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The map label for this gene is gyrA [H]

Identifier: 119774866

GI number: 119774866

Start: 2118311

End: 2121016

Strand: Direct

Name: gyrA [H]

Synonym: Sama_1731

Alternate gene names: 119774866

Gene position: 2118311-2121016 (Clockwise)

Preceding gene: 119774860

Following gene: 119774867

Centisome position: 49.19

GC content: 54.55

Gene sequence:

>2706_bases
ATGACTGATTTGGCTTCATCTATTTCGCCAATTAATATCGAAGACGAACTCAAGAATTCGTACCTGGATTACGCCATGAG
CGTGATCGTGGGTCGGGCACTGCCGGATGTGCGTGACGGCCTTAAGCCTGTGCATCGCCGTGTGCTGTTCGCGATGAACG
AACTTAAAAACGACTGGAACAAGCCTTATAAAAAGTCGGCACGTGTGGTCGGTGACGTTATCGGTAAATACCACCCTCAC
GGCGACAGCGCTGTATACGACACCATAGTCCGTATGGCCCAGCCGTTCTCGTTGCGTTACACCCTGGTAGACGGTCAGGG
TAACTTCGGTTCTATCGACGGCGACGCCGCAGCAGCAATGCGTTATACCGAAATCCGCATGGAAAAGCTGGCTCACGAGC
TGCTCGCGGATTTGGAAAAAGAAACGGTAGACTTCGTGCCCAACTATGACGGCACAGAACAAATCCCTGCCGTTCTGCCT
ACCAAAATTCCCAACCTGCTGGTAAACGGTGCCTCCGGTATCGCCGTGGGTATGGCTACCAATATTCCGCCTCACAACCT
GACCGAAGTGGTTAAAGGTTGTTTGGCGCTGATTGAAGAGCCTGAGCTGTCCATCGAACAGCTGATGGAGTACATTCCAG
GCCCTGACTTCCCAACTGCCGCCATCATCAATGGCAAAAAGGGCATAGAAGAAGCCTATCGCACCGGTCGCGGCAAGGCC
ATTATGCGTGCCCGCGCCGAAGTGGAAATCGAAGACAACGGCCGTGAGCGCATTATTGTCACCGAGATCCCGTATCAGGT
GAACAAAGCCCGTCTGATTGAAAAAATCGCCGAGCTGGTAAAAGACAAGAAGATTGAAGGCATCAGCGGCCTGCGTGATG
AGTCCGACAAGGACGGCATGCGCATCGTGATTGAAATCAAGCGCGGTGAAGTAGGCGAAGTGGTTCTGAATAACCTTTAC
GCCCAAACCCAGATGCAGTCGTCGTTCGGTATCAACATGGTGGCACTGGCCAACGGTCAGCCAAAGCTGTTTAACCTCAA
GGAGATGCTGGAAGCCTTTATCCTGCACCGCCGTGAAGTAGTTACCCGCCGCACCGTGTACGAACTGCGTAAAGCCCGTG
ACAGAGCCCATATTTTGGAAGCGTTGGCGGTTGCCCTTGCCAACATCGACCCCATCATTGCCCTTATCAAGGCCTCTGCC
AGTCCTTCCGACGCCAAAGCAGGCCTGATTGCCAAGGGGTGGGAACTCGGCACTGTTAAAGCCATGCTGGAAAAGGCCGG
TGACGACGCCGCCCGTCCCGAGTGGCTGGAGCCCGAGTTCGGTATTCGTGATGGTCTCTACTTTATGACCGAGCCACAGG
CCCAGGCAATTCTGGACCTGCGTCTGCATAAGCTGACTGGCCTTGAGCATGAGAAGATCCTCCAGGAATACGAAGAGCTG
CTGGAAATCATTGCCGGTTTGCTTCACATCCTCAGAAGCCCAGAGCGTCTGATGGAAGTCATCAAAGAAGAGCTTGAGCT
GATTCTCGAACAGTTTGGCGATAACCGCCGCACTGAAATCAACGCATCTGCCGTGGATATCAGCCTCGAAGATCTGATTA
ACGAAGAAGACGTGGTAGTGACCCTGTCGCACCTCGGCTACGCCAAGTATCAGCCGCTGACCGACTACCAGGCCCAGCGC
CGCGGTGGCAAGGGCAAAGCTGCAACCAAGGTAAAAGACGAAGATTTCGTTGAAAAGCTGCTGGTTGCCAACACCCACGA
CACCATCTTGTGCTTCTCCGACTTCGGTAAGCTCTACTGGCTTAAGGTTTACCAGCTGCCGCTGGCAAGCCGTCAGGCCC
GTGGTCGCCCCATCGTTAACCTGCTGCCATTGCAGGAAGGTGAACGCATTACCGCGATTCTGCCGGTGCGTGAATACGAA
GAAGGCAAGTATATCCTGATGGCCACCTCTCACGGTACCGTGAAGAAGACTGCCCTGACCGAGTACAGCCGTCCACGCTC
CAACGGTATTATTGCTGTGAACCTCAAAGACGGTGACCAGCTGATTGGCGTTGATATTACTGATGGCAGCAGCGAAATCA
TGCTGTTCTCTGATGCCGGTAAAGTGGTGCGCTTCAAAGAAGGCGAAGAAGTTGCCGTAGTCGATGAAAACGGCAACCCT
GTGCTGGATGAAGAAGGCAAGCCACAAATCAACTTCAAAGGCGTGCGCCCAATGGGCCGCGGTGCCACCGGAGTGCGTGG
TATTGCCCTGGAAGAAGGCCAACGTGTGGTGTCGCTGATTGTACCGAAAGACGACAGCGCCATTCTGACCGTGACTGCCA
ACGGCTTTGGTAAGCGTACTGAGCTTGCTGAATACCCGGCCAAGAGCCGCGCCACCAAGGGCGTGGTGTCCATCAAGGTC
ACCGAGCGTAACGGCCCTGTGGTTGGCGCCGTACAGGTGGGCGAGAACGATGAAATCATGCTCATCAGCGACAAGGGTAC
CCTGGTGCGTACTCCTGCCATTGGTGTGTCCATCATCGGCCGAAACACCCAGGGTGTAACCATCATACGTACCGCTGACG
ATGAAACCGTGGTTGGTCTGCAGCGCATCGATGAAATACAGGATGACGGCAGCGAATATCTGGAAGAGGGTGTTGAAGGA
GCCGAGGGCGACATCATCGCCGAAGCCGATACACAGCCGACAGATGATGCCAACGACGAGGCATAA

