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The map label for this gene is frdA [C]

Identifier: 119773749

GI number: 119773749

Start: 763431

End: 765212

Strand: Direct

Name: frdA [C]

Synonym: Sama_0611

Alternate gene names: 119773749

Gene position: 763431-765212 (Clockwise)

Preceding gene: 119773745

Following gene: 119773750

Centisome position: 17.73

GC content: 55.44

Gene sequence:

>1782_bases
ATGTTCACGGGAGCGATGAAAAAAACGGTACTGGCGGCACTGATCTCCGGGATCATGGCGGGCACTGCATGGGCGGGTGC
CGATAACCTGGCCGATTTCCACGGTGATAACGGCTGCGACAGTTGTCACCAAAGCGATAAAGGTCCCAGCAACGATAATC
TGACTTTTGAAAATGGTCAGTGCGTTAGCTGCCATGGCAGTCTTACAGAGGTAGCCGAAGGGGAGCGCGAAGGCATAGTC
TCTCCACATAAATCACACCTGATAGGTGATATTGCCTGTACCAGCTGCCACAAAGGCCACGAAAAGTCAGTTACTTACTG
TGATGCTTGCCATAACTTCGGCTATGAGATCCCCTTCGCCGGCAAGTGGGAGCGCAAATTTGTGCCCGTGGACGCCGACA
AAGCCGCTCAGGATAAGGCCATTGCCGCAGGTCCCCGTGAAACCACAGATGTGGTCATCATAGGTTCCGGTGGTGCAGGG
CTTGCGGCCGCTGTTTCTGCCCGCGATGCCGGTGCCAAGGTCGTGGTGCTTGAAAAAGAACCCGTTCCCGGTGGTAATAC
CAAGCTTGCTGCCGGTGGTATGAATGCCGCCGAAACCAAGCCTCAGGCCAAACTGGGTATTGTTGATAAAAAGCAGATCA
TGATTGACGACACCATGAAAGGTGGCCGCAACATCAACAATCCTGAGTTGGTACAGGTTCTCGCCAATAACTCTTCCGAC
TCTATTGATTGGCTGACAGCGCTGGGCGCCGATATGAATGACGTTGGCCGTATGGGGGGCGCCAGCGTTAACCGCAGTCA
CCGTCCAACCGGTGGTGCCGGTGTGGGAGCACACGTGGCGCAGGTTCTGTGGGACGCTGCTGTGGCCCGTGATGCCGATA
TTCGCCTCAACAGCCGTGTGGTTCGCATTCTCGAAGACGGTGCCGGTCAGGTGACCGGTGTGCTGGTACAGGGGGCCTAT
ACAGGTTACTACGTGATTAAGGCCGATGCTGTGGTGGTAGCCACCGGCGGCTTTGCCAAGAACAACGATCGCGTTGCCAA
GTACGATGCCAAACTCAAAGGCTTTAAAGCCACCAACCACCCCGGTGCCACCGGTGACGGTTTGGATGTAGCCACCCAGG
CCGGTGCTGACACAGTGGATCTGGAATACGTGCAGGCTCACCCCACCTACAGCCCTGTGGGCGGTGTGATGGTGACCGAA
GCCGTACGTGGTAACGGTGCGATTCTGGTTAACCGCGAAGGCAAGCGCTTCGTGAACGAAATCACCACCCGTGATAAGGC
ATCTGCCGCTATCCTGGCCCAGAAAGGTGAGAGCGCGTATCTGCTTTTCGATGACTCTGTACGTAAGAGTCTGAGCAAAA
TTGAGGGTTACGTGCACCTCAAGATTGTAAACGAAGGCAAATCGGTGAAGGAACTGGCCGACAAGCTGGGTATGCCCGCC
GCTGAACTCGAAAAAACCATAGGGACTTACAATGGTTTTGTGAAGAGTGGTAAAGATGAGCAGTTCGAGCGTGCCGACAT
GCCACGTGAACTGGCGAGCGCGCCTTACTATGCCATTGAAGTTGCACCGGCTGTTCACCACACCATGGGCGGTGTGAAGA
TTGATACCAAGGCCGAGGTTGTGGGCAAAGAAGGCAAGCTCATCAGGGGCATGTACGCTGCCGGTGAAGTAACAGGTGGT
GTCCATGGTGCCAACCGTCTGGGCGGTAACGCCATCTCCGATATCGTGACCTTTGGTCGTATCGCAGGTGCCGAAGCGGC
CAAGTTTGCCAAAGACAATTGA

Upstream 100 bases:

>100_bases
TTTGCGGTGGCCAGTGTTTTGCTCCGAATATCAACAGTAATTAAGTGTAAAACACGCCATAAAAATACCTCTTTATAAGT
AGTTTTTTGGAGGAACACTT

Downstream 100 bases:

>100_bases
TCTTCCTTAGCACGCAGTGGGTGTGATGATACCCTGTCTGAGGCGGCCCAACCGGGCCGCCTTTTTCTTATCCCGGATTT
TAAGTAAAGGTGATCCACAT

Product: fumarate reductase flavoprotein subunit precursor

Products: NA

Alternate protein names: Flavocytochrome c; FL cyt [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MFTGAMKKTVLAALISGIMAGTAWAGADNLADFHGDNGCDSCHQSDKGPSNDNLTFENGQCVSCHGSLTEVAEGEREGIV
SPHKSHLIGDIACTSCHKGHEKSVTYCDACHNFGYEIPFAGKWERKFVPVDADKAAQDKAIAAGPRETTDVVIIGSGGAG
LAAAVSARDAGAKVVVLEKEPVPGGNTKLAAGGMNAAETKPQAKLGIVDKKQIMIDDTMKGGRNINNPELVQVLANNSSD
SIDWLTALGADMNDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDAAVARDADIRLNSRVVRILEDGAGQVTGVLVQGAY
TGYYVIKADAVVVATGGFAKNNDRVAKYDAKLKGFKATNHPGATGDGLDVATQAGADTVDLEYVQAHPTYSPVGGVMVTE
AVRGNGAILVNREGKRFVNEITTRDKASAAILAQKGESAYLLFDDSVRKSLSKIEGYVHLKIVNEGKSVKELADKLGMPA
AELEKTIGTYNGFVKSGKDEQFERADMPRELASAPYYAIEVAPAVHHTMGGVKIDTKAEVVGKEGKLIRGMYAAGEVTGG
VHGANRLGGNAISDIVTFGRIAGAEAAKFAKDN

Sequences:

>Translated_593_residues
MFTGAMKKTVLAALISGIMAGTAWAGADNLADFHGDNGCDSCHQSDKGPSNDNLTFENGQCVSCHGSLTEVAEGEREGIV
SPHKSHLIGDIACTSCHKGHEKSVTYCDACHNFGYEIPFAGKWERKFVPVDADKAAQDKAIAAGPRETTDVVIIGSGGAG
LAAAVSARDAGAKVVVLEKEPVPGGNTKLAAGGMNAAETKPQAKLGIVDKKQIMIDDTMKGGRNINNPELVQVLANNSSD
SIDWLTALGADMNDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDAAVARDADIRLNSRVVRILEDGAGQVTGVLVQGAY
TGYYVIKADAVVVATGGFAKNNDRVAKYDAKLKGFKATNHPGATGDGLDVATQAGADTVDLEYVQAHPTYSPVGGVMVTE
AVRGNGAILVNREGKRFVNEITTRDKASAAILAQKGESAYLLFDDSVRKSLSKIEGYVHLKIVNEGKSVKELADKLGMPA
AELEKTIGTYNGFVKSGKDEQFERADMPRELASAPYYAIEVAPAVHHTMGGVKIDTKAEVVGKEGKLIRGMYAAGEVTGG
VHGANRLGGNAISDIVTFGRIAGAEAAKFAKDN
>Mature_593_residues
MFTGAMKKTVLAALISGIMAGTAWAGADNLADFHGDNGCDSCHQSDKGPSNDNLTFENGQCVSCHGSLTEVAEGEREGIV
SPHKSHLIGDIACTSCHKGHEKSVTYCDACHNFGYEIPFAGKWERKFVPVDADKAAQDKAIAAGPRETTDVVIIGSGGAG
LAAAVSARDAGAKVVVLEKEPVPGGNTKLAAGGMNAAETKPQAKLGIVDKKQIMIDDTMKGGRNINNPELVQVLANNSSD
SIDWLTALGADMNDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDAAVARDADIRLNSRVVRILEDGAGQVTGVLVQGAY
TGYYVIKADAVVVATGGFAKNNDRVAKYDAKLKGFKATNHPGATGDGLDVATQAGADTVDLEYVQAHPTYSPVGGVMVTE
AVRGNGAILVNREGKRFVNEITTRDKASAAILAQKGESAYLLFDDSVRKSLSKIEGYVHLKIVNEGKSVKELADKLGMPA
AELEKTIGTYNGFVKSGKDEQFERADMPRELASAPYYAIEVAPAVHHTMGGVKIDTKAEVVGKEGKLIRGMYAAGEVTGG
VHGANRLGGNAISDIVTFGRIAGAEAAKFAKDN

Specific function: Catalyzes fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown, but evidence indicates that flavocytochrome c participates in electron transfer from formate to fumarate and possibly also to tr

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=434, Percent_Identity=27.1889400921659, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1790597, Length=411, Percent_Identity=28.7104622871046, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788928, Length=477, Percent_Identity=28.7211740041929, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786942, Length=472, Percent_Identity=27.7542372881356, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71986328, Length=468, Percent_Identity=33.3333333333333, Blast_Score=231, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17505833, Length=443, Percent_Identity=28.6681715575621, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17550100, Length=451, Percent_Identity=26.8292682926829, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320788, Length=464, Percent_Identity=33.8362068965517, Blast_Score=224, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6322511, Length=464, Percent_Identity=32.9741379310345, Blast_Score=213, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6322701, Length=453, Percent_Identity=27.5938189845475, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322416, Length=455, Percent_Identity=27.4725274725275, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137288, Length=450, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24655642, Length=450, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24655647, Length=450, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24663005, Length=283, Percent_Identity=28.6219081272085, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR010960
- InterPro:   IPR011031
- InterPro:   IPR012286 [H]

Pfam domain/function: PF00890 FAD_binding_2 [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 61904; Mature: 61904

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00583 PFKB_KINASES_1 ; PS51008 MULTIHEME_CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGAMKKTVLAALISGIMAGTAWAGADNLADFHGDNGCDSCHQSDKGPSNDNLTFENGQ
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHCCCCCCCCCCEEECCCE
CVSCHGSLTEVAEGEREGIVSPHKSHLIGDIACTSCHKGHEKSVTYCDACHNFGYEIPFA
EEEECCCHHHHHCCCCCCCCCCCHHHHEEHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC
GKWERKFVPVDADKAAQDKAIAAGPRETTDVVIIGSGGAGLAAAVSARDAGAKVVVLEKE
CCCCCEEECCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCEEEEECCCCCCEEEEEECC
PVPGGNTKLAAGGMNAAETKPQAKLGIVDKKQIMIDDTMKGGRNINNPELVQVLANNSSD
CCCCCCCEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCHHEEEEEECCCCC
SIDWLTALGADMNDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDAAVARDADIRLNSRV
CHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECHHE
VRILEDGAGQVTGVLVQGAYTGYYVIKADAVVVATGGFAKNNDRVAKYDAKLKGFKATNH
EEEECCCCCCEEEEEEECCCCEEEEEEECEEEEEECCCCCCCCCEEEECCCCCCCCCCCC
PGATGDGLDVATQAGADTVDLEYVQAHPTYSPVGGVMVTEAVRGNGAILVNREGKRFVNE
CCCCCCCCCHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHH
ITTRDKASAAILAQKGESAYLLFDDSVRKSLSKIEGYVHLKIVNEGKSVKELADKLGMPA
HHCCCCCCEEEEEECCCEEEEEECHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCH
AELEKTIGTYNGFVKSGKDEQFERADMPRELASAPYYAIEVAPAVHHTMGGVKIDTKAEV
HHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHCCCEEEEEECHHHHHHCCCEEECCHHHE
VGKEGKLIRGMYAAGEVTGGVHGANRLGGNAISDIVTFGRIAGAEAAKFAKDN
ECCCCCEEEEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure
MFTGAMKKTVLAALISGIMAGTAWAGADNLADFHGDNGCDSCHQSDKGPSNDNLTFENGQ
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHCCCCCCCCCCEEECCCE
CVSCHGSLTEVAEGEREGIVSPHKSHLIGDIACTSCHKGHEKSVTYCDACHNFGYEIPFA
EEEECCCHHHHHCCCCCCCCCCCHHHHEEHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC
GKWERKFVPVDADKAAQDKAIAAGPRETTDVVIIGSGGAGLAAAVSARDAGAKVVVLEKE
CCCCCEEECCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCEEEEECCCCCCEEEEEECC
PVPGGNTKLAAGGMNAAETKPQAKLGIVDKKQIMIDDTMKGGRNINNPELVQVLANNSSD
CCCCCCCEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCHHEEEEEECCCCC
SIDWLTALGADMNDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDAAVARDADIRLNSRV
CHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECHHE
VRILEDGAGQVTGVLVQGAYTGYYVIKADAVVVATGGFAKNNDRVAKYDAKLKGFKATNH
EEEECCCCCCEEEEEEECCCCEEEEEEECEEEEEECCCCCCCCCEEEECCCCCCCCCCCC
PGATGDGLDVATQAGADTVDLEYVQAHPTYSPVGGVMVTEAVRGNGAILVNREGKRFVNE
CCCCCCCCCHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHH
ITTRDKASAAILAQKGESAYLLFDDSVRKSLSKIEGYVHLKIVNEGKSVKELADKLGMPA
HHCCCCCCEEEEEECCCEEEEEECHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCH
AELEKTIGTYNGFVKSGKDEQFERADMPRELASAPYYAIEVAPAVHHTMGGVKIDTKAEV
HHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHCCCEEEEEECHHHHHHCCCEEECCHHHE
VGKEGKLIRGMYAAGEVTGGVHGANRLGGNAISDIVTFGRIAGAEAAKFAKDN
ECCCCCEEEEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11425747; 12368813; 10581551 [H]