Click here to switch to the map view.

The map label for this gene is lysC [H]

Identifier: 119774186

GI number: 119774186

Start: 1269889

End: 1271100

Strand: Direct

Name: lysC [H]

Synonym: Sama_1049

Alternate gene names: 119774186

Gene position: 1269889-1271100 (Clockwise)

Preceding gene: 119774185

Following gene: 119774187

Centisome position: 29.49

GC content: 54.87

Gene sequence:

>1212_bases
GTGACAAAAATTTATGTAAAGAAGTTCGGAGGCACCTCTGTGGGTACCTTCGAACGCATTGAGGCGGTGGCAGATGCCAT
CGCCAAAGCGCATTTTGAAGGTGAGAGGCAGGTGTTGGTGCTCTCGGCTATGGCCGGCGAAACCAACAGGCTTTATGCCA
TGGCCGCCAACATAGACCCTCTGGCACCTGCCCGGGAATTGGACATGTTGGTGAGTGCAGGTGAGCAGGTCAGTATTGCC
CTGATGTCTATCGCGCTGGCAAGACGGGGCGTTAATGCCAGGTCTTTGCTGGGTAGCCAGGTCAAGGTGCGCACTAACAG
CCAGTTTGGCAGAGCCAGTATTGAGTCCGTTGACACAGGGTTATTGATGCAGTTGCTGGACGAAGGCGCTGTACCTGTTA
TCGCCGGGTTTCAAGGCGTCAACGAGCAGGGCGATGTGACAACTCTTGGGAGGGGTGGCTCAGATACCACTGCCGTTGCC
ATTGCCGCCGCACTTGAGGCGGCTGAGTGTCAAATCTTTACTGATGTGACCGGCGTTTTTACCACAGATCCCAATATAGA
TCCCGATGCCCAGAAACTCGATAGCATCAGTTTCGAAGCCATGTATGAAATGGCAAGGCAGGGCGCTAAGGTATTGCATC
CCGACAGCGTTGCCTGTGCACGCCGTCATGGCGTGGTGCTTAGGGTGTTGTCGAGTTTTGAGTCCGGCAGTGGCACCCTT
ATCCGCTTCGATGAGCCAGAGCACTCCGGCTCGGGCATTGTGGGCATTGCCGTTACCCGTGGACAAGGCCTGGTCTCTGT
TGCCGGTTTGGTGGATCAGCCGCAGGCGGAAGTAGCCCTGTTTCAGGCGCTGGCAAACGCCTCTGTGGATACTGACCTGG
TGGTACAGCTGGCGGAAGAAAAGGCACTGGCATTTACCCTGGCGCAAGGTGCACTCGATAAGGTGTTGACCCTGATAGAC
AGGTTGGCGCTTGAGCAGCCTCTGGCGGACGTTCGCCATGAGTCGCCATTGGCCAAGGTGTCCCTCGTCAGCACCGGTAA
AGCAGTCATGGCTGAAGTGGGGGCTCGTGTTACCGAGCTTTTGGAAGCACAAAACATTCGTGTTAAGTTACTTTCGACAT
CAGAAATCAAACTGTCGGTGGTAATCGATGAGGTGCATCTGCAGCATGCCGTCAGAAGTTTGCACAGAGCGTTTGACCTC
AATAAAGTATGA

Upstream 100 bases:

>100_bases
CAGTGAACCTGCCAAGCTCGACGGTGCCCTGGCCAGTGTTGTGCCTTGGCTTAATGAGCGTCTGTAACAACGGACGGGTC
TGAGTAGTAGCAGGCTGTTT

Downstream 100 bases:

>100_bases
ATATCCAAGCGTTTTGGTATTCAATACTATAATTTGTACTAAGCTGACTTTATAATAATGTGACGTCCAGGTGTCTGTCC
TGGCGTATGGAATGGGACTA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTKIYVKKFGGTSVGTFERIEAVADAIAKAHFEGERQVLVLSAMAGETNRLYAMAANIDPLAPARELDMLVSAGEQVSIA
LMSIALARRGVNARSLLGSQVKVRTNSQFGRASIESVDTGLLMQLLDEGAVPVIAGFQGVNEQGDVTTLGRGGSDTTAVA
IAAALEAAECQIFTDVTGVFTTDPNIDPDAQKLDSISFEAMYEMARQGAKVLHPDSVACARRHGVVLRVLSSFESGSGTL
IRFDEPEHSGSGIVGIAVTRGQGLVSVAGLVDQPQAEVALFQALANASVDTDLVVQLAEEKALAFTLAQGALDKVLTLID
RLALEQPLADVRHESPLAKVSLVSTGKAVMAEVGARVTELLEAQNIRVKLLSTSEIKLSVVIDEVHLQHAVRSLHRAFDL
NKV

Sequences:

>Translated_403_residues
MTKIYVKKFGGTSVGTFERIEAVADAIAKAHFEGERQVLVLSAMAGETNRLYAMAANIDPLAPARELDMLVSAGEQVSIA
LMSIALARRGVNARSLLGSQVKVRTNSQFGRASIESVDTGLLMQLLDEGAVPVIAGFQGVNEQGDVTTLGRGGSDTTAVA
IAAALEAAECQIFTDVTGVFTTDPNIDPDAQKLDSISFEAMYEMARQGAKVLHPDSVACARRHGVVLRVLSSFESGSGTL
IRFDEPEHSGSGIVGIAVTRGQGLVSVAGLVDQPQAEVALFQALANASVDTDLVVQLAEEKALAFTLAQGALDKVLTLID
RLALEQPLADVRHESPLAKVSLVSTGKAVMAEVGARVTELLEAQNIRVKLLSTSEIKLSVVIDEVHLQHAVRSLHRAFDL
NKV
>Mature_402_residues
TKIYVKKFGGTSVGTFERIEAVADAIAKAHFEGERQVLVLSAMAGETNRLYAMAANIDPLAPARELDMLVSAGEQVSIAL
MSIALARRGVNARSLLGSQVKVRTNSQFGRASIESVDTGLLMQLLDEGAVPVIAGFQGVNEQGDVTTLGRGGSDTTAVAI
AAALEAAECQIFTDVTGVFTTDPNIDPDAQKLDSISFEAMYEMARQGAKVLHPDSVACARRHGVVLRVLSSFESGSGTLI
RFDEPEHSGSGIVGIAVTRGQGLVSVAGLVDQPQAEVALFQALANASVDTDLVVQLAEEKALAFTLAQGALDKVLTLIDR
LALEQPLADVRHESPLAKVSLVSTGKAVMAEVGARVTELLEAQNIRVKLLSTSEIKLSVVIDEVHLQHAVRSLHRAFDLN
KV

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=450, Percent_Identity=30.8888888888889, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786183, Length=364, Percent_Identity=28.8461538461538, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790376, Length=449, Percent_Identity=24.4988864142539, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=387, Percent_Identity=25.5813953488372, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 42646; Mature: 42515

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIYVKKFGGTSVGTFERIEAVADAIAKAHFEGERQVLVLSAMAGETNRLYAMAANIDP
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCC
LAPARELDMLVSAGEQVSIALMSIALARRGVNARSLLGSQVKVRTNSQFGRASIESVDTG
CCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCCHHHHHHHH
LLMQLLDEGAVPVIAGFQGVNEQGDVTTLGRGGSDTTAVAIAAALEAAECQIFTDVTGVF
HHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCEEEEECCCEEE
TTDPNIDPDAQKLDSISFEAMYEMARQGAKVLHPDSVACARRHGVVLRVLSSFESGSGTL
ECCCCCCCCHHHHHCCHHHHHHHHHHCCCCEECCCCHHHHHHCCHHHHHHHHCCCCCCCE
IRFDEPEHSGSGIVGIAVTRGQGLVSVAGLVDQPQAEVALFQALANASVDTDLVVQLAEE
EEECCCCCCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
KALAFTLAQGALDKVLTLIDRLALEQPLADVRHESPLAKVSLVSTGKAVMAEVGARVTEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
LEAQNIRVKLLSTSEIKLSVVIDEVHLQHAVRSLHRAFDLNKV
HHCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKIYVKKFGGTSVGTFERIEAVADAIAKAHFEGERQVLVLSAMAGETNRLYAMAANIDP
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCC
LAPARELDMLVSAGEQVSIALMSIALARRGVNARSLLGSQVKVRTNSQFGRASIESVDTG
CCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCCHHHHHHHH
LLMQLLDEGAVPVIAGFQGVNEQGDVTTLGRGGSDTTAVAIAAALEAAECQIFTDVTGVF
HHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCEEEEECCCEEE
TTDPNIDPDAQKLDSISFEAMYEMARQGAKVLHPDSVACARRHGVVLRVLSSFESGSGTL
ECCCCCCCCHHHHHCCHHHHHHHHHHCCCCEECCCCHHHHHHCCHHHHHHHHCCCCCCCE
IRFDEPEHSGSGIVGIAVTRGQGLVSVAGLVDQPQAEVALFQALANASVDTDLVVQLAEE
EEECCCCCCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
KALAFTLAQGALDKVLTLIDRLALEQPLADVRHESPLAKVSLVSTGKAVMAEVGARVTEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
LEAQNIRVKLLSTSEIKLSVVIDEVHLQHAVRSLHRAFDLNKV
HHCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]