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The map label for this gene is mtaD [H]

Identifier: 119718319

GI number: 119718319

Start: 4331326

End: 4332777

Strand: Reverse

Name: mtaD [H]

Synonym: Noca_4100

Alternate gene names: 119718319

Gene position: 4332777-4331326 (Counterclockwise)

Preceding gene: 119718320

Following gene: 119718317

Centisome position: 86.9

GC content: 70.8

Gene sequence:

>1452_bases
GTGACGGACCAGCCGGCCGGCCCGGAGGTCGAGACCGCTGACCTGCTCCTACGCGGTGCCACGGTCGTCACGATGGACGC
GGACCGCACGGTCTACGAGAGGGGCTACGTCGCCGTGCGCGGCCAGGAGATCCTCTCGGTCGGGGCCGACGACGGCGACG
TGCCCCGCGCTCGGGAGGTCCGCGACCTCGATGGACACGTGGTGTTGCCGGGGCTGGTCAACTGCCACACGCACCTGTCG
AACGGCATCTCCCGAGGCCTCTTCGACGAGTTGCCCCTCGCCGACTGGGTGGAGAAGGGGATGTGGCCCTCGTTGCGCGC
CAACACCCGGGAGGCGACGTACCACGGGGCGCGGGTCGCCCTGGCCGAGAACCTGCTCGGCGGCGTGACGACCACGGTCG
TGGGTGAGTTCGGCGTCCCCGCCCGCGACACGCTCGACGGGGTGTTGGCGGCCGTCACCGAGTCCGGTTCGCGCTCGGTC
GTGGCCCGCATCTCGGTGGACTCCGCCGACGACCACGACTCCAGTCAGGCCGTCCCCCCTGACGTTCGCGAGGACATCGA
CGCGGCGTTGGCCGAGGTGGACCGGCTGCGATCCGGCTACGGCTCGGACCTCCTCGAGGTGGTCCCTGAAGCCCTCGGCG
TGCTTCGCTGCTCGGCGGACATGGTCACGGAGTTCGCTCGCTACGCCCGGGACCGGGGCACCCGGATGACGATGCACGTC
GCGAGCTCTCCCGACGAGCGCGACGAGGCGCAGTACCGCTTCGGCAAAGGGTCCGTCGAGCGCCTGCACGACCTGGGTGT
CCTCGGGCCGCACCTGTTGGTCGCCCACTGCGTGTGGAACGACGACCGCGAGCGTGCACTGCTCGCCGAGAGCAGGACCG
GGGTCTCCCACAATCCCGTGGCGAACCTGATGTACGCCTCGGGTCTGGCACCCCTCTCGGAGATGCTCGAAGCAGGCGTG
CGAGTGGGACTCGGCACCGACGGGGCGTCCACCAACAACGGCCAGAACATGTGGGAGGTCATGAAGACCGCCATGTTCCT
GCAGAAGTCGCGCTTCGGCGCCGGGTGGGGATCGGCCGAGCTCGCCCTGGAGCTGGCCACTCTCGGTGGAGCGCGGGCCA
TCGGCATGGAGGACCGCATCGGCTCGCTCGGAGCCGGCAAGCGTGCCGACATCGTGGTGGCCACGTTGAACAAGCCGGAG
CTGGTCCCGCACGCCACCTGGCCGTCGAACCTGGTCTACTCCTTCAGCCCGAGCGCGGTGCGGACCGTGCTGGTCGACGG
GCGCGTGGTGGTCGACGACGGTCGAGTCGTCGCGTGGGAGCACGACGACGTCATCGCGCACGGCAACCGGATGGCCCTCG
AGATGGACGCCCACACCGGTCTGGCCCGGGCCTACCGGCAGCGGAGCCGCTGGCGCTGGGTGGGCGAGCGAGGCGGTCAG
CCGGCCTCCTGA

Upstream 100 bases:

>100_bases
GGCGGATCGTCCACGAGCACGGCTCGCAGCCGCTCGTCGACCCCTATGGATCCGGCGACTGGTGGCCCGAAGGTGCGACG
CCTCTGCCCACGGCCGGATC

Downstream 100 bases:

>100_bases
GCGGGGCGTGTGCCGAAGCGTCAGGAGAAGCTGGCGACCTCGACGACGGCCTTGCCGCGGTTGGCGCCCGACATCAGCTC
ACAGAAGGCGGCGGGCGCGC

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTDQPAGPEVETADLLLRGATVVTMDADRTVYERGYVAVRGQEILSVGADDGDVPRAREVRDLDGHVVLPGLVNCHTHLS
NGISRGLFDELPLADWVEKGMWPSLRANTREATYHGARVALAENLLGGVTTTVVGEFGVPARDTLDGVLAAVTESGSRSV
VARISVDSADDHDSSQAVPPDVREDIDAALAEVDRLRSGYGSDLLEVVPEALGVLRCSADMVTEFARYARDRGTRMTMHV
ASSPDERDEAQYRFGKGSVERLHDLGVLGPHLLVAHCVWNDDRERALLAESRTGVSHNPVANLMYASGLAPLSEMLEAGV
RVGLGTDGASTNNGQNMWEVMKTAMFLQKSRFGAGWGSAELALELATLGGARAIGMEDRIGSLGAGKRADIVVATLNKPE
LVPHATWPSNLVYSFSPSAVRTVLVDGRVVVDDGRVVAWEHDDVIAHGNRMALEMDAHTGLARAYRQRSRWRWVGERGGQ
PAS

Sequences:

>Translated_483_residues
MTDQPAGPEVETADLLLRGATVVTMDADRTVYERGYVAVRGQEILSVGADDGDVPRAREVRDLDGHVVLPGLVNCHTHLS
NGISRGLFDELPLADWVEKGMWPSLRANTREATYHGARVALAENLLGGVTTTVVGEFGVPARDTLDGVLAAVTESGSRSV
VARISVDSADDHDSSQAVPPDVREDIDAALAEVDRLRSGYGSDLLEVVPEALGVLRCSADMVTEFARYARDRGTRMTMHV
ASSPDERDEAQYRFGKGSVERLHDLGVLGPHLLVAHCVWNDDRERALLAESRTGVSHNPVANLMYASGLAPLSEMLEAGV
RVGLGTDGASTNNGQNMWEVMKTAMFLQKSRFGAGWGSAELALELATLGGARAIGMEDRIGSLGAGKRADIVVATLNKPE
LVPHATWPSNLVYSFSPSAVRTVLVDGRVVVDDGRVVAWEHDDVIAHGNRMALEMDAHTGLARAYRQRSRWRWVGERGGQ
PAS
>Mature_482_residues
TDQPAGPEVETADLLLRGATVVTMDADRTVYERGYVAVRGQEILSVGADDGDVPRAREVRDLDGHVVLPGLVNCHTHLSN
GISRGLFDELPLADWVEKGMWPSLRANTREATYHGARVALAENLLGGVTTTVVGEFGVPARDTLDGVLAAVTESGSRSVV
ARISVDSADDHDSSQAVPPDVREDIDAALAEVDRLRSGYGSDLLEVVPEALGVLRCSADMVTEFARYARDRGTRMTMHVA
SSPDERDEAQYRFGKGSVERLHDLGVLGPHLLVAHCVWNDDRERALLAESRTGVSHNPVANLMYASGLAPLSEMLEAGVR
VGLGTDGASTNNGQNMWEVMKTAMFLQKSRFGAGWGSAELALELATLGGARAIGMEDRIGSLGAGKRADIVVATLNKPEL
VPHATWPSNLVYSFSPSAVRTVLVDGRVVVDDGRVVAWEHDDVIAHGNRMALEMDAHTGLARAYRQRSRWRWVGERGGQP
AS

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=355, Percent_Identity=25.3521126760563, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1789249, Length=401, Percent_Identity=27.431421446384, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI87082177, Length=458, Percent_Identity=24.4541484716157, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319963, Length=337, Percent_Identity=24.3323442136499, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24643849, Length=444, Percent_Identity=25.9009009009009, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 51983; Mature: 51852

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQPAGPEVETADLLLRGATVVTMDADRTVYERGYVAVRGQEILSVGADDGDVPRAREV
CCCCCCCCCCCHHHHEEECCEEEEECCCCHHHHCCEEEEECHHHEEECCCCCCCCCCHHH
RDLDGHVVLPGLVNCHTHLSNGISRGLFDELPLADWVEKGMWPSLRANTREATYHGARVA
HCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHCCHHHH
LAENLLGGVTTTVVGEFGVPARDTLDGVLAAVTESGSRSVVARISVDSADDHDSSQAVPP
HHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCC
DVREDIDAALAEVDRLRSGYGSDLLEVVPEALGVLRCSADMVTEFARYARDRGTRMTMHV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEE
ASSPDERDEAQYRFGKGSVERLHDLGVLGPHLLVAHCVWNDDRERALLAESRTGVSHNPV
CCCCCCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCH
ANLMYASGLAPLSEMLEAGVRVGLGTDGASTNNGQNMWEVMKTAMFLQKSRFGAGWGSAE
HHHHHHCCCHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHH
LALELATLGGARAIGMEDRIGSLGAGKRADIVVATLNKPELVPHATWPSNLVYSFSPSAV
HEEEEECCCCCEEECCHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCHHE
RTVLVDGRVVVDDGRVVAWEHDDVIAHGNRMALEMDAHTGLARAYRQRSRWRWVGERGGQ
EEEEECCEEEEECCEEEEEECCCEEECCCEEEEEECCHHHHHHHHHHHHHHEEHHCCCCC
PAS
CCC
>Mature Secondary Structure 
TDQPAGPEVETADLLLRGATVVTMDADRTVYERGYVAVRGQEILSVGADDGDVPRAREV
CCCCCCCCCCHHHHEEECCEEEEECCCCHHHHCCEEEEECHHHEEECCCCCCCCCCHHH
RDLDGHVVLPGLVNCHTHLSNGISRGLFDELPLADWVEKGMWPSLRANTREATYHGARVA
HCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHCCHHHH
LAENLLGGVTTTVVGEFGVPARDTLDGVLAAVTESGSRSVVARISVDSADDHDSSQAVPP
HHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCC
DVREDIDAALAEVDRLRSGYGSDLLEVVPEALGVLRCSADMVTEFARYARDRGTRMTMHV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEE
ASSPDERDEAQYRFGKGSVERLHDLGVLGPHLLVAHCVWNDDRERALLAESRTGVSHNPV
CCCCCCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCH
ANLMYASGLAPLSEMLEAGVRVGLGTDGASTNNGQNMWEVMKTAMFLQKSRFGAGWGSAE
HHHHHHCCCHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHH
LALELATLGGARAIGMEDRIGSLGAGKRADIVVATLNKPELVPHATWPSNLVYSFSPSAV
HEEEEECCCCCEEECCHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCHHE
RTVLVDGRVVVDDGRVVAWEHDDVIAHGNRMALEMDAHTGLARAYRQRSRWRWVGERGGQ
EEEEECCEEEEECCEEEEEECCCEEECCCEEEEEECCHHHHHHHHHHHHHHEEHHCCCCC
PAS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]