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The map label for this gene is ywrD [H]

Identifier: 119773807

GI number: 119773807

Start: 824619

End: 826325

Strand: Direct

Name: ywrD [H]

Synonym: Sama_0669

Alternate gene names: 119773807

Gene position: 824619-826325 (Clockwise)

Preceding gene: 119773806

Following gene: 119773808

Centisome position: 19.15

GC content: 54.89

Gene sequence:

>1707_bases
ATGAACCGGTTTACAATCACTATTTTAGCCCTGGCCGCTATCGGACTGGGCTGCAGCGAAGGAGTGTTGGCCATGGACAG
GATCACAGGTAAGGCGTTTGCCAGTCGTTCGGAGGTATATGCCACCCAGGGCATGGCGGCGACCAGCCAGCCTTTGGCCA
CTCAAGTTGCTCTGGATATATTGAAAGCCGGCGGCAGTGCGGTGGATGCCGCCATTGCCGCCAATGCCATGTTGGGGCTG
GTAGAACCCACAGGCTCGGGTGTCGGTGGCGACCTGTTTGCCATCGTCTGGAGCGCTAAAGACAAACGCTTATACGGCTT
AAATGCCTCGGGCCGCAGCCCAAAAACGCTCACGCTGGATATGCTTAAGGCGCAGGGACTTGAATTTTTACCGCCCTTTG
GTCCATTGCCTGTGTCTGTGCCCGGCGCAGTGGATGGCTGGTTTGAGCTGCATGACCGCTTTGGCAAATTGCCAATGTCG
CAAATTTTGTCGCCATCCATTGATTACGCGCGCAAGGGCTTCCCGGTTTCTGAACTCATCGCCTTTTATCTTGAAGGCAG
CGCCCGACGTCTCGCCAAATATCCGGGGTTCAGTGAAACCTATATGCCCAATGGCAAAATGCCCGCCAGGGGCGACATCA
TGAAAAATCCCGCCCTGGCCAACACCTACGAAAAAATAGCCAAGGGTGGCCGGGATGCGTTTTATAAGGGCGACATAGCC
CGCAGCATAGACAAGTACATGAAAGCCAATGGCGGTTACCTCGGCTACGAGGACCTGGCCTCACATACCAGTGAGTGGGT
TGAACCCGTATCGGTAAATTACCGCGGTTTTGATGTGTGGGAGCTGCCGCCAAACGGTCAGGGCATAGCAGCGCTGCAAA
TTTTAAAAACGCTGGAGCCGTTTGATTTAAGAGCCATGGGTCATGACAGCGTTGAGTATGTGCACCATTTTGTGGAGGCT
AAAAAGCTTGCCTTCGCTGACAGAGCGCGTTTTTACGCCGACATGGCCTTTGCTGATGTGCCCGTGAGTGAGCTTATTTC
AGAGCGCTACAACCAAGAGCGTGCCAAGCAGATAGGCCCCAGAGCGGCCAAGTCGGTAGAGCCGGGCAATCCCAATCTGC
AGCAGGGCGATACCGTGTATCTCACCACCGCAGACAGTGACGGTAACATGGTGTCACTTATTCAAAGTAATTTCCGCGGC
ATGGGCTCGGGCATGACACCTCCGGATCTCGGCTTTGTACTGCAGGACAGAGGGCAGTTGTTTGATTTAACGCCGGGGCG
CCCTAATTCTTACGCACCCGGCAAGCGTCCCTTCCATACCATCATTCCGGCGTTTGTGACCAAAGACGGTAAACCCTGGC
TCAGTTTTGGGGTGATGGGCGGTGCCACACAGCCGCAAATGCATGCGCAAATTATCATTAATCTCATCGATTTTGACATG
AACCTGCAGGAAGCCGGCGATGCGCCACGTATTCTGCATTCAGGCTCCAGTGAACCCACCGGCGAAGTGATGACCGATGG
TGGTTATGTGAGCCTGGAGTCGGGCTTTTCCATGGAGACGCGTCGAGAACTGGTGAAAAAAGGCCATGTGCTCCGGGATG
CCCTGGGGGAGTTTGGTGGTTATCAGGCTATCGGCATCAATGTGGAAACCGGTGTCTATCGCGGTGCTTCCGAGAGCCGC
AAAGATGGTCAGGCCGCCGGCTATTAG

Upstream 100 bases:

>100_bases
GTGTCAGCTTGTCTGCTGCGGCTGATACACCGGTAATCTTTGCTTAAACAGGTGATTATTGAGGTAAACCTGTGTAGTTT
GTGTTCTGGGAGGACTCAGC

Downstream 100 bases:

>100_bases
GGTGAATAACAAGCAATCTTGTGTAATGTGCGTCGGTCGGTGATATTTTTTCCTAAAGTACGGGATAATGTGACCGACAA
AGACATACTCAGTAAGGCCT

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MNRFTITILALAAIGLGCSEGVLAMDRITGKAFASRSEVYATQGMAATSQPLATQVALDILKAGGSAVDAAIAANAMLGL
VEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKTLTLDMLKAQGLEFLPPFGPLPVSVPGAVDGWFELHDRFGKLPMS
QILSPSIDYARKGFPVSELIAFYLEGSARRLAKYPGFSETYMPNGKMPARGDIMKNPALANTYEKIAKGGRDAFYKGDIA
RSIDKYMKANGGYLGYEDLASHTSEWVEPVSVNYRGFDVWELPPNGQGIAALQILKTLEPFDLRAMGHDSVEYVHHFVEA
KKLAFADRARFYADMAFADVPVSELISERYNQERAKQIGPRAAKSVEPGNPNLQQGDTVYLTTADSDGNMVSLIQSNFRG
MGSGMTPPDLGFVLQDRGQLFDLTPGRPNSYAPGKRPFHTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQIIINLIDFDM
NLQEAGDAPRILHSGSSEPTGEVMTDGGYVSLESGFSMETRRELVKKGHVLRDALGEFGGYQAIGINVETGVYRGASESR
KDGQAAGY

Sequences:

>Translated_568_residues
MNRFTITILALAAIGLGCSEGVLAMDRITGKAFASRSEVYATQGMAATSQPLATQVALDILKAGGSAVDAAIAANAMLGL
VEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKTLTLDMLKAQGLEFLPPFGPLPVSVPGAVDGWFELHDRFGKLPMS
QILSPSIDYARKGFPVSELIAFYLEGSARRLAKYPGFSETYMPNGKMPARGDIMKNPALANTYEKIAKGGRDAFYKGDIA
RSIDKYMKANGGYLGYEDLASHTSEWVEPVSVNYRGFDVWELPPNGQGIAALQILKTLEPFDLRAMGHDSVEYVHHFVEA
KKLAFADRARFYADMAFADVPVSELISERYNQERAKQIGPRAAKSVEPGNPNLQQGDTVYLTTADSDGNMVSLIQSNFRG
MGSGMTPPDLGFVLQDRGQLFDLTPGRPNSYAPGKRPFHTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQIIINLIDFDM
NLQEAGDAPRILHSGSSEPTGEVMTDGGYVSLESGFSMETRRELVKKGHVLRDALGEFGGYQAIGINVETGVYRGASESR
KDGQAAGY
>Mature_568_residues
MNRFTITILALAAIGLGCSEGVLAMDRITGKAFASRSEVYATQGMAATSQPLATQVALDILKAGGSAVDAAIAANAMLGL
VEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKTLTLDMLKAQGLEFLPPFGPLPVSVPGAVDGWFELHDRFGKLPMS
QILSPSIDYARKGFPVSELIAFYLEGSARRLAKYPGFSETYMPNGKMPARGDIMKNPALANTYEKIAKGGRDAFYKGDIA
RSIDKYMKANGGYLGYEDLASHTSEWVEPVSVNYRGFDVWELPPNGQGIAALQILKTLEPFDLRAMGHDSVEYVHHFVEA
KKLAFADRARFYADMAFADVPVSELISERYNQERAKQIGPRAAKSVEPGNPNLQQGDTVYLTTADSDGNMVSLIQSNFRG
MGSGMTPPDLGFVLQDRGQLFDLTPGRPNSYAPGKRPFHTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQIIINLIDFDM
NLQEAGDAPRILHSGSSEPTGEVMTDGGYVSLESGFSMETRRELVKKGHVLRDALGEFGGYQAIGINVETGVYRGASESR
KDGQAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=555, Percent_Identity=28.8288288288288, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI73915090, Length=555, Percent_Identity=28.8288288288288, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI73915096, Length=555, Percent_Identity=28.8288288288288, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI73915094, Length=555, Percent_Identity=28.8288288288288, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI113429324, Length=556, Percent_Identity=28.2374100719424, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI113429326, Length=561, Percent_Identity=27.6292335115865, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI153266885, Length=551, Percent_Identity=26.1343012704174, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI153266901, Length=552, Percent_Identity=26.0869565217391, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI109148539, Length=508, Percent_Identity=26.7716535433071, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI153266907, Length=550, Percent_Identity=24.7272727272727, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1789856, Length=554, Percent_Identity=32.8519855595668, Blast_Score=252, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI193208245, Length=474, Percent_Identity=27.6371308016878, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI193208247, Length=474, Percent_Identity=27.6371308016878, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17506189, Length=528, Percent_Identity=24.2424242424242, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI212646519, Length=474, Percent_Identity=25.9493670886076, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI72000294, Length=474, Percent_Identity=25.9493670886076, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17542894, Length=502, Percent_Identity=25.4980079681275, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323330, Length=474, Percent_Identity=25.3164556962025, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161077880, Length=563, Percent_Identity=27.3534635879218, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI161077878, Length=563, Percent_Identity=27.3534635879218, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45551474, Length=563, Percent_Identity=27.3534635879218, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24642670, Length=563, Percent_Identity=27.3534635879218, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24642666, Length=563, Percent_Identity=27.3534635879218, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI161077496, Length=525, Percent_Identity=25.3333333333333, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI18859893, Length=461, Percent_Identity=26.8980477223427, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI18859741, Length=476, Percent_Identity=25, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61253; Mature: 61253

