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The map label for this gene is purC [H]

Identifier: 119718556

GI number: 119718556

Start: 4585468

End: 4586322

Strand: Reverse

Name: purC [H]

Synonym: Noca_4337

Alternate gene names: 119718556

Gene position: 4586322-4585468 (Counterclockwise)

Preceding gene: 119718558

Following gene: 119718555

Centisome position: 91.99

GC content: 73.45

Gene sequence:

>855_bases
GTGATCCCGGGCGCCACGCACCTCCACTCCGGCAAGGTCCGCGACCTCTACGAGCTGCCGGGCGGCGAGCTGCTGATGGT
CGCCAGCGACCGGATCTCGATCTTCGACTTCGTGCTGGACACGACGATCCCGGACAAGGGCGAGATCCTGACCCGGATGT
CGCTGTGGTGGTTCGACCGGCTCGCCGACCTGGTCCCCAACCACGTGCTCTCGACCGACGTGCCCCCCGAGGTGAGGGGC
CGTGCCGTCGTGTGCGAGCGGCTGGCGATGTACCCCGTCGAGTGCGTCGCCCGCGGCTACCTCACCGGCTCCGGCCTGGT
CGACTACCGGGCCTCCGGCGCCGTCTGCGGGATCGCGCTCCCGGCCGGGCTGGTGGACGGCAGCCGGCTGCCGGAGCCGG
TCTTCACCCCGGCCACCAAGGCCGAGCTCGGCGAGCACGACGAGAACGTCTCGTACGACGCGGTCGCGGGCACCGTCGGG
GCCGACCGCGCGGCCGAGCTGCGGGACCTCACGCTGCGCGTCTACGCCCGGGCCGAGTCGATCGCCCGCGAGCGCGGCAT
CATCCTCGCCGACACCAAGCTGGAGTTCGGTGCCCGCCCCGACGGCACGACGGTCCTCGCGGACGAGGTGCTGACGCCCG
ACTCGTCGCGGTTCTGGCCGGCCGCCGAGTGGGAGCCCGGCCACGCGCAGCCGTCGTACGACAAGCAGATCGTGCGCAAC
TGGGCGCTCTCCCCGGAGTCGGGCTGGGACCGCTCGTCGGGCGAGGCGCCGCCGCCGCTGCCGGCCGAGGTGGTCGAGCG
GACCCGCAGCCGGTACGTCGAGGCCTTCGAGCTGCTGACCGGGGAGCGGTGGTAG

Upstream 100 bases:

>100_bases
CCGGCATGACCCCACTCTGCCAGCACGAGCAGCCCGCGGGCCCGCGGCCCCCACGCCCTACAGTGGCGTCGTGGCCGACC
TCAACCTCCCGACCGCGCCG

Downstream 100 bases:

>100_bases
CGGTCGCGTTCGCGGTGTCGCGCGAGGTCGCCTTCGACTACCTCTCCGACCCGCGCCGCCGTCCGGAGTGGCAGTCCAGC
CTGGCCCGCGTCGAGCAGGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MIPGATHLHSGKVRDLYELPGGELLMVASDRISIFDFVLDTTIPDKGEILTRMSLWWFDRLADLVPNHVLSTDVPPEVRG
RAVVCERLAMYPVECVARGYLTGSGLVDYRASGAVCGIALPAGLVDGSRLPEPVFTPATKAELGEHDENVSYDAVAGTVG
ADRAAELRDLTLRVYARAESIARERGIILADTKLEFGARPDGTTVLADEVLTPDSSRFWPAAEWEPGHAQPSYDKQIVRN
WALSPESGWDRSSGEAPPPLPAEVVERTRSRYVEAFELLTGERW

Sequences:

>Translated_284_residues
MIPGATHLHSGKVRDLYELPGGELLMVASDRISIFDFVLDTTIPDKGEILTRMSLWWFDRLADLVPNHVLSTDVPPEVRG
RAVVCERLAMYPVECVARGYLTGSGLVDYRASGAVCGIALPAGLVDGSRLPEPVFTPATKAELGEHDENVSYDAVAGTVG
ADRAAELRDLTLRVYARAESIARERGIILADTKLEFGARPDGTTVLADEVLTPDSSRFWPAAEWEPGHAQPSYDKQIVRN
WALSPESGWDRSSGEAPPPLPAEVVERTRSRYVEAFELLTGERW
>Mature_284_residues
MIPGATHLHSGKVRDLYELPGGELLMVASDRISIFDFVLDTTIPDKGEILTRMSLWWFDRLADLVPNHVLSTDVPPEVRG
RAVVCERLAMYPVECVARGYLTGSGLVDYRASGAVCGIALPAGLVDGSRLPEPVFTPATKAELGEHDENVSYDAVAGTVG
ADRAAELRDLTLRVYARAESIARERGIILADTKLEFGARPDGTTVLADEVLTPDSSRFWPAAEWEPGHAQPSYDKQIVRN
WALSPESGWDRSSGEAPPPLPAEVVERTRSRYVEAFELLTGERW

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=26.5822784810127, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319326, Length=294, Percent_Identity=40.8163265306122, Blast_Score=248, Evalue=9e-67,
Organism=Drosophila melanogaster, GI18860083, Length=250, Percent_Identity=28, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 31126; Mature: 31126

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPGATHLHSGKVRDLYELPGGELLMVASDRISIFDFVLDTTIPDKGEILTRMSLWWFDR
CCCCCCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LADLVPNHVLSTDVPPEVRGRAVVCERLAMYPVECVARGYLTGSGLVDYRASGAVCGIAL
HHHHCCCHHCCCCCCHHHCCHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCCCEEEEEC
PAGLVDGSRLPEPVFTPATKAELGEHDENVSYDAVAGTVGADRAAELRDLTLRVYARAES
CCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
IARERGIILADTKLEFGARPDGTTVLADEVLTPDSSRFWPAAEWEPGHAQPSYDKQIVRN
HHHHCCEEEEECCEECCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
WALSPESGWDRSSGEAPPPLPAEVVERTRSRYVEAFELLTGERW
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIPGATHLHSGKVRDLYELPGGELLMVASDRISIFDFVLDTTIPDKGEILTRMSLWWFDR
CCCCCCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LADLVPNHVLSTDVPPEVRGRAVVCERLAMYPVECVARGYLTGSGLVDYRASGAVCGIAL
HHHHCCCHHCCCCCCHHHCCHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCCCEEEEEC
PAGLVDGSRLPEPVFTPATKAELGEHDENVSYDAVAGTVGADRAAELRDLTLRVYARAES
CCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
IARERGIILADTKLEFGARPDGTTVLADEVLTPDSSRFWPAAEWEPGHAQPSYDKQIVRN
HHHHCCEEEEECCEECCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
WALSPESGWDRSSGEAPPPLPAEVVERTRSRYVEAFELLTGERW
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]