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The map label for this gene is mtnC

Identifier: 119773216

GI number: 119773216

Start: 79435

End: 80115

Strand: Reverse

Name: mtnC

Synonym: Sama_0074

Alternate gene names: 119773216

Gene position: 80115-79435 (Counterclockwise)

Preceding gene: 119773219

Following gene: 119773215

Centisome position: 1.86

GC content: 52.42

Gene sequence:

>681_bases
ATGGGTATCAGAGCCATAGTCGTAGACACCGCCGGCACCACCACGGATCTCAACTTTATTCAGCAAACCCTGTTCCCTTA
CTCCGCCAAAGTCATGGCCGATTTTCTGCGCGAACATCAGCACAATCCATTGGTGGACTATTGCATCGGCGATGTGCGTG
ATATCGCCCTCGAAACCGATGCCGACATCGATCGAGTGGCCGAGATTTTGGTGCAGTGGATTGCCGAAGACCGTAAGGTG
ACGCCGCTGAAAACCCTCCAGGGCCTGATTTGGAAGCAGGGTTATGCCAACGATGAGTTCAAGGGACACATTTACCCTGA
CTTTATCGATGCCATAAAAACCTATCGTGCCCAGGGTTTACGGGTCTACAGCTTTTCTTCAGGCTCAGTGGATGCCCAAA
AGCTGCTGTTCAGCCACAGCGACAGCGGCGATCTGACCGAGTTGTTCAATGGCCACTTCGATACCCGCACCGGCAACAAG
CTCGACAAACAGGCCTATGCCAACATTGTTAACACCATCAGCCTGACACCAAGGCAGATCCTCTTTGTTTCCGATGTGGT
TGAAGAGCTGAAAGCCGCCGAAGCCGCTGGCATGATCACGTGCCAAATGGTGCGCGAACCCTCTCAGCGCACCGGTAAGT
ACCGGATTATTCAGAGCTTCAGCGAACTTAATTTCGAATAA

Upstream 100 bases:

>100_bases
CAACTGACCGAATTCTCTGGCAAAGGGGCGCAATTCACTTTAGGATCTGCCTGCATCTTGGGCACTGTCTTTTGGCAGCA
GTTAGTGGAGTATCAATATC

Downstream 100 bases:

>100_bases
GTTCATGGTTCTGAAAACGCCCCGCACAGCGGGGCGTTTTTGTTGTTCTTGAGCACCGGGCAGACCCCTGTTAAGCTCGA
ATTTTGTTAAACAATCGTTT

Product: HAD-superfamily hydrolase, subfamily IA, variant 1 family protein

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MGIRAIVVDTAGTTTDLNFIQQTLFPYSAKVMADFLREHQHNPLVDYCIGDVRDIALETDADIDRVAEILVQWIAEDRKV
TPLKTLQGLIWKQGYANDEFKGHIYPDFIDAIKTYRAQGLRVYSFSSGSVDAQKLLFSHSDSGDLTELFNGHFDTRTGNK
LDKQAYANIVNTISLTPRQILFVSDVVEELKAAEAAGMITCQMVREPSQRTGKYRIIQSFSELNFE

Sequences:

>Translated_226_residues
MGIRAIVVDTAGTTTDLNFIQQTLFPYSAKVMADFLREHQHNPLVDYCIGDVRDIALETDADIDRVAEILVQWIAEDRKV
TPLKTLQGLIWKQGYANDEFKGHIYPDFIDAIKTYRAQGLRVYSFSSGSVDAQKLLFSHSDSGDLTELFNGHFDTRTGNK
LDKQAYANIVNTISLTPRQILFVSDVVEELKAAEAAGMITCQMVREPSQRTGKYRIIQSFSELNFE
>Mature_225_residues
GIRAIVVDTAGTTTDLNFIQQTLFPYSAKVMADFLREHQHNPLVDYCIGDVRDIALETDADIDRVAEILVQWIAEDRKVT
PLKTLQGLIWKQGYANDEFKGHIYPDFIDAIKTYRAQGLRVYSFSSGSVDAQKLLFSHSDSGDLTELFNGHFDTRTGNKL
DKQAYANIVNTISLTPRQILFVSDVVEELKAAEAAGMITCQMVREPSQRTGKYRIIQSFSELNFE

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family

Homologues:

Organism=Homo sapiens, GI10864017, Length=247, Percent_Identity=34.0080971659919, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115533232, Length=215, Percent_Identity=38.6046511627907, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320797, Length=229, Percent_Identity=33.6244541484716, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281360080, Length=238, Percent_Identity=37.8151260504202, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24644163, Length=238, Percent_Identity=37.8151260504202, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNC_SHEAM (A1S1N0)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_925956.1
- ProteinModelPortal:   A1S1N0
- SMR:   A1S1N0
- STRING:   A1S1N0
- GeneID:   4602331
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0074
- NMPDR:   fig|326297.7.peg.68
- eggNOG:   COG4229
- HOGENOM:   HBG294242
- OMA:   TTDLNFI
- PhylomeDB:   A1S1N0
- ProtClustDB:   CLSK866737
- HAMAP:   MF_01681
- InterPro:   IPR005834
- InterPro:   IPR010041
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR005833
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR20371
- PRINTS:   PR00413
- TIGRFAMs:   TIGR01691
- TIGRFAMs:   TIGR01549

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: =3.1.3.77

Molecular weight: Translated: 25505; Mature: 25374

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRAIVVDTAGTTTDLNFIQQTLFPYSAKVMADFLREHQHNPLVDYCIGDVRDIALETD
CCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
ADIDRVAEILVQWIAEDRKVTPLKTLQGLIWKQGYANDEFKGHIYPDFIDAIKTYRAQGL
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCE
RVYSFSSGSVDAQKLLFSHSDSGDLTELFNGHFDTRTGNKLDKQAYANIVNTISLTPRQI
EEEEECCCCCHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
LFVSDVVEELKAAEAAGMITCQMVREPSQRTGKYRIIQSFSELNFE
HHHHHHHHHHHHHHHHCHHHHHHHHCCHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
GIRAIVVDTAGTTTDLNFIQQTLFPYSAKVMADFLREHQHNPLVDYCIGDVRDIALETD
CCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
ADIDRVAEILVQWIAEDRKVTPLKTLQGLIWKQGYANDEFKGHIYPDFIDAIKTYRAQGL
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCE
RVYSFSSGSVDAQKLLFSHSDSGDLTELFNGHFDTRTGNKLDKQAYANIVNTISLTPRQI
EEEEECCCCCHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
LFVSDVVEELKAAEAAGMITCQMVREPSQRTGKYRIIQSFSELNFE
HHHHHHHHHHHHHHHHCHHHHHHHHCCHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA