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The map label for this gene is lysC [H]

Identifier: 119773741

GI number: 119773741

Start: 754982

End: 756340

Strand: Direct

Name: lysC [H]

Synonym: Sama_0603

Alternate gene names: 119773741

Gene position: 754982-756340 (Clockwise)

Preceding gene: 119773740

Following gene: 119773742

Centisome position: 17.53

GC content: 57.25

Gene sequence:

>1359_bases
ATGTCTCTTGTTGTAGCCAAATTCGGTGGCACCTCGGTCGCCGATTTCAATGCCATGTCACGCTGCGCCGCCATAGTGCT
GGCCAATTCTGCTACCCGTTTGGTGGTGGTCAGTGCATCCAGTGGTGTGACCAACTTGCTGGTAGAGCTGACCCAGGCCA
CAGTGACCGATGAGCGTCGCCTGCAACTGCTCAAGCAGATTGCACAAATTCAATATGCCATCCTCGATAAGCTGGAGCGC
CCACAGGATGTGGCGGCCGCGCTGGATGCTCTGTTATCGCGGATTTCTGTGCTCAGTGAGTCGCTCATCCTCAATCGCAG
CAAGGCCATCATGGACGAGCTCTTGTCCATGGGAGAGCAATGTTCCGCGCTGTTGTTTTCGGCTGTACTGAGGCAGCAAG
GGGCAAAGAGCAGCAGCTTCGATGTGCGTCAGGTCATGCGAACCGACAGCCACTTCGGCCGCGCCGAGCCGCAGATTGAA
GATATCGCGGCGCTGGCCCGGGATTTCCTGCAGCCGTTGCTCGAACGGGACATAGTGGTGACCCAGGGCTTTATCGGTGC
CGATGCAGAAGGTCGCACCACCACCCTGGGTCGCGGTGGCAGCGATTATTCTGCCGCCTTGTTGGCAGAAGCCCTGCGTG
CCGATGCGGTAGAGATTTGGACCGATGTGGCCGGTATTTACACCACTGATCCACGTCTGGCGCCCAACGCCAGACCCATT
GCCGAAATCAGTTTTAACGAAGCGGCCGAAATGGCGACTTTCGGTGCAAAGGTATTGCACCCAGCCACAATTTTGCCTGC
GGTTCGCCAGCAAATTCAGGTGTTTGTCGGCTCAAGCCGCGAACCAGAAAAGGGTGGCACCTGGATCCGCCATCAGGTGG
ACAATCCCCCTATTTACCGCGCCGTGGCCGTGCGCCGCGATCAGACGCTGCTGAACCTGCACAGCCTGCAGATGCTCCAT
GCCCGTGGCTTTTTGGCAGAAACCTTTGCCACTCTGGCGCGTCATAAAATCTCGGTGGACCTTATTACCACTTCAGAAGT
GAACGTGTCACTGACGTTGGATAAAACCGGCTCCGATTCCACCGGCAGCGGTTTGCTCAGTGAAGCCTTGCTGCAGGAGC
TGTCCCAGCATTGCCGGGTTAGGGTAGAGGACAATCTGGCACTGGTGGCCATAATTGGTAACCGTATCGCCAGCACCCCG
GGGATTTGCCGCCAGGTGTTTACCGTGCTCGAAAACCACAATGTGCGTATGATTTGTCAGGGCGCGAGCCCCCATAACCT
GTGCGTGCTGGTAGCTGAGAGTGAAGCGGCGCAAGTCGTGAAGGCACTGCACGAGAACCTGTTTGAAGGTCAGGCATAA

Upstream 100 bases:

>100_bases
ACCAGGCTCTTCGAACGAAGTCAGTTCGGAGATTACTCATGAAAACCCGTTTTAGCTTGAATGTCGCTGTCTTCCACTCG
CCGTCGATGGAGGTGTGCTG

Downstream 100 bases:

>100_bases
TGCGGGTCGATAAACACGAAGTTCGGGTCGGCGAGCTGGCTGCAGGACAGCCGCTGTCTTTGCCTGTGTATCGCTTTAAA
GGCAAGGGAGCTGGCCCCAG

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSLVVAKFGGTSVADFNAMSRCAAIVLANSATRLVVVSASSGVTNLLVELTQATVTDERRLQLLKQIAQIQYAILDKLER
PQDVAAALDALLSRISVLSESLILNRSKAIMDELLSMGEQCSALLFSAVLRQQGAKSSSFDVRQVMRTDSHFGRAEPQIE
DIAALARDFLQPLLERDIVVTQGFIGADAEGRTTTLGRGGSDYSAALLAEALRADAVEIWTDVAGIYTTDPRLAPNARPI
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSREPEKGGTWIRHQVDNPPIYRAVAVRRDQTLLNLHSLQMLH
ARGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSTGSGLLSEALLQELSQHCRVRVEDNLALVAIIGNRIASTP
GICRQVFTVLENHNVRMICQGASPHNLCVLVAESEAAQVVKALHENLFEGQA

Sequences:

>Translated_452_residues
MSLVVAKFGGTSVADFNAMSRCAAIVLANSATRLVVVSASSGVTNLLVELTQATVTDERRLQLLKQIAQIQYAILDKLER
PQDVAAALDALLSRISVLSESLILNRSKAIMDELLSMGEQCSALLFSAVLRQQGAKSSSFDVRQVMRTDSHFGRAEPQIE
DIAALARDFLQPLLERDIVVTQGFIGADAEGRTTTLGRGGSDYSAALLAEALRADAVEIWTDVAGIYTTDPRLAPNARPI
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSREPEKGGTWIRHQVDNPPIYRAVAVRRDQTLLNLHSLQMLH
ARGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSTGSGLLSEALLQELSQHCRVRVEDNLALVAIIGNRIASTP
GICRQVFTVLENHNVRMICQGASPHNLCVLVAESEAAQVVKALHENLFEGQA
>Mature_451_residues
SLVVAKFGGTSVADFNAMSRCAAIVLANSATRLVVVSASSGVTNLLVELTQATVTDERRLQLLKQIAQIQYAILDKLERP
QDVAAALDALLSRISVLSESLILNRSKAIMDELLSMGEQCSALLFSAVLRQQGAKSSSFDVRQVMRTDSHFGRAEPQIED
IAALARDFLQPLLERDIVVTQGFIGADAEGRTTTLGRGGSDYSAALLAEALRADAVEIWTDVAGIYTTDPRLAPNARPIA
EISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSREPEKGGTWIRHQVDNPPIYRAVAVRRDQTLLNLHSLQMLHA
RGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSTGSGLLSEALLQELSQHCRVRVEDNLALVAIIGNRIASTPG
ICRQVFTVLENHNVRMICQGASPHNLCVLVAESEAAQVVKALHENLFEGQA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=447, Percent_Identity=60.1789709172259, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1786183, Length=468, Percent_Identity=31.4102564102564, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI1790376, Length=456, Percent_Identity=28.0701754385965, Blast_Score=145, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320893, Length=492, Percent_Identity=27.8455284552846, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 48838; Mature: 48706

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVVAKFGGTSVADFNAMSRCAAIVLANSATRLVVVSASSGVTNLLVELTQATVTDERR
CCEEEEECCCCCCHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHHCCHHHH
LQLLKQIAQIQYAILDKLERPQDVAAALDALLSRISVLSESLILNRSKAIMDELLSMGEQ
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSALLFSAVLRQQGAKSSSFDVRQVMRTDSHFGRAEPQIEDIAALARDFLQPLLERDIVV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEE
TQGFIGADAEGRTTTLGRGGSDYSAALLAEALRADAVEIWTDVAGIYTTDPRLAPNARPI
ECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCC
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSREPEKGGTWIRHQVDNPPIYR
EEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHH
AVAVRRDQTLLNLHSLQMLHARGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCEEEEEEEECCCCCC
TGSGLLSEALLQELSQHCRVRVEDNLALVAIIGNRIASTPGICRQVFTVLENHNVRMICQ
CCCHHHHHHHHHHHHHHCCEEECCCEEEEEEECCHHCCCHHHHHHHHHHHHCCCEEEEEC
GASPHNLCVLVAESEAAQVVKALHENLFEGQA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLVVAKFGGTSVADFNAMSRCAAIVLANSATRLVVVSASSGVTNLLVELTQATVTDERR
CEEEEECCCCCCHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHHCCHHHH
LQLLKQIAQIQYAILDKLERPQDVAAALDALLSRISVLSESLILNRSKAIMDELLSMGEQ
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSALLFSAVLRQQGAKSSSFDVRQVMRTDSHFGRAEPQIEDIAALARDFLQPLLERDIVV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEE
TQGFIGADAEGRTTTLGRGGSDYSAALLAEALRADAVEIWTDVAGIYTTDPRLAPNARPI
ECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCC
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSREPEKGGTWIRHQVDNPPIYR
EEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHH
AVAVRRDQTLLNLHSLQMLHARGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCEEEEEEEECCCCCC
TGSGLLSEALLQELSQHCRVRVEDNLALVAIIGNRIASTPGICRQVFTVLENHNVRMICQ
CCCHHHHHHHHHHHHHHCCEEECCCEEEEEEECCHHCCCHHHHHHHHHHHHCCCEEEEEC
GASPHNLCVLVAESEAAQVVKALHENLFEGQA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]