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The map label for this gene is lpxB

Identifier: 119774289

GI number: 119774289

Start: 1402156

End: 1403337

Strand: Direct

Name: lpxB

Synonym: Sama_1152

Alternate gene names: 119774289

Gene position: 1402156-1403337 (Clockwise)

Preceding gene: 119774288

Following gene: 119774290

Centisome position: 32.56

GC content: 54.48

Gene sequence:

>1182_bases
ATGAGCCAATCCAAGCCACTTGTGTTTGCCATGGTCGCCGGAGAACTCTCCGGCGATATTTTAGGTGCCGGTTTAGTTAA
AGCACTCAAAGCCCGACATCCCGACGCCCGCTTTGTCGGTATCGGTGGTCCCCGTATGGAGGCGCTTGGATTCGAGTCCC
TTTTTGCCATGGAAGAGCTGGCTGTGATGGGGATAGTCGAAGTCCTCTCCCGCCTGCCAAGACTCTTGAAGGTACGCTCC
TCTCTGGTATCTCAACTGCTTGCACTTAAGCCCGATTGCTTTATTGGCATAGACGCGCCGGATTTCAATATCGGTGTCGA
GCTGAAACTTAAGCAACAGGGTATCAAGACGGTGCACTATGTCAGCCCCTCCGTGTGGGCCTGGCGGCCAAAGCGTATCT
TCAAGATAGCCAAGGCCACCAACATGGTGTTGTCCTTGTTGCCGTTTGAGAAAGCCTTTTACGACCAGCATCAGGTTCCC
TGTACCTTCGTGGGGCATACCCTGGCCGATGATATCCCCCTTGAGCTCAGTAAAGCCGATGCCCGTGAAACTCTGGGGCT
CGATAGGGATGCTGAATATCTGGCGATACTCCCGGGCAGCCGCGGCGGTGAGCTTAAAATGCTCAGTGAACCTTTTATTA
AGGCCGCCGTTGCCATTAAAGAGGCTTTGCCTGATGTTCGCTTTATTACCCCCCTGGTGAATGAGAAGCGCCGCGAGCAG
TTCCTTACCGCCCTTGAAACCCATGCCCCCGGGCTTGAAATTCAGCTCTTTGATGGTCAAAGCCGTGAAATTATGGCCGC
CAGTGACGGCATACTGCTGGCGTCGGGCACAGCGACCCTCGAAGCCATGTTGGTAAAGCGTCCCATGGTCGTCGCCTATC
GGGTGGCGCCACTCACGTACAGTATTGCCAGTCGCATGATGCTGATTAAACGTTATTCGTTGCCCAACCTCCTATCCGGT
AAGGATCTGGTTCCTGAGCTCATTCAGGCCGATTGCACGCCACAGAAGATTGCCTCCGAAGTGGTTGCCATGATGAACCG
GGATAACAGGGCACTGATTGCCGAATTTACCGAAATGCATCAAAACCTCAGGCAAAATGCCAGCGAGCGGGCTGCCGATG
CGGTCGATGTGCTGATTGGTGCCAATGCGCCACATGGCCGCAGCTCCAATGAGGTGGGTTGA

Upstream 100 bases:

>100_bases
AAATCGCCACAGTGCCGGAAGTGAAGCAACTGATGGACTTCGTTGCCAGCTCTGGCCGCGGCATTATTCGATAACGGATT
ATGGGTCGTTAAGAGAAAAC

Downstream 100 bases:

>100_bases
TGGCGGTGTATAAAAATCTTAGCCCAGAGCAAACCGTGCTGCTGCAACAGGGACGGGTCGCCGGCGTTGATGAAGTGGGC
CGTGGCCCGCTGGTGGGCGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSQSKPLVFAMVAGELSGDILGAGLVKALKARHPDARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLKVRS
SLVSQLLALKPDCFIGIDAPDFNIGVELKLKQQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDQHQVP
CTFVGHTLADDIPLELSKADARETLGLDRDAEYLAILPGSRGGELKMLSEPFIKAAVAIKEALPDVRFITPLVNEKRREQ
FLTALETHAPGLEIQLFDGQSREIMAASDGILLASGTATLEAMLVKRPMVVAYRVAPLTYSIASRMMLIKRYSLPNLLSG
KDLVPELIQADCTPQKIASEVVAMMNRDNRALIAEFTEMHQNLRQNASERAADAVDVLIGANAPHGRSSNEVG

Sequences:

>Translated_393_residues
MSQSKPLVFAMVAGELSGDILGAGLVKALKARHPDARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLKVRS
SLVSQLLALKPDCFIGIDAPDFNIGVELKLKQQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDQHQVP
CTFVGHTLADDIPLELSKADARETLGLDRDAEYLAILPGSRGGELKMLSEPFIKAAVAIKEALPDVRFITPLVNEKRREQ
FLTALETHAPGLEIQLFDGQSREIMAASDGILLASGTATLEAMLVKRPMVVAYRVAPLTYSIASRMMLIKRYSLPNLLSG
KDLVPELIQADCTPQKIASEVVAMMNRDNRALIAEFTEMHQNLRQNASERAADAVDVLIGANAPHGRSSNEVG
>Mature_392_residues
SQSKPLVFAMVAGELSGDILGAGLVKALKARHPDARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLKVRSS
LVSQLLALKPDCFIGIDAPDFNIGVELKLKQQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDQHQVPC
TFVGHTLADDIPLELSKADARETLGLDRDAEYLAILPGSRGGELKMLSEPFIKAAVAIKEALPDVRFITPLVNEKRREQF
LTALETHAPGLEIQLFDGQSREIMAASDGILLASGTATLEAMLVKRPMVVAYRVAPLTYSIASRMMLIKRYSLPNLLSGK
DLVPELIQADCTPQKIASEVVAMMNRDNRALIAEFTEMHQNLRQNASERAADAVDVLIGANAPHGRSSNEVG

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=377, Percent_Identity=56.4986737400531, Blast_Score=436, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_SHEAM (A1S4Q3)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927029.1
- ProteinModelPortal:   A1S4Q3
- STRING:   A1S4Q3
- GeneID:   4603404
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1152
- NMPDR:   fig|326297.7.peg.1084
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   A1S4Q3
- ProtClustDB:   PRK00025
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42994; Mature: 42863

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSKPLVFAMVAGELSGDILGAGLVKALKARHPDARFVGIGGPRMEALGFESLFAMEEL
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
AVMGIVEVLSRLPRLLKVRSSLVSQLLALKPDCFIGIDAPDFNIGVELKLKQQGIKTVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCEEEE
VSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDQHQVPCTFVGHTLADDIPLELSKAD
ECCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCEEECHHHCCCCCCCCCCCC
ARETLGLDRDAEYLAILPGSRGGELKMLSEPFIKAAVAIKEALPDVRFITPLVNEKRREQ
HHHHCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FLTALETHAPGLEIQLFDGQSREIMAASDGILLASGTATLEAMLVKRPMVVAYRVAPLTY
HHHHHHHCCCCCEEEEECCCCCEEEEECCCEEEECCHHHHHHHHHHCCEEEEEEEHHHHH
SIASRMMLIKRYSLPNLLSGKDLVPELIQADCTPQKIASEVVAMMNRDNRALIAEFTEMH
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
QNLRQNASERAADAVDVLIGANAPHGRSSNEVG
HHHHHCHHHHHHHHHHEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SQSKPLVFAMVAGELSGDILGAGLVKALKARHPDARFVGIGGPRMEALGFESLFAMEEL
CCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
AVMGIVEVLSRLPRLLKVRSSLVSQLLALKPDCFIGIDAPDFNIGVELKLKQQGIKTVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCEEEE
VSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDQHQVPCTFVGHTLADDIPLELSKAD
ECCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCEEECHHHCCCCCCCCCCCC
ARETLGLDRDAEYLAILPGSRGGELKMLSEPFIKAAVAIKEALPDVRFITPLVNEKRREQ
HHHHCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FLTALETHAPGLEIQLFDGQSREIMAASDGILLASGTATLEAMLVKRPMVVAYRVAPLTY
HHHHHHHCCCCCEEEEECCCCCEEEEECCCEEEECCHHHHHHHHHHCCEEEEEEEHHHHH
SIASRMMLIKRYSLPNLLSGKDLVPELIQADCTPQKIASEVVAMMNRDNRALIAEFTEMH
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
QNLRQNASERAADAVDVLIGANAPHGRSSNEVG
HHHHHCHHHHHHHHHHEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA