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The map label for this gene is menA [H]

Identifier: 119774503

GI number: 119774503

Start: 1657990

End: 1658955

Strand: Reverse

Name: menA [H]

Synonym: Sama_1366

Alternate gene names: 119774503

Gene position: 1658955-1657990 (Counterclockwise)

Preceding gene: 119774509

Following gene: 119774500

Centisome position: 38.53

GC content: 58.28

Gene sequence:

>966_bases
ATGCGTGTTTTCGATTGTGCTAACTTTCAACGCAATTCTTGTTATCCTATGGGCTGCAATCGTTTTTATCTTTTAAAGGC
CACCATGAACCCCTGGATCCTTGCCATCAGACCCCGTACCCTGCCAGCGGCTATCGGCCCACTCCTGGTGGGAAATACCC
TCGCGCTCGGTCTGGAAAGCTTCAGCATTACTATTGCCATCGCCTCGATGATCTGTGCCCTGTTGTTGCAAATTGCCGTG
AACCTGGCCAATGACTATTTTGATTTTAAAAGCGGCGTGGATACCGAAGAGCGCCTGGGCCCTGTGCGGGTAACCCAAAG
TGGCCTGATAGCCCCGGCCAGGGTTAAAGCGGCCATGATAGCGTCTTTGCTGGCGGCGCTTGCGGTCGGCTCTTATCTGA
TTTGGCACGGAGGCGCCCCCATCGCCGTGCTCGCCGCCGCCTCCATTTTGGGTGCGCTTTGTTACAGCGGCGGGCCCTAT
CCCCTCGCCTCCCACGGTCTGGGTGAAGTGGCCGCCTTTGTGTTTTTCGGCTTGGTCGCGGTTGTGGGCAGCTTTTATCT
GCAGTCGGGCTTCGCCTCCATGGATGCCTGGATACTGGGTGCAGCAATTGGCCTTTTCAACGCCGCCATCATGCTGGTCA
ACAACACCCGGGACATCCGCACCGACACCCGCGCCGGTAAGCGCACCCTGGCGGTACGCATCGGCGAAGCCCAGTCACGG
GTGCTGTATCAGGCATTGGTGTATTTGCCTTTTGGCTTGATTATCGGCAGTTTTCTGATGGGCTTACTGCCGGGCTGGCC
TGTGCTCCTGTCCGGCTTGTCTCTGGTCATCGCAAGACGCCTGTCCCGGGAGTTCAGCGAGACCAGCGGCGGCGCCTTAA
ACCCCTTGCTGGGCCGCACCGCGAGGCTGACGCTGGTGTTCAGTGTACTCTTTTCCGTTGGGCTGCTTATTCCGGCTCAG
GCCTGA

Upstream 100 bases:

>100_bases
CGATTAAATAAAGCACAGCGTTAACGGTAAAACTTTGACCTTGACGGCAAATTTACCCGAAGGCCCCAGTGGCTGTGTGC
GCCTTGTCCCAGTCTGCTAA

Downstream 100 bases:

>100_bases
CGGCGTCATTGTAAGTCAGTAAATAAAAAGGCTTCCCGAGGGAAGCCTTTTTATTTACTGGTGTGAAGCGCGTAGCGTCA
GCCGCTCACAGCGTTTACAG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MRVFDCANFQRNSCYPMGCNRFYLLKATMNPWILAIRPRTLPAAIGPLLVGNTLALGLESFSITIAIASMICALLLQIAV
NLANDYFDFKSGVDTEERLGPVRVTQSGLIAPARVKAAMIASLLAALAVGSYLIWHGGAPIAVLAAASILGALCYSGGPY
PLASHGLGEVAAFVFFGLVAVVGSFYLQSGFASMDAWILGAAIGLFNAAIMLVNNTRDIRTDTRAGKRTLAVRIGEAQSR
VLYQALVYLPFGLIIGSFLMGLLPGWPVLLSGLSLVIARRLSREFSETSGGALNPLLGRTARLTLVFSVLFSVGLLIPAQ
A

Sequences:

>Translated_321_residues
MRVFDCANFQRNSCYPMGCNRFYLLKATMNPWILAIRPRTLPAAIGPLLVGNTLALGLESFSITIAIASMICALLLQIAV
NLANDYFDFKSGVDTEERLGPVRVTQSGLIAPARVKAAMIASLLAALAVGSYLIWHGGAPIAVLAAASILGALCYSGGPY
PLASHGLGEVAAFVFFGLVAVVGSFYLQSGFASMDAWILGAAIGLFNAAIMLVNNTRDIRTDTRAGKRTLAVRIGEAQSR
VLYQALVYLPFGLIIGSFLMGLLPGWPVLLSGLSLVIARRLSREFSETSGGALNPLLGRTARLTLVFSVLFSVGLLIPAQ
A
>Mature_321_residues
MRVFDCANFQRNSCYPMGCNRFYLLKATMNPWILAIRPRTLPAAIGPLLVGNTLALGLESFSITIAIASMICALLLQIAV
NLANDYFDFKSGVDTEERLGPVRVTQSGLIAPARVKAAMIASLLAALAVGSYLIWHGGAPIAVLAAASILGALCYSGGPY
PLASHGLGEVAAFVFFGLVAVVGSFYLQSGFASMDAWILGAAIGLFNAAIMLVNNTRDIRTDTRAGKRTLAVRIGEAQSR
VLYQALVYLPFGLIIGSFLMGLLPGWPVLLSGLSLVIARRLSREFSETSGGALNPLLGRTARLTLVFSVLFSVGLLIPAQ
A

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=298, Percent_Identity=27.8523489932886, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1790365, Length=300, Percent_Identity=36, Blast_Score=149, Evalue=4e-37,
Organism=Drosophila melanogaster, GI17737429, Length=320, Percent_Identity=28.125, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34013; Mature: 34013

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFDCANFQRNSCYPMGCNRFYLLKATMNPWILAIRPRTLPAAIGPLLVGNTLALGLES
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHH
FSITIAIASMICALLLQIAVNLANDYFDFKSGVDTEERLGPVRVTQSGLIAPARVKAAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEECCCCCCCHHHHHHHHH
ASLLAALAVGSYLIWHGGAPIAVLAAASILGALCYSGGPYPLASHGLGEVAAFVFFGLVA
HHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
VVGSFYLQSGFASMDAWILGAAIGLFNAAIMLVNNTRDIRTDTRAGKRTLAVRIGEAQSR
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEEECCHHHH
VLYQALVYLPFGLIIGSFLMGLLPGWPVLLSGLSLVIARRLSREFSETSGGALNPLLGRT
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ARLTLVFSVLFSVGLLIPAQA
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRVFDCANFQRNSCYPMGCNRFYLLKATMNPWILAIRPRTLPAAIGPLLVGNTLALGLES
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHH
FSITIAIASMICALLLQIAVNLANDYFDFKSGVDTEERLGPVRVTQSGLIAPARVKAAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEECCCCCCCHHHHHHHHH
ASLLAALAVGSYLIWHGGAPIAVLAAASILGALCYSGGPYPLASHGLGEVAAFVFFGLVA
HHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
VVGSFYLQSGFASMDAWILGAAIGLFNAAIMLVNNTRDIRTDTRAGKRTLAVRIGEAQSR
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEEECCHHHH
VLYQALVYLPFGLIIGSFLMGLLPGWPVLLSGLSLVIARRLSREFSETSGGALNPLLGRT
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ARLTLVFSVLFSVGLLIPAQA
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]