Click here to switch to the map view.

The map label for this gene is ywrD [H]

Identifier: 119718498

GI number: 119718498

Start: 4521053

End: 4522612

Strand: Reverse

Name: ywrD [H]

Synonym: Noca_4279

Alternate gene names: 119718498

Gene position: 4522612-4521053 (Counterclockwise)

Preceding gene: 119718499

Following gene: 119718497

Centisome position: 90.71

GC content: 77.12

Gene sequence:

>1560_bases
GTGGTCACCTCGAGCAGCCCGTTCGTCTCGCTGGCCGGCGCCCGGGTCCTGGCCGACGGCGGCACGGCGATCGACGCGAC
GCTCGCGATGGCGGCCGTCGCCTGGATGGTGCTGCCCGGCCAGTGTGGCCTCGGCGGCGACGCGTTCGCGATCGTCCGGG
AGCCCGACGGCGAGGTCTGGACCGTCAGCGGCAGCGGTTTCGGCCCCGACGGGGGGACGCCGGAGCTCTACGCCGGGCTG
GGCCTCGACGCACTGCCGCTGACCGGGCCGCACGCGGTCGCGGTGCCCGGCGCGCCGGCCGCCGTCCGGACCCTCCAGGG
CCGGGCCACTCGTGGCCTCGACGAGCTGTGGGCACCGGCGCTCCGGCTCGCCCGCGAGGGCGTCGCCGCGAGCGCCAAGA
CCCGGGCGGACGTCGGGGAGTTCGCCGCGGCCCTGGACGCCGACCCCGGCGCCCGGGCCGCGTTCCTGCCGGGCGGAGTC
CCACCCGAGGTCGGTGCCCGGCTGCGCCAGGCCGACCTGGCGACCACGCTGGAGCGGCTGGCCGCCGACCCGGACGCCTT
CTACACCGGCTGGTTCGCCGACCGTGCGGTCGAGCACCTGGTCGCGAGCGGGGCGCCGTACTCCGGCGCCGAGTGGGCCG
CGGTCGCGCACGCGCCGGTGGCGCCCGCCATCGCCACGGCGTACGGCGGCGCCCGGCTGCATCAGACGCCGATGCCCTCG
GCCGGGTGGATGGTGCTCCAGCAGGCGGCGCTCTGCGACGGGGAGCTGGTCGGGTCGGAGCAGCTCGGGGCGCCGGCCGT
GCACTGGCTGGCCGAGGCCGCGGCCGCGGCGTTCCGCGACCGGTTCGCCTCCTGCGGCTCGGACACCGACGCCTGGCAGC
GGACCCTGGACCCGGCCGCGCTCGAGCGGACCCGCGCCGCGATCCGCAGCCGGGACCGGGTCGGGCCGGCGCCGATGCGG
GTCGCCGGCGACACCACCTCGACCGTGTGTGTCGACGCCGACGGCCGCGCCGTCAGCTTCATCCACTCCCTCGGCTTCAC
CTTCGGGGCCCGGCTGAGCGTGCCCGGCACGGGCGTGATCCTCAACAACCGCCTGGGCCGCGGGGCCTACCTGATCGACG
GCCACCCCAACGAGGTGCGCCCGCGCCGCAAGCCGCTGCACACCCTCAACGCGTGGCTCCTCGACGAGCCCGGTGTCGGT
CTGCTGCACGCCGGCAACTGCCCGGGCGGGGACGGTCAGGTGCAGTGGAACATGCAGGTGATCAGCCACCTGGTCGACCA
CGGCGACGACCCCCAGCGTGCGGTCTCGCTGCCCCGGTTCACCGTCTTCCCGGGCTCGGACGCGGACGTGGTCGGGCGCC
GCCGCGAGCTGCGGTGCGAAGGCGGCATCCCCGCGACGACGCTCGAGACGCTGGGGGCGTGGGGCCACGACGTGGTCCCG
GTGCCGGTGCAGGTCGGCGGGCCCGGCGGGTCCGCCCTCGCGATCTCGATGGACCACCGACACGGGTGCGTGCGCGCCGG
CGCCGACCCGCGCATGGAAGGAGTGGCGCTTGCCGTCTGA

Upstream 100 bases:

>100_bases
CCGACGGCGGGCCGCGGCGCCGCAAGCTGCGTCGGGACTGATGGGCCGCGGACCCGACCCGGTGCCGGTCGCCCGGCGAC
CGGTCCTCGGGACCGGCGGC

Downstream 100 bases:

>100_bases
GCCTCGATCCACCGATTTCCGCCTGCTGCGCGCCCCCATCTGGGCACGCTGGCTGCGTTGCCGACGCTCGATAGACGCTC
GGTATGGCTTCGCGCCGGAC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MVTSSSPFVSLAGARVLADGGTAIDATLAMAAVAWMVLPGQCGLGGDAFAIVREPDGEVWTVSGSGFGPDGGTPELYAGL
GLDALPLTGPHAVAVPGAPAAVRTLQGRATRGLDELWAPALRLAREGVAASAKTRADVGEFAAALDADPGARAAFLPGGV
PPEVGARLRQADLATTLERLAADPDAFYTGWFADRAVEHLVASGAPYSGAEWAAVAHAPVAPAIATAYGGARLHQTPMPS
AGWMVLQQAALCDGELVGSEQLGAPAVHWLAEAAAAAFRDRFASCGSDTDAWQRTLDPAALERTRAAIRSRDRVGPAPMR
VAGDTTSTVCVDADGRAVSFIHSLGFTFGARLSVPGTGVILNNRLGRGAYLIDGHPNEVRPRRKPLHTLNAWLLDEPGVG
LLHAGNCPGGDGQVQWNMQVISHLVDHGDDPQRAVSLPRFTVFPGSDADVVGRRRELRCEGGIPATTLETLGAWGHDVVP
VPVQVGGPGGSALAISMDHRHGCVRAGADPRMEGVALAV

Sequences:

>Translated_519_residues
MVTSSSPFVSLAGARVLADGGTAIDATLAMAAVAWMVLPGQCGLGGDAFAIVREPDGEVWTVSGSGFGPDGGTPELYAGL
GLDALPLTGPHAVAVPGAPAAVRTLQGRATRGLDELWAPALRLAREGVAASAKTRADVGEFAAALDADPGARAAFLPGGV
PPEVGARLRQADLATTLERLAADPDAFYTGWFADRAVEHLVASGAPYSGAEWAAVAHAPVAPAIATAYGGARLHQTPMPS
AGWMVLQQAALCDGELVGSEQLGAPAVHWLAEAAAAAFRDRFASCGSDTDAWQRTLDPAALERTRAAIRSRDRVGPAPMR
VAGDTTSTVCVDADGRAVSFIHSLGFTFGARLSVPGTGVILNNRLGRGAYLIDGHPNEVRPRRKPLHTLNAWLLDEPGVG
LLHAGNCPGGDGQVQWNMQVISHLVDHGDDPQRAVSLPRFTVFPGSDADVVGRRRELRCEGGIPATTLETLGAWGHDVVP
VPVQVGGPGGSALAISMDHRHGCVRAGADPRMEGVALAV
>Mature_519_residues
MVTSSSPFVSLAGARVLADGGTAIDATLAMAAVAWMVLPGQCGLGGDAFAIVREPDGEVWTVSGSGFGPDGGTPELYAGL
GLDALPLTGPHAVAVPGAPAAVRTLQGRATRGLDELWAPALRLAREGVAASAKTRADVGEFAAALDADPGARAAFLPGGV
PPEVGARLRQADLATTLERLAADPDAFYTGWFADRAVEHLVASGAPYSGAEWAAVAHAPVAPAIATAYGGARLHQTPMPS
AGWMVLQQAALCDGELVGSEQLGAPAVHWLAEAAAAAFRDRFASCGSDTDAWQRTLDPAALERTRAAIRSRDRVGPAPMR
VAGDTTSTVCVDADGRAVSFIHSLGFTFGARLSVPGTGVILNNRLGRGAYLIDGHPNEVRPRRKPLHTLNAWLLDEPGVG
LLHAGNCPGGDGQVQWNMQVISHLVDHGDDPQRAVSLPRFTVFPGSDADVVGRRRELRCEGGIPATTLETLGAWGHDVVP
VPVQVGGPGGSALAISMDHRHGCVRAGADPRMEGVALAV

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789856, Length=508, Percent_Identity=26.9685039370079, Blast_Score=142, Evalue=7e-35,
Organism=Drosophila melanogaster, GI18859893, Length=424, Percent_Identity=26.4150943396226, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 53469; Mature: 53469

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSSSPFVSLAGARVLADGGTAIDATLAMAAVAWMVLPGQCGLGGDAFAIVREPDGEVW
CCCCCCCCEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEE
TVSGSGFGPDGGTPELYAGLGLDALPLTGPHAVAVPGAPAAVRTLQGRATRGLDELWAPA
EEECCCCCCCCCCCHHEECCCCCCCCCCCCCEEECCCCCHHHHHHHCHHHCCHHHHHHHH
LRLAREGVAASAKTRADVGEFAAALDADPGARAAFLPGGVPPEVGARLRQADLATTLERL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
AADPDAFYTGWFADRAVEHLVASGAPYSGAEWAAVAHAPVAPAIATAYGGARLHQTPMPS
HCCCCHHEEHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCEEECCCCCC
AGWMVLQQAALCDGELVGSEQLGAPAVHWLAEAAAAAFRDRFASCGSDTDAWQRTLDPAA
CHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHH
LERTRAAIRSRDRVGPAPMRVAGDTTSTVCVDADGRAVSFIHSLGFTFGARLSVPGTGVI
HHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCEEECCCCEEE
LNNRLGRGAYLIDGHPNEVRPRRKPLHTLNAWLLDEPGVGLLHAGNCPGGDGQVQWNMQV
EECCCCCCEEEECCCCCCCCCCCCCHHHHHHEEECCCCCCEEECCCCCCCCCEEEEEHHH
ISHLVDHGDDPQRAVSLPRFTVFPGSDADVVGRRRELRCEGGIPATTLETLGAWGHDVVP
HHHHHHCCCCHHHHHCCCEEEECCCCCHHHHCCCHHEEECCCCCHHHHHHHCCCCCCEEE
VPVQVGGPGGSALAISMDHRHGCVRAGADPRMEGVALAV
EEEEECCCCCCEEEEEECCCCCCEECCCCCCCCCEEEEC
>Mature Secondary Structure
MVTSSSPFVSLAGARVLADGGTAIDATLAMAAVAWMVLPGQCGLGGDAFAIVREPDGEVW
CCCCCCCCEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEE
TVSGSGFGPDGGTPELYAGLGLDALPLTGPHAVAVPGAPAAVRTLQGRATRGLDELWAPA
EEECCCCCCCCCCCHHEECCCCCCCCCCCCCEEECCCCCHHHHHHHCHHHCCHHHHHHHH
LRLAREGVAASAKTRADVGEFAAALDADPGARAAFLPGGVPPEVGARLRQADLATTLERL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
AADPDAFYTGWFADRAVEHLVASGAPYSGAEWAAVAHAPVAPAIATAYGGARLHQTPMPS
HCCCCHHEEHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCEEECCCCCC
AGWMVLQQAALCDGELVGSEQLGAPAVHWLAEAAAAAFRDRFASCGSDTDAWQRTLDPAA
CHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHH
LERTRAAIRSRDRVGPAPMRVAGDTTSTVCVDADGRAVSFIHSLGFTFGARLSVPGTGVI
HHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCEEECCCCEEE
LNNRLGRGAYLIDGHPNEVRPRRKPLHTLNAWLLDEPGVGLLHAGNCPGGDGQVQWNMQV
EECCCCCCEEEECCCCCCCCCCCCCHHHHHHEEECCCCCCEEECCCCCCCCCEEEEEHHH
ISHLVDHGDDPQRAVSLPRFTVFPGSDADVVGRRRELRCEGGIPATTLETLGAWGHDVVP
HHHHHHCCCCHHHHHCCCEEEECCCCCHHHHCCCHHEEECCCCCHHHHHHHCCCCCCEEE
VPVQVGGPGGSALAISMDHRHGCVRAGADPRMEGVALAV
EEEEECCCCCCEEEEEECCCCCCEECCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]