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The map label for this gene is ydhC [H]

Identifier: 119774919

GI number: 119774919

Start: 2175843

End: 2177144

Strand: Direct

Name: ydhC [H]

Synonym: Sama_1784

Alternate gene names: 119774919

Gene position: 2175843-2177144 (Clockwise)

Preceding gene: 119774912

Following gene: 119774922

Centisome position: 50.53

GC content: 51.0

Gene sequence:

>1302_bases
TTGATTTCCAATTCACTGACTAAACGCAGAAGTTTAGTATTCTTCCCCTATCTTGCGCTGCTGAGTATGCTCGGATTTTT
GGCCACAGACATGTATCTTCCTGCATTCAATCAGATTGAATCTAGTTTGAACACGTCCGCCAGTTTGGTGGCCATGACCC
TTACCTGCTTTTTGGGTGGTCTCGCCATTGGGCAACTGGCATATGGCAGCCTTTGCGACAAATTTGGCAAGCGAAACACA
CTAATGGCTGGCCTTGGTGTATTTGCTGTAAGCAGCATTTTGCTGGGGTTTACCGAAAATATCAGTGTCTTTTTTGTGCT
CAGGGTTATTCAAGCATTCGGTGCATGCAGTGCCGCCGTCATCTGGCAAGCACTGGTGATGGAAAAATTTGACGAAGGCG
AGGCGAGAAAGGTGTTTTCGTCGATTATGCCCTTGGTTGCTCTGTCTCCAGCACTGGCGCCTTTGATGGGAGCCTGGGTC
AGCGAGCAGTTTGGCTGGCGTGCCATCTTCATCATCCTGGCCATTGTTGGGCTATTACTGGCCGCCATGACACCAGCGCT
GGCGAAAGAATCCCGCACTCGCAGCCAATCCGAGCCTATTCTTGTTAAGAACATCCTGAAAAACCGTGCTTTTCAGAATA
ACGTGGCGATATTTGGGGCCTGCAGTGCTGCCTTCTTTTGCTATCTGACATTGTGGCCTGCTGTGATGCAACACCATGGC
TACGCTGCTGCAGAAATTGGGCTCAGTTTTATTCCTCAAACCCTGGCATTTATGCTGGGCGGGTTTGCCTGCAAAAAAGC
ATTGCACTCCCATAGCCCTGAAGCTATCAAGAACATGCTCATCACAGGGTTTGTGGTGTTGTCTCTGGTGCTTTTTCTGT
TAACGCAACTCGGTGCGGGGATCCTGGCCGTGCTTTGGGTGTTTGCAGCCCTTGCCGCAATTAATGGTGCTGTTTATCCC
TTGCTGGTAACTGACGCCCTGGCGCCATTCTCCAACAACGCTACCAAGGCTGCCGGTTGGCAAAACTTCCTGCAATTGGG
TATGGCGTTTATTGCGTCAGCAGCTGTAGCCCTGATTGCCCATTGGTTTGAAAAGGCTATCGGCACCGGTATTCTCGTGT
GCGCTGCCATAGTGCTCGTGGCGTGGTGGCGTATGAACTGGAGTACCTGGCGTGGTAGTTGGTGTTTCCCGGACCCCGCC
AGAATGGGGGTCCTACGGACTGAAAAGCGTGAACATTCCGATAACGACACTAAAACGCACGGTGTCTGCAACGTCAGTAG
TCAACAGAAAGACACTGACTGA

Upstream 100 bases:

>100_bases
ATTATTTTGGTTACAGTATGCAAAATTAACCGTTTCACAGCGGTAAAACAAGTTATTAGACTCCACGGCGCTAAGATAAA
TCTAAATCGTGGAGGTATGT

Downstream 100 bases:

>100_bases
CAGAGGTGTCAGAGGTCACAGTGTAACGCTATTGGTTGCCATTTGGTTTATATGACCCCCTTGAGTAAGCTGCCCGGCTT
TGGCTAGGCGCCTTACTCAA

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MISNSLTKRRSLVFFPYLALLSMLGFLATDMYLPAFNQIESSLNTSASLVAMTLTCFLGGLAIGQLAYGSLCDKFGKRNT
LMAGLGVFAVSSILLGFTENISVFFVLRVIQAFGACSAAVIWQALVMEKFDEGEARKVFSSIMPLVALSPALAPLMGAWV
SEQFGWRAIFIILAIVGLLLAAMTPALAKESRTRSQSEPILVKNILKNRAFQNNVAIFGACSAAFFCYLTLWPAVMQHHG
YAAAEIGLSFIPQTLAFMLGGFACKKALHSHSPEAIKNMLITGFVVLSLVLFLLTQLGAGILAVLWVFAALAAINGAVYP
LLVTDALAPFSNNATKAAGWQNFLQLGMAFIASAAVALIAHWFEKAIGTGILVCAAIVLVAWWRMNWSTWRGSWCFPDPA
RMGVLRTEKREHSDNDTKTHGVCNVSSQQKDTD

Sequences:

>Translated_433_residues
MISNSLTKRRSLVFFPYLALLSMLGFLATDMYLPAFNQIESSLNTSASLVAMTLTCFLGGLAIGQLAYGSLCDKFGKRNT
LMAGLGVFAVSSILLGFTENISVFFVLRVIQAFGACSAAVIWQALVMEKFDEGEARKVFSSIMPLVALSPALAPLMGAWV
SEQFGWRAIFIILAIVGLLLAAMTPALAKESRTRSQSEPILVKNILKNRAFQNNVAIFGACSAAFFCYLTLWPAVMQHHG
YAAAEIGLSFIPQTLAFMLGGFACKKALHSHSPEAIKNMLITGFVVLSLVLFLLTQLGAGILAVLWVFAALAAINGAVYP
LLVTDALAPFSNNATKAAGWQNFLQLGMAFIASAAVALIAHWFEKAIGTGILVCAAIVLVAWWRMNWSTWRGSWCFPDPA
RMGVLRTEKREHSDNDTKTHGVCNVSSQQKDTD
>Mature_433_residues
MISNSLTKRRSLVFFPYLALLSMLGFLATDMYLPAFNQIESSLNTSASLVAMTLTCFLGGLAIGQLAYGSLCDKFGKRNT
LMAGLGVFAVSSILLGFTENISVFFVLRVIQAFGACSAAVIWQALVMEKFDEGEARKVFSSIMPLVALSPALAPLMGAWV
SEQFGWRAIFIILAIVGLLLAAMTPALAKESRTRSQSEPILVKNILKNRAFQNNVAIFGACSAAFFCYLTLWPAVMQHHG
YAAAEIGLSFIPQTLAFMLGGFACKKALHSHSPEAIKNMLITGFVVLSLVLFLLTQLGAGILAVLWVFAALAAINGAVYP
LLVTDALAPFSNNATKAAGWQNFLQLGMAFIASAAVALIAHWFEKAIGTGILVCAAIVLVAWWRMNWSTWRGSWCFPDPA
RMGVLRTEKREHSDNDTKTHGVCNVSSQQKDTD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=375, Percent_Identity=40.2666666666667, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788509, Length=235, Percent_Identity=30.6382978723404, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790794, Length=220, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790146, Length=220, Percent_Identity=24.5454545454545, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082312, Length=208, Percent_Identity=24.5192307692308, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787065, Length=288, Percent_Identity=22.5694444444444, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324264, Length=161, Percent_Identity=29.8136645962733, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46872; Mature: 46872

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISNSLTKRRSLVFFPYLALLSMLGFLATDMYLPAFNQIESSLNTSASLVAMTLTCFLGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
LAIGQLAYGSLCDKFGKRNTLMAGLGVFAVSSILLGFTENISVFFVLRVIQAFGACSAAV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHH
IWQALVMEKFDEGEARKVFSSIMPLVALSPALAPLMGAWVSEQFGWRAIFIILAIVGLLL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AAMTPALAKESRTRSQSEPILVKNILKNRAFQNNVAIFGACSAAFFCYLTLWPAVMQHHG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCC
YAAAEIGLSFIPQTLAFMLGGFACKKALHSHSPEAIKNMLITGFVVLSLVLFLLTQLGAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHH
ILAVLWVFAALAAINGAVYPLLVTDALAPFSNNATKAAGWQNFLQLGMAFIASAAVALIA
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HWFEKAIGTGILVCAAIVLVAWWRMNWSTWRGSWCFPDPARMGVLRTEKREHSDNDTKTH
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCHHHHHHHHCCCCCCCCC
GVCNVSSQQKDTD
CEECCCCCCCCCC
>Mature Secondary Structure
MISNSLTKRRSLVFFPYLALLSMLGFLATDMYLPAFNQIESSLNTSASLVAMTLTCFLGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
LAIGQLAYGSLCDKFGKRNTLMAGLGVFAVSSILLGFTENISVFFVLRVIQAFGACSAAV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHH
IWQALVMEKFDEGEARKVFSSIMPLVALSPALAPLMGAWVSEQFGWRAIFIILAIVGLLL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AAMTPALAKESRTRSQSEPILVKNILKNRAFQNNVAIFGACSAAFFCYLTLWPAVMQHHG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCC
YAAAEIGLSFIPQTLAFMLGGFACKKALHSHSPEAIKNMLITGFVVLSLVLFLLTQLGAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHH
ILAVLWVFAALAAINGAVYPLLVTDALAPFSNNATKAAGWQNFLQLGMAFIASAAVALIA
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HWFEKAIGTGILVCAAIVLVAWWRMNWSTWRGSWCFPDPARMGVLRTEKREHSDNDTKTH
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCHHHHHHHHCCCCCCCCC
GVCNVSSQQKDTD
CEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]