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The map label for this gene is hexR [H]

Identifier: 119774948

GI number: 119774948

Start: 2207350

End: 2208204

Strand: Direct

Name: hexR [H]

Synonym: Sama_1813

Alternate gene names: 119774948

Gene position: 2207350-2208204 (Clockwise)

Preceding gene: 119774943

Following gene: 119774949

Centisome position: 51.26

GC content: 48.19

Gene sequence:

>855_bases
ATGAATACCCTAGAAAAGGTCCAGAAAAGTCTAAACCAATTCAGCAAGTCAGAACGCAAAGTTGCCGAAGTGATTCTGGC
CTCTCCCCAAACTGCGATTCACTCCAGTATCGCTACCCTGGCCAAAATGGCCGATGTGAGTGAGCCTACGGTTAACCGTT
TCTGCCGTCGCCTTGATACCAAGGGCTTTCCTGATTTTAAGTTACATCTGGCCCAAAGTCTTGCCAACGGCACACCCTAT
GTCAGCAGACACGTGGAAGAAGATGACTCGCCAGAGTCTTACACCACTAAAATCTTCGAATCTTCAATGGCTTCCCTTGA
TACTGCACGTCAAAGCCTCGACATGCAGGCGATCAATAAAGCAGTAGATATTCTGACACAGGCCAAAACTATTTCGTTCT
TCGGCCTTGGCGCTTCGGCTGCTGTGGCCCACGATGCGCAAAACAAATTTTTCCGCTTCAATGTACCTGTCATTTGTTTC
GATGATGTGTTGATGCAGCGCATGAGTTGCATTAACAGTAACGAAGGTGACGTAGTGGTGCTTATCTCTCACACTGGCCG
CACCAAGTCACTGATTGATATAGCAAGACTTGCTCGCGAAAATGGCGCAGCCGTGATAGGCATTACCGCCAGAAACTCAC
CCTTATCAGTTGAATGTACCTTGTCGGTCACCATGGAGGTGCCGGAAGATACTGATATGTACCTGCCAATGGCGTCCCGC
CTTGCACAATTGGTCGTAATTGATGTACTCGCAACTGGATTTACCTTAAGACGCGGTCCAAGATTCAGGGACAGCCTGAA
GCGCGTAAAAGAAGCATTGAAAGAATCCCGGATCAATAAAGACCCGATCCTGTAA

Upstream 100 bases:

>100_bases
ACTGTAAGCGGCAAACCACTTTGTGATCCAGGCAGCAAATTGAAACGCTGTGATCAGAAAATAAAAAAATAACACCTTCA
TCAATAGCGGACGTACGCGT

Downstream 100 bases:

>100_bases
GTTGATTCCAACCCAAATTTGGTAGTCAGACACAGTGCTGGCTACCATTTACCCGCCTAAAACCGGCGGTTTCTCACAAA
AATAAAAAGCTTGAGATAGA

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNTLEKVQKSLNQFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VSRHVEEDDSPESYTTKIFESSMASLDTARQSLDMQAINKAVDILTQAKTISFFGLGASAAVAHDAQNKFFRFNVPVICF
DDVLMQRMSCINSNEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITARNSPLSVECTLSVTMEVPEDTDMYLPMASR
LAQLVVIDVLATGFTLRRGPRFRDSLKRVKEALKESRINKDPIL

Sequences:

>Translated_284_residues
MNTLEKVQKSLNQFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VSRHVEEDDSPESYTTKIFESSMASLDTARQSLDMQAINKAVDILTQAKTISFFGLGASAAVAHDAQNKFFRFNVPVICF
DDVLMQRMSCINSNEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITARNSPLSVECTLSVTMEVPEDTDMYLPMASR
LAQLVVIDVLATGFTLRRGPRFRDSLKRVKEALKESRINKDPIL
>Mature_284_residues
MNTLEKVQKSLNQFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VSRHVEEDDSPESYTTKIFESSMASLDTARQSLDMQAINKAVDILTQAKTISFFGLGASAAVAHDAQNKFFRFNVPVICF
DDVLMQRMSCINSNEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITARNSPLSVECTLSVTMEVPEDTDMYLPMASR
LAQLVVIDVLATGFTLRRGPRFRDSLKRVKEALKESRINKDPIL

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=280, Percent_Identity=73.5714285714286, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI87082369, Length=237, Percent_Identity=24.4725738396624, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=26.7175572519084, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI87082130, Length=214, Percent_Identity=28.0373831775701, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31353; Mature: 31353

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLEKVQKSLNQFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVSRHVEEDDSPESYTTKIFESSMASLDTARQSLDMQAINK
CCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDILTQAKTISFFGLGASAAVAHDAQNKFFRFNVPVICFDDVLMQRMSCINSNEGDVVV
HHHHHHHHHHHEEEECCCHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHHHCCCCCCEEE
LISHTGRTKSLIDIARLARENGAAVIGITARNSPLSVECTLSVTMEVPEDTDMYLPMASR
EEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCHHHHH
LAQLVVIDVLATGFTLRRGPRFRDSLKRVKEALKESRINKDPIL
HHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNTLEKVQKSLNQFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVSRHVEEDDSPESYTTKIFESSMASLDTARQSLDMQAINK
CCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDILTQAKTISFFGLGASAAVAHDAQNKFFRFNVPVICFDDVLMQRMSCINSNEGDVVV
HHHHHHHHHHHEEEECCCHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHHHCCCCCCEEE
LISHTGRTKSLIDIARLARENGAAVIGITARNSPLSVECTLSVTMEVPEDTDMYLPMASR
EEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCHHHHH
LAQLVVIDVLATGFTLRRGPRFRDSLKRVKEALKESRINKDPIL
HHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]