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFTITILALAAIGLGCSEGVLAMDRITGKAFASRSEVYATQGMAATSQPLATQVALDI
CCCEEEHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LKAGGSAVDAAIAANAMLGLVEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKTLTLD
HHCCCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCEEEHH
MLKAQGLEFLPPFGPLPVSVPGAVDGWFELHDRFGKLPMSQILSPSIDYARKGFPVSELI
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCHHHHH
AFYLEGSARRLAKYPGFSETYMPNGKMPARGDIMKNPALANTYEKIAKGGRDAFYKGDIA
HHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHH
RSIDKYMKANGGYLGYEDLASHTSEWVEPVSVNYRGFDVWELPPNGQGIAALQILKTLEP
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCHHHHHHHHHCCC
FDLRAMGHDSVEYVHHFVEAKKLAFADRARFYADMAFADVPVSELISERYNQERAKQIGP
CCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHCCC
RAAKSVEPGNPNLQQGDTVYLTTADSDGNMVSLIQSNFRGMGSGMTPPDLGFVLQDRGQL
HHHCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHCCCCCCCCCCCCCEECCCCCE
FDLTPGRPNSYAPGKRPFHTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQIIINLIDFDM
EECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHEEHHHCCC
NLQEAGDAPRILHSGSSEPTGEVMTDGGYVSLESGFSMETRRELVKKGHVLRDALGEFGG
CHHHCCCCCHHHCCCCCCCCCCEEECCCEEEECCCCCHHHHHHHHHHCHHHHHHHHHHCC
YQAIGINVETGVYRGASESRKDGQAAGY
EEEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNRFTITILALAAIGLGCSEGVLAMDRITGKAFASRSEVYATQGMAATSQPLATQVALDI
CCCEEEHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LKAGGSAVDAAIAANAMLGLVEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKTLTLD
HHCCCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCEEEHH
MLKAQGLEFLPPFGPLPVSVPGAVDGWFELHDRFGKLPMSQILSPSIDYARKGFPVSELI
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCHHHHH
AFYLEGSARRLAKYPGFSETYMPNGKMPARGDIMKNPALANTYEKIAKGGRDAFYKGDIA
HHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHH
RSIDKYMKANGGYLGYEDLASHTSEWVEPVSVNYRGFDVWELPPNGQGIAALQILKTLEP
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCHHHHHHHHHCCC
FDLRAMGHDSVEYVHHFVEAKKLAFADRARFYADMAFADVPVSELISERYNQERAKQIGP
CCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHCCC
RAAKSVEPGNPNLQQGDTVYLTTADSDGNMVSLIQSNFRGMGSGMTPPDLGFVLQDRGQL
HHHCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHCCCCCCCCCCCCCEECCCCCE
FDLTPGRPNSYAPGKRPFHTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQIIINLIDFDM
EECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHEEHHHCCC
NLQEAGDAPRILHSGSSEPTGEVMTDGGYVSLESGFSMETRRELVKKGHVLRDALGEFGG
CHHHCCCCCHHHCCCCCCCCCCEEECCCEEEECCCCCHHHHHHHHHHCHHHHHHHHHHCC
YQAIGINVETGVYRGASESRKDGQAAGY
EEEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]