Upstream 100 bases:

>100_bases
GACATTAAATTACTGTGTTAGAATGCCAAATCACGTTTGAAGGCTCGACAATGACACGGAAAACGACTTGTCAGCTAATT
TTCAGGGGATCGAGCAGTTT

Downstream 100 bases:

>100_bases
TTGAAGACGGGCGCCCAATGGGCGCTCGTTTTTTTTGCCAAACAGATTTTTTATTTTTCCAAACGTGTGACTACCAATGG
GTATCACCGAAGGCTAGCAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 901; Mature: 900

Protein sequence:

>901_residues
MTDLASSISPINIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELKNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYTLVDGQGNFGSIDGDAAAAMRYTEIRMEKLAHELLADLEKETVDFVPNYDGTEQIPAVLP
TKIPNLLVNGASGIAVGMATNIPPHNLTEVVKGCLALIEEPELSIEQLMEYIPGPDFPTAAIINGKKGIEEAYRTGRGKA
IMRARAEVEIEDNGRERIIVTEIPYQVNKARLIEKIAELVKDKKIEGISGLRDESDKDGMRIVIEIKRGEVGEVVLNNLY
AQTQMQSSFGINMVALANGQPKLFNLKEMLEAFILHRREVVTRRTVYELRKARDRAHILEALAVALANIDPIIALIKASA
SPSDAKAGLIAKGWELGTVKAMLEKAGDDAARPEWLEPEFGIRDGLYFMTEPQAQAILDLRLHKLTGLEHEKILQEYEEL
LEIIAGLLHILRSPERLMEVIKEELELILEQFGDNRRTEINASAVDISLEDLINEEDVVVTLSHLGYAKYQPLTDYQAQR
RGGKGKAATKVKDEDFVEKLLVANTHDTILCFSDFGKLYWLKVYQLPLASRQARGRPIVNLLPLQEGERITAILPVREYE
EGKYILMATSHGTVKKTALTEYSRPRSNGIIAVNLKDGDQLIGVDITDGSSEIMLFSDAGKVVRFKEGEEVAVVDENGNP
VLDEEGKPQINFKGVRPMGRGATGVRGIALEEGQRVVSLIVPKDDSAILTVTANGFGKRTELAEYPAKSRATKGVVSIKV
TERNGPVVGAVQVGENDEIMLISDKGTLVRTPAIGVSIIGRNTQGVTIIRTADDETVVGLQRIDEIQDDGSEYLEEGVEG
AEGDIIAEADTQPTDDANDEA

Sequences:

>Translated_901_residues
MTDLASSISPINIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELKNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYTLVDGQGNFGSIDGDAAAAMRYTEIRMEKLAHELLADLEKETVDFVPNYDGTEQIPAVLP
TKIPNLLVNGASGIAVGMATNIPPHNLTEVVKGCLALIEEPELSIEQLMEYIPGPDFPTAAIINGKKGIEEAYRTGRGKA
IMRARAEVEIEDNGRERIIVTEIPYQVNKARLIEKIAELVKDKKIEGISGLRDESDKDGMRIVIEIKRGEVGEVVLNNLY
AQTQMQSSFGINMVALANGQPKLFNLKEMLEAFILHRREVVTRRTVYELRKARDRAHILEALAVALANIDPIIALIKASA
SPSDAKAGLIAKGWELGTVKAMLEKAGDDAARPEWLEPEFGIRDGLYFMTEPQAQAILDLRLHKLTGLEHEKILQEYEEL
LEIIAGLLHILRSPERLMEVIKEELELILEQFGDNRRTEINASAVDISLEDLINEEDVVVTLSHLGYAKYQPLTDYQAQR
RGGKGKAATKVKDEDFVEKLLVANTHDTILCFSDFGKLYWLKVYQLPLASRQARGRPIVNLLPLQEGERITAILPVREYE
EGKYILMATSHGTVKKTALTEYSRPRSNGIIAVNLKDGDQLIGVDITDGSSEIMLFSDAGKVVRFKEGEEVAVVDENGNP
VLDEEGKPQINFKGVRPMGRGATGVRGIALEEGQRVVSLIVPKDDSAILTVTANGFGKRTELAEYPAKSRATKGVVSIKV
TERNGPVVGAVQVGENDEIMLISDKGTLVRTPAIGVSIIGRNTQGVTIIRTADDETVVGLQRIDEIQDDGSEYLEEGVEG
AEGDIIAEADTQPTDDANDEA
>Mature_900_residues
TDLASSISPINIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELKNDWNKPYKKSARVVGDVIGKYHPHG
DSAVYDTIVRMAQPFSLRYTLVDGQGNFGSIDGDAAAAMRYTEIRMEKLAHELLADLEKETVDFVPNYDGTEQIPAVLPT
KIPNLLVNGASGIAVGMATNIPPHNLTEVVKGCLALIEEPELSIEQLMEYIPGPDFPTAAIINGKKGIEEAYRTGRGKAI
MRARAEVEIEDNGRERIIVTEIPYQVNKARLIEKIAELVKDKKIEGISGLRDESDKDGMRIVIEIKRGEVGEVVLNNLYA
QTQMQSSFGINMVALANGQPKLFNLKEMLEAFILHRREVVTRRTVYELRKARDRAHILEALAVALANIDPIIALIKASAS
PSDAKAGLIAKGWELGTVKAMLEKAGDDAARPEWLEPEFGIRDGLYFMTEPQAQAILDLRLHKLTGLEHEKILQEYEELL
EIIAGLLHILRSPERLMEVIKEELELILEQFGDNRRTEINASAVDISLEDLINEEDVVVTLSHLGYAKYQPLTDYQAQRR
GGKGKAATKVKDEDFVEKLLVANTHDTILCFSDFGKLYWLKVYQLPLASRQARGRPIVNLLPLQEGERITAILPVREYEE
GKYILMATSHGTVKKTALTEYSRPRSNGIIAVNLKDGDQLIGVDITDGSSEIMLFSDAGKVVRFKEGEEVAVVDENGNPV
LDEEGKPQINFKGVRPMGRGATGVRGIALEEGQRVVSLIVPKDDSAILTVTANGFGKRTELAEYPAKSRATKGVVSIKVT
ERNGPVVGAVQVGENDEIMLISDKGTLVRTPAIGVSIIGRNTQGVTIIRTADDETVVGLQRIDEIQDDGSEYLEEGVEGA
EGDIIAEADTQPTDDANDEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=413, Percent_Identity=25.90799031477, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI19913406, Length=179, Percent_Identity=34.0782122905028, Blast_Score=77, Evalue=8e-14,
Organism=Escherichia coli, GI1788562, Length=903, Percent_Identity=71.9822812846069, Blast_Score=1308, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=739, Percent_Identity=36.2652232746955, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17535065, Length=286, Percent_Identity=29.7202797202797, Blast_Score=80, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=285, Percent_Identity=29.4736842105263, Blast_Score=79, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=349, Percent_Identity=27.7936962750716, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136538, Length=180, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 99278; Mature: 99147

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLASSISPINIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELKNDWN
CCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYTLVDGQGNFGSIDGDAAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHH
RYTEIRMEKLAHELLADLEKETVDFVPNYDGTEQIPAVLPTKIPNLLVNGASGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEECCCCEEEEEEC
NIPPHNLTEVVKGCLALIEEPELSIEQLMEYIPGPDFPTAAIINGKKGIEEAYRTGRGKA
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCCE
IMRARAEVEIEDNGRERIIVTEIPYQVNKARLIEKIAELVKDKKIEGISGLRDESDKDGM
EEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
RIVIEIKRGEVGEVVLNNLYAQTQMQSSFGINMVALANGQPKLFNLKEMLEAFILHRREV
EEEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEECHHHHHHHHHHHHHHH
VTRRTVYELRKARDRAHILEALAVALANIDPIIALIKASASPSDAKAGLIAKGWELGTVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCCEEECCCCHHHHH
AMLEKAGDDAARPEWLEPEFGIRDGLYFMTEPQAQAILDLRLHKLTGLEHEKILQEYEEL
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LEIIAGLLHILRSPERLMEVIKEELELILEQFGDNRRTEINASAVDISLEDLINEEDVVV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEHHHHCCCCCEEE
TLSHLGYAKYQPLTDYQAQRRGGKGKAATKVKDEDFVEKLLVANTHDTILCFSDFGKLYW
EHHHCCCHHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEE
LKVYQLPLASRQARGRPIVNLLPLQEGERITAILPVREYEEGKYILMATSHGTVKKTALT
EEEEECCCHHHHCCCCCCEEEECCCCCCEEEEEEECEECCCCCEEEEEECCCCEEHHHHH
EYSRPRSNGIIAVNLKDGDQLIGVDITDGSSEIMLFSDAGKVVRFKEGEEVAVVDENGNP
HCCCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEECCCCEEEEECCCEEEEEECCCCC
VLDEEGKPQINFKGVRPMGRGATGVRGIALEEGQRVVSLIVPKDDSAILTVTANGFGKRT
CCCCCCCCCEEEECCCCCCCCCCCCCEEEHHCCCEEEEEEEECCCCEEEEEEECCCCCCC
ELAEYPAKSRATKGVVSIKVTERNGPVVGAVQVGENDEIMLISDKGTLVRTPAIGVSIIG
HHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEECCCCCEEEEE
RNTQGVTIIRTADDETVVGLQRIDEIQDDGSEYLEEGVEGAEGDIIAEADTQPTDDANDE
CCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEECCCCCCCCCCCC
A
C
>Mature Secondary Structure 
TDLASSISPINIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELKNDWN
CCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYTLVDGQGNFGSIDGDAAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHH
RYTEIRMEKLAHELLADLEKETVDFVPNYDGTEQIPAVLPTKIPNLLVNGASGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEECCCCEEEEEEC
NIPPHNLTEVVKGCLALIEEPELSIEQLMEYIPGPDFPTAAIINGKKGIEEAYRTGRGKA
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCCE
IMRARAEVEIEDNGRERIIVTEIPYQVNKARLIEKIAELVKDKKIEGISGLRDESDKDGM
EEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
RIVIEIKRGEVGEVVLNNLYAQTQMQSSFGINMVALANGQPKLFNLKEMLEAFILHRREV
EEEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEECHHHHHHHHHHHHHHH
VTRRTVYELRKARDRAHILEALAVALANIDPIIALIKASASPSDAKAGLIAKGWELGTVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCCEEECCCCHHHHH
AMLEKAGDDAARPEWLEPEFGIRDGLYFMTEPQAQAILDLRLHKLTGLEHEKILQEYEEL
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LEIIAGLLHILRSPERLMEVIKEELELILEQFGDNRRTEINASAVDISLEDLINEEDVVV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEHHHHCCCCCEEE
TLSHLGYAKYQPLTDYQAQRRGGKGKAATKVKDEDFVEKLLVANTHDTILCFSDFGKLYW
EHHHCCCHHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEE
LKVYQLPLASRQARGRPIVNLLPLQEGERITAILPVREYEEGKYILMATSHGTVKKTALT
EEEEECCCHHHHCCCCCCEEEECCCCCCEEEEEEECEECCCCCEEEEEECCCCEEHHHHH
EYSRPRSNGIIAVNLKDGDQLIGVDITDGSSEIMLFSDAGKVVRFKEGEEVAVVDENGNP
HCCCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEECCCCEEEEECCCEEEEEECCCCC
VLDEEGKPQINFKGVRPMGRGATGVRGIALEEGQRVVSLIVPKDDSAILTVTANGFGKRT
CCCCCCCCCEEEECCCCCCCCCCCCCEEEHHCCCEEEEEEEECCCCEEEEEEECCCCCCC
ELAEYPAKSRATKGVVSIKVTERNGPVVGAVQVGENDEIMLISDKGTLVRTPAIGVSIIG
HHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEECCCCCEEEEE
RNTQGVTIIRTADDETVVGLQRIDEIQDDGSEYLEEGVEGAEGDIIAEADTQPTDDANDE
CCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEECCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]