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The map label for this gene is truC [H]

Identifier: 119774268

GI number: 119774268

Start: 1380060

End: 1380836

Strand: Direct

Name: truC [H]

Synonym: Sama_1131

Alternate gene names: 119774268

Gene position: 1380060-1380836 (Clockwise)

Preceding gene: 119774267

Following gene: 119774269

Centisome position: 32.05

GC content: 53.8

Gene sequence:

>777_bases
TTGGCATTTGCCGACACGGCGCCTGCCATTGAAATCCTCTACGAGGATGAGGCCATGGTGGCCATTCATAAGCCTGCAGG
GCTGCTTGTGCATCGTACATATCTTGCACGAAAAGAACATTGGTTTGCGATGCAGCTGACACGTGATCTGGTGGGTTGTC
ATGTATTTCCGGTTCACCGCCTTGACCGGCCCACATCGGGCGTATTGCTCTTTGCCAAATCCAGCGAGGTGGCCAATAGC
CTTTGTGGTCAGTTTGCCAGCCATAGCATCCGCAAACACTATCTGGCACTGGTACGCGGCAATATGTTTGACGCAGGCGT
GCTTGATTACGCTCTCAAAGAAGAGCTGGACGAGCTTGCCGACAAAGACGTTGACCCCGATAAGCCCGCCCAAGAGGCGA
TTACTGCTTACCGGCCACTGCTCAATAGTGAAATTCCGTATTCATCAGGGCGTTATCCAAGCAGCCGTTTTGCCCTGATG
CATCTGCAGCCCCAAACGGGACGCAAACATCAGCTGCGCAGGCATATGGCGCATCTGCGCCATCCTATTGTGGGTGATAC
AACCCATGGCGATGGCAAGCAAAACCGCTTTTTCCGAGAGCACTTTGGAGTCAATCGTTTGTGGCTGATTGCCAAACGAC
TTGAGCTGACGCACCCACTGACGGGGGCGCCAATCGCCATTGAAACTGAATTGGAGCCTGAATGGCTTGACGTGTTTTCC
GGGCTTGGATGGGACGAGGAGACGCTGGCGTTATCGCCATCCATGCTTATTGCGTGA

Upstream 100 bases:

>100_bases
TGGGGCACTCACGCAGACAAAGACGCTCTGTTGATTATCCTTGCCAATCTGGATGATGCCGTTAATGGAAAATGAAACAG
TACAGGCCGGTACTTTTGAG

Downstream 100 bases:

>100_bases
AATCAGCCTGTTTGTTTCAGCCTTGCTTTGATTTCGGCAAGGCTAACAAAACCTGCCACTTGAGTATGGGGAACATCGGG
CCAGATTTTTTGACTTTGAA

Product: pseudouridylate synthase

Products: NA

Alternate protein names: tRNA pseudouridylate synthase C; tRNA-uridine isomerase C [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MAFADTAPAIEILYEDEAMVAIHKPAGLLVHRTYLARKEHWFAMQLTRDLVGCHVFPVHRLDRPTSGVLLFAKSSEVANS
LCGQFASHSIRKHYLALVRGNMFDAGVLDYALKEELDELADKDVDPDKPAQEAITAYRPLLNSEIPYSSGRYPSSRFALM
HLQPQTGRKHQLRRHMAHLRHPIVGDTTHGDGKQNRFFREHFGVNRLWLIAKRLELTHPLTGAPIAIETELEPEWLDVFS
GLGWDEETLALSPSMLIA

Sequences:

>Translated_258_residues
MAFADTAPAIEILYEDEAMVAIHKPAGLLVHRTYLARKEHWFAMQLTRDLVGCHVFPVHRLDRPTSGVLLFAKSSEVANS
LCGQFASHSIRKHYLALVRGNMFDAGVLDYALKEELDELADKDVDPDKPAQEAITAYRPLLNSEIPYSSGRYPSSRFALM
HLQPQTGRKHQLRRHMAHLRHPIVGDTTHGDGKQNRFFREHFGVNRLWLIAKRLELTHPLTGAPIAIETELEPEWLDVFS
GLGWDEETLALSPSMLIA
>Mature_257_residues
AFADTAPAIEILYEDEAMVAIHKPAGLLVHRTYLARKEHWFAMQLTRDLVGCHVFPVHRLDRPTSGVLLFAKSSEVANSL
CGQFASHSIRKHYLALVRGNMFDAGVLDYALKEELDELADKDVDPDKPAQEAITAYRPLLNSEIPYSSGRYPSSRFALMH
LQPQTGRKHQLRRHMAHLRHPIVGDTTHGDGKQNRFFREHFGVNRLWLIAKRLELTHPLTGAPIAIETELEPEWLDVFSG
LGWDEETLALSPSMLIA

Specific function: Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs [H]

COG id: COG0564

COG function: function code J; Pseudouridylate synthases, 23S RNA-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudouridine synthase rluA family [H]

Homologues:

Organism=Homo sapiens, GI17158025, Length=145, Percent_Identity=32.4137931034483, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI23308689, Length=187, Percent_Identity=31.0160427807487, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI221316667, Length=202, Percent_Identity=31.6831683168317, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789155, Length=235, Percent_Identity=54.8936170212766, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1786244, Length=216, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788946, Length=240, Percent_Identity=29.1666666666667, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320168, Length=189, Percent_Identity=29.6296296296296, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321608, Length=195, Percent_Identity=30.2564102564103, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324506, Length=197, Percent_Identity=29.9492385786802, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921090, Length=185, Percent_Identity=29.7297297297297, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583449, Length=183, Percent_Identity=27.3224043715847, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583447, Length=183, Percent_Identity=27.3224043715847, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583445, Length=183, Percent_Identity=27.3224043715847, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR006224
- InterPro:   IPR006145 [H]

Pfam domain/function: PF00849 PseudoU_synth_2 [H]

EC number: NA

Molecular weight: Translated: 29178; Mature: 29047

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01129 PSI_RLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFADTAPAIEILYEDEAMVAIHKPAGLLVHRTYLARKEHWFAMQLTRDLVGCHVFPVHR
CCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHH
LDRPTSGVLLFAKSSEVANSLCGQFASHSIRKHYLALVRGNMFDAGVLDYALKEELDELA
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
DKDVDPDKPAQEAITAYRPLLNSEIPYSSGRYPSSRFALMHLQPQTGRKHQLRRHMAHLR
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHC
HPIVGDTTHGDGKQNRFFREHFGVNRLWLIAKRLELTHPLTGAPIAIETELEPEWLDVFS
CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHH
GLGWDEETLALSPSMLIA
CCCCCCCCEEECCHHHCC
>Mature Secondary Structure 
AFADTAPAIEILYEDEAMVAIHKPAGLLVHRTYLARKEHWFAMQLTRDLVGCHVFPVHR
CCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHH
LDRPTSGVLLFAKSSEVANSLCGQFASHSIRKHYLALVRGNMFDAGVLDYALKEELDELA
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
DKDVDPDKPAQEAITAYRPLLNSEIPYSSGRYPSSRFALMHLQPQTGRKHQLRRHMAHLR
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHC
HPIVGDTTHGDGKQNRFFREHFGVNRLWLIAKRLELTHPLTGAPIAIETELEPEWLDVFS
CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHH
GLGWDEETLALSPSMLIA
CCCCCCCCEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]