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The map label for this gene is cysM [C]

Identifier: 119774959

GI number: 119774959

Start: 2220855

End: 2221925

Strand: Direct

Name: cysM [C]

Synonym: Sama_1824

Alternate gene names: 119774959

Gene position: 2220855-2221925 (Clockwise)

Preceding gene: 119774955

Following gene: 119774961

Centisome position: 51.57

GC content: 54.15

Gene sequence:

>1071_bases
ATGAGCCTCCCCATTTGCACTAATTGGGTAGCCAATGCCATCGGCAAAATTGAAGCCGACTTTCAGCGCAGCGCCGACAC
CCACCTGATTAAGCTCGAATTACCGATGCTCGACGGCATCGATATCTATTTAAAAGACGAAAGCACCCACCCCACCGGTA
GCCTCAAACATCGTCTGGCCCGTTCATTGTTTCTGTACGCACTTTGCAATGGCTGGATTAAAGAAGGTACGTCGGTCATC
GAGTCCTCATCCGGCAGCACTGCGGTGTCTGAGGCCTATTTTGCCCGCCTGCTCGGTTTACCCTTTATTGCGGTGATGCC
AAAGAGCACCGCCAAGCGCAAAATCGAACAAATTGAGTTTTACGGCGGACGTTGCCATTTTGTTGAACATTCCAGCGAGA
TTTACGCCGAGTCAGAGAAACTCGCCAAAGAACTGGGTGGCCACTACATGGATCAGTTCACCTACGCCGAACGGGCCACC
GACTGGCGCGGCAACAACAACATTGCCAACGCTATTTTTGGCCAGATGGAGCGCGAACCCCATCCCATCCCCAGCTGGAT
TGTGATGAGTCCCGGCACCGGTGGCACCTCGGCGACCATAGGTCGCTATATCCGCTATCAGCGCCTCGCCACTAAATTGC
TGGTGGTCGACCCGCAGCACTCGGTGTTTTACGACTACTTCAAAACCGGTGACGCCGGTATTACCTGTGAAAAAGGCAGC
TGTATTGAAGGCATTGGTCGCCCCAGGGTGGAGCCTTCCTTTATTCCAGGCGTGGTGGATGAGATGCTTAAAGTCGCGGA
TGTGGACTCCATCGCCACCATGTATTGGCTCGAAGCCTTAATCGGCCGTAAAACCGGCCCCTCTACAGGCACTAACCTCT
ATGGCGCACTGAAACTGGCTTCCCAAATGAAGGCCCGCGGCGAAACCGGCAGTATCGTTACGCTTATCTGCGATCCGGGC
GAACGGTATCTGGATACCTACTACAACAGCGACTGGGTAAGTTCGCACATTGGCGATATCACGGCAGCAAGTACGGCGCT
TGCCGCCTTCAGTGAAAGTGGCAAGCTGTGA

Upstream 100 bases:

>100_bases
TCCAAATGCAATAATCTCTGTCAGTTTTGATCCTGACGCTGTGAAATCCTGTTGATTTTTCATATTATCCAAGCTCGTAT
TGCAAAACACAGGACTCCCC

Downstream 100 bases:

>100_bases
GTTCCTGATGCCCCAATAAAAAAGCTCCCTCGGGAGCTTTTTTATTGGCACGACCGAAATGAGCGATTTACCAAATTAAT
CGATATTCAAATACTTGTGG

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSLPICTNWVANAIGKIEADFQRSADTHLIKLELPMLDGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTSVI
ESSSGSTAVSEAYFARLLGLPFIAVMPKSTAKRKIEQIEFYGGRCHFVEHSSEIYAESEKLAKELGGHYMDQFTYAERAT
DWRGNNNIANAIFGQMEREPHPIPSWIVMSPGTGGTSATIGRYIRYQRLATKLLVVDPQHSVFYDYFKTGDAGITCEKGS
CIEGIGRPRVEPSFIPGVVDEMLKVADVDSIATMYWLEALIGRKTGPSTGTNLYGALKLASQMKARGETGSIVTLICDPG
ERYLDTYYNSDWVSSHIGDITAASTALAAFSESGKL

Sequences:

>Translated_356_residues
MSLPICTNWVANAIGKIEADFQRSADTHLIKLELPMLDGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTSVI
ESSSGSTAVSEAYFARLLGLPFIAVMPKSTAKRKIEQIEFYGGRCHFVEHSSEIYAESEKLAKELGGHYMDQFTYAERAT
DWRGNNNIANAIFGQMEREPHPIPSWIVMSPGTGGTSATIGRYIRYQRLATKLLVVDPQHSVFYDYFKTGDAGITCEKGS
CIEGIGRPRVEPSFIPGVVDEMLKVADVDSIATMYWLEALIGRKTGPSTGTNLYGALKLASQMKARGETGSIVTLICDPG
ERYLDTYYNSDWVSSHIGDITAASTALAAFSESGKL
>Mature_355_residues
SLPICTNWVANAIGKIEADFQRSADTHLIKLELPMLDGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTSVIE
SSSGSTAVSEAYFARLLGLPFIAVMPKSTAKRKIEQIEFYGGRCHFVEHSSEIYAESEKLAKELGGHYMDQFTYAERATD
WRGNNNIANAIFGQMEREPHPIPSWIVMSPGTGGTSATIGRYIRYQRLATKLLVVDPQHSVFYDYFKTGDAGITCEKGSC
IEGIGRPRVEPSFIPGVVDEMLKVADVDSIATMYWLEALIGRKTGPSTGTNLYGALKLASQMKARGETGSIVTLICDPGE
RYLDTYYNSDWVSSHIGDITAASTALAAFSESGKL

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=289, Percent_Identity=24.2214532871972, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI295821200, Length=289, Percent_Identity=24.2214532871972, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4557415, Length=289, Percent_Identity=24.2214532871972, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI2367138, Length=319, Percent_Identity=29.153605015674, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=349, Percent_Identity=34.3839541547278, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17539800, Length=354, Percent_Identity=34.7457627118644, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17539640, Length=367, Percent_Identity=30.5177111716621, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17562970, Length=322, Percent_Identity=27.639751552795, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=27.8145695364238, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=335, Percent_Identity=25.0746268656716, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=338, Percent_Identity=25.7396449704142, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24643623, Length=327, Percent_Identity=26.605504587156, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129101, Length=327, Percent_Identity=26.605504587156, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39136; Mature: 39005

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPICTNWVANAIGKIEADFQRSADTHLIKLELPMLDGIDIYLKDESTHPTGSLKHRLA
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHH
RSLFLYALCNGWIKEGTSVIESSSGSTAVSEAYFARLLGLPFIAVMPKSTAKRKIEQIEF
HHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHE
YGGRCHFVEHSSEIYAESEKLAKELGGHYMDQFTYAERATDWRGNNNIANAIFGQMEREP
ECCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
HPIPSWIVMSPGTGGTSATIGRYIRYQRLATKLLVVDPQHSVFYDYFKTGDAGITCEKGS
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEECCCC
CIEGIGRPRVEPSFIPGVVDEMLKVADVDSIATMYWLEALIGRKTGPSTGTNLYGALKLA
HHHCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
SQMKARGETGSIVTLICDPGERYLDTYYNSDWVSSHIGDITAASTALAAFSESGKL
HHHHHCCCCCCEEEEEECCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLPICTNWVANAIGKIEADFQRSADTHLIKLELPMLDGIDIYLKDESTHPTGSLKHRLA
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHH
RSLFLYALCNGWIKEGTSVIESSSGSTAVSEAYFARLLGLPFIAVMPKSTAKRKIEQIEF
HHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHE
YGGRCHFVEHSSEIYAESEKLAKELGGHYMDQFTYAERATDWRGNNNIANAIFGQMEREP
ECCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
HPIPSWIVMSPGTGGTSATIGRYIRYQRLATKLLVVDPQHSVFYDYFKTGDAGITCEKGS
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEECCCC
CIEGIGRPRVEPSFIPGVVDEMLKVADVDSIATMYWLEALIGRKTGPSTGTNLYGALKLA
HHHCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
SQMKARGETGSIVTLICDPGERYLDTYYNSDWVSSHIGDITAASTALAAFSESGKL
HHHHHCCCCCCEEEEEECCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]