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The map label for this gene is fhs

Identifier: 119718780

GI number: 119718780

Start: 4826186

End: 4827865

Strand: Reverse

Name: fhs

Synonym: Noca_4561

Alternate gene names: 119718780

Gene position: 4827865-4826186 (Counterclockwise)

Preceding gene: 119718781

Following gene: 119718779

Centisome position: 96.83

GC content: 72.08

Gene sequence:

>1680_bases
GTGCTGTCCGACATCGAGATCGCCGGGGCCGCCACGCTGCGGCCGATCACCGAGGTAGCGACCGAGTCGCTCGGCATCGG
GGCCGAGCACCTGGTGCCGTACGGCCACTACAAGGCGAAGGTCGGCATCACCTACCTGAACTCGCTCGCCGACCGCCCGC
TCGGCCGGCTGATCCTGGTGACGGCGCTCTCGCCGACCCCGCCGGGCGAGGGGAAGACGACCACGTCGGTGGGGCTCACC
GACGCGCTGCACGGGCTCGGCAAGCGGGCCATCGCGTGCCTGCGCGAGCCGTCGATGGGTCCGGTCTTCGGTCTCAAGGG
CGGGGCCGCCGGCGGCGGCTACAGCCAGGTGGTGCCGATGACCGACATCAACCTGCACTTCACCGGGGACTTCGCCGCGA
TCGCCGCGGCCAACAACCTGCTCGCCGCGCTGATCGACAACCACGTGCACCACGGCAACGAGCTCGACATCGACGTGCGA
AGCGTGACCTGGAAGCGGGTGCTCGACACCAACGACCGCGCGCTGCGCGAGGTGGTCGTCGGGCTGGGCGGCCCGCCCAA
CGGGTTCCCCCGCCAGGACGGCTTCGACATCGTGGTCGCCTCGGAGCTGATGGCGATCTTCTGCCTCACCGAGTCCTGGG
CCGACCTGAAGCGCCGCATCGGCGACATCGTGATCGGCTACTCCCGTGCCGGCGCGCCGGTCACCGCCCGCGACCTCGGC
GCCGACGGCGCGATGGCGGTGCTGCTGCGCGACGCGATCGCGCCGAACCTCGTGCAGACCCTCGAGGGCGCACCGGCGCT
GGTCCACGGCGGGCCGTTCGCCAACATCGCACACGGCTGCAGCTCGGTGATGGCGACGCGGGCCGGCCTGCGGCTGGCCG
ACTACGTCGTCACCGAGGCGGGGTTCGGGGCCGACCTCGGCGCGGAGAAGTTCATCGACATCAAGTGCCGGATGTCCGGG
ATGCGCCCCGACGTCGCGGTCGTCGTCGCGACGGTGCGGGCCCTGAAGTACCACGGCGGCGTGGCCCTGGCCGACCTGGA
CCGCGAAGACCTGGGCGCGGTCGAGGCCGGGATGGACAACCTGCGTCGCCACCTGGACAACCTGCGGCACCTGAACGGCG
TCCCGTGCGTGGTCGCGGTCAACCGGTTCCCCACGGACACCGACCTCGAGGTGGTCAGGGTCGTCGAGCTCGCCGCGTCG
TACGGCGTCCCCGCCTATCAGGCCACCCACTTCACCGACGGCGGCATCGGGGCGCAGGACCTCGCCAAGGGCGTCCTGCA
GGCGCTCGAGGAGCCGGCGCGCGACGAGTTCTCCTTCACCTACCCCGACGAGCTGTCCCTGACCGAGAAGGTCGAGGCGG
TCGCGACCCGGGTGTACGGCGCCGGCCAGGTCACCTGGGACGGCAAGGCGCGCAAGCGGCTGGCGCGCATCGAGCGCGAC
GGGTACGGCACGCTGCCGGTCTGCGTGGCGAAGACGCAGTACTCGTTCTCGACCGACCCGGGCCTCCTCGGGGCGCCCAC
CGGTCACGAGCTCCGGGTCCGCGAGGTCCGGCTGTCGGCGGGCGCGGGCTTCGTGGTGGTGATCTGCGGCGACATGATGA
CCATGCCCGGCCTGCCCACGCGCCCGGCCGCGACCCGGATCGACCTCGCCGACGACGGCACGATCATCGGGCTGTCCTAG

Upstream 100 bases:

>100_bases
CGGATCCGTGCCGATTCACCTACCTCGCGAGGGCGATCGGGTTAGCGTTCCCGCAGAGGCCCGGGGAGGCCCGGACCGGC
GCACGAAGGAGTGCTCGACG

Downstream 100 bases:

>100_bases
TGTCCTGACAGGACACTAGCTAGTGGATCCCAGCCGCTGGGCCGCCCGGAACCGATGGCGGGTCGACCTCTAGGTTGGCG
CCCATGGGTGTGGTGCTGCT

Product: formate-tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MLSDIEIAGAATLRPITEVATESLGIGAEHLVPYGHYKAKVGITYLNSLADRPLGRLILVTALSPTPPGEGKTTTSVGLT
DALHGLGKRAIACLREPSMGPVFGLKGGAAGGGYSQVVPMTDINLHFTGDFAAIAAANNLLAALIDNHVHHGNELDIDVR
SVTWKRVLDTNDRALREVVVGLGGPPNGFPRQDGFDIVVASELMAIFCLTESWADLKRRIGDIVIGYSRAGAPVTARDLG
ADGAMAVLLRDAIAPNLVQTLEGAPALVHGGPFANIAHGCSSVMATRAGLRLADYVVTEAGFGADLGAEKFIDIKCRMSG
MRPDVAVVVATVRALKYHGGVALADLDREDLGAVEAGMDNLRRHLDNLRHLNGVPCVVAVNRFPTDTDLEVVRVVELAAS
YGVPAYQATHFTDGGIGAQDLAKGVLQALEEPARDEFSFTYPDELSLTEKVEAVATRVYGAGQVTWDGKARKRLARIERD
GYGTLPVCVAKTQYSFSTDPGLLGAPTGHELRVREVRLSAGAGFVVVICGDMMTMPGLPTRPAATRIDLADDGTIIGLS

Sequences:

>Translated_559_residues
MLSDIEIAGAATLRPITEVATESLGIGAEHLVPYGHYKAKVGITYLNSLADRPLGRLILVTALSPTPPGEGKTTTSVGLT
DALHGLGKRAIACLREPSMGPVFGLKGGAAGGGYSQVVPMTDINLHFTGDFAAIAAANNLLAALIDNHVHHGNELDIDVR
SVTWKRVLDTNDRALREVVVGLGGPPNGFPRQDGFDIVVASELMAIFCLTESWADLKRRIGDIVIGYSRAGAPVTARDLG
ADGAMAVLLRDAIAPNLVQTLEGAPALVHGGPFANIAHGCSSVMATRAGLRLADYVVTEAGFGADLGAEKFIDIKCRMSG
MRPDVAVVVATVRALKYHGGVALADLDREDLGAVEAGMDNLRRHLDNLRHLNGVPCVVAVNRFPTDTDLEVVRVVELAAS
YGVPAYQATHFTDGGIGAQDLAKGVLQALEEPARDEFSFTYPDELSLTEKVEAVATRVYGAGQVTWDGKARKRLARIERD
GYGTLPVCVAKTQYSFSTDPGLLGAPTGHELRVREVRLSAGAGFVVVICGDMMTMPGLPTRPAATRIDLADDGTIIGLS
>Mature_559_residues
MLSDIEIAGAATLRPITEVATESLGIGAEHLVPYGHYKAKVGITYLNSLADRPLGRLILVTALSPTPPGEGKTTTSVGLT
DALHGLGKRAIACLREPSMGPVFGLKGGAAGGGYSQVVPMTDINLHFTGDFAAIAAANNLLAALIDNHVHHGNELDIDVR
SVTWKRVLDTNDRALREVVVGLGGPPNGFPRQDGFDIVVASELMAIFCLTESWADLKRRIGDIVIGYSRAGAPVTARDLG
ADGAMAVLLRDAIAPNLVQTLEGAPALVHGGPFANIAHGCSSVMATRAGLRLADYVVTEAGFGADLGAEKFIDIKCRMSG
MRPDVAVVVATVRALKYHGGVALADLDREDLGAVEAGMDNLRRHLDNLRHLNGVPCVVAVNRFPTDTDLEVVRVVELAAS
YGVPAYQATHFTDGGIGAQDLAKGVLQALEEPARDEFSFTYPDELSLTEKVEAVATRVYGAGQVTWDGKARKRLARIERD
GYGTLPVCVAKTQYSFSTDPGLLGAPTGHELRVREVRLSAGAGFVVVICGDMMTMPGLPTRPAATRIDLADDGTIIGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=611, Percent_Identity=44.189852700491, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI36796743, Length=614, Percent_Identity=44.9511400651466, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17568737, Length=608, Percent_Identity=46.2171052631579, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17568739, Length=608, Percent_Identity=46.2171052631579, Blast_Score=458, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=41.390205371248, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321643, Length=628, Percent_Identity=42.0382165605096, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI62472483, Length=623, Percent_Identity=43.6597110754414, Blast_Score=457, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45551871, Length=623, Percent_Identity=43.6597110754414, Blast_Score=457, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24645718, Length=623, Percent_Identity=43.6597110754414, Blast_Score=457, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17137370, Length=623, Percent_Identity=43.6597110754414, Blast_Score=457, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_NOCSJ (A1SQH3)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_925745.1
- STRING:   A1SQH3
- GeneID:   4597080
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_4561
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   VVASEVM
- PhylomeDB:   A1SQH3
- BioCyc:   NSP35761:NOCA_4561-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 58922; Mature: 58922

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDIEIAGAATLRPITEVATESLGIGAEHLVPYGHYKAKVGITYLNSLADRPLGRLILV
CCCCEEECCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEHHHHHHHHHCCCCCEEEEE
TALSPTPPGEGKTTTSVGLTDALHGLGKRAIACLREPSMGPVFGLKGGAAGGGYSQVVPM
EEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEE
TDINLHFTGDFAAIAAANNLLAALIDNHVHHGNELDIDVRSVTWKRVLDTNDRALREVVV
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHH
GLGGPPNGFPRQDGFDIVVASELMAIFCLTESWADLKRRIGDIVIGYSRAGAPVTARDLG
HCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEHHHCC
ADGAMAVLLRDAIAPNLVQTLEGAPALVHGGPFANIAHGCSSVMATRAGLRLADYVVTEA
CCCHHHHHHHHHHCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCC
GFGADLGAEKFIDIKCRMSGMRPDVAVVVATVRALKYHGGVALADLDREDLGAVEAGMDN
CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
LRRHLDNLRHLNGVPCVVAVNRFPTDTDLEVVRVVELAASYGVPAYQATHFTDGGIGAQD
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHH
LAKGVLQALEEPARDEFSFTYPDELSLTEKVEAVATRVYGAGQVTWDGKARKRLARIERD
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCC
GYGTLPVCVAKTQYSFSTDPGLLGAPTGHELRVREVRLSAGAGFVVVICGDMMTMPGLPT
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHCCCCCC
RPAATRIDLADDGTIIGLS
CCCCEEEEECCCCEEEECC
>Mature Secondary Structure
MLSDIEIAGAATLRPITEVATESLGIGAEHLVPYGHYKAKVGITYLNSLADRPLGRLILV
CCCCEEECCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEHHHHHHHHHCCCCCEEEEE
TALSPTPPGEGKTTTSVGLTDALHGLGKRAIACLREPSMGPVFGLKGGAAGGGYSQVVPM
EEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEE
TDINLHFTGDFAAIAAANNLLAALIDNHVHHGNELDIDVRSVTWKRVLDTNDRALREVVV
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHH
GLGGPPNGFPRQDGFDIVVASELMAIFCLTESWADLKRRIGDIVIGYSRAGAPVTARDLG
HCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEHHHCC
ADGAMAVLLRDAIAPNLVQTLEGAPALVHGGPFANIAHGCSSVMATRAGLRLADYVVTEA
CCCHHHHHHHHHHCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCC
GFGADLGAEKFIDIKCRMSGMRPDVAVVVATVRALKYHGGVALADLDREDLGAVEAGMDN
CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
LRRHLDNLRHLNGVPCVVAVNRFPTDTDLEVVRVVELAASYGVPAYQATHFTDGGIGAQD
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHH
LAKGVLQALEEPARDEFSFTYPDELSLTEKVEAVATRVYGAGQVTWDGKARKRLARIERD
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCC
GYGTLPVCVAKTQYSFSTDPGLLGAPTGHELRVREVRLSAGAGFVVVICGDMMTMPGLPT
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHCCCCCC
RPAATRIDLADDGTIIGLS
CCCCEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA