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The map label for this gene is trxC [H]

Identifier: 119773876

GI number: 119773876

Start: 906249

End: 906671

Strand: Direct

Name: trxC [H]

Synonym: Sama_0738

Alternate gene names: 119773876

Gene position: 906249-906671 (Clockwise)

Preceding gene: 119773874

Following gene: 119773877

Centisome position: 21.05

GC content: 59.57

Gene sequence:

>423_bases
ATGATCCTTGCCTGCCCCCACTGCCACGGTCTGAACCGGGTGCCCGACACCAGACTCAGCGACGCCCCCAGCTGTGGTCG
CTGTAAATCGCCCTTGTTTACCGGCGCGCCGATGGAGCTGACCGCCGAAAACTTCGATGCCCATGCCGTCAAATCCGAGT
TGCCTCTGGTGGTGGACTTTTGGGCGGCCTGGTGTGGCCCTTGCCAAAGCTTTGCGCCCGTATTCAGTGCGGCTGCAGAG
GAGATTGAACCCGGTTTTCGTTTTGGCAAGTTGGATACCGAAAGCCAGCAGGCTCTGGCGGCCCGCTTCGGCATTCGCTC
CATTCCCACGCTGATGGTCATCAAGGGGGGCAAGATATTGGGGCAACAGGCCGGCGCTATGCCCAAACAGGCCTTTATCC
AGTGGCTGAAACAGTTTTCCTGA

Upstream 100 bases:

>100_bases
TTGGCTGCAAAAGTGAAGAATGCAGGCTTTTTCGCCTTGTAATAGAGGCGCTCTGCCCCCATGTTTTGTGTCATCCTGCG
TTTATTTTGGAGCCATTGTT

Downstream 100 bases:

>100_bases
TAAATCAGCCGCTTTGACTTGCCATTACGCTCCGATAGCCGGAGGATAAACCCAGGTGGGTCGGGGGAGTTGAACTATGC
TGGATGTACGCTGTGAGCAG

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MILACPHCHGLNRVPDTRLSDAPSCGRCKSPLFTGAPMELTAENFDAHAVKSELPLVVDFWAAWCGPCQSFAPVFSAAAE
EIEPGFRFGKLDTESQQALAARFGIRSIPTLMVIKGGKILGQQAGAMPKQAFIQWLKQFS

Sequences:

>Translated_140_residues
MILACPHCHGLNRVPDTRLSDAPSCGRCKSPLFTGAPMELTAENFDAHAVKSELPLVVDFWAAWCGPCQSFAPVFSAAAE
EIEPGFRFGKLDTESQQALAARFGIRSIPTLMVIKGGKILGQQAGAMPKQAFIQWLKQFS
>Mature_140_residues
MILACPHCHGLNRVPDTRLSDAPSCGRCKSPLFTGAPMELTAENFDAHAVKSELPLVVDFWAAWCGPCQSFAPVFSAAAE
EIEPGFRFGKLDTESQQALAARFGIRSIPTLMVIKGGKILGQQAGAMPKQAFIQWLKQFS

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1788936, Length=138, Percent_Identity=47.1014492753623, Blast_Score=151, Evalue=1e-38,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=35.3535353535354, Blast_Score=86, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=41.025641025641, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=102, Percent_Identity=35.2941176470588, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=102, Percent_Identity=35.2941176470588, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=102, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=37.5, Blast_Score=64, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=36.3636363636364, Blast_Score=63, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573567, Length=110, Percent_Identity=30.9090909090909, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921434, Length=80, Percent_Identity=36.25, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15180; Mature: 15180

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILACPHCHGLNRVPDTRLSDAPSCGRCKSPLFTGAPMELTAENFDAHAVKSELPLVVDF
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHCCCHHHHH
WAAWCGPCQSFAPVFSAAAEEIEPGFRFGKLDTESQQALAARFGIRSIPTLMVIKGGKIL
HHHHHCCHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCHHCCCEEEEEECCCCC
GQQAGAMPKQAFIQWLKQFS
CHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MILACPHCHGLNRVPDTRLSDAPSCGRCKSPLFTGAPMELTAENFDAHAVKSELPLVVDF
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHCCCHHHHH
WAAWCGPCQSFAPVFSAAAEEIEPGFRFGKLDTESQQALAARFGIRSIPTLMVIKGGKIL
HHHHHCCHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCHHCCCEEEEEECCCCC
GQQAGAMPKQAFIQWLKQFS
CHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]