATAAATCCGATACTCTTTTACCTGAACCCCTTTATTGCAGGTTGGGTTTTGGTTATCCAGTTTATTTTCA
CCCTGGCCATGGCCCTTAAATGTTATCCCCTGCAGCCCGGTGGTTTGCTTGCCATTGAAGCCGTGATCATCGGCATGACC
AGCCCCACACAGGTGTTACACGAAATCCAGGCCAATCTGGAAGTACTGCTGCTTCTGGTGTTTATGGTCGCTGGCATCTA
CTTTATGAAACAGCTGCTGCTGTACGCCTTCACCAAGATGTTGACCAAGGTACGTTCGAAAATCGTCGTATCCATGCTGT
TTTGTATTGCGTCGGCGTTTTTGTCGGCCTTCCTCGATGCCCTTACTGTCATTGCGGTGATCATTACAGTGGCTGTGGGT
TTCTACTCTATCTACCATAAAGTGGCATCGGGTAAAGACTTCAGCTCCGATCACGACCACACCTCGGAAGCACCGGAGCA
GCTTAACGAAAGCGAGCTTGAGTCATTCCGTGGATTTTTGCGTAACCTCTTGATGCACGCCGGTGTGGGTACTGCCCTTG
GTGGCGTGTGCACCATGGTTGGCGAGCCCCAAAACCTCATTATCGCAGCTCAGGCCAACTGGCAATTTGGCGAATTTGCC
ATTCGCATGTCACCTGTCACTGTGCCGGTGTTTTTTGCCGGGATCTTGACCTGTTTTATCGTGGAAAAATTTAAATGGTT
TGGTTACGGCGCCAAACTGCCTGAGGCTGTACATAAGATCTTGAGCGAATACGATGCATACGAAGATGCCCGCCGCACAC
CTAAAGATAAGGTCAAGCTCATCGTACAGGCATTGGTGGGTGTTTGGCTGATTGTAGGTCTTGCATTCCACCTCGCATCA
GTAGGCCTGATTGGTCTCTCTGTGATTATCCTTAACACCGCCTTCAACGGCATTACCGACGAGCATGCTCTGGGTAAAGC
GTTTGAAGAAGCCCTACCCTTTACGGCGCTGCTGGCGGTATTCTTTGCAGTAGTAGGGGTTATTATTGACCAGCAACTTT
TCGCGCCGGTTATCCAGTGGGCACTCAGCTACGAAGGCAATGTACAGCTGGTTATCTTCTACATCGCCAATGGCCTGCTC
TCTATGGTCAGTGACAACGTGTTTGTGGGTACCGTGTATATCAACGAGGTGAAGGCTGCGCTGCTTAATGGGCAAATTAC
CCGTGACCAGTTTGATTTGCTGGCCGTTGCCATCAACACTGGCACCAACCTGCCATCTGTGGCCACCCCAAATGGTCAGG
CTGCCTTCCTGTTCCTGCTGACCTCAGCCCTGGCTCCGCTCATTCGCCTGTCCTATGGTCGCATGGTGATGATGGCTCTG
CCATACACCATAGTGCTGTCTATCGTAGGCATCCTGGCCATTGAATCGGGCTTTCTCACCGATATGACCCAGTATTTCTA
TGACAGCCATCTGATTAACCATCACACCGCAGCGGAAGCTGCAGGCAAGGCTCTGGGTGGACATTAA

Upstream 100 bases:

>100_bases
ACTTTAGGTTAAGGTTTAGGCTAGACTGAAGTACGTGTCAGTTCCGCTATACTAATAAATAATAAACCTCATTAATTATC
AAGCATATGGAGAGGGGAAA

Downstream 100 bases:

>100_bases
TTCTCTGGATTGACTGAACTTAGCTGCTTAAGTAAAGTCAGAAATAGCCCGCACTCTTGTGTGCGGGCTTTTTTATGGAC
ATTCCACCCATGGAGACCCT

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MPLTLGQSLFANFLGNSPRWYKFAILSFLAINPILFYLNPFIAGWVLVIQFIFTLAMALKCYPLQPGGLLAIEAVIIGMT
SPTQVLHEIQANLEVLLLLVFMVAGIYFMKQLLLYAFTKMLTKVRSKIVVSMLFCIASAFLSAFLDALTVIAVIITVAVG
FYSIYHKVASGKDFSSDHDHTSEAPEQLNESELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFGEFA
IRMSPVTVPVFFAGILTCFIVEKFKWFGYGAKLPEAVHKILSEYDAYEDARRTPKDKVKLIVQALVGVWLIVGLAFHLAS
VGLIGLSVIILNTAFNGITDEHALGKAFEEALPFTALLAVFFAVVGVIIDQQLFAPVIQWALSYEGNVQLVIFYIANGLL
SMVSDNVFVGTVYINEVKAALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVMMAL
PYTIVLSIVGILAIESGFLTDMTQYFYDSHLINHHTAAEAAGKALGGH

Sequences:

>Translated_528_residues
MPLTLGQSLFANFLGNSPRWYKFAILSFLAINPILFYLNPFIAGWVLVIQFIFTLAMALKCYPLQPGGLLAIEAVIIGMT
SPTQVLHEIQANLEVLLLLVFMVAGIYFMKQLLLYAFTKMLTKVRSKIVVSMLFCIASAFLSAFLDALTVIAVIITVAVG
FYSIYHKVASGKDFSSDHDHTSEAPEQLNESELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFGEFA
IRMSPVTVPVFFAGILTCFIVEKFKWFGYGAKLPEAVHKILSEYDAYEDARRTPKDKVKLIVQALVGVWLIVGLAFHLAS
VGLIGLSVIILNTAFNGITDEHALGKAFEEALPFTALLAVFFAVVGVIIDQQLFAPVIQWALSYEGNVQLVIFYIANGLL
SMVSDNVFVGTVYINEVKAALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVMMAL
PYTIVLSIVGILAIESGFLTDMTQYFYDSHLINHHTAAEAAGKALGGH
>Mature_527_residues
PLTLGQSLFANFLGNSPRWYKFAILSFLAINPILFYLNPFIAGWVLVIQFIFTLAMALKCYPLQPGGLLAIEAVIIGMTS
PTQVLHEIQANLEVLLLLVFMVAGIYFMKQLLLYAFTKMLTKVRSKIVVSMLFCIASAFLSAFLDALTVIAVIITVAVGF
YSIYHKVASGKDFSSDHDHTSEAPEQLNESELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFGEFAI
RMSPVTVPVFFAGILTCFIVEKFKWFGYGAKLPEAVHKILSEYDAYEDARRTPKDKVKLIVQALVGVWLIVGLAFHLASV
GLIGLSVIILNTAFNGITDEHALGKAFEEALPFTALLAVFFAVVGVIIDQQLFAPVIQWALSYEGNVQLVIFYIANGLLS
MVSDNVFVGTVYINEVKAALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVMMALP
YTIVLSIVGILAIESGFLTDMTQYFYDSHLINHHTAAEAAGKALGGH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family

Homologues:

Organism=Escherichia coli, GI1787435, Length=506, Percent_Identity=66.403162055336, Blast_Score=657, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAB_SHEAM (A1S6X4)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927800.1
- STRING:   A1S6X4
- GeneID:   4604175
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1925
- NMPDR:   fig|326297.7.peg.1810
- eggNOG:   COG3067
- HOGENOM:   HBG296776
- OMA:   CFLVEKF
- PhylomeDB:   A1S6X4
- ProtClustDB:   PRK09547
- HAMAP:   MF_01599
- InterPro:   IPR004671
- TIGRFAMs:   TIGR00774

Pfam domain/function: PF06450 NhaB

EC number: NA

Molecular weight: Translated: 57632; Mature: 57501

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13de4694)-; HASH(0x13e887a8)-; HASH(0x101f2db4)-; HASH(0x1448435c)-; HASH(0x13688d1c)-; HASH(0x1340cc70)-; HASH(0x10f99308)-; HASH(0x14473cdc)-; HASH(0x143180d4)-; HASH(0x138294c0)-; HASH(0x14426324)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
PLTLGQSLFANFLGNSPRWYKFAILSFLAINPILFYLNPFIAGWVLVIQFIFTLAMALK
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CYPLQPGGLLAIEAVIIGMTSPTQVLHEIQANLEVLLLLVFMVAGIYFMKQLLLYAFTKM
CCCCCCCCHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKVRSKIVVSMLFCIASAFLSAFLDALTVIAVIITVAVGFYSIYHKVASGKDFSSDHDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TSEAPEQLNESELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFGEFA
CHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEE
IRMSPVTVPVFFAGILTCFIVEKFKWFGYGAKLPEAVHKILSEYDAYEDARRTPKDKVKL
EEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
IVQALVGVWLIVGLAFHLASVGLIGLSVIILNTAFNGITDEHALGKAFEEALPFTALLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHH
FFAVVGVIIDQQLFAPVIQWALSYEGNVQLVIFYIANGLLSMVSDNVFVGTVYINEVKAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
LLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVMMAL
HHCCCCCHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHH
PYTIVLSIVGILAIESGFLTDMTQYFYDSHLINHHTAAEAAGKALGGH
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA