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The map label for this gene is yeiG [H]

Identifier: 119773145

GI number: 119773145

Start: 1522

End: 2367

Strand: Reverse

Name: yeiG [H]

Synonym: Sama_0003

Alternate gene names: 119773145

Gene position: 2367-1522 (Counterclockwise)

Preceding gene: 119773146

Following gene: 119773143

Centisome position: 0.05

GC content: 55.91

Gene sequence:

>846_bases
ATGACGCTGGAATTAGTCAGTGCCAATCGCAGTTTTGATGGCTGGCACAAACAGTACAGTCATCAATCCAGCAGCCTGGA
TTGCAAGATGCGCTTTGCGATTTTTCTGCCGCCCCAGGCCGAAACCCAAAGCGTACCAGTGCTTTATTGGCTGTCAGGGC
TCACCTGCAGCGATGAAAACTTCATGCAGAAGGCAGGCGCTCAGCGCCTGGCCGCGACGCTCGGGCTTGCGATTGTTGCC
ATGGACACCAGCCCCCGCGGCGAAGGTGTGGCCGACGATCCCGATGGCGCCTGGGACTTTGGCCTGGGGGCGGGCTTTTA
TCTCAATGCCACTGAAGCGCCCTGGAATAAACACTACCGCATGTACGATTATGTGGTGAAAGAGCTGCCGAAGCTGATTG
AAACCAACTTTCCGGTCAGCAGCAAACGCAGCATTGCCGGCCATTCCATGGGCGGCCACGGCGCCCTGACAATAGCGCTG
AAAAACCCCGGTCGCTATGCCAGCGTGTCGGCCTTCAGCCCTATTTGTAATCCAAGCCAAAGCCCCTGGGGACAAAAGGC
CTTTGGCAATTACCTGGGCAAAGACAGGGAAAGCTGGCGCGAGTATGACAGCTGTGAATTGATTGGCCGCGGCGCCGAAC
CTATCCCCATGCTGGTGGATCAAGGTGATGCGGACAGCTTTTTAGAGGCAGAGCTCATGCCGCAGCGTCTGCAACATGCC
GCAGACAATGCCGACTTTCCGCTGAATCTGCGAATGCAGCCTGGCTACGATCACAGCTACTACTTTATCGCGAGCTTTAT
CGATGAACACCTGGAGTTTCATCATCACTGGTTGACCCGGAGATAA

Upstream 100 bases:

>100_bases
CACCATGGGACTGGATGCGATTAACGAAGCGTTCGATCTGATGCACGAAGGCAAAAGTATCCGCAGCGTGATCCATTACG
ATCGTAAATAAGGAGCCGCC

Downstream 100 bases:

>100_bases
GTTCAAACTGCACCATAAGGGGCGCATGATCCGACACATTTGTTGTGGGTGATTGCGCCTTTTTCAGATGTAAACCTCGG
TAAAATACCCAATCAAGTGG

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTLELVSANRSFDGWHKQYSHQSSSLDCKMRFAIFLPPQAETQSVPVLYWLSGLTCSDENFMQKAGAQRLAATLGLAIVA
MDTSPRGEGVADDPDGAWDFGLGAGFYLNATEAPWNKHYRMYDYVVKELPKLIETNFPVSSKRSIAGHSMGGHGALTIAL
KNPGRYASVSAFSPICNPSQSPWGQKAFGNYLGKDRESWREYDSCELIGRGAEPIPMLVDQGDADSFLEAELMPQRLQHA
ADNADFPLNLRMQPGYDHSYYFIASFIDEHLEFHHHWLTRR

Sequences:

>Translated_281_residues
MTLELVSANRSFDGWHKQYSHQSSSLDCKMRFAIFLPPQAETQSVPVLYWLSGLTCSDENFMQKAGAQRLAATLGLAIVA
MDTSPRGEGVADDPDGAWDFGLGAGFYLNATEAPWNKHYRMYDYVVKELPKLIETNFPVSSKRSIAGHSMGGHGALTIAL
KNPGRYASVSAFSPICNPSQSPWGQKAFGNYLGKDRESWREYDSCELIGRGAEPIPMLVDQGDADSFLEAELMPQRLQHA
ADNADFPLNLRMQPGYDHSYYFIASFIDEHLEFHHHWLTRR
>Mature_280_residues
TLELVSANRSFDGWHKQYSHQSSSLDCKMRFAIFLPPQAETQSVPVLYWLSGLTCSDENFMQKAGAQRLAATLGLAIVAM
DTSPRGEGVADDPDGAWDFGLGAGFYLNATEAPWNKHYRMYDYVVKELPKLIETNFPVSSKRSIAGHSMGGHGALTIALK
NPGRYASVSAFSPICNPSQSPWGQKAFGNYLGKDRESWREYDSCELIGRGAEPIPMLVDQGDADSFLEAELMPQRLQHAA
DNADFPLNLRMQPGYDHSYYFIASFIDEHLEFHHHWLTRR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=282, Percent_Identity=52.1276595744681, Blast_Score=315, Evalue=4e-86,
Organism=Escherichia coli, GI1788477, Length=280, Percent_Identity=58.2142857142857, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI1786551, Length=279, Percent_Identity=50.5376344086022, Blast_Score=307, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17510185, Length=284, Percent_Identity=48.943661971831, Blast_Score=270, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6322393, Length=275, Percent_Identity=45.0909090909091, Blast_Score=231, Evalue=7e-62,
Organism=Drosophila melanogaster, GI45551932, Length=284, Percent_Identity=51.056338028169, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24648347, Length=284, Percent_Identity=51.056338028169, Blast_Score=287, Evalue=7e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31488; Mature: 31356

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLELVSANRSFDGWHKQYSHQSSSLDCKMRFAIFLPPQAETQSVPVLYWLSGLTCSDEN
CEEEEEECCCCCCHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCCCCCHH
FMQKAGAQRLAATLGLAIVAMDTSPRGEGVADDPDGAWDFGLGAGFYLNATEAPWNKHYR
HHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCCHHCHH
MYDYVVKELPKLIETNFPVSSKRSIAGHSMGGHGALTIALKNPGRYASVSAFSPICNPSQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEHHHCCCCCCCCC
SPWGQKAFGNYLGKDRESWREYDSCELIGRGAEPIPMLVDQGDADSFLEAELMPQRLQHA
CCCCHHHHHHHHCCCHHHHHCCCCHHEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
ADNADFPLNLRMQPGYDHSYYFIASFIDEHLEFHHHWLTRR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLELVSANRSFDGWHKQYSHQSSSLDCKMRFAIFLPPQAETQSVPVLYWLSGLTCSDEN
EEEEEECCCCCCHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCCCCCHH
FMQKAGAQRLAATLGLAIVAMDTSPRGEGVADDPDGAWDFGLGAGFYLNATEAPWNKHYR
HHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCCHHCHH
MYDYVVKELPKLIETNFPVSSKRSIAGHSMGGHGALTIALKNPGRYASVSAFSPICNPSQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEHHHCCCCCCCCC
SPWGQKAFGNYLGKDRESWREYDSCELIGRGAEPIPMLVDQGDADSFLEAELMPQRLQHA
CCCCHHHHHHHHCCCHHHHHCCCCHHEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
ADNADFPLNLRMQPGYDHSYYFIASFIDEHLEFHHHWLTRR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA