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The map label for this gene is livM [H]

Identifier: 119718236

GI number: 119718236

Start: 4239525

End: 4241618

Strand: Reverse

Name: livM [H]

Synonym: Noca_4017

Alternate gene names: 119718236

Gene position: 4241618-4239525 (Counterclockwise)

Preceding gene: 119718237

Following gene: 119718235

Centisome position: 85.07

GC content: 72.11

Gene sequence:

>2094_bases
ATGCCTGCCATGACCTCGATCCTGTCCTTCACGATCCTCGGCCTGTTCACCGGCGCGGCGTACGCGATCGCGGCGAGCGG
CCTGGTGCTGACCTACACGACCACGCGGGTGTTCAACATCGCGCACGGCGCGTTCGGCATGGTCATGGCCTTCACGTTCT
GGGACTTCAGCCAGCGGCAGGGGATGCCGACCTGGTTGGCGCTGACCCTGGTGCTCGGGGTGGTCGCGCCCGGGATCGGC
TGGTTCGTGCAGCGGTTCGTGACCCGCGGGCTCGGCGAGGGACCGGTGAGCGTCTCGCTCGTGGTCACGGTCGGGCTGTT
CGTCGGCCTGATCGGGGTGGCGCAGTACATCTGGCCACCGGCGCCGCGCACGGTGCCCCCGTTCCTGCCCGACGACGGGA
TCCGCATCGGCAGCACCTACGTCACCGCCCACCAGGTCATCACGATCGCGCTGTCCGCGCTGGTCGCGGCCGCCCTGTAC
GTGCTGCTCAACCGGACCCGGATCGGCACCGCGATGCGCGCCTCGGTCGACAACCCGGTGCTGTTGCGGCTCTTCGGCGG
CAGGCCCGACCTGGTCGCCTCGCTGTCCTGGGCGATCGGGATCTCGCTGGCCGCGCTGGCCGGCATCCTGCTGACCCCGG
TCATCGGCCTGTCCTACTACGACCTCACCCTGCTGGTCATCAACGCGTACGCCGCGGCGATGCTCGGGCGGCTCAAGAGC
CTGCCGCTCACGTTCGTCGGCGCGATGGGCCTCGGCATCCTGCAGTCCTTCTCGGTCGCCTACCTGCCCTCCGAGGGCAA
CCTGGCCGGCCTGCGTGCGGTCGTGCCGGCCCTGTTCCTCTTCGTCGTCATCGTCGCGATGCCCCAGGCCCAGCTGCGGA
TCGGCCAGGTCAAGGGCATCGTGTCCGCGCCGCTGCCGACGTTCACCAAGTCGCTCAGCTGGGGTGCGGTCCTGCTCGTC
CTCGTCGCGCTGCTGACGGTCACCACGGGCGACGCCGACCTGCTGCTGGTCGGCACCGCCGCGACGTACGCGATGGTGAT
GCTCTCGCTGGTGCTGCTCACGGGCTACGGCGGGCACGTGTCACTGGCCCAGTTCACCTTCGCCGGCGTCGGAGCCCTCG
CCTACGCCAAGCTCGACGAGCCCAACCTGTTCGGGCTGCTCGTCGCGGCCGGCATCGCGGCCGGGGTAGGCGCCCTGGTG
GCGCTGCCGGTGCTGCGGCTGACCGGGCTCTACCTGGCGCTCTCGACGCTGGCGTTCGGCGTGCTCATGGACAAGCTGGT
CTTCCAGGCCGACTTCGCCTTCGGCTACAACGGCACGCTGCACGCCGAGCGGCTCTCGCTGCTCGGCCGGGAGTTCTCCT
CCACCGGCGGCTACGTCCTGGTGATGACCGTGTTCTTCGTGCTGATGGCACTCGGCCTCCTGCTGCTGCGCCGGGGCGCG
CTCGGCCGGCTGCTGATCGCGATGCGCGACAGCCCGGCCGCGTGCGGCACCCTCGGCCTGGACATGCGGTGGTTCCGGGT
CGCCCTGTTCGGCCTGTCCGCCGGGATGGCCGGCCTGGCCGGCGGCCTGTTCGCGGGGCTGCGCGGCACGATCGGGGCCG
CCGACTTCCAGCTGTTCAACAGCCTGCCGCTGCTGTTGCTGGCGGTCGTCTGCGGCGTCACCTCGGTGACCGGCGCGGCG
CTCGGGGGCGTCGGCCTGATGCTGCTGCCGGTGCTGCAGAGCTCCCGGCCCGAGCTGGCCGGCCTGGTGTTCGCGGTCCT
CGGCTTCGGCGCGGTCGCGCTCGGCCGGGACCCGAACGGCCTGGCCAACCTGGTCTTCGCGTTCGGGCGGCGCCTGGAGA
GCCGGTTCGGCGACCGGGTCCGCTCCGTGGTCCCGGTGCTGCCCCTGCCCGGCGCGCGGGTCGGGGACGACAGCGCGACC
GCCGTACCCCTCGCCGACCCTGGCTCCGGGTCGGTGTTGATCGTGCCCGAGCACGGGCCCGTTCCCACGACGGCGGCCGA
GGCCGGCCCGGATCCCGAGCCGACCCAACCGCCCGGTCACCGCGCCGCTACGGCGATCGAGCCCTCCAAGGAGGCGCCTG
CCCATGTCCGCTGA

Upstream 100 bases:

>100_bases
GCGTTGCCGTCGCTCGACAGACAACCCGGTATGCCCTCGCTCCGGCGCCTTGCGATCGCACGCGCCGGACGACGCTCGCT
CCGGCCGGGGACAAGGAGAC

Downstream 100 bases:

>100_bases
GAGACCGCTCCTCGAGGTCGAGGACGTCGTCGTCCAGTTCGGCGGCGTGACGGCTGTCGACCACGCCGGCTTCGCCGCCC
ACGCCGGCCGGATCACCGGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MPAMTSILSFTILGLFTGAAYAIAASGLVLTYTTTRVFNIAHGAFGMVMAFTFWDFSQRQGMPTWLALTLVLGVVAPGIG
WFVQRFVTRGLGEGPVSVSLVVTVGLFVGLIGVAQYIWPPAPRTVPPFLPDDGIRIGSTYVTAHQVITIALSALVAAALY
VLLNRTRIGTAMRASVDNPVLLRLFGGRPDLVASLSWAIGISLAALAGILLTPVIGLSYYDLTLLVINAYAAAMLGRLKS
LPLTFVGAMGLGILQSFSVAYLPSEGNLAGLRAVVPALFLFVVIVAMPQAQLRIGQVKGIVSAPLPTFTKSLSWGAVLLV
LVALLTVTTGDADLLLVGTAATYAMVMLSLVLLTGYGGHVSLAQFTFAGVGALAYAKLDEPNLFGLLVAAGIAAGVGALV
ALPVLRLTGLYLALSTLAFGVLMDKLVFQADFAFGYNGTLHAERLSLLGREFSSTGGYVLVMTVFFVLMALGLLLLRRGA
LGRLLIAMRDSPAACGTLGLDMRWFRVALFGLSAGMAGLAGGLFAGLRGTIGAADFQLFNSLPLLLLAVVCGVTSVTGAA
LGGVGLMLLPVLQSSRPELAGLVFAVLGFGAVALGRDPNGLANLVFAFGRRLESRFGDRVRSVVPVLPLPGARVGDDSAT
AVPLADPGSGSVLIVPEHGPVPTTAAEAGPDPEPTQPPGHRAATAIEPSKEAPAHVR

Sequences:

>Translated_697_residues
MPAMTSILSFTILGLFTGAAYAIAASGLVLTYTTTRVFNIAHGAFGMVMAFTFWDFSQRQGMPTWLALTLVLGVVAPGIG
WFVQRFVTRGLGEGPVSVSLVVTVGLFVGLIGVAQYIWPPAPRTVPPFLPDDGIRIGSTYVTAHQVITIALSALVAAALY
VLLNRTRIGTAMRASVDNPVLLRLFGGRPDLVASLSWAIGISLAALAGILLTPVIGLSYYDLTLLVINAYAAAMLGRLKS
LPLTFVGAMGLGILQSFSVAYLPSEGNLAGLRAVVPALFLFVVIVAMPQAQLRIGQVKGIVSAPLPTFTKSLSWGAVLLV
LVALLTVTTGDADLLLVGTAATYAMVMLSLVLLTGYGGHVSLAQFTFAGVGALAYAKLDEPNLFGLLVAAGIAAGVGALV
ALPVLRLTGLYLALSTLAFGVLMDKLVFQADFAFGYNGTLHAERLSLLGREFSSTGGYVLVMTVFFVLMALGLLLLRRGA
LGRLLIAMRDSPAACGTLGLDMRWFRVALFGLSAGMAGLAGGLFAGLRGTIGAADFQLFNSLPLLLLAVVCGVTSVTGAA
LGGVGLMLLPVLQSSRPELAGLVFAVLGFGAVALGRDPNGLANLVFAFGRRLESRFGDRVRSVVPVLPLPGARVGDDSAT
AVPLADPGSGSVLIVPEHGPVPTTAAEAGPDPEPTQPPGHRAATAIEPSKEAPAHVR
>Mature_696_residues
PAMTSILSFTILGLFTGAAYAIAASGLVLTYTTTRVFNIAHGAFGMVMAFTFWDFSQRQGMPTWLALTLVLGVVAPGIGW
FVQRFVTRGLGEGPVSVSLVVTVGLFVGLIGVAQYIWPPAPRTVPPFLPDDGIRIGSTYVTAHQVITIALSALVAAALYV
LLNRTRIGTAMRASVDNPVLLRLFGGRPDLVASLSWAIGISLAALAGILLTPVIGLSYYDLTLLVINAYAAAMLGRLKSL
PLTFVGAMGLGILQSFSVAYLPSEGNLAGLRAVVPALFLFVVIVAMPQAQLRIGQVKGIVSAPLPTFTKSLSWGAVLLVL
VALLTVTTGDADLLLVGTAATYAMVMLSLVLLTGYGGHVSLAQFTFAGVGALAYAKLDEPNLFGLLVAAGIAAGVGALVA
LPVLRLTGLYLALSTLAFGVLMDKLVFQADFAFGYNGTLHAERLSLLGREFSSTGGYVLVMTVFFVLMALGLLLLRRGAL
GRLLIAMRDSPAACGTLGLDMRWFRVALFGLSAGMAGLAGGLFAGLRGTIGAADFQLFNSLPLLLLAVVCGVTSVTGAAL
GGVGLMLLPVLQSSRPELAGLVFAVLGFGAVALGRDPNGLANLVFAFGRRLESRFGDRVRSVVPVLPLPGARVGDDSATA
VPLADPGSGSVLIVPEHGPVPTTAAEAGPDPEPTQPPGHRAATAIEPSKEAPAHVR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=236, Percent_Identity=32.6271186440678, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 72154; Mature: 72023

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMTSILSFTILGLFTGAAYAIAASGLVLTYTTTRVFNIAHGAFGMVMAFTFWDFSQRQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCHHHHC
GMPTWLALTLVLGVVAPGIGWFVQRFVTRGLGEGPVSVSLVVTVGLFVGLIGVAQYIWPP
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
APRTVPPFLPDDGIRIGSTYVTAHQVITIALSALVAAALYVLLNRTRIGTAMRASVDNPV
CCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCE
LLRLFGGRPDLVASLSWAIGISLAALAGILLTPVIGLSYYDLTLLVINAYAAAMLGRLKS
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHC
LPLTFVGAMGLGILQSFSVAYLPSEGNLAGLRAVVPALFLFVVIVAMPQAQLRIGQVKGI
CCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VSAPLPTFTKSLSWGAVLLVLVALLTVTTGDADLLLVGTAATYAMVMLSLVLLTGYGGHV
HHCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCC
SLAQFTFAGVGALAYAKLDEPNLFGLLVAAGIAAGVGALVALPVLRLTGLYLALSTLAFG
HHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLMDKLVFQADFAFGYNGTLHAERLSLLGREFSSTGGYVLVMTVFFVLMALGLLLLRRGA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LGRLLIAMRDSPAACGTLGLDMRWFRVALFGLSAGMAGLAGGLFAGLRGTIGAADFQLFN
HHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SLPLLLLAVVCGVTSVTGAALGGVGLMLLPVLQSSRPELAGLVFAVLGFGAVALGRDPNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCCH
LANLVFAFGRRLESRFGDRVRSVVPVLPLPGARVGDDSATAVPLADPGSGSVLIVPEHGP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCC
VPTTAAEAGPDPEPTQPPGHRAATAIEPSKEAPAHVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAMTSILSFTILGLFTGAAYAIAASGLVLTYTTTRVFNIAHGAFGMVMAFTFWDFSQRQ
CHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCHHHHC
GMPTWLALTLVLGVVAPGIGWFVQRFVTRGLGEGPVSVSLVVTVGLFVGLIGVAQYIWPP
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
APRTVPPFLPDDGIRIGSTYVTAHQVITIALSALVAAALYVLLNRTRIGTAMRASVDNPV
CCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCE
LLRLFGGRPDLVASLSWAIGISLAALAGILLTPVIGLSYYDLTLLVINAYAAAMLGRLKS
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHC
LPLTFVGAMGLGILQSFSVAYLPSEGNLAGLRAVVPALFLFVVIVAMPQAQLRIGQVKGI
CCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VSAPLPTFTKSLSWGAVLLVLVALLTVTTGDADLLLVGTAATYAMVMLSLVLLTGYGGHV
HHCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCC
SLAQFTFAGVGALAYAKLDEPNLFGLLVAAGIAAGVGALVALPVLRLTGLYLALSTLAFG
HHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLMDKLVFQADFAFGYNGTLHAERLSLLGREFSSTGGYVLVMTVFFVLMALGLLLLRRGA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LGRLLIAMRDSPAACGTLGLDMRWFRVALFGLSAGMAGLAGGLFAGLRGTIGAADFQLFN
HHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SLPLLLLAVVCGVTSVTGAALGGVGLMLLPVLQSSRPELAGLVFAVLGFGAVALGRDPNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCCH
LANLVFAFGRRLESRFGDRVRSVVPVLPLPGARVGDDSATAVPLADPGSGSVLIVPEHGP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCC
VPTTAAEAGPDPEPTQPPGHRAATAIEPSKEAPAHVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]