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The map label for this gene is strL [H]

Identifier: 119773649

GI number: 119773649

Start: 624129

End: 625034

Strand: Direct

Name: strL [H]

Synonym: Sama_0509

Alternate gene names: 119773649

Gene position: 624129-625034 (Clockwise)

Preceding gene: 119773647

Following gene: 119773651

Centisome position: 14.49

GC content: 59.49

Gene sequence:

>906_bases
ATGGCAAATATCATGGTGACGGGCGCAACCGGGCTTCTGGGGCGTGCCGTGGTGAAGTCTTTGTCTGCGAGCCACACAGT
CACGGGCACTGGTTTCAGCCGCGCCGCCGAAGGCATTCTGCGTCTGGATTTAACCGATGCCGACGCAGTGGCAGCAGCGG
TGGCTGAGATTGCACCTCAGGTGATAGTGCACTGCGCCGCCGAGCGCAGGCCCGATGTCTCAGCGCAAAACCCGGACGCA
GCCAAGGCGCTGAATCTGTCAGCCACCGAGGCGCTGTGTCAGGCCGCCAAGGCTTGTGGTGCCTGGCTGATTTATATCTC
CACCGACTATGTGTTCGATGGCACTGAGGCGCCCTATGCGGAAGATGCCGCGCCCAACCCAGTCAATTTTTACGGTGAGA
CCAAGCTGATGGGCGAGCAGGCGGTCACGCGGCTGCTCCCTGAGTCGGCCATTTTACGACTGCCCATTTTGTATGGTGAA
GTTGAGCGCCTGAGCGAGTCGGCGGTGCTGGTGCTGATTGAGCAGCTTTTGGATTATCAAAAACAAGGGGTGGATGACTG
GGCCGTGCGCAGACCAACCTCGACAGCGGATATTGCCGAAGCCATCAAGGGCATGATTGCCAAGCATGTTGAGGGTGAGA
AAATCAGCGGCATCTATCATTTCAGTGCTGCCGAAACCATGACCAAACACGGCATGGTGGTGGCGCTGGCAGAGGTGTTG
GGGAAAGACAGCGGCCATTTGATTGCCCAGTCGAGCCCAACAGATACCGCCAAGCGACCAAAGGATTGTACCTTGAGCTG
CAAGCGGCTTGAGGCGCTGGGGCTGCTCAATACCCGACCTTTCAGGGTGGCGGCGGCCGAAGCGCTTACTGCCTCGGCGG
CGGCGCTTGCCAGGGCCGGCAAGTAA

Upstream 100 bases:

>100_bases
ATTTAATCGTAAGCTGATGTAAAGGCAGGGCTTGCCGTGCTAGGCTTTGGCCATTCTTTGCCAGATTTATCGTAATTCAG
GACGATTCAGGGAGTGTTTT

Downstream 100 bases:

>100_bases
GCTATCGGTGAATTGACATATCATCGTCAATGAAAAGGGGCCATTCGGCCCCTTTTGCACATCTCTCGCCGCTATTTCGC
GACGGCCGAGAGTTATTCAA

Product: NAD dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MANIMVTGATGLLGRAVVKSLSASHTVTGTGFSRAAEGILRLDLTDADAVAAAVAEIAPQVIVHCAAERRPDVSAQNPDA
AKALNLSATEALCQAAKACGAWLIYISTDYVFDGTEAPYAEDAAPNPVNFYGETKLMGEQAVTRLLPESAILRLPILYGE
VERLSESAVLVLIEQLLDYQKQGVDDWAVRRPTSTADIAEAIKGMIAKHVEGEKISGIYHFSAAETMTKHGMVVALAEVL
GKDSGHLIAQSSPTDTAKRPKDCTLSCKRLEALGLLNTRPFRVAAAEALTASAAALARAGK

Sequences:

>Translated_301_residues
MANIMVTGATGLLGRAVVKSLSASHTVTGTGFSRAAEGILRLDLTDADAVAAAVAEIAPQVIVHCAAERRPDVSAQNPDA
AKALNLSATEALCQAAKACGAWLIYISTDYVFDGTEAPYAEDAAPNPVNFYGETKLMGEQAVTRLLPESAILRLPILYGE
VERLSESAVLVLIEQLLDYQKQGVDDWAVRRPTSTADIAEAIKGMIAKHVEGEKISGIYHFSAAETMTKHGMVVALAEVL
GKDSGHLIAQSSPTDTAKRPKDCTLSCKRLEALGLLNTRPFRVAAAEALTASAAALARAGK
>Mature_300_residues
ANIMVTGATGLLGRAVVKSLSASHTVTGTGFSRAAEGILRLDLTDADAVAAAVAEIAPQVIVHCAAERRPDVSAQNPDAA
KALNLSATEALCQAAKACGAWLIYISTDYVFDGTEAPYAEDAAPNPVNFYGETKLMGEQAVTRLLPESAILRLPILYGEV
ERLSESAVLVLIEQLLDYQKQGVDDWAVRRPTSTADIAEAIKGMIAKHVEGEKISGIYHFSAAETMTKHGMVVALAEVLG
KDSGHLIAQSSPTDTAKRPKDCTLSCKRLEALGLLNTRPFRVAAAEALTASAAALARAGK

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=290, Percent_Identity=45.5172413793103, Blast_Score=249, Evalue=1e-66,
Organism=Homo sapiens, GI11034825, Length=290, Percent_Identity=45.5172413793103, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI1788352, Length=283, Percent_Identity=26.1484098939929, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31670; Mature: 31539

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIMVTGATGLLGRAVVKSLSASHTVTGTGFSRAAEGILRLDLTDADAVAAAVAEIAPQ
CCCEEEECCHHHHHHHHHHHHCCCCEECCCCHHHHHCCEEEEECCCHHHHHHHHHHHHHH
VIVHCAAERRPDVSAQNPDAAKALNLSATEALCQAAKACGAWLIYISTDYVFDGTEAPYA
HHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCEEEEEEEECEEECCCCCCCC
EDAAPNPVNFYGETKLMGEQAVTRLLPESAILRLPILYGEVERLSESAVLVLIEQLLDYQ
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQGVDDWAVRRPTSTADIAEAIKGMIAKHVEGEKISGIYHFSAAETMTKHGMVVALAEVL
HCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCEECEEEEEHHHHHHHHCCHHHHHHHHH
GKDSGHLIAQSSPTDTAKRPKDCTLSCKRLEALGLLNTRPFRVAAAEALTASAAALARAG
CCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure 
ANIMVTGATGLLGRAVVKSLSASHTVTGTGFSRAAEGILRLDLTDADAVAAAVAEIAPQ
CCEEEECCHHHHHHHHHHHHCCCCEECCCCHHHHHCCEEEEECCCHHHHHHHHHHHHHH
VIVHCAAERRPDVSAQNPDAAKALNLSATEALCQAAKACGAWLIYISTDYVFDGTEAPYA
HHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCEEEEEEEECEEECCCCCCCC
EDAAPNPVNFYGETKLMGEQAVTRLLPESAILRLPILYGEVERLSESAVLVLIEQLLDYQ
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQGVDDWAVRRPTSTADIAEAIKGMIAKHVEGEKISGIYHFSAAETMTKHGMVVALAEVL
HCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCEECEEEEEHHHHHHHHCCHHHHHHHHH
GKDSGHLIAQSSPTDTAKRPKDCTLSCKRLEALGLLNTRPFRVAAAEALTASAAALARAG
CCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1661369 [H]